ES8601884A1 - Procedimiento para separar mezclas racemicas de esteres de acidos a-imino-carboxilicos biciclicos - Google Patents

Procedimiento para separar mezclas racemicas de esteres de acidos a-imino-carboxilicos biciclicos

Info

Publication number
ES8601884A1
ES8601884A1 ES538556A ES538556A ES8601884A1 ES 8601884 A1 ES8601884 A1 ES 8601884A1 ES 538556 A ES538556 A ES 538556A ES 538556 A ES538556 A ES 538556A ES 8601884 A1 ES8601884 A1 ES 8601884A1
Authority
ES
Spain
Prior art keywords
acid esters
pch
prod
formula
racemic separation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES538556A
Other languages
English (en)
Other versions
ES538556A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hoechst AG
Original Assignee
Hoechst AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst AG filed Critical Hoechst AG
Publication of ES8601884A1 publication Critical patent/ES8601884A1/es
Publication of ES538556A0 publication Critical patent/ES538556A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/52—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring condensed with a ring other than six-membered

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Indole Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Cephalosporin Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

METODO DE SEPARACION DE MEZCLAS RACEMICAS DE ESTERES DE ACIDOS A-IMINOCARBOXILICOS BICICLICOS, MEDIANTE CRISTALIZACION DE SALES DIASTEREOISOMERAS DE LOS COMPUESTOS DE FORMULAS (I) Y (II), EN LAS QUE A, B, C Y R1 PUEDEN SER VARIOS TIPOS DE RADICALES. COMPRENDE LA PREPARACION EN UN DISOLVENTE O MEZCLA DE DISOLVENTES ADECUADOS, LAS SALES DE LOS ESTERES RACEMICOS (I) Y (II) CON ACIDOS 0,0-DIACIL-TARTARICOS, OPTICAMENTE ACTIVOS, DE FORMULA (III), EN LA QUE R2 REPRESENTA ACILO; CRISTALIZACION DE UNA SOLA DE LAS SALES DIASTEREOISOMERAS EN FORMA OPTICAMENTE ACTIVA; PURIFICACION DE ESTA MEDIANTE RECRISTALIZACION; REDISOLUCION O EXTRACCION POR AGITACION; Y, FINALMENTE, DESCOMPOSICION, MEDIANTE ADICION DE UNA BASE EN LOS ENANTIOMEROS PUROS DE FORMULAS (I) Y (II). ESTOS COMPUESTOS TIENEN APLICACIONES COMO INTERMEDIOS PARA LA SINTESIS DE INHIBIDORES DE LA ENZIMA CONVERTIDORA DE ANGIOTENSINA.
ES538556A 1983-12-15 1984-12-13 Procedimiento para separar mezclas racemicas de esteres de acidos a-imino-carboxilicos biciclicos Granted ES538556A0 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19833345355 DE3345355A1 (de) 1983-12-15 1983-12-15 Verfahren zur racematspaltung bicyclischer imino-(alpha)-carbonsaeureester

Publications (2)

Publication Number Publication Date
ES8601884A1 true ES8601884A1 (es) 1985-11-01
ES538556A0 ES538556A0 (es) 1985-11-01

Family

ID=6216990

Family Applications (1)

Application Number Title Priority Date Filing Date
ES538556A Granted ES538556A0 (es) 1983-12-15 1984-12-13 Procedimiento para separar mezclas racemicas de esteres de acidos a-imino-carboxilicos biciclicos

Country Status (15)

Country Link
US (1) US4659838A (es)
EP (1) EP0146080B1 (es)
JP (2) JPH062734B2 (es)
KR (1) KR910009935B1 (es)
AT (1) ATE44953T1 (es)
CA (1) CA1232910A (es)
DE (2) DE3345355A1 (es)
DK (1) DK163819C (es)
ES (1) ES538556A0 (es)
FI (1) FI81783C (es)
GR (1) GR82456B (es)
HU (1) HU195952B (es)
IE (1) IE57752B1 (es)
IL (1) IL73822A (es)
PT (1) PT79669B (es)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3226768A1 (de) * 1981-11-05 1983-05-26 Hoechst Ag, 6230 Frankfurt Derivate der cis, endo-2-azabicyclo-(3.3.0)-octan-3-carbonsaeure, verfahren zu ihrer herstellung, diese enthaltende mittel und deren verwendung
NZ202903A (en) * 1981-12-29 1988-01-08 Hoechst Ag 1-- pe pyrrol-2-yl-carboxylic acid derivatives and pharmaceutical compositions
US5175306A (en) * 1983-01-31 1992-12-29 Hoechst Aktiengesellschaft Process for the resolution of racemates of optically active bicyclic imino-α-carboxylic esters
DE3333455A1 (de) * 1983-09-16 1985-04-11 Hoechst Ag, 6230 Frankfurt Verfahren zur herstellung n-alkylierter dipeptide und deren estern
DE3413710A1 (de) * 1984-04-12 1985-10-24 Hoechst Ag, 6230 Frankfurt Verfahren zur behandlung der herzinsuffizienz
US5684016A (en) * 1984-04-12 1997-11-04 Hoechst Aktiengesellschaft Method of treating cardiac insufficiency
DE3431541A1 (de) * 1984-08-28 1986-03-06 Hoechst Ag, 6230 Frankfurt Cis,endo-2-azabicycloalkan-3-carbonsaeure-derivate, verfahren zu deren herstellung, deren verwendung sowie zwischenprodukte bei deren herstellung
US5231080A (en) * 1985-10-15 1993-07-27 Hoechst Aktiengesellschaft Method for the treatment of atherosclerosis, thrombosis, and peripheral vessel disease
US5231084A (en) * 1986-03-27 1993-07-27 Hoechst Aktiengesellschaft Compounds having a cognition adjuvant action, agents containing them, and the use thereof for the treatment and prophylaxis of cognitive dysfuncitons
DE3633496A1 (de) * 1986-10-02 1988-04-14 Hoechst Ag Kombination von angiotensin-converting-enzyme-hemmern mit calciumantagonisten sowie deren verwendung in arzneimitteln
DE3639879A1 (de) * 1986-11-21 1988-06-01 Hoechst Ag Verfahren zur herstellung von mono-, bi- und tricyclischen aminosaeuren, zwischenprodukte dieses verfahrens sowie ein verfahren zu deren herstellung
DE3722007A1 (de) * 1987-07-03 1989-01-12 Hoechst Ag Verfahren zur herstellung bicyclischer aminocarbonsaeuren, zwischenprodukte dieses verfahrens und deren verwendung
FR2620703B1 (fr) * 1987-09-17 1991-10-04 Adir Procede de synthese industrielle de l'acide perhydroindole carboxylique - 2(2s, 3as, 7as). application a la synthese de carboxyalkyl dipeptides
HU904967D0 (en) * 1988-04-22 1991-01-28 Hoechst Ag Process for producing new azabicyclo(3.3.o)octane-3-carboxylic acid-octylesther derivatives
GB0216416D0 (en) * 2002-07-15 2002-08-21 Novartis Ag Organic compounds
BRPI0409428A (pt) * 2003-04-15 2006-04-18 Warner Lambert Co derivados de prolina bicìclicos [c]-fundidos e a sua utilização para tratar estados artrìticos
EP1615885A1 (en) * 2003-04-15 2006-01-18 Warner-Lambert Company LLC B -fused bicyclic proline derivatives and their use for treating arthritic conditions
CN101384551B (zh) * 2005-12-22 2012-08-29 先灵公司 制备6,6-二甲基-3-氮杂双环-[3.1.0]-己烷化合物和其对映体盐的方法
KR20090020702A (ko) * 2006-06-19 2009-02-26 메르크 파텐트 게엠베하 다형체 및 방법
EP2560493B1 (en) * 2010-04-20 2018-06-06 Chiral Quest, Inc. An enantioselective process for cycloalkenyl b-substituted alanines

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3880866A (en) * 1972-05-01 1975-04-29 American Home Prod 7-Azaindole fused heterocyclic compounds
JPS50101355A (es) * 1974-01-17 1975-08-11
SU573480A1 (ru) * 1976-01-12 1977-09-25 Предприятие П/Я М-5043 Способ получени -пролина
JPS5346967A (en) * 1976-10-08 1978-04-27 Kyowa Hakko Kogyo Co Ltd R-2-(beta-halogenoethyl)-1-methyl-pyrrolidine
US4111951A (en) * 1977-01-17 1978-09-05 Hoffmann-La Roche Inc. Process for L-3,4-dehydroproline
YU93877A (en) * 1977-04-08 1982-06-30 Krka Process for the resolution of racemic alpha-aminonitrils
CA1117127A (en) * 1978-06-27 1982-01-26 Janet A. Day Derivatives of 3-azabicyclo(3.1.0)hexane and a process for their preparation
ZA811493B (en) * 1980-04-02 1982-03-31 Warner Lambert Co Substituted acyl derivatives of octahydro-1h-indole-2-carboxylic acids
US4344949A (en) * 1980-10-03 1982-08-17 Warner-Lambert Company Substituted acyl derivatives of 1,2,3,4-tetrahydroisoquinoline-3-carboxylic acids
HU191120B (en) * 1983-01-31 1987-01-28 Hoechts Ag,De Process for raceme separation of optically active byciclic imino-alpha-carbonic acid esthers

Also Published As

Publication number Publication date
PT79669B (de) 1986-11-24
CA1232910A (en) 1988-02-16
DK163819B (da) 1992-04-06
FI844929L (fi) 1985-06-16
JPH06312977A (ja) 1994-11-08
DE3479118D1 (en) 1989-08-31
KR910009935B1 (ko) 1991-12-06
DK163819C (da) 1992-09-07
US4659838A (en) 1987-04-21
FI844929A0 (fi) 1984-12-13
FI81783C (fi) 1990-12-10
FI81783B (fi) 1990-08-31
EP0146080A2 (de) 1985-06-26
HUT39427A (en) 1986-09-29
KR850004461A (ko) 1985-07-15
ES538556A0 (es) 1985-11-01
DK602084D0 (da) 1984-12-14
JPH0723359B2 (ja) 1995-03-15
IL73822A (en) 1989-02-28
ATE44953T1 (de) 1989-08-15
PT79669A (de) 1985-01-01
JPH062734B2 (ja) 1994-01-12
GR82456B (en) 1985-04-08
IL73822A0 (en) 1985-03-31
EP0146080A3 (en) 1985-08-07
IE843222L (en) 1985-06-15
JPS60146871A (ja) 1985-08-02
HU195952B (en) 1988-08-29
DK602084A (da) 1985-06-16
EP0146080B1 (de) 1989-07-26
IE57752B1 (en) 1993-03-24
DE3345355A1 (de) 1985-06-27

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 20050716