IT1198306B - 7-thiazolyl-acetamido-cephalosporin derivs. - useful as antibacterials in human and veterinary medicine e.g. against proteus vulgaris and bacillus subtilis - Google Patents

7-thiazolyl-acetamido-cephalosporin derivs. - useful as antibacterials in human and veterinary medicine e.g. against proteus vulgaris and bacillus subtilis

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Publication number
IT1198306B
IT1198306B IT3142778A IT3142778A IT1198306B IT 1198306 B IT1198306 B IT 1198306B IT 3142778 A IT3142778 A IT 3142778A IT 3142778 A IT3142778 A IT 3142778A IT 1198306 B IT1198306 B IT 1198306B
Authority
IT
Italy
Prior art keywords
substd
alkyl
opt
alkynyl
cycloalkyl
Prior art date
Application number
IT3142778A
Other languages
Italian (it)
Other versions
IT7831427A0 (en
Original Assignee
Fujisawa Pharmaceutical Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US05/887,999 external-priority patent/US4279818A/en
Application filed by Fujisawa Pharmaceutical Co filed Critical Fujisawa Pharmaceutical Co
Publication of IT7831427A0 publication Critical patent/IT7831427A0/en
Application granted granted Critical
Publication of IT1198306B publication Critical patent/IT1198306B/en

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Abstract

Cephalosporins of formula (I) and their pharmaceutically acceptable salts are new: R1=opt. protected amino; R3=opt. protected carboxy-R2= isobutyl and R4= acetoxy; or R=lower cycloalkyl or alkynyl and R4 = lower alkanoyloxy; or R2 = lower alkyl and R4 = 5-6C alkanoyloxy; or R2 = 2-6C alkyl, lower alkenyl, cycloalkyl or alkynyl and R4 = H, carbamoyloxy, thiadiazolythio (opt. lower alkyl substd.) or triazolylthio; or R2 = 2-6C alkyl lower cycloalkyl or alkynyl and R4=methyl-substd. tetrazolylthio; or R2 = lower alkyl, alkenyl, cycloalkyl or alkynyl and R4 = aroyloxy (opt. substd. by NO2 ro NH2), lower cycloalkylcarbonyloxy, arylcarbamoyloxy (opt. halo substd.), lower aralkanoyloxy, lower aryloxyalkanoyloxy substd. by lower alkoxy, thenoyloxy, tetrazolylthio substd. by 3-6C alkyl or benzothiazolylthio. Also new are the intermediates (IIa) and (IIb) and their salts. In (IIa) Q is 1-R7-tetrazol-5-ylthio with R7=3-6C alkyl; In (IIb) Q is OR4c with R4v = arylcarbamoyl (opt. halo substd.), lower aryloxyalkanoyl substd by alkoxy, thenoyl, lower cycloalkylcarbonyloxy or nitro-substd. aroyl.
IT3142778A 1978-02-15 1978-12-29 7-thiazolyl-acetamido-cephalosporin derivs. - useful as antibacterials in human and veterinary medicine e.g. against proteus vulgaris and bacillus subtilis IT1198306B (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US87784878A 1978-02-15 1978-02-15
US05/887,999 US4279818A (en) 1976-04-12 1978-03-20 Syn-isomers of 7-[2-alkoxyimino-2-(2-amino-thiazol-4-yl)acetamido]-3-[nitrobenzoyl-, or benzoyl-oxymethyl]-3-cephem-4-carboxylic acid
GB7835195 1978-08-31
GB7835435 1978-09-04
GB7836563 1978-09-12

Publications (2)

Publication Number Publication Date
IT7831427A0 IT7831427A0 (en) 1978-12-29
IT1198306B true IT1198306B (en) 1988-12-21

Family

ID=27516375

Family Applications (1)

Application Number Title Priority Date Filing Date
IT3142778A IT1198306B (en) 1978-02-15 1978-12-29 7-thiazolyl-acetamido-cephalosporin derivs. - useful as antibacterials in human and veterinary medicine e.g. against proteus vulgaris and bacillus subtilis

Country Status (1)

Country Link
IT (1) IT1198306B (en)

Also Published As

Publication number Publication date
IT7831427A0 (en) 1978-12-29

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