FR2434810A1 - PROCESS FOR THE PREPARATION OF COMPOUNDS OF 3-CEPHEM-4-CARBOXYLIC ACID WITH DISUBSTITUTION IN POSITIONS 3 AND 7, NEW PRODUCTS THUS OBTAINED AND THEIR USE FOR THEIR ANTIBACTERIAL ACTIVITY - Google Patents

PROCESS FOR THE PREPARATION OF COMPOUNDS OF 3-CEPHEM-4-CARBOXYLIC ACID WITH DISUBSTITUTION IN POSITIONS 3 AND 7, NEW PRODUCTS THUS OBTAINED AND THEIR USE FOR THEIR ANTIBACTERIAL ACTIVITY

Info

Publication number
FR2434810A1
FR2434810A1 FR7921925A FR7921925A FR2434810A1 FR 2434810 A1 FR2434810 A1 FR 2434810A1 FR 7921925 A FR7921925 A FR 7921925A FR 7921925 A FR7921925 A FR 7921925A FR 2434810 A1 FR2434810 A1 FR 2434810A1
Authority
FR
France
Prior art keywords
compounds
carboxylic acid
disubstitution
cephem
positions
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7921925A
Other languages
French (fr)
Other versions
FR2434810B1 (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Fujisawa Pharmaceutical Co Ltd
Original Assignee
Fujisawa Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fujisawa Pharmaceutical Co Ltd filed Critical Fujisawa Pharmaceutical Co Ltd
Publication of FR2434810A1 publication Critical patent/FR2434810A1/en
Application granted granted Critical
Publication of FR2434810B1 publication Critical patent/FR2434810B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/38—Nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Abstract

The compounds correspond to the formula in which R' and R'' denote hydrogen or a protective group, R<2> denotes a substituted aliphatic group, R denotes hydrogen or a protective group, and R<4> denotes hydrogen, acyloxy or a heterocyclic thio group. They are prepared by forming the amide bond from the carboxylic acid and the 7-aminocephem compound, followed by the removal of any protective groups present. The compounds have an antibacterial action and can be used, for example in the form of their salts, for treating infectious diseases.
FR7921925A 1978-09-04 1979-08-31 PROCESS FOR THE PREPARATION OF COMPOUNDS OF 3-CEPHEM-4-CARBOXYLIC ACID WITH DISUBSTITUTION IN POSITIONS 3 AND 7, NEW PRODUCTS THUS OBTAINED AND THEIR USE FOR THEIR ANTIBACTERIAL ACTIVITY Granted FR2434810A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB7835435 1978-09-04

Publications (2)

Publication Number Publication Date
FR2434810A1 true FR2434810A1 (en) 1980-03-28
FR2434810B1 FR2434810B1 (en) 1983-06-03

Family

ID=10499419

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7921925A Granted FR2434810A1 (en) 1978-09-04 1979-08-31 PROCESS FOR THE PREPARATION OF COMPOUNDS OF 3-CEPHEM-4-CARBOXYLIC ACID WITH DISUBSTITUTION IN POSITIONS 3 AND 7, NEW PRODUCTS THUS OBTAINED AND THEIR USE FOR THEIR ANTIBACTERIAL ACTIVITY

Country Status (8)

Country Link
JP (1) JPS5535096A (en)
BE (1) BE878514A (en)
CH (1) CH643849A5 (en)
DE (1) DE2935232A1 (en)
ES (2) ES483839A1 (en)
FR (1) FR2434810A1 (en)
NL (1) NL7906624A (en)
SE (1) SE7907320L (en)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5585594A (en) * 1978-11-13 1980-06-27 Fujisawa Pharmaceut Co Ltd Cephem compound and their preparation
DE2945248A1 (en) * 1978-11-13 1980-05-22 Fujisawa Pharmaceutical Co CEPHEM COMPOUNDS, METHOD FOR THEIR PRODUCTION AND ANTIBACTERIAL PHARMACEUTICAL AGENTS CONTAINING THE SAME
US4331666A (en) * 1979-05-11 1982-05-25 Farmitalia Carlo Erba S.P.A. 3-[(8-Carboxy-6-tetrazolo[1,5-b]pyridazinyl)-thiomethyl]-7-[2-(2-amino-4-thiazolyl)-2-methoxyimino-acetamido]-3-cephem-4-carboxylic acid
JPS56131591A (en) * 1980-02-20 1981-10-15 Fujisawa Pharmaceut Co Ltd 3,7-disubstituted-3-cephem-4-carboxylic acid compound, its salt, preparation thereof and preventing agent and remedy for microbism containing the same as active consitutent
JPS57131794A (en) * 1980-12-31 1982-08-14 Fujisawa Pharmaceut Co Ltd Novel cephem compound or salt thereof, preparation of the same and preventing agent and remedy for microbism containing the same as active constituent
JPS5849382A (en) * 1981-09-18 1983-03-23 Kyowa Hakko Kogyo Co Ltd Beta-lactam compound
JPS5874680A (en) * 1981-10-01 1983-05-06 Kyowa Hakko Kogyo Co Ltd Beta-lactam compound
US4499088A (en) * 1983-01-04 1985-02-12 Fujisawa Pharmaceutical Co., Ltd. Cephem compounds

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1576625A (en) * 1976-04-12 1980-10-08 Fujisawa Pharmaceutical Co Syn isomer 3,7 disubstituted 3 cephem 4 carboxylic acid compounds and processes for the preparation thereof
DK162391C (en) * 1976-04-12 1992-03-09 Fujisawa Pharmaceutical Co ANALOGY PROCEDURE FOR PREPARING SYN-ISOMERS OF 3,7-DISUBSTITUTED 3-CEPHEM-4-CARBOXYLIC ACID COMPOUNDS
DE2715385A1 (en) * 1976-04-14 1977-11-10 Takeda Chemical Industries Ltd CEPHALOSPORIN DERIVATIVES, THE PROCESS FOR THEIR MANUFACTURING AND MEDICINAL PRODUCTS CONTAINING THEM
FR2381053A1 (en) * 1977-02-18 1978-09-15 Roussel Uclaf NEW OXIMES DERIVED FROM 3-THIADIAZOLYL THIOMETHYL 7-AMINOTHIAZOLYL ACETAMIDO CEPHALOSPORANIC, THEIR PREPARATION PROCESS AND THEIR APPLICATION AS MEDICINAL PRODUCTS
ZA781502B (en) * 1977-03-14 1979-09-26 Fujisawa Pharmaceutical Co New cephem and cepham compounds and processes for preparation thereof
SE439312B (en) * 1977-03-25 1985-06-10 Roussel Uclaf SET TO MAKE NEW OXIME DERIVATIVES OF 3-ACETOXIMETHYL-7-AMINOTIAZOLYLACETAMIDO CEPHALOSPORANIC ACID
DE2716677C2 (en) * 1977-04-15 1985-10-10 Hoechst Ag, 6230 Frankfurt Cephem derivatives and processes for their preparation
DE2714880A1 (en) * 1977-04-02 1978-10-26 Hoechst Ag CEPHEMDER DERIVATIVES AND PROCESS FOR THEIR PRODUCTION
FR2410655A1 (en) * 1977-12-05 1979-06-29 Roussel Uclaf NEW OXIMES DERIVED FROM 3-SUBSTITUTE 7-AMINO THIAZOLYL ACETAMIDO CEPHALOSPORANIC, THEIR METHOD OF PREPARATION AND THEIR APPLICATION AS MEDICINAL PRODUCTS
FR2387235A1 (en) * 1978-01-23 1978-11-10 Fujisawa Pharmaceutical Co PROCESS FOR THE PREPARATION OF COMPOUNDS OF 3,7-DISUBSTITUE-3-CEPHEM-4-CARBOXYLIC ACID AND NEW PRODUCTS THUS OBTAINED, HAVING A STRONG ANTIBACTERIAL ACTIVITY
DE2804040C3 (en) * 1978-01-31 1981-03-19 Hoechst Ag, 6000 Frankfurt Process for the preparation of cephem compounds
SE7901262L (en) * 1978-02-15 1979-08-16 Fujisawa Pharmaceutical Co 3,7-DISUBSTITUTED 3-CEFEM-4-CARBOXYLIC ACID COMPOUNDS AND PROCEDURES FOR THEIR PREPARATION
FR2432521A1 (en) * 1978-03-31 1980-02-29 Roussel Uclaf NOVEL O-SUBSTITUTED OXIMES DERIVED FROM 7-AMINO THIAZOLYL ACETAMIDO CEPHALOSPORANIC ACID, THEIR PREPARATION PROCESS AND THEIR USE AS MEDICAMENTS
FR2421907A1 (en) * 1978-04-07 1979-11-02 Roussel Uclaf NEW CEPHALOSPORINS DERIVED FROM 7- / 2- (2-AMINO 4-THIAZOLYL) 2- (CARBOXYMETHOXYIMINO / ACETAMIDO 3-SUBSTITUTE CEPHALOSPORANIC ACID, THEIR METHOD OF PREPARATION AND THEIR APPLICATION AS MEDICINAL PRODUCTS
ZA792583B (en) * 1978-05-26 1980-07-30 Glaxo Group Ltd Cephalosporin antibiotics
GB1604722A (en) * 1978-05-26 1981-12-16 Glaxo Operations Ltd 7-(2-(2-amino-4-thiozolyl)-2-oxymino-acetamido)-cephem derivatives
IT1116187B (en) * 1978-05-26 1986-02-10 Glaxo Group Ltd CEPHALOSPORIN ANTIBIOTICS COMPOSITIONS CONTAINING THEM AND RELATED PRODUCTION PROCESS
DE2921369A1 (en) * 1978-05-26 1979-12-06 Glaxo Group Ltd CEPHALOSPORINE COMPOUNDS
AR231986A1 (en) * 1978-05-26 1985-04-30 Glaxo Group Ltd PROCEDURE FOR PREPARING CEPHALOSPORIN ANTIBIOTICS
ATE15897T1 (en) * 1978-07-17 1985-10-15 Fujisawa Pharmaceutical Co STARTING PRODUCTS FOR THE MANUFACTURE OF CEPHALOSPORINS AND PROCESS FOR THEIR MANUFACTURE.
US4237128A (en) * 1979-04-12 1980-12-02 E. R. Squibb & Sons, Inc. 7-[2-(2-Amino-4-thiazolyl)-2-[(1-carboxy-1,1-dialkyl)alkoxyimino]acetamido]cephem sulfoxides
JPS5858353A (en) * 1981-09-30 1983-04-06 ピ−シ−株式会社 Compression anchoring method of concrete member

Also Published As

Publication number Publication date
BE878514A (en) 1980-02-29
JPS5535096A (en) 1980-03-11
ES490888A0 (en) 1980-12-16
ES483839A1 (en) 1980-09-01
DE2935232A1 (en) 1980-03-13
FR2434810B1 (en) 1983-06-03
CH643849A5 (en) 1984-06-29
SE7907320L (en) 1980-03-05
JPH0240678B2 (en) 1990-09-12
ES8102142A1 (en) 1980-12-16
NL7906624A (en) 1980-03-06

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