JPS56139488A - Sesquiterpene compound and its preparation - Google Patents

Sesquiterpene compound and its preparation

Info

Publication number
JPS56139488A
JPS56139488A JP4258180A JP4258180A JPS56139488A JP S56139488 A JPS56139488 A JP S56139488A JP 4258180 A JP4258180 A JP 4258180A JP 4258180 A JP4258180 A JP 4258180A JP S56139488 A JPS56139488 A JP S56139488A
Authority
JP
Japan
Prior art keywords
formula
compound shown
methanol
give
reaction
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP4258180A
Other languages
Japanese (ja)
Other versions
JPS5719115B2 (en
Inventor
Yasuo Fujimoto
Takashi Tatsuno
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
RIKEN Institute of Physical and Chemical Research
Original Assignee
RIKEN Institute of Physical and Chemical Research
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by RIKEN Institute of Physical and Chemical Research filed Critical RIKEN Institute of Physical and Chemical Research
Priority to JP4258180A priority Critical patent/JPS56139488A/en
Publication of JPS56139488A publication Critical patent/JPS56139488A/en
Publication of JPS5719115B2 publication Critical patent/JPS5719115B2/ja
Granted legal-status Critical Current

Links

Abstract

NEW MATERIAL:A sesquiterpene compound shown by the formula IV.
USE: A synthetic intermediate for an antitumor agent.
PROCESS: A compound shown by the formula III is heated under refulx and acidic conditions, to give a compound shown by the formula IV. The reaction is preferably carried out in dilute hydrochloric acid- methanol or dilute sulfuric acid -methanol, the reaction temperature is 50W100°C, and the reaction time is about 5W30min. The prepared compound shown by the formula IV, for example, is converted to 10α- vinyl derivative shown by the formula V, which is reacted with phenylselenyl chloride in the presence of a strong base and treated with an oxidizing agent, to give 8-deoxybernolepin shown by the formula IV, an antitumor agent.
COPYRIGHT: (C)1981,JPO&Japio
JP4258180A 1980-04-01 1980-04-01 Sesquiterpene compound and its preparation Granted JPS56139488A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP4258180A JPS56139488A (en) 1980-04-01 1980-04-01 Sesquiterpene compound and its preparation

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP4258180A JPS56139488A (en) 1980-04-01 1980-04-01 Sesquiterpene compound and its preparation

Publications (2)

Publication Number Publication Date
JPS56139488A true JPS56139488A (en) 1981-10-30
JPS5719115B2 JPS5719115B2 (en) 1982-04-20

Family

ID=12640029

Family Applications (1)

Application Number Title Priority Date Filing Date
JP4258180A Granted JPS56139488A (en) 1980-04-01 1980-04-01 Sesquiterpene compound and its preparation

Country Status (1)

Country Link
JP (1) JPS56139488A (en)

Also Published As

Publication number Publication date
JPS5719115B2 (en) 1982-04-20

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