ES8704449A1 - Procedimiento para preparar a escala industrial hidrocloruro de 7-fenil-i-dietilamino-carbonil-2-aminometil-ciclopropano (z) - Google Patents

Procedimiento para preparar a escala industrial hidrocloruro de 7-fenil-i-dietilamino-carbonil-2-aminometil-ciclopropano (z)

Info

Publication number
ES8704449A1
ES8704449A1 ES554321A ES554321A ES8704449A1 ES 8704449 A1 ES8704449 A1 ES 8704449A1 ES 554321 A ES554321 A ES 554321A ES 554321 A ES554321 A ES 554321A ES 8704449 A1 ES8704449 A1 ES 8704449A1
Authority
ES
Spain
Prior art keywords
phenyl
formula
preparation
see diagramm
methyl cyclopropane
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES554321A
Other languages
English (en)
Other versions
ES554321A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pierre Fabre Medicament SA
Original Assignee
Pierre Fabre Medicament SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=9318686&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES8704449(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Pierre Fabre Medicament SA filed Critical Pierre Fabre Medicament SA
Publication of ES8704449A1 publication Critical patent/ES8704449A1/es
Publication of ES554321A0 publication Critical patent/ES554321A0/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/24—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/12—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by halogen atoms or by nitro or nitroso groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Indole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Furan Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE UN COMPUESTO DE FORMULA (I). COMPRENDE LA REACCION DE APERTURA DE ANILLO DEL 1-FENIL-2-OXO-3-OXABICICLO(3:1:0)HEXANO, POR TRATAMIENTO CON UNA SAL FTALIMIDA, EN UN DISOLVENTE ORGANICO; SEGUIDA DE LA REACCION DEL COMPUESTO FORMADO CON UN CLORURO DE ACIDO Y CONDENSACION CON DIETILAMINA; TRATAMIENTO CON UNA HIDROXIALQUILAMINA PRIMARIA; Y FINALMENTE HIDROCLORURACION DEL COMPUESTO OBTENIDO. ESTE COMPUESTO TIENE APLICACIONES FARMACOLOGICAS COMO ANTIDEPRESOR.
ES554321A 1985-04-25 1986-04-24 Procedimiento para preparar a escala industrial hidrocloruro de 7-fenil-i-dietilamino-carbonil-2-aminometil-ciclopropano (z) Expired ES8704449A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR8506335A FR2581059B1 (fr) 1985-04-25 1985-04-25 Procede de preparation du chlorhydrate de phenyl-1 diethyl amino carbonyl-1 aminomethyl-2 cyclopropane (z)

Publications (2)

Publication Number Publication Date
ES8704449A1 true ES8704449A1 (es) 1987-04-01
ES554321A0 ES554321A0 (es) 1987-04-01

Family

ID=9318686

Family Applications (1)

Application Number Title Priority Date Filing Date
ES554321A Expired ES8704449A1 (es) 1985-04-25 1986-04-24 Procedimiento para preparar a escala industrial hidrocloruro de 7-fenil-i-dietilamino-carbonil-2-aminometil-ciclopropano (z)

Country Status (23)

Country Link
EP (1) EP0200638B1 (es)
JP (1) JPS61251650A (es)
KR (1) KR940006764B1 (es)
AR (1) AR240695A1 (es)
AT (1) ATE42273T1 (es)
AU (1) AU587613B2 (es)
CA (1) CA1266486A (es)
DE (1) DE3662877D1 (es)
DK (1) DK170888B1 (es)
ES (1) ES8704449A1 (es)
FI (1) FI87196C (es)
FR (1) FR2581059B1 (es)
GE (1) GEP19970789B (es)
GR (1) GR860980B (es)
HU (1) HU195182B (es)
IE (1) IE59015B1 (es)
MX (1) MX162896B (es)
NO (1) NO165143C (es)
OA (1) OA08241A (es)
PT (1) PT82461B (es)
SU (1) SU1443797A3 (es)
YU (1) YU44915B (es)
ZA (1) ZA862929B (es)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2640972B1 (es) * 1988-12-28 1991-04-19 Pf Medicament
EP0747348A4 (en) * 1994-02-22 1999-07-07 Asahi Chemical Ind AMINOALKYLCYCLOPROPAN DERIVATIVES
FR2752732B1 (fr) * 1996-08-28 1998-11-20 Pf Medicament Forme galenique a liberation prolongee de milnacipran
JP4418717B2 (ja) * 2004-06-24 2010-02-24 住友化学株式会社 （ｚ）−１−フェニル−１−ジエチルアミノカルボニル−２−アミノメチルシクロプロパン塩酸塩の製造方法
JP4828863B2 (ja) * 2005-01-28 2011-11-30 住友化学株式会社 （ｚ）−１−フェニル−１−（ｎ，ｎ−ジエチルアミノカルボニル）−２−フタルイミドメチルシクロプロパンの製造方法
CA2611724C (en) 2005-06-10 2014-07-29 Pierre Fabre Medicament S.A. Stabilized milnacipran formulation
KR100772244B1 (ko) * 2005-07-20 2007-11-01 안국약품 주식회사 밀나시프란염산염의 제조방법
JP5338035B2 (ja) * 2006-04-17 2013-11-13 住友化学株式会社 多環式ラクタム類の製造方法
EP2014647A4 (en) * 2006-04-17 2010-09-08 Sumitomo Chemical Co METHOD FOR THE PRODUCTION OF POLYCYCLIC LACTAM
WO2008104957A2 (en) * 2007-02-28 2008-09-04 Ranbaxy Laboratories Limited Novel polymorphic forms of milnacipran hydrochloride
FR2941454B1 (fr) 2009-01-29 2011-04-01 Pf Medicament Proced de synthese du (1s,2r)-milnacipran
US20100274050A1 (en) * 2009-04-23 2010-10-28 Glenmark Generics Limited Solid milnacipran and process for the preparation of the same
EP2699539B1 (en) 2011-04-21 2019-03-06 Emory University Cyclopropyl derivatives and methods of use
CN103242289B (zh) * 2012-02-03 2015-01-07 暨明医药科技（苏州）有限公司 N,n-二烯丙基-(1r, 2r)-2-胺甲基-1-(2-噻吩)环丙烷酰胺盐酸盐的制备方法
WO2014009767A1 (en) 2012-07-07 2014-01-16 Micro Labs Limited An improved process for the preparation of 1-aryl 2-aminomethyl cyclopropane carboxyamide (z) derivatives, their isomers and salts
JP2015534464A (ja) 2012-10-09 2015-12-03 カリフォルニア インスティチュート オブ テクノロジー ヘム酵素によって触媒されるインビボおよびインビトロオレフィンシクロプロパン化
FR2998892B1 (fr) * 2012-12-04 2015-01-02 Pf Medicament Derives d'aminocyclobutane, leur procede de preparation et leur utilisation a titre de medicaments
CN103613513B (zh) * 2013-12-09 2016-01-20 上海现代制药股份有限公司 盐酸米那普仑中间体及其制备方法和应用
US9399762B2 (en) 2014-02-18 2016-07-26 California Institute Of Technology Methods and systems for sulfimidation or sulfoximidation of organic molecules
CN104058992A (zh) * 2014-06-13 2014-09-24 上海现代制药股份有限公司 左旋米那普仑盐酸盐的晶型
US10131624B2 (en) 2014-11-04 2018-11-20 Quimica Sintetica, S.A. Process for the preparation of (1S,2R)-Milnacipran

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2508035A1 (fr) * 1981-06-23 1982-12-24 Fabre Sa Pierre Derives d'aryl-1-aminomethyl-2 cyclopropanes carboxamides (z), leur preparation et leur application en tant que medicaments utiles dans le traitement des troubles du systeme nerveux central

Also Published As

Publication number Publication date
IE861057L (en) 1986-10-25
KR860008126A (ko) 1986-11-12
JPS61251650A (ja) 1986-11-08
YU65586A (en) 1987-12-31
EP0200638A1 (fr) 1986-11-05
HUT40618A (en) 1987-01-28
DK170888B1 (da) 1996-03-04
OA08241A (fr) 1987-10-30
PT82461B (pt) 1988-10-14
AR240695A1 (es) 1990-09-28
FR2581059A1 (fr) 1986-10-31
KR940006764B1 (ko) 1994-07-27
HU195182B (en) 1988-04-28
NO861573L (no) 1986-10-27
SU1443797A3 (ru) 1988-12-07
NO165143B (no) 1990-09-24
FI87196C (fi) 1992-12-10
PT82461A (fr) 1986-05-01
FI87196B (fi) 1992-08-31
ES554321A0 (es) 1987-04-01
AU587613B2 (en) 1989-08-24
IE59015B1 (en) 1993-12-15
ZA862929B (en) 1986-12-30
GR860980B (en) 1986-08-25
FI861755A (fi) 1986-10-26
YU44915B (en) 1991-04-30
DK191286D0 (da) 1986-04-24
FI861755A0 (fi) 1986-04-25
GEP19970789B (en) 1997-01-28
FR2581059B1 (fr) 1988-04-22
MX162896B (es) 1991-07-08
AU5634386A (en) 1986-10-30
DE3662877D1 (en) 1989-05-24
JPH0567136B2 (es) 1993-09-24
DK191286A (da) 1986-10-26
CA1266486A (fr) 1990-03-06
EP0200638B1 (fr) 1989-04-19
ATE42273T1 (de) 1989-05-15
NO165143C (no) 1991-01-09

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Effective date: 20151230