IE861057L - Preparation of midalcipran - Google Patents

Preparation of midalcipran

Info

Publication number
IE861057L
IE861057L IE861057A IE105786A IE861057L IE 861057 L IE861057 L IE 861057L IE 861057 A IE861057 A IE 861057A IE 105786 A IE105786 A IE 105786A IE 861057 L IE861057 L IE 861057L
Authority
IE
Ireland
Prior art keywords
formula
phenyl
see diagramm
phthalimidomethylcyclopropane
diethylaminocarbonyl
Prior art date
Application number
IE861057A
Other versions
IE59015B1 (en
Original Assignee
Pf Medicament
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=9318686&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=IE861057(L) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Pf Medicament filed Critical Pf Medicament
Publication of IE861057L publication Critical patent/IE861057L/en
Publication of IE59015B1 publication Critical patent/IE59015B1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/24—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/12—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by halogen atoms or by nitro or nitroso groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Indole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Furan Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

1. Process for the industrial preparation of (Z)-1-phenyl-1-diethylaminocarbonyl-2- aminomethylcyclopropane of formula I : see diagramm : EP0200638,P7,F2 characterized by the use of the following successive reaction steps : i) 1-phenyl-2-oxo-3-oxa(3: 1: 0) bicyclohexane of formula II : see diagramm : EP0200638,P8,F1 is opened by treatment with a phthalimide salt in an organic solvent ; ii) (Z)-1-phenyl-2-phthalimidomethylcyclopropane-carboxylic acid of formula III thus obtained see diagramm : EP0200638,P8,F2 is treated with an acid chloride, and then the acid chloride thus formed is amidified by condensation with diethylamine in an organic solvent ; and iii) (Z)-1-phenyl-1-diethylaminocarbonyl-2- phthalimidomethylcyclopropane of formula IV thus obtained : see diagramm : EP0200638,P8,F3 is then treated with an alkylamine or a primary hydroxyalkylamine by itself or in the presence of a solvent to obtain, after hydrochlorination, the compound of abovementioned formula I. [EP0200638A1]
IE105786A 1985-04-25 1986-04-21 Process for preparing (z)-1-phenyl-1-diethyl amino carbonyl-2-aminomethylcyclopropanehydrochloride IE59015B1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR8506335A FR2581059B1 (en) 1985-04-25 1985-04-25 PROCESS FOR THE PREPARATION OF PHENYL-1 HYDROCHLORIDE DIETHYL AMINO CARBONYL-1 AMINOMETHYL-2 CYCLOPROPANE (Z)

Publications (2)

Publication Number Publication Date
IE861057L true IE861057L (en) 1986-10-25
IE59015B1 IE59015B1 (en) 1993-12-15

Family

ID=9318686

Family Applications (1)

Application Number Title Priority Date Filing Date
IE105786A IE59015B1 (en) 1985-04-25 1986-04-21 Process for preparing (z)-1-phenyl-1-diethyl amino carbonyl-2-aminomethylcyclopropanehydrochloride

Country Status (23)

Country Link
EP (1) EP0200638B1 (en)
JP (1) JPS61251650A (en)
KR (1) KR940006764B1 (en)
AR (1) AR240695A1 (en)
AT (1) ATE42273T1 (en)
AU (1) AU587613B2 (en)
CA (1) CA1266486A (en)
DE (1) DE3662877D1 (en)
DK (1) DK170888B1 (en)
ES (1) ES8704449A1 (en)
FI (1) FI87196C (en)
FR (1) FR2581059B1 (en)
GE (1) GEP19970789B (en)
GR (1) GR860980B (en)
HU (1) HU195182B (en)
IE (1) IE59015B1 (en)
MX (1) MX162896B (en)
NO (1) NO165143C (en)
OA (1) OA08241A (en)
PT (1) PT82461B (en)
SU (1) SU1443797A3 (en)
YU (1) YU44915B (en)
ZA (1) ZA862929B (en)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2640972B1 (en) * 1988-12-28 1991-04-19 Pf Medicament
EP0747348A4 (en) * 1994-02-22 1999-07-07 Asahi Chemical Ind Aminoalkylcyclopropane derivative
FR2752732B1 (en) * 1996-08-28 1998-11-20 Pf Medicament EXTENDED RELEASE GALENIC FORM OF MILNACIPRAN
JP4418717B2 (en) * 2004-06-24 2010-02-24 住友化学株式会社 Process for producing (Z) -1-phenyl-1-diethylaminocarbonyl-2-aminomethylcyclopropane hydrochloride
JP4828863B2 (en) * 2005-01-28 2011-11-30 住友化学株式会社 Process for producing (Z) -1-phenyl-1- (N, N-diethylaminocarbonyl) -2-phthalimidomethylcyclopropane
CA2611724C (en) 2005-06-10 2014-07-29 Pierre Fabre Medicament S.A. Stabilized milnacipran formulation
KR100772244B1 (en) * 2005-07-20 2007-11-01 안국약품 주식회사 Method for the preparation of milnacipran hydrogen chloride salt
JP5338035B2 (en) * 2006-04-17 2013-11-13 住友化学株式会社 Process for producing polycyclic lactams
EP2014647A4 (en) * 2006-04-17 2010-09-08 Sumitomo Chemical Co Process for producing polycyclic lactam
WO2008104957A2 (en) * 2007-02-28 2008-09-04 Ranbaxy Laboratories Limited Novel polymorphic forms of milnacipran hydrochloride
FR2941454B1 (en) 2009-01-29 2011-04-01 Pf Medicament PROCESS FOR THE SYNTHESIS OF (1S, 2R) -MILNACIPRAN
US20100274050A1 (en) * 2009-04-23 2010-10-28 Glenmark Generics Limited Solid milnacipran and process for the preparation of the same
EP2699539B1 (en) 2011-04-21 2019-03-06 Emory University Cyclopropyl derivatives and methods of use
CN103242289B (en) * 2012-02-03 2015-01-07 暨明医药科技（苏州）有限公司 Preparation method of N,N-diallyl-(1R,2R)-2-aminomethyl-1-(2-thienyl)cyclopropanecarboxamide hydrochloride
WO2014009767A1 (en) 2012-07-07 2014-01-16 Micro Labs Limited An improved process for the preparation of 1-aryl 2-aminomethyl cyclopropane carboxyamide (z) derivatives, their isomers and salts
JP2015534464A (en) 2012-10-09 2015-12-03 カリフォルニア インスティチュート オブ テクノロジー In vivo and in vitro olefin cyclopropanation catalyzed by heme enzymes
FR2998892B1 (en) * 2012-12-04 2015-01-02 Pf Medicament AMINOCYCLOBUTANE DERIVATIVES, PROCESS FOR PREPARING THEM AND THEIR USE AS MEDICAMENTS
CN103613513B (en) * 2013-12-09 2016-01-20 上海现代制药股份有限公司 Milnacipran hydrochloride intermediate and its preparation method and application
US9399762B2 (en) 2014-02-18 2016-07-26 California Institute Of Technology Methods and systems for sulfimidation or sulfoximidation of organic molecules
CN104058992A (en) * 2014-06-13 2014-09-24 上海现代制药股份有限公司 Crystal form of levomilnacipran hydrochloride
US10131624B2 (en) 2014-11-04 2018-11-20 Quimica Sintetica, S.A. Process for the preparation of (1S,2R)-Milnacipran

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2508035A1 (en) * 1981-06-23 1982-12-24 Fabre Sa Pierre ARYL-1-AMINOMETHYL-2 CYCLOPROPANES CARBOXAMIDE (Z) DERIVATIVES, THEIR PREPARATION AND THEIR USE AS MEDICAMENTS USEFUL IN THE TREATMENT OF CENTRAL NERVOUS SYSTEM DISORDERS

Also Published As

Publication number Publication date
KR860008126A (en) 1986-11-12
JPS61251650A (en) 1986-11-08
YU65586A (en) 1987-12-31
EP0200638A1 (en) 1986-11-05
HUT40618A (en) 1987-01-28
DK170888B1 (en) 1996-03-04
OA08241A (en) 1987-10-30
PT82461B (en) 1988-10-14
AR240695A1 (en) 1990-09-28
FR2581059A1 (en) 1986-10-31
KR940006764B1 (en) 1994-07-27
HU195182B (en) 1988-04-28
NO861573L (en) 1986-10-27
ES8704449A1 (en) 1987-04-01
SU1443797A3 (en) 1988-12-07
NO165143B (en) 1990-09-24
FI87196C (en) 1992-12-10
PT82461A (en) 1986-05-01
FI87196B (en) 1992-08-31
ES554321A0 (en) 1987-04-01
AU587613B2 (en) 1989-08-24
IE59015B1 (en) 1993-12-15
ZA862929B (en) 1986-12-30
GR860980B (en) 1986-08-25
FI861755A (en) 1986-10-26
YU44915B (en) 1991-04-30
DK191286D0 (en) 1986-04-24
FI861755A0 (en) 1986-04-25
GEP19970789B (en) 1997-01-28
FR2581059B1 (en) 1988-04-22
MX162896B (en) 1991-07-08
AU5634386A (en) 1986-10-30
DE3662877D1 (en) 1989-05-24
JPH0567136B2 (en) 1993-09-24
DK191286A (en) 1986-10-26
CA1266486A (en) 1990-03-06
EP0200638B1 (en) 1989-04-19
ATE42273T1 (en) 1989-05-15
NO165143C (en) 1991-01-09

Similar Documents

Publication Publication Date Title
IE861057L (en) Preparation of midalcipran
PL276047A1 (en) Method of obatining amycacine
IL62981A0 (en) Preparation of concentrated nikkomicin mixtures
EP0255673A3 (en) Process for the recovery of rhodium from aqueous solutions containing rhodium complex compounds
AU621203B2 (en) Sodium n-acetylneuraminate trihydrate and method for the preparation thereof
ZA802708B (en) Method of purifying iso-alpha-acids
FR2428025B1 (en)
AU562861B2 (en) Cinnamoylanthranilic acid compounds
DE3375931D1 (en) Process for obtaining l-malic acid
KR860008174A (en) Method for preparing antipsychotic benzisothiazole S-oxide
ES8609208A1 (en) A PROCESS FOR PREPARING p-AMINO PHENOLS BY ELECTROLYSIS.
IE810732L (en) Salts of dicarboxylic acids
CA2200604A1 (en) Novel production intermediate and process for producing pyridine derivative
SU725822A1 (en) Method of producing metal powder
CA2002958A1 (en) Boehmite-type aluminum hydroxide, process for preparing same and phosphate ion adsorbent containing same as effective component
ES8402256A1 (en) Preparation of acetophenone derivative
SE8503811L (en) NEW PROCEDURE FOR PREPARING AN AMINOLACTON
TH4055EX (en) Process for preparation (Z) -1-phenyl-1-diethylaminoccarbonyl -2-aminomethyl cyclopropane hydrochloride
JPS51119398A (en) A method for purifying and concentrating caustic soda and hydrochloric acid using a liquid phase thermosyphon process
JPS5266685A (en) Purification and separarion of 2-keto-l-glonic acid
JPS57185234A (en) Preparation of hydroxyphenylacetic acid
ES8604152A1 (en) Pyridyl di-sulphoxy di:phenyl-methane
JPS5350231A (en) Preparation of quinoline
JPS5533450A (en) Preparation of monohalogenosilane
JPS5527150A (en) Treatment of thermal decomposition product of 1,1'-peroxy-dicyclohexylamine

Legal Events

Date Code Title Description
MK9A Patent expired