FI861755A - Foerfarande foer framstaellning av hydroklorid av 1-fenyl-1-dietylaminokarbonyl- 2-aminometylcyklopropan (z). - Google Patents

Foerfarande foer framstaellning av hydroklorid av 1-fenyl-1-dietylaminokarbonyl- 2-aminometylcyklopropan (z). Download PDF

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Publication number
FI861755A
FI861755A FI861755A FI861755A FI861755A FI 861755 A FI861755 A FI 861755A FI 861755 A FI861755 A FI 861755A FI 861755 A FI861755 A FI 861755A FI 861755 A FI861755 A FI 861755A
Authority
FI
Finland
Prior art keywords
aminomethylcyclopropan
hydrochlorid
diethylaminocarbonyl
phenyl
foerfarande foer
Prior art date
Application number
FI861755A
Other languages
English (en)
Other versions
FI861755A0 (fi
FI87196C (fi
FI87196B (fi
Inventor
Bernard Bonnaud
Henri Cousse
Gilbert Mouzin
Jean-Francois Patoiseau
Original Assignee
Pf Medicament
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
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Application filed by Pf Medicament filed Critical Pf Medicament
Publication of FI861755A0 publication Critical patent/FI861755A0/fi
Publication of FI861755A publication Critical patent/FI861755A/fi
Application granted granted Critical
Publication of FI87196B publication Critical patent/FI87196B/fi
Publication of FI87196C publication Critical patent/FI87196C/fi

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Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/24Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring of the carbon skeleton
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00Carboxylic acid amides
    • C07C233/01Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/12Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by halogen atoms or by nitro or nitroso groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Indole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Furan Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
FI861755A 1985-04-25 1986-04-25 Foerfarande foer framstaellning av (z)-1-fenyl-1-dietylaminokarbonyl-2-aminometylcyklopropan hydroklorid FI87196C (fi)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR8506335A FR2581059B1 (fr) 1985-04-25 1985-04-25 Procede de preparation du chlorhydrate de phenyl-1 diethyl amino carbonyl-1 aminomethyl-2 cyclopropane (z)
FR8506335 1985-04-25

Publications (4)

Publication Number Publication Date
FI861755A0 FI861755A0 (fi) 1986-04-25
FI861755A true FI861755A (fi) 1986-10-26
FI87196B FI87196B (fi) 1992-08-31
FI87196C FI87196C (fi) 1992-12-10

Family

ID=9318686

Family Applications (1)

Application Number Title Priority Date Filing Date
FI861755A FI87196C (fi) 1985-04-25 1986-04-25 Foerfarande foer framstaellning av (z)-1-fenyl-1-dietylaminokarbonyl-2-aminometylcyklopropan hydroklorid

Country Status (23)

Country Link
EP (1) EP0200638B1 (fi)
JP (1) JPS61251650A (fi)
KR (1) KR940006764B1 (fi)
AR (1) AR240695A1 (fi)
AT (1) ATE42273T1 (fi)
AU (1) AU587613B2 (fi)
CA (1) CA1266486A (fi)
DE (1) DE3662877D1 (fi)
DK (1) DK170888B1 (fi)
ES (1) ES8704449A1 (fi)
FI (1) FI87196C (fi)
FR (1) FR2581059B1 (fi)
GE (1) GEP19970789B (fi)
GR (1) GR860980B (fi)
HU (1) HU195182B (fi)
IE (1) IE59015B1 (fi)
MX (1) MX162896B (fi)
NO (1) NO165143C (fi)
OA (1) OA08241A (fi)
PT (1) PT82461B (fi)
SU (1) SU1443797A3 (fi)
YU (1) YU44915B (fi)
ZA (1) ZA862929B (fi)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2640972B1 (fi) * 1988-12-28 1991-04-19 Pf Medicament
US5621142A (en) * 1994-02-22 1997-04-15 Asahi Kasei Kogyo Kabushiki Kaisha Aminoalkylcyclopropane derivatives
FR2752732B1 (fr) * 1996-08-28 1998-11-20 Pf Medicament Forme galenique a liberation prolongee de milnacipran
JP4418717B2 (ja) * 2004-06-24 2010-02-24 住友化学株式会社 (z)−1−フェニル−1−ジエチルアミノカルボニル−2−アミノメチルシクロプロパン塩酸塩の製造方法
JP4828863B2 (ja) 2005-01-28 2011-11-30 住友化学株式会社 (z)−1−フェニル−1−(n,n−ジエチルアミノカルボニル)−2−フタルイミドメチルシクロプロパンの製造方法
CA2611724C (en) 2005-06-10 2014-07-29 Pierre Fabre Medicament S.A. Stabilized milnacipran formulation
KR100772244B1 (ko) * 2005-07-20 2007-11-01 안국약품 주식회사 밀나시프란염산염의 제조방법
JP5338035B2 (ja) * 2006-04-17 2013-11-13 住友化学株式会社 多環式ラクタム類の製造方法
SG160363A1 (en) * 2006-04-17 2010-04-29 Sumitomo Chemical Company Limt Ester of cyclic carboxylic acid
WO2008104957A2 (en) * 2007-02-28 2008-09-04 Ranbaxy Laboratories Limited Novel polymorphic forms of milnacipran hydrochloride
FR2941454B1 (fr) 2009-01-29 2011-04-01 Pf Medicament Proced de synthese du (1s,2r)-milnacipran
US20100274050A1 (en) * 2009-04-23 2010-10-28 Glenmark Generics Limited Solid milnacipran and process for the preparation of the same
EP2699539B1 (en) 2011-04-21 2019-03-06 Emory University Cyclopropyl derivatives and methods of use
CN103242289B (zh) * 2012-02-03 2015-01-07 暨明医药科技(苏州)有限公司 N,n-二烯丙基-(1r, 2r)-2-胺甲基-1-(2-噻吩)环丙烷酰胺盐酸盐的制备方法
WO2014009767A1 (en) 2012-07-07 2014-01-16 Micro Labs Limited An improved process for the preparation of 1-aryl 2-aminomethyl cyclopropane carboxyamide (z) derivatives, their isomers and salts
EP2906518A4 (en) 2012-10-09 2016-07-27 California Inst Of Techn CYCLOPROPANATION OF OLEFIN IN VIVO AND IN VITRO CATALYZED BY ENZYMES HEMMES
FR2998892B1 (fr) * 2012-12-04 2015-01-02 Pf Medicament Derives d'aminocyclobutane, leur procede de preparation et leur utilisation a titre de medicaments
CN103613513B (zh) * 2013-12-09 2016-01-20 上海现代制药股份有限公司 盐酸米那普仑中间体及其制备方法和应用
US9399762B2 (en) 2014-02-18 2016-07-26 California Institute Of Technology Methods and systems for sulfimidation or sulfoximidation of organic molecules
CN104058992A (zh) * 2014-06-13 2014-09-24 上海现代制药股份有限公司 左旋米那普仑盐酸盐的晶型
CA2966437A1 (en) 2014-11-04 2016-05-12 Quimica Sintetica, S.A. Process for the preparation of (1s,2r)-milnacipran

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2508035A1 (fr) * 1981-06-23 1982-12-24 Fabre Sa Pierre Derives d'aryl-1-aminomethyl-2 cyclopropanes carboxamides (z), leur preparation et leur application en tant que medicaments utiles dans le traitement des troubles du systeme nerveux central

Also Published As

Publication number Publication date
AU5634386A (en) 1986-10-30
YU44915B (en) 1991-04-30
GR860980B (en) 1986-08-25
HU195182B (en) 1988-04-28
ES554321A0 (es) 1987-04-01
HUT40618A (en) 1987-01-28
ATE42273T1 (de) 1989-05-15
FI861755A0 (fi) 1986-04-25
IE59015B1 (en) 1993-12-15
MX162896B (es) 1991-07-08
ES8704449A1 (es) 1987-04-01
AR240695A1 (es) 1990-09-28
DE3662877D1 (en) 1989-05-24
JPH0567136B2 (fi) 1993-09-24
AU587613B2 (en) 1989-08-24
NO861573L (no) 1986-10-27
FR2581059B1 (fr) 1988-04-22
NO165143B (no) 1990-09-24
DK191286D0 (da) 1986-04-24
FI87196C (fi) 1992-12-10
PT82461B (pt) 1988-10-14
IE861057L (en) 1986-10-25
EP0200638B1 (fr) 1989-04-19
YU65586A (en) 1987-12-31
FR2581059A1 (fr) 1986-10-31
SU1443797A3 (ru) 1988-12-07
PT82461A (fr) 1986-05-01
DK170888B1 (da) 1996-03-04
OA08241A (fr) 1987-10-30
KR860008126A (ko) 1986-11-12
GEP19970789B (en) 1997-01-28
DK191286A (da) 1986-10-26
EP0200638A1 (fr) 1986-11-05
CA1266486A (fr) 1990-03-06
JPS61251650A (ja) 1986-11-08
FI87196B (fi) 1992-08-31
ZA862929B (en) 1986-12-30
KR940006764B1 (ko) 1994-07-27
NO165143C (no) 1991-01-09

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Legal Events

Date Code Title Description
SPCG Supplementary protection certificate granted

Spc suppl protection certif: L139

Extension date: 20090224

FG Patent granted

Owner name: P. F. MEDICAMENT

MA Patent expired