CS103488A2 - Method of new cephalosporin derivatives production - Google Patents
Method of new cephalosporin derivatives productionInfo
- Publication number
- CS103488A2 CS103488A2 CS881034A CS103488A CS103488A2 CS 103488 A2 CS103488 A2 CS 103488A2 CS 881034 A CS881034 A CS 881034A CS 103488 A CS103488 A CS 103488A CS 103488 A2 CS103488 A2 CS 103488A2
- Authority
- CS
- Czechoslovakia
- Prior art keywords
- opt
- substd
- amino
- cpds
- lower alkyl
- Prior art date
Links
- 229930186147 Cephalosporin Natural products 0.000 title 1
- 229940124587 cephalosporin Drugs 0.000 title 1
- 150000001780 cephalosporins Chemical class 0.000 title 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 6
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 125000004414 alkyl thio group Chemical group 0.000 abstract 2
- -1 sulphamoyl Chemical group 0.000 abstract 2
- 108090000204 Dipeptidase 1 Proteins 0.000 abstract 1
- 241000589517 Pseudomonas aeruginosa Species 0.000 abstract 1
- 125000004442 acylamino group Chemical group 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000004390 alkyl sulfonyl group Chemical group 0.000 abstract 1
- 125000002947 alkylene group Chemical group 0.000 abstract 1
- 239000004599 antimicrobial Substances 0.000 abstract 1
- 102000006635 beta-lactamase Human genes 0.000 abstract 1
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 abstract 1
- 239000006052 feed supplement Substances 0.000 abstract 1
- 125000001475 halogen functional group Chemical group 0.000 abstract 1
- 125000000896 monocarboxylic acid group Chemical group 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 241000894007 species Species 0.000 abstract 1
Landscapes
- Cephalosporin Compounds (AREA)
Abstract
3-Pyridinium-methyl -cephem-4-carboxylic acid derivs of formula (I) and their salts are new. In (I), R1 = opt protected amino; one of R2 and R3 = opt substd lower alkylthio, sulphamoyl, lower alkylsulphonyl, sulpho, opt substd amino, lower alkyl (opt substd by lower alkylthio, amino or acylamino), halo, COOH or lower alkoxy, the other is H, carbamoyl, opt. substd. amino or lower alkyl (opt substd by OH); R2 and R3 may together complete lower alkylene. - Pref. R1 = NH2; one of R2 and R3 = MeO or Me, the other is NH2; and cpds have the Z(syn) configuration. USE/ADVANTAGE - (I) are antimicrobials with better activity, compared with cpds of EP101265, against a wide variety of Gram positive and negative species, e.g. Staph aureus or Pseudomonas aeruginosa, including strains which produce beta-lactamase. They can be used therapeutically and as animal feed supplements.(0/0)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CS881034A CS268549B2 (en) | 1986-06-16 | 1988-02-18 | Method of new cephalosporin derivatives production |
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP14098886 | 1986-06-16 | ||
| JP28808086 | 1986-12-03 | ||
| CS874397A CS268536B2 (en) | 1986-06-16 | 1987-06-15 | Method of new cephalosporin derivatives production |
| CS881034A CS268549B2 (en) | 1986-06-16 | 1988-02-18 | Method of new cephalosporin derivatives production |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CS103488A2 true CS103488A2 (en) | 1989-06-13 |
| CS268549B2 CS268549B2 (en) | 1990-03-14 |
Family
ID=27179456
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CS881034A CS268549B2 (en) | 1986-06-16 | 1988-02-18 | Method of new cephalosporin derivatives production |
Country Status (1)
| Country | Link |
|---|---|
| CS (1) | CS268549B2 (en) |
-
1988
- 1988-02-18 CS CS881034A patent/CS268549B2/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CS268549B2 (en) | 1990-03-14 |
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