ES8102142A1 - 33cephem compound* its salt* their preparation* and preventive and remedy for microbism comprising thema active constituent - Google Patents
33cephem compound* its salt* their preparation* and preventive and remedy for microbism comprising thema active constituentInfo
- Publication number
- ES8102142A1 ES8102142A1 ES490888A ES490888A ES8102142A1 ES 8102142 A1 ES8102142 A1 ES 8102142A1 ES 490888 A ES490888 A ES 490888A ES 490888 A ES490888 A ES 490888A ES 8102142 A1 ES8102142 A1 ES 8102142A1
- Authority
- ES
- Spain
- Prior art keywords
- compound
- salt
- formula
- 33cephem
- microbism
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/38—Nitrogen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Abstract
NEW MATERIAL:A compound of formula I: (R<1> is NH2 which may be protected R<2> is substituted aliphatic hydrocarbon group R<3> is CO2H which may be substituted R<4> is H, acyloxy, heterocyclic thio group which may be substituted), or formula III: [R<2> is aryl (lower) alkenyl group], and its salt. EXAMPLE:7-[2-methylthiomethoxyimino-2-(2-aminothiazol-4-yl)acetamido]- 3-(1, 3,4-thiadiazol-2-yl)thiomethyl-3-cephem-4-carboxylic acid (syn-isomer). USE:Antibacterials and their intermediates effective against a wide variety of pathogenic microorganisms. PROCESS:A compound of formula IV is reacted with a compound of formula V or its salt to give a compound of formula III or its salt, which is reacted with a compound of formula II to form the compound of formula I or its salt.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB7835435 | 1978-09-04 |
Publications (2)
Publication Number | Publication Date |
---|---|
ES490888A0 ES490888A0 (en) | 1980-12-16 |
ES8102142A1 true ES8102142A1 (en) | 1980-12-16 |
Family
ID=10499419
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES483839A Expired ES483839A1 (en) | 1978-09-04 | 1979-09-03 | 33cephem compound* its salt* their preparation* and preventive and remedy for microbism comprising thema active constituent |
ES490888A Expired ES8102142A1 (en) | 1978-09-04 | 1980-04-25 | 33cephem compound* its salt* their preparation* and preventive and remedy for microbism comprising thema active constituent |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES483839A Expired ES483839A1 (en) | 1978-09-04 | 1979-09-03 | 33cephem compound* its salt* their preparation* and preventive and remedy for microbism comprising thema active constituent |
Country Status (8)
Country | Link |
---|---|
JP (1) | JPS5535096A (en) |
BE (1) | BE878514A (en) |
CH (1) | CH643849A5 (en) |
DE (1) | DE2935232A1 (en) |
ES (2) | ES483839A1 (en) |
FR (1) | FR2434810A1 (en) |
NL (1) | NL7906624A (en) |
SE (1) | SE7907320L (en) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5585594A (en) * | 1978-11-13 | 1980-06-27 | Fujisawa Pharmaceut Co Ltd | Cephem compound and their preparation |
DE2945248A1 (en) * | 1978-11-13 | 1980-05-22 | Fujisawa Pharmaceutical Co | CEPHEM COMPOUNDS, METHOD FOR THEIR PRODUCTION AND ANTIBACTERIAL PHARMACEUTICAL AGENTS CONTAINING THE SAME |
US4331666A (en) * | 1979-05-11 | 1982-05-25 | Farmitalia Carlo Erba S.P.A. | 3-[(8-Carboxy-6-tetrazolo[1,5-b]pyridazinyl)-thiomethyl]-7-[2-(2-amino-4-thiazolyl)-2-methoxyimino-acetamido]-3-cephem-4-carboxylic acid |
JPS56131591A (en) * | 1980-02-20 | 1981-10-15 | Fujisawa Pharmaceut Co Ltd | 3,7-disubstituted-3-cephem-4-carboxylic acid compound, its salt, preparation thereof and preventing agent and remedy for microbism containing the same as active consitutent |
JPS57131794A (en) * | 1980-12-31 | 1982-08-14 | Fujisawa Pharmaceut Co Ltd | Novel cephem compound or salt thereof, preparation of the same and preventing agent and remedy for microbism containing the same as active constituent |
JPS5849382A (en) * | 1981-09-18 | 1983-03-23 | Kyowa Hakko Kogyo Co Ltd | Beta-lactam compound |
JPS5874680A (en) * | 1981-10-01 | 1983-05-06 | Kyowa Hakko Kogyo Co Ltd | Beta-lactam compound |
US4499088A (en) * | 1983-01-04 | 1985-02-12 | Fujisawa Pharmaceutical Co., Ltd. | Cephem compounds |
Family Cites Families (22)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1576625A (en) * | 1976-04-12 | 1980-10-08 | Fujisawa Pharmaceutical Co | Syn isomer 3,7 disubstituted 3 cephem 4 carboxylic acid compounds and processes for the preparation thereof |
DK162391C (en) * | 1976-04-12 | 1992-03-09 | Fujisawa Pharmaceutical Co | ANALOGY PROCEDURE FOR PREPARING SYN-ISOMERS OF 3,7-DISUBSTITUTED 3-CEPHEM-4-CARBOXYLIC ACID COMPOUNDS |
DE2715385A1 (en) * | 1976-04-14 | 1977-11-10 | Takeda Chemical Industries Ltd | CEPHALOSPORIN DERIVATIVES, THE PROCESS FOR THEIR MANUFACTURING AND MEDICINAL PRODUCTS CONTAINING THEM |
FR2381053A1 (en) * | 1977-02-18 | 1978-09-15 | Roussel Uclaf | NEW OXIMES DERIVED FROM 3-THIADIAZOLYL THIOMETHYL 7-AMINOTHIAZOLYL ACETAMIDO CEPHALOSPORANIC, THEIR PREPARATION PROCESS AND THEIR APPLICATION AS MEDICINAL PRODUCTS |
ZA781502B (en) * | 1977-03-14 | 1979-09-26 | Fujisawa Pharmaceutical Co | New cephem and cepham compounds and processes for preparation thereof |
SE439312B (en) * | 1977-03-25 | 1985-06-10 | Roussel Uclaf | SET TO MAKE NEW OXIME DERIVATIVES OF 3-ACETOXIMETHYL-7-AMINOTIAZOLYLACETAMIDO CEPHALOSPORANIC ACID |
DE2716677C2 (en) * | 1977-04-15 | 1985-10-10 | Hoechst Ag, 6230 Frankfurt | Cephem derivatives and processes for their preparation |
DE2714880A1 (en) * | 1977-04-02 | 1978-10-26 | Hoechst Ag | CEPHEMDER DERIVATIVES AND PROCESS FOR THEIR PRODUCTION |
FR2410655A1 (en) * | 1977-12-05 | 1979-06-29 | Roussel Uclaf | NEW OXIMES DERIVED FROM 3-SUBSTITUTE 7-AMINO THIAZOLYL ACETAMIDO CEPHALOSPORANIC, THEIR METHOD OF PREPARATION AND THEIR APPLICATION AS MEDICINAL PRODUCTS |
FR2387235A1 (en) * | 1978-01-23 | 1978-11-10 | Fujisawa Pharmaceutical Co | PROCESS FOR THE PREPARATION OF COMPOUNDS OF 3,7-DISUBSTITUE-3-CEPHEM-4-CARBOXYLIC ACID AND NEW PRODUCTS THUS OBTAINED, HAVING A STRONG ANTIBACTERIAL ACTIVITY |
DE2804040C3 (en) * | 1978-01-31 | 1981-03-19 | Hoechst Ag, 6000 Frankfurt | Process for the preparation of cephem compounds |
SE7901262L (en) * | 1978-02-15 | 1979-08-16 | Fujisawa Pharmaceutical Co | 3,7-DISUBSTITUTED 3-CEFEM-4-CARBOXYLIC ACID COMPOUNDS AND PROCEDURES FOR THEIR PREPARATION |
FR2432521A1 (en) * | 1978-03-31 | 1980-02-29 | Roussel Uclaf | NOVEL O-SUBSTITUTED OXIMES DERIVED FROM 7-AMINO THIAZOLYL ACETAMIDO CEPHALOSPORANIC ACID, THEIR PREPARATION PROCESS AND THEIR USE AS MEDICAMENTS |
FR2421907A1 (en) * | 1978-04-07 | 1979-11-02 | Roussel Uclaf | NEW CEPHALOSPORINS DERIVED FROM 7- / 2- (2-AMINO 4-THIAZOLYL) 2- (CARBOXYMETHOXYIMINO / ACETAMIDO 3-SUBSTITUTE CEPHALOSPORANIC ACID, THEIR METHOD OF PREPARATION AND THEIR APPLICATION AS MEDICINAL PRODUCTS |
ZA792583B (en) * | 1978-05-26 | 1980-07-30 | Glaxo Group Ltd | Cephalosporin antibiotics |
GB1604722A (en) * | 1978-05-26 | 1981-12-16 | Glaxo Operations Ltd | 7-(2-(2-amino-4-thiozolyl)-2-oxymino-acetamido)-cephem derivatives |
IT1116187B (en) * | 1978-05-26 | 1986-02-10 | Glaxo Group Ltd | CEPHALOSPORIN ANTIBIOTICS COMPOSITIONS CONTAINING THEM AND RELATED PRODUCTION PROCESS |
DE2921369A1 (en) * | 1978-05-26 | 1979-12-06 | Glaxo Group Ltd | CEPHALOSPORINE COMPOUNDS |
AR231986A1 (en) * | 1978-05-26 | 1985-04-30 | Glaxo Group Ltd | PROCEDURE FOR PREPARING CEPHALOSPORIN ANTIBIOTICS |
ATE15897T1 (en) * | 1978-07-17 | 1985-10-15 | Fujisawa Pharmaceutical Co | STARTING PRODUCTS FOR THE MANUFACTURE OF CEPHALOSPORINS AND PROCESS FOR THEIR MANUFACTURE. |
US4237128A (en) * | 1979-04-12 | 1980-12-02 | E. R. Squibb & Sons, Inc. | 7-[2-(2-Amino-4-thiazolyl)-2-[(1-carboxy-1,1-dialkyl)alkoxyimino]acetamido]cephem sulfoxides |
JPS5858353A (en) * | 1981-09-30 | 1983-04-06 | ピ−シ−株式会社 | Compression anchoring method of concrete member |
-
1979
- 1979-08-30 BE BE0/196949A patent/BE878514A/en not_active IP Right Cessation
- 1979-08-31 DE DE19792935232 patent/DE2935232A1/en not_active Withdrawn
- 1979-08-31 FR FR7921925A patent/FR2434810A1/en active Granted
- 1979-09-03 SE SE7907320A patent/SE7907320L/en not_active Application Discontinuation
- 1979-09-03 ES ES483839A patent/ES483839A1/en not_active Expired
- 1979-09-03 JP JP11314779A patent/JPS5535096A/en active Granted
- 1979-09-04 CH CH798279A patent/CH643849A5/en not_active IP Right Cessation
- 1979-09-04 NL NL7906624A patent/NL7906624A/en not_active Application Discontinuation
-
1980
- 1980-04-25 ES ES490888A patent/ES8102142A1/en not_active Expired
Also Published As
Publication number | Publication date |
---|---|
BE878514A (en) | 1980-02-29 |
JPS5535096A (en) | 1980-03-11 |
ES490888A0 (en) | 1980-12-16 |
ES483839A1 (en) | 1980-09-01 |
DE2935232A1 (en) | 1980-03-13 |
FR2434810B1 (en) | 1983-06-03 |
CH643849A5 (en) | 1984-06-29 |
SE7907320L (en) | 1980-03-05 |
FR2434810A1 (en) | 1980-03-28 |
JPH0240678B2 (en) | 1990-09-12 |
NL7906624A (en) | 1980-03-06 |
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