ES8402256A1 - Preparation of acetophenone derivative - Google Patents
Preparation of acetophenone derivativeInfo
- Publication number
- ES8402256A1 ES8402256A1 ES518106A ES518106A ES8402256A1 ES 8402256 A1 ES8402256 A1 ES 8402256A1 ES 518106 A ES518106 A ES 518106A ES 518106 A ES518106 A ES 518106A ES 8402256 A1 ES8402256 A1 ES 8402256A1
- Authority
- ES
- Spain
- Prior art keywords
- solvent
- derivative
- halogenoacetophenone
- dimethoxyphenethylamine
- formula
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 150000008062 acetophenones Chemical class 0.000 title 1
- ANOUKFYBOAKOIR-UHFFFAOYSA-N 3,4-dimethoxyphenylethylamine Chemical compound COC1=CC=C(CCN)C=C1OC ANOUKFYBOAKOIR-UHFFFAOYSA-N 0.000 abstract 4
- 150000001875 compounds Chemical class 0.000 abstract 2
- 150000007529 inorganic bases Chemical class 0.000 abstract 2
- 239000003960 organic solvent Substances 0.000 abstract 2
- 239000002904 solvent Substances 0.000 abstract 2
- JHDOTXIGIMCIEJ-UHFFFAOYSA-N 2-[2-(3,4-dimethoxyphenyl)ethylamino]-1-phenylethanone Chemical class C1=C(OC)C(OC)=CC=C1CCNCC(=O)C1=CC=CC=C1 JHDOTXIGIMCIEJ-UHFFFAOYSA-N 0.000 abstract 1
- 238000000354 decomposition reaction Methods 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 150000008282 halocarbons Chemical class 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000002994 raw material Substances 0.000 abstract 1
- 238000007086 side reaction Methods 0.000 abstract 1
- 230000000638 stimulation Effects 0.000 abstract 1
- 230000002194 synthesizing effect Effects 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C1/00—Preparation of hydrocarbons from one or more compounds, none of them being a hydrocarbon
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C221/00—Preparation of compounds containing amino groups and doubly-bound oxygen atoms bound to the same carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
- C07C217/54—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
- C07C217/56—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by singly-bound oxygen atoms
- C07C217/60—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by singly-bound oxygen atoms linked by carbon chains having two carbon atoms between the amino groups and the six-membered aromatic ring or the condensed ring system containing that ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C225/00—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones
- C07C225/02—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones having amino groups bound to acyclic carbon atoms of the carbon skeleton
- C07C225/14—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones having amino groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being unsaturated
- C07C225/16—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones having amino groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being unsaturated and containing six-membered aromatic rings
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Abstract
PURPOSE:To obtain the titled compound in high yield in high quality useful as an intermediate for synthesizing drugs, by condensing a halogenoacetophenone derivative with 3,4-dimethoxyphenethylamine in a solvent of two phase system in the presence of an inorganic base. CONSTITUTION:A halogenoacetophenone derivative shown by the formulaI(R is hydroxyl-protecting group X is halogen) is condensed with 3,4-dimethoxyphenethylamine in a solvent of two phase system consisting of a nonhydrophilic organic solvent and water in the presence of an inorganic base, to give an alpha- (3,4-dimethoxyphenethylamino)acetophenone derivative shown by the formula II. A halogenated hydrocarbon is used as the nonhydrophilic organic solvent. EFFECT:Side reactions such as the decomposition of the compound shown by the formula II, etc. are suppressed, the chance wherein a raw material having high stimulation and corrosive properties is brought into contact with man can be reduced, and operations are extremely advantageous in this process with respect to safety.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP56200536A JPS58103344A (en) | 1981-12-11 | 1981-12-11 | Preparation of acetophenone derivative |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES518106A0 ES518106A0 (en) | 1984-01-16 |
| ES8402256A1 true ES8402256A1 (en) | 1984-01-16 |
Family
ID=16425933
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES518106A Expired ES8402256A1 (en) | 1981-12-11 | 1982-12-10 | Preparation of acetophenone derivative |
Country Status (10)
| Country | Link |
|---|---|
| JP (1) | JPS58103344A (en) |
| KR (1) | KR870000247B1 (en) |
| AT (1) | AT382613B (en) |
| CA (1) | CA1211126A (en) |
| CH (1) | CH649759A5 (en) |
| DK (1) | DK158643C (en) |
| ES (1) | ES8402256A1 (en) |
| HU (1) | HU187806B (en) |
| IT (1) | IT1191242B (en) |
| SE (1) | SE454776B (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW200740779A (en) | 2005-07-22 | 2007-11-01 | Mitsubishi Pharma Corp | Intermediate compound for synthesizing pharmaceutical agent and production method thereof |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2784193A (en) * | 1955-01-19 | 1957-03-05 | Merck & Co Inc | Phenalkylamines |
| GB1535435A (en) * | 1975-12-11 | 1978-12-13 | Tanabe Seiyaku Co | Benzyl alcohol derivatives |
-
1981
- 1981-12-11 JP JP56200536A patent/JPS58103344A/en active Granted
-
1982
- 1982-12-08 CA CA000417254A patent/CA1211126A/en not_active Expired
- 1982-12-08 CH CH7143/82A patent/CH649759A5/en not_active IP Right Cessation
- 1982-12-10 HU HU823990A patent/HU187806B/en not_active IP Right Cessation
- 1982-12-10 SE SE8207080A patent/SE454776B/en not_active IP Right Cessation
- 1982-12-10 AT AT0449782A patent/AT382613B/en not_active IP Right Cessation
- 1982-12-10 KR KR8205547A patent/KR870000247B1/en active
- 1982-12-10 ES ES518106A patent/ES8402256A1/en not_active Expired
- 1982-12-10 DK DK550482A patent/DK158643C/en not_active IP Right Cessation
- 1982-12-13 IT IT68462/82A patent/IT1191242B/en active
Also Published As
| Publication number | Publication date |
|---|---|
| SE454776B (en) | 1988-05-30 |
| JPS6335619B2 (en) | 1988-07-15 |
| SE8207080D0 (en) | 1982-12-10 |
| DK158643C (en) | 1990-11-19 |
| CA1211126A (en) | 1986-09-09 |
| JPS58103344A (en) | 1983-06-20 |
| KR840002770A (en) | 1984-07-16 |
| ATA449782A (en) | 1986-08-15 |
| ES518106A0 (en) | 1984-01-16 |
| IT8268462A0 (en) | 1982-12-13 |
| IT1191242B (en) | 1988-02-24 |
| CH649759A5 (en) | 1985-06-14 |
| KR870000247B1 (en) | 1987-02-21 |
| DK158643B (en) | 1990-06-25 |
| DK550482A (en) | 1983-06-12 |
| AT382613B (en) | 1987-03-25 |
| HU187806B (en) | 1986-02-28 |
| SE8207080L (en) | 1983-06-12 |
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