ES533170A0 - Preparacion de igf y egf de humano por tecnologia de adn recombinante - Google Patents
Preparacion de igf y egf de humano por tecnologia de adn recombinanteInfo
- Publication number
- ES533170A0 ES533170A0 ES533170A ES533170A ES533170A0 ES 533170 A0 ES533170 A0 ES 533170A0 ES 533170 A ES533170 A ES 533170A ES 533170 A ES533170 A ES 533170A ES 533170 A0 ES533170 A0 ES 533170A0
- Authority
- ES
- Spain
- Prior art keywords
- egf
- preparation
- recombinant dna
- dna technology
- human igf
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 108020004511 Recombinant DNA Proteins 0.000 title 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/24—Hydrolases (3) acting on glycosyl compounds (3.2)
- C12N9/2402—Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1)
- C12N9/2405—Glucanases
- C12N9/2408—Glucanases acting on alpha -1,4-glucosidic bonds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C07K14/485—Epidermal growth factor [EGF], i.e. urogastrone
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/65—Insulin-like growth factors, i.e. somatomedins, e.g. IGF-1, IGF-2
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
- C12N15/81—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/036—Fusion polypeptide containing a localisation/targetting motif targeting to the medium outside of the cell, e.g. type III secretion
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
- C07K2319/74—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor
- C07K2319/75—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor containing a fusion for activation of a cell surface receptor, e.g. thrombopoeitin, NPY and other peptide hormones
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Biophysics (AREA)
- Medicinal Chemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Microbiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Toxicology (AREA)
- Mycology (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Diabetes (AREA)
- Endocrinology (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Saccharide Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US50135383A | 1983-06-06 | 1983-06-06 | |
US50607883A | 1983-06-20 | 1983-06-20 |
Publications (2)
Publication Number | Publication Date |
---|---|
ES8603955A1 ES8603955A1 (es) | 1986-01-16 |
ES533170A0 true ES533170A0 (es) | 1986-01-16 |
Family
ID=27053789
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES533170A Expired ES8603955A1 (es) | 1983-06-06 | 1984-06-06 | Preparacion de igf y egf de humano por tecnologia de adn recombinante |
Country Status (10)
Country | Link |
---|---|
US (3) | US6331609B1 (es) |
EP (1) | EP0128733B1 (es) |
JP (2) | JP2608870B2 (es) |
KR (1) | KR850000525A (es) |
AU (1) | AU594301B2 (es) |
DE (1) | DE3485693D1 (es) |
DK (1) | DK172480B1 (es) |
ES (1) | ES8603955A1 (es) |
IE (1) | IE58317B1 (es) |
IL (1) | IL71991A (es) |
Families Citing this family (96)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IE52036B1 (en) * | 1979-05-24 | 1987-05-27 | Univ California | Non-passageable viruses |
DE3486216T2 (de) * | 1983-04-25 | 1994-02-17 | Chiron Corp | Hybrid-DNS-Synthesis von reifen insulinähnlichen Wachstumsfaktoren. |
NZ207926A (en) * | 1983-04-25 | 1988-04-29 | Genentech Inc | Use of yeast #a#-factor to assist in expression of proteins heterologus to yeast |
US7198919B1 (en) | 1983-04-25 | 2007-04-03 | Genentech, Inc. | Use of alpha factor sequences in yeast expression systems |
JPS60501989A (ja) * | 1983-08-10 | 1985-11-21 | アムジエン | インシュリン様成長因子の微生物発現 |
WO1985000831A1 (en) * | 1983-08-10 | 1985-02-28 | Amgen | Microbial expression of insulin-like growth factor |
US4870008A (en) * | 1983-08-12 | 1989-09-26 | Chiron Corporation | Secretory expression in eukaryotes |
ATE85080T1 (de) * | 1984-02-17 | 1993-02-15 | Genentech Inc | Menschlicher transformationswachstumsfaktor und vorlaeufer oder fragment hiervon, zellen, dna, vektoren und verfahren zu ihrer herstellung, zusammensetzungen und produkte, die diese enthalten, sowie davon abgeleitete antikoerper und diagnostizierverfahren. |
US4758512A (en) * | 1984-03-06 | 1988-07-19 | President And Fellows Of Harvard College | Hosts and methods for producing recombinant products in high yields |
DK108685A (da) * | 1984-03-19 | 1985-09-20 | Fujisawa Pharmaceutical Co | Vaekstfaktor i |
JPS61502657A (ja) * | 1984-07-13 | 1986-11-20 | チロン コ−ポレイシヨン | プレプロインシュリン様成長因子1及び2 |
US4738921A (en) * | 1984-09-27 | 1988-04-19 | Eli Lilly And Company | Derivative of the tryptophan operon for expression of fused gene products |
EP0193112A3 (en) * | 1985-02-22 | 1987-02-25 | The Trustees Of Columbia University In The City Of New York | Cdna encoding mammalian insulin-like growth factor ii |
GB8507666D0 (en) * | 1985-03-25 | 1985-05-01 | Wellcome Found | Epidermal growth factor production |
US5242811A (en) * | 1985-03-26 | 1993-09-07 | Biogen, Inc. | Production of human somatomedin C |
GB8507833D0 (en) * | 1985-03-26 | 1985-05-01 | Biogen Nv | Production of human somatomedin c |
US4783524A (en) * | 1985-09-17 | 1988-11-08 | Monsanto Company | Growth factors |
ATE67243T1 (de) * | 1985-10-21 | 1991-09-15 | Fujisawa Pharmaceutical Co | Verfahren zur herstellung von insulinaehnlichem wachstumsfaktor i (igf-i) und plasmid zu dessen herstellung. |
GB8529014D0 (en) * | 1985-11-25 | 1986-01-02 | Biogen Nv | Enhanced secretion of heterologous proteins |
US5298603A (en) * | 1985-12-21 | 1994-03-29 | Hoechst Aktiengesellschaft | GM-CSF protein, its derivatives, the preparation of proteins of this type, and their use |
DE3545568A1 (de) * | 1985-12-21 | 1987-07-16 | Hoechst Ag | Gm-csf-protein, seine derivate, herstellung solcher proteine und ihre verwendung |
US4743679A (en) * | 1986-02-24 | 1988-05-10 | Creative Biomolecules, Inc. | Process for producing human epidermal growth factor and analogs thereof |
IN165717B (es) * | 1986-08-07 | 1989-12-23 | Battelle Memorial Institute | |
AU613876B2 (en) * | 1986-10-01 | 1991-08-15 | Merck & Co., Inc. | Synthetic genes encoding proteins from plasmid containing eucaryotic secretory signal peptides and process for secreting encoded proteins |
DK175535B1 (da) * | 1987-03-04 | 2004-11-29 | Daiichi Suntory Pharma Co Ltd | Fremgangsmåde til fremstilling af et fysiologisk aktivt cysteinholdigt peptid |
EP0289314B1 (en) * | 1987-04-28 | 1994-10-12 | Roche Diagnostics GmbH | Use of IGF-II in the treatment of bone disorders |
US5688763A (en) * | 1987-06-12 | 1997-11-18 | Hammonds, Jr.; R. Glenn | Compositions and methods for the synthesis of growth hormone receptor and growth hormone binding protein |
US5472702A (en) * | 1987-08-26 | 1995-12-05 | United States Surgical Corporation | Sterilization of growth factors |
US5366081A (en) | 1987-08-26 | 1994-11-22 | United States Surgical Corporation | Packaged synthetic absorbable surgical elements |
US5306289A (en) * | 1987-08-26 | 1994-04-26 | United States Surgical Corporation | Braided suture of improved characteristics |
US5226912A (en) | 1987-08-26 | 1993-07-13 | United States Surgical Corporation | Combined surgical needle-braided suture device |
US5222978A (en) | 1987-08-26 | 1993-06-29 | United States Surgical Corporation | Packaged synthetic absorbable surgical elements |
SE8703625D0 (sv) * | 1987-09-18 | 1987-09-18 | Kabivitrum Ab | New medical use |
US5102789A (en) * | 1989-03-15 | 1992-04-07 | The Salk Institute Biotechnology/Industrial Associates, Inc. | Production of epideramal growth factor in pichia pastoris yeast cells |
WO1990012877A1 (en) * | 1989-04-19 | 1990-11-01 | Cetus Corporation | Multifunctional m-csf proteins and genes encoding therefor |
US5359831A (en) | 1989-08-01 | 1994-11-01 | United States Surgical Corporation | Molded suture retainer |
KR920003787B1 (ko) * | 1990-03-05 | 1992-05-14 | 한국과학기술 연구원 | 신규 플라스미드 제조 및 그를 함유한 균주를 배양하여 아이 지 에프-1(igf-1)을 생산하는 방법 |
US5374620A (en) * | 1990-06-07 | 1994-12-20 | Genentech, Inc. | Growth-promoting composition and its use |
US5681814A (en) * | 1990-06-07 | 1997-10-28 | Genentech, Inc. | Formulated IGF-I Composition |
US5612198A (en) * | 1990-09-04 | 1997-03-18 | The Salk Institute | Production of insulin-like growth factor-1 in methylotrophic yeast cells |
WO1992004363A1 (en) * | 1990-09-04 | 1992-03-19 | The Salk Institute Biotechnology/Industrial Associates, Inc. | Production of insulin-like growth factor-1 in methylotrophic yeast cells |
CA2059245C (en) * | 1991-02-08 | 2004-07-06 | Michael P. Chesterfield | Method and apparatus for calendering and coating/filling sutures |
ATE220105T1 (de) * | 1991-04-01 | 2002-07-15 | Merck & Co Inc | Gene, die die proteolytische aktivitaet von pichia beeinflussen und deren verwendung |
US5736363A (en) * | 1991-07-29 | 1998-04-07 | British Bio-Technology Limited | IGF-II analogues |
US5288931A (en) * | 1991-12-06 | 1994-02-22 | Genentech, Inc. | Method for refolding insoluble, misfolded insulin-like growth factor-I into an active conformation |
US5643867A (en) * | 1992-08-26 | 1997-07-01 | Celtrix Pharmaceuticals, Inc. | Method for treating catabolic conditions |
US5663304A (en) * | 1993-08-20 | 1997-09-02 | Genentech, Inc. | Refolding of misfolded insulin-like growth factor-I |
ATE297214T1 (de) * | 1993-09-20 | 2005-06-15 | Celtrix Pharma | Behandlung von immunologischen und hematologischen störungen mit igfbp allein oder als komplex mit igf |
EP0732933B1 (en) * | 1993-11-15 | 2002-10-09 | Celtrix Pharmaceuticals, Inc. | Use of igf-1 and igfbp-3 in the manufacture of a medicament for treating a renal disorder |
US5728676A (en) * | 1994-09-08 | 1998-03-17 | Ciba-Geigy Corporation | Use of insulin-like growth factors I and II for inhibition of inflammatory response |
EP0779927A1 (en) * | 1994-09-08 | 1997-06-25 | Chiron Corporation | A method of improved production of insulin-like growth factor |
US5904716A (en) * | 1995-04-26 | 1999-05-18 | Gendler; El | Method for reconstituting cartilage tissue using demineralized bone and product thereof |
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US5948757A (en) * | 1996-03-01 | 1999-09-07 | Celtrix Pharmaceuticals, Inc. | High dose IGF-1 therapy |
US5783556A (en) * | 1996-08-13 | 1998-07-21 | Genentech, Inc. | Formulated insulin-containing composition |
AU4196697A (en) * | 1996-09-16 | 1998-04-14 | Dalhousie University | Use of igf-i for the treatment of polycystic kidney disease and related indications |
US6593290B1 (en) | 1996-11-01 | 2003-07-15 | Genentech, Inc. | Treatment of inner ear hair cells |
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US6514937B1 (en) | 1997-02-25 | 2003-02-04 | Celtrix Pharmaceuticals, Inc. | Method of treating psychological and metabolic disorders using IGF or IGF/IGFBP-3 |
US6025368A (en) * | 1997-02-25 | 2000-02-15 | Celtrix Pharmaceuticals, Inc. | Method for treating the symptoms of chronic stress-related disorders using IGF |
US6015786A (en) * | 1997-02-25 | 2000-01-18 | Celtrix Pharmaceuticals, Inc. | Method for increasing sex steroid levels using IGF or IGF/IGFBP-3 |
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CA2631327C (en) | 2005-12-02 | 2015-10-13 | Genentech, Inc. | Her2 binding polypeptides and uses thereof |
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EP2148695B1 (en) | 2007-04-18 | 2014-10-15 | Premacure AB | Method and product for treatment and/or prevention of complications of prematurity |
EP1988154B1 (en) | 2007-04-30 | 2013-08-21 | Ajinomoto Co., Inc. | Method for producing human insulin-like growth factor I |
EP2164509A1 (en) * | 2007-06-08 | 2010-03-24 | Massachusetts Institute of Technology | Igf for the treatment of rett syndrome and synaptic disorders |
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WO2010146059A2 (en) | 2009-06-16 | 2010-12-23 | F. Hoffmann-La Roche Ag | Biomarkers for igf-1r inhibitor therapy |
BR112012000865A2 (pt) | 2009-07-17 | 2019-09-24 | T Tabor Aaron | "composição e método para a modificação genética cosmética de células substancialmente intactas" |
UA108994C2 (uk) | 2009-11-17 | 2015-07-10 | Ипсен Фарма С.А.С. | Фармацевтична композиція, що містить комбінацію hgh і rhigf-1, і процес її приготування (варіанти) |
US20110152188A1 (en) | 2009-12-23 | 2011-06-23 | Hanns-Christian Mahler | Pharmaceutical compositions of igf/i proteins |
KR101687815B1 (ko) | 2015-06-19 | 2016-12-20 | 이영근 | 파력 발전 장치 및 이 파력 발전 장치를 복수 개 연결한 파력 발전 시스템 |
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EP0108132A1 (en) | 1982-05-06 | 1984-05-16 | Applied Molecular Genetics Inc. | The manufacture and expression of genes for urogastrone and polypeptide analogs thereof |
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US4530904A (en) | 1982-09-03 | 1985-07-23 | Eli Lilly And Company | Method for conferring bacteriophage resistance to bacteria |
DE3382547D1 (de) | 1983-01-12 | 1992-05-27 | Chiron Corp | Sekretorische expression in eukaryoten. |
SE8300693L (sv) * | 1983-02-09 | 1984-08-10 | Sven Lofdahl | Sett att framstella och isolera proteiner och polypeptider samt en hybridvektor for detta |
GB8308483D0 (en) | 1983-03-28 | 1983-05-05 | Health Lab Service Board | Secretion of gene products |
US5015575A (en) | 1983-04-07 | 1991-05-14 | Chiron Corporation | Hybrid DNA synthesis of insulin |
JPS60501140A (ja) | 1983-04-22 | 1985-07-25 | アムジエン | 酵母による外因性ポリペプチドの分泌 |
NZ207926A (en) | 1983-04-25 | 1988-04-29 | Genentech Inc | Use of yeast #a#-factor to assist in expression of proteins heterologus to yeast |
DE3486216T2 (de) * | 1983-04-25 | 1994-02-17 | Chiron Corp | Hybrid-DNS-Synthesis von reifen insulinähnlichen Wachstumsfaktoren. |
US4755465A (en) | 1983-04-25 | 1988-07-05 | Genentech, Inc. | Secretion of correctly processed human growth hormone in E. coli and Pseudomonas |
US4588684A (en) | 1983-04-26 | 1986-05-13 | Chiron Corporation | a-Factor and its processing signals |
SE8303626D0 (sv) | 1983-06-23 | 1983-06-23 | Kabigen Ab | A recombinant plasmid a transformant microorganism, a polydoxyrebonucleotide segment, a process for producing a biologically active protein, and the protein thus produced |
NL8302324A (nl) | 1983-06-30 | 1985-01-16 | Rijksuniversiteit Utrecht De | Escherichia coli stam, een voor deze stam karakteristiek plasmide, een werkwijze ter bereiding van dit plasmide, een precursor van een somatomedine, alsmede een groeibevorderend preparaat. |
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GB8927008D0 (en) * | 1989-11-29 | 1990-01-17 | Ciba Geigy | Novel process for the production of unfused protein in e.coli |
-
1984
- 1984-06-01 IL IL7199184A patent/IL71991A/en unknown
- 1984-06-04 DK DK198402761A patent/DK172480B1/da not_active IP Right Cessation
- 1984-06-05 KR KR1019840003134A patent/KR850000525A/ko not_active Application Discontinuation
- 1984-06-05 DE DE8484303783T patent/DE3485693D1/de not_active Revoked
- 1984-06-05 EP EP84303783A patent/EP0128733B1/en not_active Expired - Lifetime
- 1984-06-05 IE IE140084A patent/IE58317B1/en not_active IP Right Cessation
- 1984-06-06 JP JP59117422A patent/JP2608870B2/ja not_active Expired - Lifetime
- 1984-06-06 AU AU29133/84A patent/AU594301B2/en not_active Expired
- 1984-06-06 ES ES533170A patent/ES8603955A1/es not_active Expired
-
1994
- 1994-06-08 JP JP6126496A patent/JPH0759578A/ja active Pending
-
1995
- 1995-06-05 US US08/464,361 patent/US6331609B1/en not_active Ceased
- 1995-06-05 US US08/464,255 patent/US6331414B1/en not_active Expired - Lifetime
-
2003
- 2003-06-13 US US10/461,712 patent/USRE39355E1/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
US6331414B1 (en) | 2001-12-18 |
IE841400L (en) | 1984-12-06 |
KR850000525A (ko) | 1985-02-27 |
DE3485693D1 (de) | 1992-06-11 |
EP0128733B1 (en) | 1992-05-06 |
AU2913384A (en) | 1984-12-13 |
DK276184D0 (da) | 1984-06-04 |
EP0128733A1 (en) | 1984-12-19 |
US6331609B1 (en) | 2001-12-18 |
JPH0759578A (ja) | 1995-03-07 |
IL71991A (en) | 1994-05-30 |
DK172480B1 (da) | 1998-10-05 |
JP2608870B2 (ja) | 1997-05-14 |
DK276184A (da) | 1985-01-21 |
IE58317B1 (en) | 1993-09-08 |
USRE39355E1 (en) | 2006-10-17 |
JPS6069029A (ja) | 1985-04-19 |
ES8603955A1 (es) | 1986-01-16 |
IL71991A0 (en) | 1984-10-31 |
AU594301B2 (en) | 1990-03-08 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FD1A | Patent lapsed |
Effective date: 20051004 |