IE45597L - Cephalosporins. - Google Patents

Cephalosporins.

Info

Publication number
IE45597L
IE45597L IE770440A IE44077A IE45597L IE 45597 L IE45597 L IE 45597L IE 770440 A IE770440 A IE 770440A IE 44077 A IE44077 A IE 44077A IE 45597 L IE45597 L IE 45597L
Authority
IE
Ireland
Prior art keywords
group
img
formula
hydroxy
protected
Prior art date
Application number
IE770440A
Other versions
IE45597B1 (en
Original Assignee
Fujisawa Pharmaceutical Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB14916/76A external-priority patent/GB1576625A/en
Application filed by Fujisawa Pharmaceutical Co filed Critical Fujisawa Pharmaceutical Co
Priority to IE2634/80A priority Critical patent/IE45598B1/en
Publication of IE45597L publication Critical patent/IE45597L/en
Publication of IE45597B1 publication Critical patent/IE45597B1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/38—Nitrogen atoms
    • C07D277/44—Acylated amino or imino radicals
    • C07D277/48—Acylated amino or imino radicals by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof, e.g. carbonylguanidines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/587—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with aliphatic hydrocarbon radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms, said aliphatic radicals being substituted in the alpha-position to the ring by a hetero atom, e.g. with m >= 0, Z being a singly or a doubly bound hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/14—Radicals substituted by singly bound hetero atoms other than halogen
    • C07D333/16—Radicals substituted by singly bound hetero atoms other than halogen by oxygen atoms
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Cephalosporin Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Novel syn-isomer of 3,7-disubstituted-3-cephem-4-carboxylic acid compounds are provided of the formula: <IMG> in which R1 is a group of the formula: <IMG> wherein R5 is hydrogen, halogen, nitro, hydroxy, lower alkoxy or acyloxy and R6 is hydroxy, lower alkoxy, acyloxy, acylamino or di(lower)alkylamino; a group of the formula: <IMG> wherein R7 is amino, protected amino, hydroxy or lower alkyl; or a group of the formula: <IMG> wherein R8 is lower alkyl and R9 is imino, protected imino or oxo; R2 is an aliphatic hydrocarbon group which may have suitable substituent (s); R3 is carboxy or protected carboxy; and R4 is acyloxymethyl, hydroxymethyl, formyl or a heterocyclicthiomethyl group which may have suitable substituent (s); or R3 and R4 are linked together to form -COOCH2-, and pharmaceutically acceptable salts and tautomers thereof; the novel compounds are highly active against a number of pathogenic bacteria. (From CA1337522 C) [FR2348219A1]
IE440/77A 1976-04-12 1977-03-01 Syn isomer of 3,7-disubstituted 3 cephem 4 carboxylic acid compounds and processes for the preparation thereof IE45597B1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
IE2634/80A IE45598B1 (en) 1976-04-12 1977-03-01 Intermediates in the preparation of syn-isomers of 3,7-disubstituted-3-cephem-4-carboxylic acid compounds and processes for the preparation thereof

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB14916/76A GB1576625A (en) 1976-04-12 1976-04-12 Syn isomer 3,7 disubstituted 3 cephem 4 carboxylic acid compounds and processes for the preparation thereof
GB2349076 1976-06-07
JP51125826A JPS5941995B2 (en) 1976-04-12 1976-10-19 3,7-disubstituted-3-cephem-4-carboxylic acid compounds and salts thereof and methods for producing them

Publications (2)

Publication Number Publication Date
IE45597L true IE45597L (en) 1977-10-12
IE45597B1 IE45597B1 (en) 1982-10-06

Family

ID=27257189

Family Applications (1)

Application Number Title Priority Date Filing Date
IE440/77A IE45597B1 (en) 1976-04-12 1977-03-01 Syn isomer of 3,7-disubstituted 3 cephem 4 carboxylic acid compounds and processes for the preparation thereof

Country Status (13)

Country Link
AR (2) AR227864A1 (en)
AT (1) AT358728B (en)
CA (1) CA1337522C (en)
CH (2) CH638532A5 (en)
DE (1) DE2707565A1 (en)
DK (1) DK162391C (en)
ES (7) ES457191A1 (en)
FR (1) FR2348219A1 (en)
HU (1) HU177441B (en)
IE (1) IE45597B1 (en)
MX (1) MX4985E (en)
NL (1) NL191259C (en)
SE (2) SE443981B (en)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3192167A (en) * 1962-09-20 1965-06-29 Ogawa Abiko Low pressure liquid vaporizer which is electrically heated
BE878514A (en) * 1978-09-04 1980-02-29 Fujisawa Pharmaceutical Co PROCESS FOR THE PREPARATION OF 3-CEPHEM-4-CARBOXYLIC ACID COMPOUNDS WITH DISUBSTITUTION IN POSITIONS 3 AND 7, NOVEL PRODUCTS THUS OBTAINED AND THEIR USE FOR THEIR ANTIBACTERIAL ACTIVITY
DE2760484C2 (en) * 1976-04-14 1992-12-03 Takeda Chemical Industries, Ltd., Osaka, Jp
FR2381053A1 (en) * 1977-02-18 1978-09-15 Roussel Uclaf NEW OXIMES DERIVED FROM 3-THIADIAZOLYL THIOMETHYL 7-AMINOTHIAZOLYL ACETAMIDO CEPHALOSPORANIC, THEIR PREPARATION PROCESS AND THEIR APPLICATION AS MEDICINAL PRODUCTS
FR2399418A1 (en) * 1977-03-14 1979-03-02 Fujisawa Pharmaceutical Co Heterocyclyl-imino-acetamido-cephalosporin derivs.
PH17188A (en) 1977-03-14 1984-06-14 Fujisawa Pharmaceutical Co New cephem and cepham compounds and their pharmaceutical compositions and method of use
SE439312B (en) * 1977-03-25 1985-06-10 Roussel Uclaf SET TO MAKE NEW OXIME DERIVATIVES OF 3-ACETOXIMETHYL-7-AMINOTIAZOLYLACETAMIDO CEPHALOSPORANIC ACID
DE2714880A1 (en) * 1977-04-02 1978-10-26 Hoechst Ag CEPHEMDER DERIVATIVES AND PROCESS FOR THEIR PRODUCTION
JPS5498795A (en) * 1978-01-13 1979-08-03 Takeda Chem Ind Ltd Cephalosporin derivative and its preparation
FR2553770B2 (en) * 1978-03-31 1986-03-14 Roussel Uclaf NOVEL PRODUCTS DERIVED FROM ACID 2 (2-AMINO THIAZOL-4-YL) 2-ALCOXY-IMINO ACETIC SUBSTITUTED ON OXIME AND THEIR PREPARATION PROCESS
FR2432521A1 (en) * 1978-03-31 1980-02-29 Roussel Uclaf NOVEL O-SUBSTITUTED OXIMES DERIVED FROM 7-AMINO THIAZOLYL ACETAMIDO CEPHALOSPORANIC ACID, THEIR PREPARATION PROCESS AND THEIR USE AS MEDICAMENTS
FR2421907A1 (en) * 1978-04-07 1979-11-02 Roussel Uclaf NEW CEPHALOSPORINS DERIVED FROM 7- / 2- (2-AMINO 4-THIAZOLYL) 2- (CARBOXYMETHOXYIMINO / ACETAMIDO 3-SUBSTITUTE CEPHALOSPORANIC ACID, THEIR METHOD OF PREPARATION AND THEIR APPLICATION AS MEDICINAL PRODUCTS
FR2438051A2 (en) * 1978-10-05 1980-04-30 Roussel Uclaf 3-Azido:methyl-3-cephem-4-carboxylic acid derivs. - useful as broad-spectrum antibacterial agents and disinfectants (BE 15.10.79)
MC1259A1 (en) 1978-05-30 1980-01-14 Hoffmann La Roche ACYL DERIVATIVES
US4284631A (en) * 1978-07-31 1981-08-18 Fujisawa Pharmaceutical Co., Ltd. 7-Substituted cephem compounds and pharmaceutical antibacterial compositions containing them
FR2453161A1 (en) * 1978-08-31 1980-10-31 Fujisawa Pharmaceutical Co Antibacterial amino-thiazolyl cephalosporin derivs.
US4341775A (en) * 1978-09-11 1982-07-27 Fujisawa Pharmaceutical Co., Ltd. Cephem compounds
ATE4214T1 (en) * 1978-10-17 1983-08-15 Fujisawa Pharmaceutical Co., Ltd. CEPHAM COMPOUNDS, THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM, PROCESSES FOR THE PREPARATION THEREOF, AND THE PREPARATION OF KNOWN CEPHEM COMPOUNDS.
DE2945248A1 (en) * 1978-11-13 1980-05-22 Fujisawa Pharmaceutical Co CEPHEM COMPOUNDS, METHOD FOR THEIR PRODUCTION AND ANTIBACTERIAL PHARMACEUTICAL AGENTS CONTAINING THE SAME
FR2448543A1 (en) * 1979-02-09 1980-09-05 Roussel Uclaf NOVEL OXIMES O-SUBSTITUTED BY A RADICAL COMPRISING A QUATERNARY AMMONIUM AND DERIVATIVES OF 7-AMINO THIAZOLYL ACETAMIDO CEPHALOSPORANIC, THEIR PREPARATION PROCESS AND THEIR APPLICATION AS MEDICAMENTS
FR2461713A1 (en) * 1979-07-19 1981-02-06 Roussel Uclaf SUBSTITUTED ALKYLOXIMIC NEWS DERIVED FROM 7- (2-AMINO 4-THIAZOLYL) ACETAMIDO CEPHALOSPORANIC ACID, PROCESS FOR PREPARING THEM AND THEIR APPLICATION AS MEDICAMENTS
FR2462439A1 (en) * 1979-07-26 1981-02-13 Roussel Uclaf NOVEL PROCESS FOR THE PREPARATION OF PRODUCTS DERIVED FROM 7 - / (2-ARYL) 2-HYDROXYIMINO ACETAMIDO / CEPHALOSPORANIC ACID
IL61458A0 (en) * 1979-12-07 1980-12-31 Erba Farmitalia N-substituted thiazolyl derivatives of oximino-substituted cephalosporins, their preparation and pharmalceutical compositions containing them
FR2506307A1 (en) * 1981-05-22 1982-11-26 Roussel Uclaf 7-thiazolyl-acetamido-cephalosporin oxime derivs. - useful as broad spectrum antibacterials and disinfectants (BE 1.10.79)
US4426528A (en) * 1982-04-01 1984-01-17 Eli Lilly And Company Purification of syn-(2-aminothiazol-4-yl)methoxyimino)acetic acid
FR2532936A1 (en) * 1982-09-13 1984-03-16 Roussel Uclaf New 2-aminothiazolyl-4-ylacetic acid derivatives containing a substituted oxime functional group and process for their preparation.
GB8324152D0 (en) * 1983-09-09 1983-10-12 Glaxo Group Ltd Chemical process
IT8448798A0 (en) * 1983-09-12 1984-09-05 Biochemie Gmbh PROCEDURE FOR THE PREPARATION OF CEPHALOSPORIN-TYPE ANTIBIOTICS
GB2161476B (en) * 1984-05-25 1988-01-27 Toyama Chemical Co Ltd 2-aminothiazolyl-2-methoxyimino acetamides and their use in preparing cephalosporins
DE3750411T2 (en) * 1986-04-14 1995-03-16 Banyu Pharma Co Ltd Cephalosporin derivatives, processes for their preparation and antibacterial preparations.

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1399086A (en) * 1971-05-14 1975-06-25 Glaxo Lab Ltd Cephalosporin compounds
NZ176206A (en) * 1973-12-25 1978-03-06 Takeda Chemical Industries Ltd Cephalosporins
DK154939C (en) * 1974-12-19 1989-06-12 Takeda Chemical Industries Ltd METHOD OF ANALOGUE FOR THE PREPARATION OF THIAZOLYLACETAMIDO-CEPHEM COMPOUNDS OR PHARMACEUTICAL ACCEPTABLE SALTS OR ESTERS THEREOF
SE432254B (en) * 1975-02-04 1984-03-26 Fujisawa Pharmaceutical Co ANALOGY PROCEDURE FOR PREPARATION OF 3-SUBSTITUTED 7- (ALFA, ALFA-DISUBSTITUTED ACETAMIDO) -3-CEFEM-4-CARBOXYL ACID
DE2760123C2 (en) * 1976-01-23 1986-04-30 Roussel-Uclaf, Paris 7-Aminothiazolyl-syn-oxyiminoacetamidocephalosporanic acids, their preparation and pharmaceutical compositions containing them
FR2346014A1 (en) * 1976-01-23 1977-10-28 Roussel Uclaf Amino-thiazolyl-hydroxyimino-acetamido-cephalosporanic acids - with antibacterial activity
SE440655B (en) * 1976-01-23 1985-08-12 Roussel Uclaf SET TO MAKE NEW OXIME DERIVATIVES OF 7-AMINO-THIAZOLYL-ACETAMIDO-CEPHALOSPORANIC ACID
FR2345153A1 (en) * 1976-03-25 1977-10-21 Roussel Uclaf NEW ALCOYLOXIMES DERIVED FROM 7-AMINO THIAZOLYL ACETAMIDO CEPHALOSPORANIC ACID, THEIR PREPARATION PROCESS AND THEIR APPLICATION AS MEDICINAL PRODUCTS
DE2760484C2 (en) * 1976-04-14 1992-12-03 Takeda Chemical Industries, Ltd., Osaka, Jp

Also Published As

Publication number Publication date
ES485063A1 (en) 1980-06-16
MX4985E (en) 1983-01-31
SE8304465D0 (en) 1983-08-17
DK75077A (en) 1977-10-13
IE45597B1 (en) 1982-10-06
DK162391C (en) 1992-03-09
ATA138477A (en) 1980-02-15
SE7701964L (en) 1977-10-13
DE2707565A1 (en) 1978-02-23
AT358728B (en) 1980-09-25
HU177441B (en) 1981-10-28
SE457351B (en) 1988-12-19
NL191259B (en) 1994-11-16
AR227864A1 (en) 1982-12-30
NL191259C (en) 1995-04-18
ES457191A1 (en) 1978-08-16
FR2348219B1 (en) 1982-12-03
CH643557A5 (en) 1984-06-15
FR2348219A1 (en) 1977-11-10
ES485064A1 (en) 1980-10-01
SE443981B (en) 1986-03-17
DK162391B (en) 1991-10-21
ES485062A1 (en) 1980-06-16
ES477741A1 (en) 1980-04-01
AR223143A1 (en) 1981-07-31
DE2707565C2 (en) 1988-06-30
NL7703969A (en) 1977-10-14
CH638532A5 (en) 1983-09-30
ES468719A1 (en) 1979-10-16
ES485061A1 (en) 1980-06-16
CA1337522C (en) 1995-11-07

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Legal Events

Date Code Title Description
MK9A Patent expired