ES456625A1 - Un procedimiento para preparar compuestos de acidos 3-cefem-4-carboxilicos 3,7-sustituidos. - Google Patents

Un procedimiento para preparar compuestos de acidos 3-cefem-4-carboxilicos 3,7-sustituidos.

Info

Publication number
ES456625A1
ES456625A1 ES456625A ES456625A ES456625A1 ES 456625 A1 ES456625 A1 ES 456625A1 ES 456625 A ES456625 A ES 456625A ES 456625 A ES456625 A ES 456625A ES 456625 A1 ES456625 A1 ES 456625A1
Authority
ES
Spain
Prior art keywords
hydroxy
cephem
disubstituted
processes
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES456625A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Fujisawa Pharmaceutical Co Ltd
Original Assignee
Fujisawa Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB9425/76A external-priority patent/GB1575803A/en
Application filed by Fujisawa Pharmaceutical Co Ltd filed Critical Fujisawa Pharmaceutical Co Ltd
Publication of ES456625A1 publication Critical patent/ES456625A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/542—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/545—Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins, cefaclor, or cephalexine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/34—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/38—Nitrogen atoms
    • C07D277/40—Unsubstituted amino or imino radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/38—Nitrogen atoms
    • C07D277/44—Acylated amino or imino radicals
    • C07D277/46—Acylated amino or imino radicals by carboxylic acids, or sulfur or nitrogen analogues thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/38—Nitrogen atoms
    • C07D277/44—Acylated amino or imino radicals
    • C07D277/48—Acylated amino or imino radicals by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof, e.g. carbonylguanidines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/38—Nitrogen atoms
    • C07D277/50—Nitrogen atoms bound to hetero atoms
    • C07D277/52—Nitrogen atoms bound to hetero atoms to sulfur atoms, e.g. sulfonamides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/587—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with aliphatic hydrocarbon radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms, said aliphatic radicals being substituted in the alpha-position to the ring by a hetero atom, e.g. with m >= 0, Z being a singly or a doubly bound hetero atom

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Oncology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Communicable Diseases (AREA)
  • Cephalosporin Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Un procedimiento para preparar compuestos de ácidos 3-cefem-4-carboxílicos 3,7-substituidos, de la fórmula: **(Fórmula)** donde R1 es amino, alquilamino inferior, un amino protegido, un alquilamino inferior protegido, hidroxi, o alcoxi inferior, R2 es hidrógeno, aciloxi, piridinio o un grupo tio heterocíclico que puede tener uno o más substituyentes apropiados, R3 es carboxi o su derivado, A es carbonilo, hidroxialquileno(inferior) o un hidroxialquileno(inferior) protegido, y R4 es hidrógeno o halógeno, o R2 y R3 están enlazados entre sí de modo que representan un grupo de la fórmula: -COO-, en la cual R3 es -COO- cuando R2 es piridinio.
ES456625A 1976-03-09 1977-03-08 Un procedimiento para preparar compuestos de acidos 3-cefem-4-carboxilicos 3,7-sustituidos. Expired ES456625A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB9425/76A GB1575803A (en) 1976-03-09 1976-03-09 3,7 disubstituted 3 cephem 4 carboxylic acid compounds andprocesses for the preparation thereof
GB4114576 1976-10-04

Publications (1)

Publication Number Publication Date
ES456625A1 true ES456625A1 (es) 1978-07-16

Family

ID=26242927

Family Applications (5)

Application Number Title Priority Date Filing Date
ES456625A Expired ES456625A1 (es) 1976-03-09 1977-03-08 Un procedimiento para preparar compuestos de acidos 3-cefem-4-carboxilicos 3,7-sustituidos.
ES467635A Expired ES467635A1 (es) 1976-03-09 1978-03-07 Un procedimiento para preparar compuestos de acidos 3-cefem-4-carboxilicos 3,7-disubstituidos
ES476077A Expired ES476077A1 (es) 1976-03-09 1978-12-16 Un procedimiento para preparar derivados del acido 1,3-tia- zol-glioxilico.
ES476075A Expired ES476075A1 (es) 1976-03-09 1978-12-16 Un procedimiento para preparar compuestos de acidos 3-cefem-4-carboxilicos 3,7-disubstituidos.
ES476076A Expired ES476076A1 (es) 1976-03-09 1978-12-16 Un procedimiento para preparar derivados de 1,3-tiazol.

Family Applications After (4)

Application Number Title Priority Date Filing Date
ES467635A Expired ES467635A1 (es) 1976-03-09 1978-03-07 Un procedimiento para preparar compuestos de acidos 3-cefem-4-carboxilicos 3,7-disubstituidos
ES476077A Expired ES476077A1 (es) 1976-03-09 1978-12-16 Un procedimiento para preparar derivados del acido 1,3-tia- zol-glioxilico.
ES476075A Expired ES476075A1 (es) 1976-03-09 1978-12-16 Un procedimiento para preparar compuestos de acidos 3-cefem-4-carboxilicos 3,7-disubstituidos.
ES476076A Expired ES476076A1 (es) 1976-03-09 1978-12-16 Un procedimiento para preparar derivados de 1,3-tiazol.

Country Status (10)

Country Link
US (1) US4560765A (es)
AR (2) AR218241A1 (es)
CA (1) CA1218054A (es)
DE (1) DE2760288A1 (es)
DK (2) DK168863B1 (es)
ES (5) ES456625A1 (es)
HU (2) HU176455B (es)
IE (1) IE44888B1 (es)
MX (1) MX4658E (es)
SE (2) SE437832B (es)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE55406B1 (en) * 1982-08-07 1990-09-12 Tanabe Seiyaku Co Novel cephalosporin compounds and preparation thereof

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1399086A (en) * 1971-05-14 1975-06-25 Glaxo Lab Ltd Cephalosporin compounds
US4093803A (en) * 1971-05-14 1978-06-06 Glaxo Laboratories Limited 7β-[2-Etherified oximino-2-(thienyl-, furyl- or pyridylacetamido)] cephalosporins
SE417968B (sv) * 1972-10-20 1981-04-27 Fujisawa Pharmaceutical Co Forfarande for framstellning av penamderivat
US4113940A (en) * 1973-03-15 1978-09-12 Fujisawa Pharmaceutical Co., Ltd. 7-amino 2-lower alkyl-2 or 3-cephem-4-carboxylic acid derivatives and processes for preparation thereof
JPS5119765A (en) * 1974-08-09 1976-02-17 Takeda Chemical Industries Ltd Aminochiazoorujudotaino seizoho
US4298606A (en) * 1974-12-19 1981-11-03 Takeda Chemical Industries, Ltd. Thiazolylacetamido compounds
DK154939C (da) * 1974-12-19 1989-06-12 Takeda Chemical Industries Ltd Analogifremgangsmaade til fremstilling af thiazolylacetamido-cephemforbindelser eller farmaceutisk acceptable salte eller estere deraf
GR63088B (en) * 1976-04-14 1979-08-09 Takeda Chemical Industries Ltd Preparation process of novel cephalosporins

Also Published As

Publication number Publication date
DK139691A (da) 1991-07-25
US4560765A (en) 1985-12-24
SE8302027D0 (sv) 1983-04-12
SE437832B (sv) 1985-03-18
AR222010A1 (es) 1981-04-15
ES476076A1 (es) 1979-05-16
SE7702547L (sv) 1977-09-10
AR218241A1 (es) 1980-05-30
ES476077A1 (es) 1979-05-16
DK168863B1 (da) 1994-06-27
IE44888L (en) 1977-09-09
HU176455B (en) 1981-03-28
CA1218054A (en) 1987-02-17
IE44888B1 (en) 1982-05-05
ES467635A1 (es) 1979-09-01
DE2760288A1 (es) 1985-05-09
MX4658E (es) 1982-07-19
ES476075A1 (es) 1979-05-16
DK139691D0 (da) 1991-07-25
SE8302027L (sv) 1983-04-12
HU179016B (en) 1982-08-28
DK101477A (da) 1977-09-10
SE454988B (sv) 1988-06-13

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19980302