ES8503663A1 - Procedimiento para la obtencion de derivados de quinolinona. (como desglose y con prioridad de la patente espanola no. 510.685, presentada el 23 de marzo de 1.982) - Google Patents

Procedimiento para la obtencion de derivados de quinolinona. (como desglose y con prioridad de la patente espanola no. 510.685, presentada el 23 de marzo de 1.982)

Info

Publication number
ES8503663A1
ES8503663A1 ES523339A ES523339A ES8503663A1 ES 8503663 A1 ES8503663 A1 ES 8503663A1 ES 523339 A ES523339 A ES 523339A ES 523339 A ES523339 A ES 523339A ES 8503663 A1 ES8503663 A1 ES 8503663A1
Authority
ES
Spain
Prior art keywords
radical
aliphatic
together represent
hydrogen
heterocyclic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES523339A
Other languages
English (en)
Other versions
ES523339A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis AG
Original Assignee
Ciba Geigy AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ciba Geigy AG filed Critical Ciba Geigy AG
Publication of ES8503663A1 publication Critical patent/ES8503663A1/es
Publication of ES523339A0 publication Critical patent/ES523339A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/04—1,3-Oxazines; Hydrogenated 1,3-oxazines
    • C07D265/12—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems
    • C07D265/14—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D265/24—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring with hetero atoms directly attached in positions 2 and 4
    • C07D265/26—Two oxygen atoms, e.g. isatoic anhydride
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/32—Oxygen atoms
    • C07D209/34—Oxygen atoms in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/32—Oxygen atoms
    • C07D209/38—Oxygen atoms in positions 2 and 3, e.g. isatin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
    • C07D215/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3 with oxygen atoms in position 4

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pulmonology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Quinoline Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE DERIVADOS DE QUINOLINONA.CONSISTE EN QUE UN COMPUESTO DE FORMULA (II) SE TRANSFORMA POR HIDROLISIS BASICA O POR TRATAMIENTO CON UN ACIDO PROTONICO FUERTE EN EL GRUPO CARBOXI, Y EL COMPUESTO ASI OBTENIDO SE TRANSFORMA EN UN DERIVADO DE QUINOLINONA DE FORMULA (I), DONDE R1 ES H O RESTO ALIFATICO Y OTROS; X ESTA POR OXI O UN ENLACE DIRECTO; PH ES 1,2-FENILENO; R2 Y R3 SIGNIFICAN UN GRUPO CARBOXI; R4 ES M O UN RESTO ALIFATICO; RA Y RB REPRESENTAN OXO; RC Y RD REPRESENTAN H U OXO; RE SIGNIFICA UN ENLACE ADICIONAL; Y R2 Y R3 SIGNIFICAN UN GRUPO CARBOXI.TIENEN APLICACION POR SUS EFECTOS ANTIALERGICOS.
ES523339A 1981-03-24 1983-06-16 Procedimiento para la obtencion de derivados de quinolinona. (como desglose y con prioridad de la patente espanola no. 510.685, presentada el 23 de marzo de 1.982) Granted ES523339A0 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH198681 1981-03-24

Publications (2)

Publication Number Publication Date
ES8503663A1 true ES8503663A1 (es) 1985-03-01
ES523339A0 ES523339A0 (es) 1985-03-01

Family

ID=4223231

Family Applications (7)

Application Number Title Priority Date Filing Date
ES510685A Expired ES8400092A1 (es) 1981-03-24 1982-03-23 Procedimiento para la obtencion de derivados de quinolinona.
ES523341A Expired ES8503334A1 (es) 1981-03-24 1983-06-16 Procedimiento para la obtencion de derivados de quinolinona. (como desglose y con prioridad de la patente espanola no. 510.685, presentada el 23 de marzo de 1.982)
ES523339A Granted ES523339A0 (es) 1981-03-24 1983-06-16 Procedimiento para la obtencion de derivados de quinolinona. (como desglose y con prioridad de la patente espanola no. 510.685, presentada el 23 de marzo de 1.982)
ES523342A Expired ES8503665A1 (es) 1981-03-24 1983-06-16 Procedimiento para la obtencion de derivados de quinolinona. (como desglose y con prioridad de la patente espanola no. 510.685, presentada el 23 de marzo de 1.982)
ES523338A Expired ES8503662A1 (es) 1981-03-24 1983-06-16 Procedimiento para la obtencion de derivados de quinolinona. (como desglose y con prioridad de la patente espanola no.510.685, presentada el 23 de marzo de 1.982).
ES523340A Expired ES8503664A1 (es) 1981-03-24 1983-06-16 Procedimiento para la obtencion de derivados de quinolinona. (como desglose y con prioridad de la patente espanola no. 510.685, presentada el 23 de marzo de 1.982)
ES523337A Expired ES8503661A1 (es) 1981-03-24 1983-06-16 Procedimiento para la obtencion de derivados de quinolinona.

Family Applications Before (2)

Application Number Title Priority Date Filing Date
ES510685A Expired ES8400092A1 (es) 1981-03-24 1982-03-23 Procedimiento para la obtencion de derivados de quinolinona.
ES523341A Expired ES8503334A1 (es) 1981-03-24 1983-06-16 Procedimiento para la obtencion de derivados de quinolinona. (como desglose y con prioridad de la patente espanola no. 510.685, presentada el 23 de marzo de 1.982)

Family Applications After (4)

Application Number Title Priority Date Filing Date
ES523342A Expired ES8503665A1 (es) 1981-03-24 1983-06-16 Procedimiento para la obtencion de derivados de quinolinona. (como desglose y con prioridad de la patente espanola no. 510.685, presentada el 23 de marzo de 1.982)
ES523338A Expired ES8503662A1 (es) 1981-03-24 1983-06-16 Procedimiento para la obtencion de derivados de quinolinona. (como desglose y con prioridad de la patente espanola no.510.685, presentada el 23 de marzo de 1.982).
ES523340A Expired ES8503664A1 (es) 1981-03-24 1983-06-16 Procedimiento para la obtencion de derivados de quinolinona. (como desglose y con prioridad de la patente espanola no. 510.685, presentada el 23 de marzo de 1.982)
ES523337A Expired ES8503661A1 (es) 1981-03-24 1983-06-16 Procedimiento para la obtencion de derivados de quinolinona.

Country Status (22)

Country Link
US (1) US4476132A (es)
EP (1) EP0062001B1 (es)
JP (1) JPH066576B2 (es)
AR (4) AR242189A1 (es)
AT (1) ATE27451T1 (es)
AU (1) AU560003B2 (es)
CY (1) CY1412A (es)
DE (1) DE3276432D1 (es)
DK (1) DK159427C (es)
ES (7) ES8400092A1 (es)
FI (1) FI77853C (es)
GB (1) GB2095668B (es)
GR (1) GR78345B (es)
HK (1) HK3988A (es)
HU (1) HU192103B (es)
IE (1) IE53158B1 (es)
IL (1) IL65327A0 (es)
MY (1) MY8700806A (es)
NO (1) NO160074C (es)
NZ (1) NZ200106A (es)
PT (1) PT74634B (es)
ZA (1) ZA821957B (es)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS58219166A (ja) * 1982-06-14 1983-12-20 Nippon Shinyaku Co Ltd ４−キノロン誘導体
JPS58225065A (ja) * 1982-06-21 1983-12-27 Nippon Shinyaku Co Ltd ２−キノロン誘導体
US4675432A (en) * 1986-08-29 1987-06-23 American Cyanamid Company Method for the preparation of anilinofumarate
US6034100A (en) * 1993-03-10 2000-03-07 Otsuka Pharmaceutical Co., Ltd. Method for inhibiting cytokine secretion
EA007464B1 (ru) * 2000-10-02 2006-10-27 Янссен Фармацевтика Н.В. Антагонисты метаботропных рецепторов глутамата
BR0308945A (pt) * 2002-03-29 2005-01-04 Janssen Pharmaceutica Nv Derivados radiomarcados de quinolina e quinolinona e uso dos mesmos como ligantes para receptores de glutamato metabotrópicos
CA2888210C (en) 2012-10-16 2021-02-09 Janssen Pharmaceutica Nv Methylene linked quinolinyl modulators of ror-gamma-t
KR20150070348A (ko) 2012-10-16 2015-06-24 얀센 파마슈티카 엔.브이. RoRγt의 헤테로아릴 결합 퀴놀리닐 조절제
EP2909193B1 (en) 2012-10-16 2017-04-19 Janssen Pharmaceutica NV Phenyl linked quinolinyl modulators of ror-gamma-t
US9403816B2 (en) 2013-10-15 2016-08-02 Janssen Pharmaceutica Nv Phenyl linked quinolinyl modulators of RORγt
KR20160068956A (ko) 2013-10-15 2016-06-15 얀센 파마슈티카 엔.브이. RORyT의 퀴놀리닐 조절제
JP6423423B2 (ja) 2013-10-15 2018-11-14 ヤンセン ファーマシューティカ エヌ．ベー． Ｒｏｒγｔのアルキル結合キノリニルモジュレーター
US9221804B2 (en) 2013-10-15 2015-12-29 Janssen Pharmaceutica Nv Secondary alcohol quinolinyl modulators of RORγt
US9284308B2 (en) 2013-10-15 2016-03-15 Janssen Pharmaceutica Nv Methylene linked quinolinyl modulators of RORγt
US10555941B2 (en) 2013-10-15 2020-02-11 Janssen Pharmaceutica Nv Alkyl linked quinolinyl modulators of RORγt
US9328095B2 (en) 2013-10-15 2016-05-03 Janssen Pharmaceutica Nv Heteroaryl linked quinolinyl modulators of RORgammat

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB830832A (en) * 1957-02-15 1960-03-23 Ici Ltd New quinolones and therapeutic compositions containing them
GB1013224A (en) * 1962-06-21 1965-12-15 Ici Ltd Heterocyclic aminoethanols
CH529136A (de) * 1966-09-29 1972-10-15 Ciba Geigy Ag Verfahren zur Herstellung von heterocyclischen Carbonsäuren
US3496184A (en) * 1969-03-18 1970-02-17 Ciba Geigy Corp Cyclopropylmethoxy-3-quinoline carboxylic acids and esters
CA947301A (en) * 1970-01-28 1974-05-14 Sumitomo Chemical Company Process for the preparation of compound having antibacterial action
GB1334705A (en) * 1970-06-19 1973-10-24 Ici Ltd Pharmaceutical compositions containing kynurenic acid derivatives
CA942748A (en) * 1970-09-18 1974-02-26 Venkatachala L. Narayanan 1-aziridinylcarbonyl substituted-3-quinolinecarboxylic acid compounds
US4190659A (en) * 1973-08-27 1980-02-26 Sandoz, Inc. Pharmaceutical preparation and use of 4-hydroxy-2-quinolinone-3-carboxylic acid esters
US4086349A (en) * 1975-07-30 1978-04-25 Mitsubishi Yuka Pharmaceutical Co., Ltd. Quinolopyran-4-one-2-carboxylic acid derivatives and salts thereof as novel compounds and as medicines for treatment of allergic asthma
JPS609511B2 (ja) * 1976-07-16 1985-03-11 大塚製薬株式会社 ５−カルボスチリルメタノ−ル誘導体
JPS609713B2 (ja) * 1976-10-08 1985-03-12 大塚製薬株式会社 カルボスチリル誘導体
US4186201A (en) * 1977-02-07 1980-01-29 Riker Laboratories, Inc. Methods of using 8(tetrazol-5-ylcarbamoyl)isoquinoline compounds
US4187309A (en) * 1977-06-20 1980-02-05 Sandoz, Inc. 4-Hydroxy-2-quinolinone-3-carboxylic acids and salts thereof
US4119720A (en) * 1977-07-06 1978-10-10 Sandoz, Inc. Unsaturated esters of 4-hydroxy-2-quinolinone-3-carboxylic acids and salts thereof
DE2806879A1 (de) * 1978-02-17 1979-08-23 Sandoz Ag 4-hydroxy-2-chinolinon-3-carbonsaeure- esterderivate

Also Published As

Publication number Publication date
NZ200106A (en) 1985-07-31
ES510685A0 (es) 1983-10-16
NO160074B (no) 1988-11-28
AR240044A1 (es) 1990-01-31
NO820959L (no) 1982-09-27
ES523338A0 (es) 1985-03-01
DK159427C (da) 1991-03-18
ES523342A0 (es) 1985-03-01
PT74634B (de) 1984-11-26
NO160074C (no) 1989-03-08
AU560003B2 (en) 1987-03-26
FI77853B (fi) 1989-01-31
ES523340A0 (es) 1985-03-01
DK159427B (da) 1990-10-15
ES523341A0 (es) 1985-02-16
IE53158B1 (en) 1988-08-03
HK3988A (en) 1988-01-22
ES523337A0 (es) 1985-03-01
ES8503662A1 (es) 1985-03-01
AR242189A1 (es) 1993-03-31
US4476132A (en) 1984-10-09
IL65327A0 (en) 1982-05-31
DE3276432D1 (en) 1987-07-02
HU192103B (en) 1987-05-28
AU8181982A (en) 1982-09-30
MY8700806A (en) 1987-12-31
FI77853C (fi) 1989-05-10
ZA821957B (en) 1983-02-23
GB2095668A (en) 1982-10-06
ES8400092A1 (es) 1983-10-16
JPH066576B2 (ja) 1994-01-26
GB2095668B (en) 1985-04-11
ES8503665A1 (es) 1985-03-01
ES8503334A1 (es) 1985-02-16
DK130382A (da) 1982-09-25
PT74634A (de) 1982-04-01
EP0062001B1 (de) 1987-05-27
EP0062001A3 (en) 1983-01-26
JPS57192366A (en) 1982-11-26
FI820983L (fi) 1982-09-25
ES8503661A1 (es) 1985-03-01
GR78345B (es) 1984-09-26
AR242376A1 (es) 1993-03-31
AR240739A1 (es) 1990-10-31
IE820670L (en) 1982-09-24
ATE27451T1 (de) 1987-06-15
EP0062001A2 (de) 1982-10-06
ES8503664A1 (es) 1985-03-01
CY1412A (en) 1988-04-22
ES523339A0 (es) 1985-03-01

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19970401