ES8609329A1 - Procedimiento para preparar nuevos derivados de 5-(1-ciano- -1-alquil-n-metil-n-metoxi-fenetil)-alquilamino-2,2,8-trime-til-4h-dioxino-(4,5-c)piridina - Google Patents

Procedimiento para preparar nuevos derivados de 5-(1-ciano- -1-alquil-n-metil-n-metoxi-fenetil)-alquilamino-2,2,8-trime-til-4h-dioxino-(4,5-c)piridina

Info

Publication number
ES8609329A1
ES8609329A1 ES548108A ES548108A ES8609329A1 ES 8609329 A1 ES8609329 A1 ES 8609329A1 ES 548108 A ES548108 A ES 548108A ES 548108 A ES548108 A ES 548108A ES 8609329 A1 ES8609329 A1 ES 8609329A1
Authority
ES
Spain
Prior art keywords
methyl
dioxino
phenethyl
cyano
methoxy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES548108A
Other languages
English (en)
Other versions
ES548108A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ipsen Pharma SAS
Original Assignee
Societe de Conseils de Recherches et dApplications Scientifiques SCRAS SAS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Societe de Conseils de Recherches et dApplications Scientifiques SCRAS SAS filed Critical Societe de Conseils de Recherches et dApplications Scientifiques SCRAS SAS
Publication of ES8609329A1 publication Critical patent/ES8609329A1/es
Publication of ES548108A0 publication Critical patent/ES548108A0/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
    • A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE DERIVADOS DE 4H-DIXINO-(4,5-C)-PIRIDINA, DE FORMULA (I), Y DE SUS SALES FISIOLOGICAMENTE COMPATIBLES. CONSISTE EN LA REACCION DE SUSTITUCION ENTRE CANTIDADES ESTEQUIOMETRICAS DE 5-(1-CIANO-1-R1)-METIL-2,2,8-TRIMETIL-4H-DIOXINO-(4,5-C)-PIRIDINA, DE FORMULA (II), CON UN CLORURO DE N-METIL-N-(METOXIFENETIL)-W-ALQUILO, DE FORMULA (III), EN LAS QUE R1 REPRESENTA ALQUILO CON 1 A 5 ATOMOS DE CARBONO, R2 REPRESENTA 2 O 3 GRUPOS METOXILO Y N VALE 2-5. LA REACCION SE LLEVA A CABO EN DIMETILSULFOXIDO, EN PRESENCIA DE HIDRURO SODICO A UNA TEMPERATURA ENTRE 15JC Y 65JC. ESTOS COMPUESTOS TIENEN APLICACIONES FARMACOLOGICAS COMO ANTAGONISTAS DEL CALCIO.
ES548108A 1984-10-23 1985-10-22 Procedimiento para preparar nuevos derivados de 5-(1-ciano- -1-alquil-n-metil-n-metoxi-fenetil)-alquilamino-2,2,8-trime-til-4h-dioxino-(4,5-c)piridina Expired ES8609329A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB848426738A GB8426738D0 (en) 1984-10-23 1984-10-23 Pyridine derivatives

Publications (2)

Publication Number Publication Date
ES8609329A1 true ES8609329A1 (es) 1986-09-01
ES548108A0 ES548108A0 (es) 1986-09-01

Family

ID=10568592

Family Applications (1)

Application Number Title Priority Date Filing Date
ES548108A Expired ES8609329A1 (es) 1984-10-23 1985-10-22 Procedimiento para preparar nuevos derivados de 5-(1-ciano- -1-alquil-n-metil-n-metoxi-fenetil)-alquilamino-2,2,8-trime-til-4h-dioxino-(4,5-c)piridina

Country Status (26)

Country Link
US (1) US4610990A (es)
JP (1) JPS61106578A (es)
AR (1) AR240942A1 (es)
AT (1) AT393682B (es)
BE (1) BE903403A (es)
CA (1) CA1286300C (es)
CH (1) CH665842A5 (es)
DE (1) DE3537715A1 (es)
DK (1) DK159319C (es)
DZ (1) DZ851A1 (es)
ES (1) ES8609329A1 (es)
FI (1) FI82249C (es)
FR (2) FR2571965B1 (es)
GB (2) GB8426738D0 (es)
HK (1) HK44388A (es)
IE (1) IE58499B1 (es)
IT (1) IT1190409B (es)
LU (1) LU86117A1 (es)
MA (1) MA20559A1 (es)
MY (1) MY102281A (es)
NL (1) NL8502788A (es)
NO (1) NO163777C (es)
OA (1) OA08125A (es)
PT (1) PT81351B (es)
SE (1) SE460904B (es)
ZA (1) ZA857650B (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3642331A1 (de) * 1986-12-11 1988-06-23 Basf Ag Basisch substituierte phenylacetonitrile, ihre herstellung und diese enthaltende arzneimittel
JPH02102810U (es) * 1989-01-31 1990-08-15
GB8904182D0 (en) * 1989-02-23 1989-04-05 Glaxo Canada Pharmaceutical compositions
JPH02141516U (es) * 1989-04-25 1990-11-28
US5395939A (en) * 1993-11-30 1995-03-07 North Carolina State University Method of making asymmetric de ring intermediates for the synthesis of camptothecin and camptothecin analogs

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8427218D0 (en) * 1984-10-27 1984-12-05 Scras Pyridine derivatives

Also Published As

Publication number Publication date
SE460904B (sv) 1989-12-04
FR2572075A1 (fr) 1986-04-25
NO163777B (no) 1990-04-09
HK44388A (en) 1988-06-17
OA08125A (fr) 1987-03-31
NO854206L (no) 1986-04-24
US4610990A (en) 1986-09-09
MA20559A1 (fr) 1986-07-01
GB2165845B (en) 1988-01-06
DE3537715C2 (es) 1992-04-09
ATA305785A (de) 1991-05-15
FR2572075B1 (fr) 1988-10-14
FI854088A0 (fi) 1985-10-21
JPS638114B2 (es) 1988-02-19
NO163777C (no) 1990-07-18
FI82249C (fi) 1991-02-11
AR240942A1 (es) 1991-03-27
JPS61106578A (ja) 1986-05-24
AR240942A2 (es) 1991-03-27
SE8504825D0 (sv) 1985-10-16
FI854088L (fi) 1986-04-24
GB2165845A (en) 1986-04-23
GB8426738D0 (en) 1984-11-28
IE58499B1 (en) 1993-10-06
GB8524709D0 (en) 1985-11-13
IT8522597A0 (it) 1985-10-23
ZA857650B (en) 1986-05-28
BE903403A (fr) 1986-04-09
PT81351A (en) 1985-11-01
FR2571965B1 (fr) 1990-09-28
DE3537715A1 (de) 1986-04-24
CH665842A5 (fr) 1988-06-15
CA1286300C (en) 1991-07-16
FR2571965A1 (fr) 1986-04-25
DK483185D0 (da) 1985-10-22
MY102281A (en) 1992-05-15
DK159319C (da) 1991-02-25
DZ851A1 (fr) 2004-09-13
ES548108A0 (es) 1986-09-01
DK483185A (da) 1986-04-24
LU86117A1 (fr) 1986-03-24
DK159319B (da) 1990-10-01
IE852609L (en) 1986-04-23
FI82249B (fi) 1990-10-31
SE8504825L (sv) 1986-04-24
IT1190409B (it) 1988-02-16
AT393682B (de) 1991-11-25
NL8502788A (nl) 1986-05-16
PT81351B (pt) 1987-11-11

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 20000201