ES8800601A1 - Un procedimiento para preparar una formulacion farmaceutica liofilizada de activador de plasminogeno de tejidro (t-pa) - Google Patents
Un procedimiento para preparar una formulacion farmaceutica liofilizada de activador de plasminogeno de tejidro (t-pa)Info
- Publication number
- ES8800601A1 ES8800601A1 ES555353A ES555353A ES8800601A1 ES 8800601 A1 ES8800601 A1 ES 8800601A1 ES 555353 A ES555353 A ES 555353A ES 555353 A ES555353 A ES 555353A ES 8800601 A1 ES8800601 A1 ES 8800601A1
- Authority
- ES
- Spain
- Prior art keywords
- pharmaceutical formulation
- plasminogen activator
- tissue plasminogen
- preparing
- procedure
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 102000003978 Tissue Plasminogen Activator Human genes 0.000 title abstract 3
- 108090000373 Tissue Plasminogen Activator Proteins 0.000 title abstract 3
- 229960000187 tissue plasminogen activator Drugs 0.000 title abstract 3
- 238000000034 method Methods 0.000 title abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- 239000007864 aqueous solution Substances 0.000 abstract 1
- 238000001035 drying Methods 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6424—Serine endopeptidases (3.4.21)
- C12N9/6456—Plasminogen activators
- C12N9/6459—Plasminogen activators t-plasminogen activator (3.4.21.68), i.e. tPA
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/21—Serine endopeptidases (3.4.21)
- C12Y304/21069—Protein C activated (3.4.21.69)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- General Health & Medical Sciences (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Biomedical Technology (AREA)
- Medicinal Chemistry (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Molecular Biology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Diabetes (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Hematology (AREA)
- Veterinary Medicine (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Peptides Or Proteins (AREA)
- Enzymes And Modification Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB858513358A GB8513358D0 (en) | 1985-05-28 | 1985-05-28 | Formulation |
| GB858521705A GB8521705D0 (en) | 1985-08-31 | 1985-08-31 | Formulation |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES8800601A1 true ES8800601A1 (es) | 1987-11-16 |
| ES555353A0 ES555353A0 (es) | 1987-11-16 |
Family
ID=26289290
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES555353A Expired ES8800601A1 (es) | 1985-05-28 | 1986-05-27 | Un procedimiento para preparar una formulacion farmaceutica liofilizada de activador de plasminogeno de tejidro (t-pa) |
| ES557374A Expired ES8802439A1 (es) | 1985-05-28 | 1987-02-10 | Un procedimiento para preparar una sal fisiologicamente aceptable de activador de plasminogeno de tejido (t-pa). |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES557374A Expired ES8802439A1 (es) | 1985-05-28 | 1987-02-10 | Un procedimiento para preparar una sal fisiologicamente aceptable de activador de plasminogeno de tejido (t-pa). |
Country Status (22)
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PT82647B (pt) * | 1985-05-28 | 1989-01-30 | Wellcome Found | Processo para a preparacao de uma solucao parenteral aquosa de activador de plasminogeneo de tecido |
| ZW14486A1 (en) * | 1985-07-29 | 1986-10-22 | Smithkline Beckman Corp | Pharmaceutical dosage unit |
| US4777043A (en) * | 1985-12-17 | 1988-10-11 | Genentech, Inc. | Stabilized human tissue plasminogen activator compositions |
| US5034225A (en) * | 1985-12-17 | 1991-07-23 | Genentech Inc. | Stabilized human tissue plasminogen activator compositions |
| US4976959A (en) * | 1986-05-12 | 1990-12-11 | Burroughs Wellcome Co. | T-PA and SOD in limiting tissue damage |
| LU86875A1 (fr) * | 1986-05-12 | 1988-01-20 | Wellcome Found | Utilisation de l'activateur tissulaire du plasminogene,son association avec une superoxyde-dismutase et formulation pharmaceutique contenant cette association |
| GB8619098D0 (en) * | 1986-08-05 | 1986-09-17 | Wellcome Found | Combination |
| US5270198A (en) * | 1988-05-20 | 1993-12-14 | Genentech, Inc. | DNA molecules encoding variants of tissue plasminogen activators, vectors, and host cells |
| US5342616A (en) * | 1988-06-20 | 1994-08-30 | The Wellcome Foundation Limited | Method of administering tissue plasminogen activator |
| US5714145A (en) * | 1988-09-02 | 1998-02-03 | Genentech, Inc. | Tissue plasminogen activator having zymogenic or fibrin specific properties |
| US5262170A (en) * | 1988-09-02 | 1993-11-16 | Genentech, Inc. | Tissue plasminogen activator having zymogenic or fibrin specific properties and substituted at amino acid positions 296-299, DNA molecules encoding them, vectors, and host cells |
| DE3835350A1 (de) * | 1988-10-17 | 1990-04-19 | Boehringer Mannheim Gmbh | Aktivierung von gentechnologisch hergestellten, in prokaryonten exprimierten antikoerpern |
| US4980165A (en) * | 1989-01-27 | 1990-12-25 | Genetics Institute, Inc. | Pharmaceutical formulations of plasminogen activator proteins |
| DE3942142A1 (de) * | 1989-12-20 | 1991-06-27 | Boehringer Mannheim Gmbh | Stabilisierung von glykosyliertem t-pa |
| WO1992011866A1 (en) * | 1991-01-14 | 1992-07-23 | Duke University | LAMININ SEQUENCE AS tPA ACTIVATOR |
| ES2203668T3 (es) * | 1992-06-03 | 2004-04-16 | Genentech, Inc. | Variantes de glicosilacion del activador de plasminogeno de tejido con propiedades terapeuticas mejoradas. |
| KR19990066981A (ko) * | 1995-10-23 | 1999-08-16 | 윌리엄 뉴우 | 치료용 맥관형성억제 조성물 및 방법 |
| US6346510B1 (en) | 1995-10-23 | 2002-02-12 | The Children's Medical Center Corporation | Therapeutic antiangiogenic endostatin compositions |
| JP3684371B2 (ja) * | 1995-12-13 | 2005-08-17 | ザ チルドレンズ メディカル センター コーポレイション | 内皮細胞増殖阻害剤およびその使用法 |
| US6139838A (en) * | 1996-09-06 | 2000-10-31 | Juridical Foundation The Chemo-Sero-Therapeutic Research Institute | Tissue plasminogen activator medicinal composition |
| US20030077682A1 (en) * | 2001-09-07 | 2003-04-24 | Hung Paul Porwen | Human tissue urokinase type plasminogen activator formulation |
| US20040091465A1 (en) * | 2002-06-26 | 2004-05-13 | Zachary Yim | Therapeutic antiangiogenic compositions and methods |
| EP1636337A4 (en) * | 2003-06-20 | 2007-07-04 | Illumina Inc | METHODS AND COMPOSITIONS USEFUL FOR THE AMPLIFICATION AND GENOTYPING OF THE GENOME |
| US7491263B2 (en) * | 2004-04-05 | 2009-02-17 | Technology Innovation, Llc | Storage assembly |
| AU2006236150A1 (en) * | 2005-04-20 | 2006-10-26 | Fred Hutchinson Cancer Research Center | Methods, compositions and articles of manufacture for enhancing survivability of cells, tissues, organs, and organisms |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3998947A (en) * | 1973-11-30 | 1976-12-21 | Pierre Fabre S.A. | Process for obtaining a plasminogen activator |
| FR2252842B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) * | 1973-12-03 | 1977-11-04 | Fabre Sa Pierre | |
| DE3015699C2 (de) * | 1979-04-26 | 1982-07-15 | Asahi Kasei Kogyo K.K., Osaka | Herstellung eines Plasminogen-Aktivators |
| US4766075A (en) * | 1982-07-14 | 1988-08-23 | Genentech, Inc. | Human tissue plasminogen activator |
| JPS5951220A (ja) * | 1982-08-02 | 1984-03-24 | Asahi Chem Ind Co Ltd | 新規なプラスミノ−ゲン・アクチベ−タ−およびその製法ならびにこれを含有する薬剤 |
| EP0124613B1 (en) * | 1982-10-29 | 1992-12-30 | MITSUI TOATSU CHEMICALS, Inc. | Novel plasminogen activator derived from human kidneys, process for its preparation, and thrombolytic drug containing the same |
| AU554862B2 (en) * | 1982-12-14 | 1986-09-04 | Implico B.V. | Plasminogen activator isolated by affinity chromatography |
| NZ206699A (en) * | 1982-12-30 | 1989-08-29 | Bio Response Inc | Process for the production of serum independent cell lines |
| JPS59196824A (ja) * | 1983-04-21 | 1984-11-08 | Kowa Co | 吸着防止剤 |
| DE3584902D1 (de) * | 1984-02-29 | 1992-01-30 | Asahi Chemical Ind | Waessrige loesung eines darin in erhoehter konzentration aufgeloesten gewebe-plasminogen-aktivators und herstellungsverfahren. |
| DE3439980A1 (de) * | 1984-11-02 | 1986-05-07 | Behringwerke Ag, 3550 Marburg | Verfahren zur reinigung sowie pasteurisierung von urokinase |
| EP0201153A3 (en) * | 1985-02-09 | 1987-10-07 | Beecham Group Plc | Modified enzyme and process for its preparation |
| GB8513358D0 (en) * | 1985-05-28 | 1985-07-03 | Wellcome Found | Formulation |
| ZW14486A1 (en) * | 1985-07-29 | 1986-10-22 | Smithkline Beckman Corp | Pharmaceutical dosage unit |
| JPH0672105B2 (ja) * | 1985-10-02 | 1994-09-14 | 持田製薬株式会社 | 血栓溶解剤及びその製法 |
-
1986
- 1986-05-13 US US06/862,817 patent/US4929444A/en not_active Expired - Lifetime
- 1986-05-27 FI FI862227A patent/FI85335C/fi not_active IP Right Cessation
- 1986-05-27 LU LU86444A patent/LU86444A1/fr unknown
- 1986-05-27 CH CH2126/86A patent/CH665356A5/de not_active IP Right Cessation
- 1986-05-27 DK DK246786A patent/DK163173C/da not_active IP Right Cessation
- 1986-05-27 CA CA000510097A patent/CA1300008C/en not_active Expired - Fee Related
- 1986-05-27 HU HU862234A patent/HU195733B/hu not_active IP Right Cessation
- 1986-05-27 IT IT48065/86A patent/IT1191926B/it active
- 1986-05-27 PT PT82646A patent/PT82646B/pt not_active IP Right Cessation
- 1986-05-27 SE SE8602405A patent/SE462016B/sv not_active IP Right Cessation
- 1986-05-27 ES ES555353A patent/ES8800601A1/es not_active Expired
- 1986-05-27 FR FR8607552A patent/FR2583984B1/fr not_active Expired
- 1986-05-27 GR GR861366A patent/GR861366B/el unknown
- 1986-05-27 GB GB8612780A patent/GB2176702B/en not_active Expired
- 1986-05-27 NO NO862096A patent/NO171345C/no unknown
- 1986-05-27 BE BE0/216711A patent/BE904830A/fr not_active IP Right Cessation
- 1986-05-27 NZ NZ216307A patent/NZ216307A/xx unknown
- 1986-05-27 DE DE19863617752 patent/DE3617752A1/de active Granted
- 1986-05-27 IL IL78938A patent/IL78938A/xx not_active IP Right Cessation
- 1986-05-27 AU AU57964/86A patent/AU567236B2/en not_active Ceased
- 1986-05-27 NL NL8601355A patent/NL8601355A/nl not_active Application Discontinuation
-
1987
- 1987-02-10 ES ES557374A patent/ES8802439A1/es not_active Expired
-
1988
- 1988-07-29 US US07/226,422 patent/US4968617A/en not_active Expired - Lifetime
-
1993
- 1993-09-16 JP JP5230427A patent/JPH0759517B2/ja not_active Expired - Lifetime
Also Published As
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD1A | Patent lapsed |
Effective date: 19971001 |