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Eisai Co Ltd
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Eisai Co Ltd
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Application filed by Eisai Co LtdfiledCriticalEisai Co Ltd
Priority to JP9164488ApriorityCriticalpatent/JP2571815B2/en
Publication of JPS6425784ApublicationCriticalpatent/JPS6425784A/en
Application grantedgrantedCritical
Publication of JP2571815B2publicationCriticalpatent/JP2571815B2/en
NEW MATERIAL:The compound of formula I (A is quaternary ammonia) and its salt. EXAMPLE:7beta-[2-( 5-Amino-1,2,4-thiadiazol-3-yl )-(Z)-2-fluoromethoxyiminoacetami do]-3-(4-carbamoyl-1-quinuclidinio)methyl-3-cephem-4-carboxylate. USE:An antibacterial agent against Gram-negative bacteria and Gram-positive bacteria. PREPARATION:A compound of formula II (X is halogen or acetoxy) or its carboxyl and/or amino-protected compound or their salt {e.g. 7beta-[2-(5-amino-1,2,4- thiadiazol-3-yl)-(Z)-2-fluoromethoxyiminoacetamido]-3-acetoxymethyl-3- cephem-4- carboxylic acid trifluoroacetic acid salt} is made to react with a compound of formula A' (A' is amine corresponding to A) or its salt.