IT1198306B - 7-thiazolyl-acetamido-cephalosporin derivs. - useful as antibacterials in human and veterinary medicine e.g. against proteus vulgaris and bacillus subtilis - Google Patents
7-thiazolyl-acetamido-cephalosporin derivs. - useful as antibacterials in human and veterinary medicine e.g. against proteus vulgaris and bacillus subtilisInfo
- Publication number
- IT1198306B IT1198306B IT3142778A IT3142778A IT1198306B IT 1198306 B IT1198306 B IT 1198306B IT 3142778 A IT3142778 A IT 3142778A IT 3142778 A IT3142778 A IT 3142778A IT 1198306 B IT1198306 B IT 1198306B
- Authority
- IT
- Italy
- Prior art keywords
- substd
- alkyl
- opt
- alkynyl
- cycloalkyl
- Prior art date
Links
- 229940124587 cephalosporin Drugs 0.000 title abstract 2
- 244000063299 Bacillus subtilis Species 0.000 title 1
- 235000014469 Bacillus subtilis Nutrition 0.000 title 1
- 241000588767 Proteus vulgaris Species 0.000 title 1
- 230000000844 anti-bacterial effect Effects 0.000 title 1
- 229940088710 antibiotic agent Drugs 0.000 title 1
- 239000003814 drug Substances 0.000 title 1
- 229940007042 proteus vulgaris Drugs 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 7
- 125000000304 alkynyl group Chemical group 0.000 abstract 4
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 4
- 239000000543 intermediate Substances 0.000 abstract 3
- 125000004423 acyloxy group Chemical group 0.000 abstract 2
- 125000003342 alkenyl group Chemical group 0.000 abstract 2
- 125000003545 alkoxy group Chemical group 0.000 abstract 2
- -1 carbamoyloxy Chemical group 0.000 abstract 2
- 125000005201 cycloalkylcarbonyloxy group Chemical group 0.000 abstract 2
- 125000001475 halogen functional group Chemical group 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- 229930186147 Cephalosporin Natural products 0.000 abstract 1
- 125000003668 acetyloxy group Chemical group [H]C([H])([H])C(=O)O[*] 0.000 abstract 1
- 125000003435 aroyl group Chemical group 0.000 abstract 1
- 125000005333 aroyloxy group Chemical group 0.000 abstract 1
- 125000005116 aryl carbamoyl group Chemical group 0.000 abstract 1
- 150000001780 cephalosporins Chemical class 0.000 abstract 1
- 125000000959 isobutyl group Chemical group [H]C([H])([H])C([H])(C([H])([H])[H])C([H])([H])* 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
Abstract
Cephalosporins of formula (I) and their pharmaceutically acceptable salts are new: R1=opt. protected amino; R3=opt. protected carboxy-R2= isobutyl and R4= acetoxy; or R=lower cycloalkyl or alkynyl and R4 = lower alkanoyloxy; or R2 = lower alkyl and R4 = 5-6C alkanoyloxy; or R2 = 2-6C alkyl, lower alkenyl, cycloalkyl or alkynyl and R4 = H, carbamoyloxy, thiadiazolythio (opt. lower alkyl substd.) or triazolylthio; or R2 = 2-6C alkyl lower cycloalkyl or alkynyl and R4=methyl-substd. tetrazolylthio; or R2 = lower alkyl, alkenyl, cycloalkyl or alkynyl and R4 = aroyloxy (opt. substd. by NO2 ro NH2), lower cycloalkylcarbonyloxy, arylcarbamoyloxy (opt. halo substd.), lower aralkanoyloxy, lower aryloxyalkanoyloxy substd. by lower alkoxy, thenoyloxy, tetrazolylthio substd. by 3-6C alkyl or benzothiazolylthio. Also new are the intermediates (IIa) and (IIb) and their salts. In (IIa) Q is 1-R7-tetrazol-5-ylthio with R7=3-6C alkyl; In (IIb) Q is OR4c with R4v = arylcarbamoyl (opt. halo substd.), lower aryloxyalkanoyl substd by alkoxy, thenoyl, lower cycloalkylcarbonyloxy or nitro-substd. aroyl.
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US87784878A | 1978-02-15 | 1978-02-15 | |
US05/887,999 US4279818A (en) | 1976-04-12 | 1978-03-20 | Syn-isomers of 7-[2-alkoxyimino-2-(2-amino-thiazol-4-yl)acetamido]-3-[nitrobenzoyl-, or benzoyl-oxymethyl]-3-cephem-4-carboxylic acid |
GB7835195 | 1978-08-31 | ||
GB7835435 | 1978-09-04 | ||
GB7836563 | 1978-09-12 |
Publications (2)
Publication Number | Publication Date |
---|---|
IT7831427A0 IT7831427A0 (en) | 1978-12-29 |
IT1198306B true IT1198306B (en) | 1988-12-21 |
Family
ID=27516375
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IT3142778A IT1198306B (en) | 1978-02-15 | 1978-12-29 | 7-thiazolyl-acetamido-cephalosporin derivs. - useful as antibacterials in human and veterinary medicine e.g. against proteus vulgaris and bacillus subtilis |
Country Status (1)
Country | Link |
---|---|
IT (1) | IT1198306B (en) |
-
1978
- 1978-12-29 IT IT3142778A patent/IT1198306B/en active
Also Published As
Publication number | Publication date |
---|---|
IT7831427A0 (en) | 1978-12-29 |
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