ES8603955A1 - Preparacion de igf y egf de humano por tecnologia de adn recombinante - Google Patents

Preparacion de igf y egf de humano por tecnologia de adn recombinante

Info

Publication number
ES8603955A1
ES8603955A1 ES533170A ES533170A ES8603955A1 ES 8603955 A1 ES8603955 A1 ES 8603955A1 ES 533170 A ES533170 A ES 533170A ES 533170 A ES533170 A ES 533170A ES 8603955 A1 ES8603955 A1 ES 8603955A1
Authority
ES
Spain
Prior art keywords
igf
recombinant host
produced
pharmaceutical composition
expression vector
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES533170A
Other languages
English (en)
Other versions
ES533170A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Genentech Inc
Original Assignee
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27053789&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES8603955(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Genentech Inc filed Critical Genentech Inc
Publication of ES8603955A1 publication Critical patent/ES8603955A1/es
Publication of ES533170A0 publication Critical patent/ES533170A0/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/24—Hydrolases (3) acting on glycosyl compounds (3.2)
    • C12N9/2402—Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1)
    • C12N9/2405—Glucanases
    • C12N9/2408—Glucanases acting on alpha -1,4-glucosidic bonds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/485—Epidermal growth factor [EGF], i.e. urogastrone
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/65—Insulin-like growth factors, i.e. somatomedins, e.g. IGF-1, IGF-2
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
    • C12N15/81—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/036—Fusion polypeptide containing a localisation/targetting motif targeting to the medium outside of the cell, e.g. type III secretion
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
    • C07K2319/74—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor
    • C07K2319/75—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor containing a fusion for activation of a cell surface receptor, e.g. thrombopoeitin, NPY and other peptide hormones

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Medicinal Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Microbiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Mycology (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Saccharide Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)

Abstract

METODO DE PREPARACION DE FACTOR DE CRECIMIENTO A MODO DE INSULINA (IGF) Y FACTOR DE CRECIMIENTO EPIDERMICO (EGF) DE HUMANO MEDIANTE TECNOLOGIA DE ADN RECOMBINANTE. COMPRENDE LA PREPARACION DE UN VECTOR DE EXPRESION REPLICABLE, CAPAZ DE EXPRESAR LA SECUENCIA DE ACIDO DESOXIRRIBONUCLEICO (ADN) QUE CODIFICA IGF O EGF DE HUMANO EN UNA CELULA HOSPEDANTE ADECUADA; TRANSFORMACION DE UN CULTIVO DE CELULAS HOSPEDANTES CON ESTE VECTOR PARA FORMAR UNA CELULA HOSPEDANTE RECOMBINANTE; CULTIVO DE ESTAS CELULAS EN CONDICIONES QUE PERMITAN LA EXPRESION DE IGF O EGF DE HUMANO CODIFICADO POR SECUENCIA DE ADN PARA PRODUCIR DICHOS FACTORES; Y RECUPERACION DE LOS MISMOS. ESTOS FACTORES TIENEN APLICACIONES PARA EL TRATAMIENTO PROFILACTICO Y TERAPEUTICO DE DIVERSOS ESTADOS O CONDICIONES ASOCIADOS CON EL CRECIMIENTO.
ES533170A 1983-06-06 1984-06-06 Preparacion de igf y egf de humano por tecnologia de adn recombinante Expired ES8603955A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US50135383A 1983-06-06 1983-06-06
US50607883A 1983-06-20 1983-06-20

Publications (2)

Publication Number Publication Date
ES8603955A1 true ES8603955A1 (es) 1986-01-16
ES533170A0 ES533170A0 (es) 1986-01-16

Family

ID=27053789

Family Applications (1)

Application Number Title Priority Date Filing Date
ES533170A Expired ES8603955A1 (es) 1983-06-06 1984-06-06 Preparacion de igf y egf de humano por tecnologia de adn recombinante

Country Status (10)

Country Link
US (3) US6331609B1 (es)
EP (1) EP0128733B1 (es)
JP (2) JP2608870B2 (es)
KR (1) KR850000525A (es)
AU (1) AU594301B2 (es)
DE (1) DE3485693D1 (es)
DK (1) DK172480B1 (es)
ES (1) ES8603955A1 (es)
IE (1) IE58317B1 (es)
IL (1) IL71991A (es)

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US4870008A (en) * 1983-08-12 1989-09-26 Chiron Corporation Secretory expression in eukaryotes
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US4758512A (en) * 1984-03-06 1988-07-19 President And Fellows Of Harvard College Hosts and methods for producing recombinant products in high yields
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DK276184D0 (da) 1984-06-04
DE3485693D1 (de) 1992-06-11
IL71991A0 (en) 1984-10-31
USRE39355E1 (en) 2006-10-17
JPS6069029A (ja) 1985-04-19
US6331414B1 (en) 2001-12-18
DK276184A (da) 1985-01-21
AU2913384A (en) 1984-12-13
JPH0759578A (ja) 1995-03-07
EP0128733A1 (en) 1984-12-19
EP0128733B1 (en) 1992-05-06
ES533170A0 (es) 1986-01-16
IE58317B1 (en) 1993-09-08
AU594301B2 (en) 1990-03-08
KR850000525A (ko) 1985-02-27
IL71991A (en) 1994-05-30
JP2608870B2 (ja) 1997-05-14
DK172480B1 (da) 1998-10-05
IE841400L (en) 1984-12-06
US6331609B1 (en) 2001-12-18

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