FR2453161A1 - Antibacterial amino-thiazolyl cephalosporin derivs. - Google Patents

Antibacterial amino-thiazolyl cephalosporin derivs.

Info

Publication number
FR2453161A1
FR2453161A1 FR8005052A FR8005052A FR2453161A1 FR 2453161 A1 FR2453161 A1 FR 2453161A1 FR 8005052 A FR8005052 A FR 8005052A FR 8005052 A FR8005052 A FR 8005052A FR 2453161 A1 FR2453161 A1 FR 2453161A1
Authority
FR
France
Prior art keywords
opt
thiazolyl
substd
gram
iii
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR8005052A
Other languages
French (fr)
Other versions
FR2453161B1 (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Fujisawa Pharmaceutical Co Ltd
Original Assignee
Fujisawa Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fujisawa Pharmaceutical Co Ltd filed Critical Fujisawa Pharmaceutical Co Ltd
Priority to FR8005052A priority Critical patent/FR2453161A1/en
Publication of FR2453161A1 publication Critical patent/FR2453161A1/en
Application granted granted Critical
Publication of FR2453161B1 publication Critical patent/FR2453161B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/587—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with aliphatic hydrocarbon radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms, said aliphatic radicals being substituted in the alpha-position to the ring by a hetero atom, e.g. with m >= 0, Z being a singly or a doubly bound hetero atom

Abstract

7-(2-Aminothiazolyl-2-imino-acetamido)-3-heterocyclyl-thiomethyl-- 3-cephem-4-carboxylic acid derivs. of formula (I) and their salts and intermediates (III)' are new. (where R1 = opt. protected amino, R2 = aliphatic hydrocarbyl opt. substd. by one or more acceptable gps. R3 = opt. protected carboxy and R4 = a five-membered nitrogen-contg.heteromonocyclic gp. having one or more lower alkenyl gp(s). With the condition that R2 is not = methyl when R4 = lower alkenyl substd.tetrazolyl. In cpd. (III)', R2' = cyclopentyl or 3,4-dichlorobenzyl).(I) have high activity against both Gram-positive and Gram-negative bacteria which may be administered orally parenterally or locally in
FR8005052A 1978-08-31 1980-03-06 Antibacterial amino-thiazolyl cephalosporin derivs. Granted FR2453161A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
FR8005052A FR2453161A1 (en) 1978-08-31 1980-03-06 Antibacterial amino-thiazolyl cephalosporin derivs.

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB7835195 1978-08-31
FR8005052A FR2453161A1 (en) 1978-08-31 1980-03-06 Antibacterial amino-thiazolyl cephalosporin derivs.

Publications (2)

Publication Number Publication Date
FR2453161A1 true FR2453161A1 (en) 1980-10-31
FR2453161B1 FR2453161B1 (en) 1983-06-10

Family

ID=26221646

Family Applications (1)

Application Number Title Priority Date Filing Date
FR8005052A Granted FR2453161A1 (en) 1978-08-31 1980-03-06 Antibacterial amino-thiazolyl cephalosporin derivs.

Country Status (1)

Country Link
FR (1) FR2453161A1 (en)

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2348219A1 (en) * 1976-04-12 1977-11-10 Fujisawa Pharmaceutical Co PROCESS FOR PREPARING SYN ISOMERS OF 3,7-CEPHEM-4-CARBOXYLIC 3,7-DISUBSTITUTED ACID COMPOUNDS AND NEW PRODUCTS THUS OBTAINED, WITH ANTIBACTERIAL ACTIVITY
FR2383951A1 (en) * 1977-03-14 1978-10-13 Fujisawa Pharmaceutical Co PROCESS FOR PREPARING 7-SUBSTITUE-3-CEPHEM (OR CEPHAM) -4-CARBOXYLIC ACIDS, THEIR SALTS AND THEIR BIOPRECURSORS, AND NEW PRODUCTS THUS OBTAINED, WITH ANTIMICROBIAL ACTIVITY
FR2385722A1 (en) * 1977-04-02 1978-10-27 Hoechst Ag NEW CEPHALOSPORIN DERIVATIVES, THEIR PREPARATION PROCESS AND THEIR THERAPEUTIC APPLICATION
DE2804040A1 (en) * 1978-01-31 1979-08-02 Hoechst Ag 2-Oximino-acylamino cephem cpds. prodn. - by acylating 7-amino-cephem cpds. with complexes of 2-syn-oximino-acyl halide(s) and N,N-di:substd. amide(s)
EP0007633A2 (en) * 1978-07-31 1980-02-06 Fujisawa Pharmaceutical Co., Ltd. Cephem compounds, processes for their preparation and pharmaceutical compositions containing them

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2348219A1 (en) * 1976-04-12 1977-11-10 Fujisawa Pharmaceutical Co PROCESS FOR PREPARING SYN ISOMERS OF 3,7-CEPHEM-4-CARBOXYLIC 3,7-DISUBSTITUTED ACID COMPOUNDS AND NEW PRODUCTS THUS OBTAINED, WITH ANTIBACTERIAL ACTIVITY
FR2383951A1 (en) * 1977-03-14 1978-10-13 Fujisawa Pharmaceutical Co PROCESS FOR PREPARING 7-SUBSTITUE-3-CEPHEM (OR CEPHAM) -4-CARBOXYLIC ACIDS, THEIR SALTS AND THEIR BIOPRECURSORS, AND NEW PRODUCTS THUS OBTAINED, WITH ANTIMICROBIAL ACTIVITY
FR2385722A1 (en) * 1977-04-02 1978-10-27 Hoechst Ag NEW CEPHALOSPORIN DERIVATIVES, THEIR PREPARATION PROCESS AND THEIR THERAPEUTIC APPLICATION
DE2804040A1 (en) * 1978-01-31 1979-08-02 Hoechst Ag 2-Oximino-acylamino cephem cpds. prodn. - by acylating 7-amino-cephem cpds. with complexes of 2-syn-oximino-acyl halide(s) and N,N-di:substd. amide(s)
EP0007633A2 (en) * 1978-07-31 1980-02-06 Fujisawa Pharmaceutical Co., Ltd. Cephem compounds, processes for their preparation and pharmaceutical compositions containing them

Also Published As

Publication number Publication date
FR2453161B1 (en) 1983-06-10

Similar Documents

Publication Publication Date Title
IE45597L (en) Cephalosporins.
JPS54132592A (en) 3,7-di-substituted-3-cephem-4-carboxylic acid derivative, its salt, and their preparation
ES8104308A1 (en) Cephem compounds
JPS55105689A (en) Novel cephem and cepham compounds, their preparation and preventive and remedy for microbism
ZA9110009B (en) Methylenebisphosphonic acid derivatives
ES8606360A1 (en) Novel cephalosporin derivatives.
GB1153578A (en) Phenyl-Isopropylamine Derivatives
ES8402590A1 (en) New beta-lactam acetic acid derivatives, the process for preparing them, and their use as intermediates for 1-azabicyclo(3.2.0.)hept-2-ene antibiotics.
FR2453161A1 (en) Antibacterial amino-thiazolyl cephalosporin derivs.
ES8102109A1 (en) Aminothiazole oxime derivatives
ES483839A1 (en) 33cephem compound* its salt* their preparation* and preventive and remedy for microbism comprising thema active constituent
ES442217A1 (en) 1,4-Dihydro-4-oxo-pyridylacetamido cephalosporins and their utilization as medicinal agents for combating bacterial infections
ES482280A1 (en) Imidazolylethoxy derivatives of pyrazolo{8 3,4-b{9 pyridine-5-methanols
IE40517L (en) 3 - heterocyclic thiomethyl cephalosporins
FR2445325A1 (en) Antibacterial amino-thiazolyl cephalosporin derivs.
ES8101076A1 (en) Novel penicillins
FR2422668A1 (en) 3-Azido:methyl-3-cephem-4-carboxylic acid derivs. - useful as broad-spectrum antibacterial agents and disinfectants (BE 15.10.79)
FR2372630A1 (en) Antibacterial cephalosporin type cpds - eg 7-beta-(substd-acetamido)-3-(3-heterocyclyl prop-1-enyl)-ceph-3-em-4-carboxylic acids
CS103488A2 (en) Method of new cephalosporin derivatives production
ES8403137A1 (en) 7-Hydrocarbyl:oxy-imino-amino-thiadiazolyl acetamido-3-cephem(s)
JPS5646883A (en) Novel cephalosporin compound and its preparation
IE790752L (en) Cephalosporin derivatives
NL7205885A (en) Benzocyclobutenyl-cephalosporins - useful as antibiotics
IT1198306B (en) 7-thiazolyl-acetamido-cephalosporin derivs. - useful as antibacterials in human and veterinary medicine e.g. against proteus vulgaris and bacillus subtilis
NL7413014A (en) 7-(Alpha-Mercapto-acetamido)-cephalosporanic acid derivs - prepd. e.g. by N-acylation of 7-unsubstd. amino cpds.

Legal Events

Date Code Title Description
ST Notification of lapse