SE7907320L - 3,7-DISUBSTITUTED 3-CEFEM-4-CARBOXYLIC ACID COMPOUNDS AND PROCEDURES FOR THEIR PREPARATION - Google Patents
3,7-DISUBSTITUTED 3-CEFEM-4-CARBOXYLIC ACID COMPOUNDS AND PROCEDURES FOR THEIR PREPARATIONInfo
- Publication number
- SE7907320L SE7907320L SE7907320A SE7907320A SE7907320L SE 7907320 L SE7907320 L SE 7907320L SE 7907320 A SE7907320 A SE 7907320A SE 7907320 A SE7907320 A SE 7907320A SE 7907320 L SE7907320 L SE 7907320L
- Authority
- SE
- Sweden
- Prior art keywords
- compound
- formula
- salt
- carboxylic acid
- cefem
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/38—Nitrogen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Cephalosporin Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
NEW MATERIAL:A compound of formula I: (R<1> is NH2 which may be protected; R<2> is substituted aliphatic hydrocarbon group; R<3> is CO2H which may be substituted; R<4> is H, acyloxy, heterocyclic thio group which may be substituted), or formula III: [R<2> is aryl (lower) alkenyl group], and its salt. EXAMPLE:7-[2-methylthiomethoxyimino-2-(2-aminothiazol-4-yl)acetamido]- 3-(1, 3,4-thiadiazol-2-yl)thiomethyl-3-cephem-4-carboxylic acid (syn-isomer). USE:Antibacterials and their intermediates effective against a wide variety of pathogenic microorganisms. PROCESS:A compound of formula IV is reacted with a compound of formula V or its salt to give a compound of formula III or its salt, which is reacted with a compound of formula II to form the compound of formula I or its salt.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB7835435 | 1978-09-04 |
Publications (1)
Publication Number | Publication Date |
---|---|
SE7907320L true SE7907320L (en) | 1980-03-05 |
Family
ID=10499419
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SE7907320A SE7907320L (en) | 1978-09-04 | 1979-09-03 | 3,7-DISUBSTITUTED 3-CEFEM-4-CARBOXYLIC ACID COMPOUNDS AND PROCEDURES FOR THEIR PREPARATION |
Country Status (8)
Country | Link |
---|---|
JP (1) | JPS5535096A (en) |
BE (1) | BE878514A (en) |
CH (1) | CH643849A5 (en) |
DE (1) | DE2935232A1 (en) |
ES (2) | ES483839A1 (en) |
FR (1) | FR2434810A1 (en) |
NL (1) | NL7906624A (en) |
SE (1) | SE7907320L (en) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2945248A1 (en) * | 1978-11-13 | 1980-05-22 | Fujisawa Pharmaceutical Co | CEPHEM COMPOUNDS, METHOD FOR THEIR PRODUCTION AND ANTIBACTERIAL PHARMACEUTICAL AGENTS CONTAINING THE SAME |
JPS5585594A (en) * | 1978-11-13 | 1980-06-27 | Fujisawa Pharmaceut Co Ltd | Cephem compound and their preparation |
US4331666A (en) * | 1979-05-11 | 1982-05-25 | Farmitalia Carlo Erba S.P.A. | 3-[(8-Carboxy-6-tetrazolo[1,5-b]pyridazinyl)-thiomethyl]-7-[2-(2-amino-4-thiazolyl)-2-methoxyimino-acetamido]-3-cephem-4-carboxylic acid |
JPS56131591A (en) * | 1980-02-20 | 1981-10-15 | Fujisawa Pharmaceut Co Ltd | 3,7-disubstituted-3-cephem-4-carboxylic acid compound, its salt, preparation thereof and preventing agent and remedy for microbism containing the same as active consitutent |
JPS57131794A (en) * | 1980-12-31 | 1982-08-14 | Fujisawa Pharmaceut Co Ltd | Novel cephem compound or salt thereof, preparation of the same and preventing agent and remedy for microbism containing the same as active constituent |
JPS5849382A (en) * | 1981-09-18 | 1983-03-23 | Kyowa Hakko Kogyo Co Ltd | Beta-lactam compound |
JPS5874680A (en) * | 1981-10-01 | 1983-05-06 | Kyowa Hakko Kogyo Co Ltd | Beta-lactam compound |
US4499088A (en) * | 1983-01-04 | 1985-02-12 | Fujisawa Pharmaceutical Co., Ltd. | Cephem compounds |
Family Cites Families (22)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1576625A (en) * | 1976-04-12 | 1980-10-08 | Fujisawa Pharmaceutical Co | Syn isomer 3,7 disubstituted 3 cephem 4 carboxylic acid compounds and processes for the preparation thereof |
DK162391C (en) * | 1976-04-12 | 1992-03-09 | Fujisawa Pharmaceutical Co | ANALOGY PROCEDURE FOR PREPARING SYN-ISOMERS OF 3,7-DISUBSTITUTED 3-CEPHEM-4-CARBOXYLIC ACID COMPOUNDS |
GR63088B (en) * | 1976-04-14 | 1979-08-09 | Takeda Chemical Industries Ltd | Preparation process of novel cephalosporins |
FR2381053A1 (en) * | 1977-02-18 | 1978-09-15 | Roussel Uclaf | NEW OXIMES DERIVED FROM 3-THIADIAZOLYL THIOMETHYL 7-AMINOTHIAZOLYL ACETAMIDO CEPHALOSPORANIC, THEIR PREPARATION PROCESS AND THEIR APPLICATION AS MEDICINAL PRODUCTS |
AU520269B2 (en) * | 1977-03-14 | 1982-01-21 | Fujisawa Pharmaceutical Co., Ltd. | Cephem and cepham compounds |
SE439312B (en) * | 1977-03-25 | 1985-06-10 | Roussel Uclaf | SET TO MAKE NEW OXIME DERIVATIVES OF 3-ACETOXIMETHYL-7-AMINOTIAZOLYLACETAMIDO CEPHALOSPORANIC ACID |
DE2716677C2 (en) * | 1977-04-15 | 1985-10-10 | Hoechst Ag, 6230 Frankfurt | Cephem derivatives and processes for their preparation |
DE2714880A1 (en) * | 1977-04-02 | 1978-10-26 | Hoechst Ag | CEPHEMDER DERIVATIVES AND PROCESS FOR THEIR PRODUCTION |
FR2410655A1 (en) * | 1977-12-05 | 1979-06-29 | Roussel Uclaf | NEW OXIMES DERIVED FROM 3-SUBSTITUTE 7-AMINO THIAZOLYL ACETAMIDO CEPHALOSPORANIC, THEIR METHOD OF PREPARATION AND THEIR APPLICATION AS MEDICINAL PRODUCTS |
FR2387235A1 (en) * | 1978-01-23 | 1978-11-10 | Fujisawa Pharmaceutical Co | PROCESS FOR THE PREPARATION OF COMPOUNDS OF 3,7-DISUBSTITUE-3-CEPHEM-4-CARBOXYLIC ACID AND NEW PRODUCTS THUS OBTAINED, HAVING A STRONG ANTIBACTERIAL ACTIVITY |
DE2804040C3 (en) * | 1978-01-31 | 1981-03-19 | Hoechst Ag, 6000 Frankfurt | Process for the preparation of cephem compounds |
SE7901262L (en) * | 1978-02-15 | 1979-08-16 | Fujisawa Pharmaceutical Co | 3,7-DISUBSTITUTED 3-CEFEM-4-CARBOXYLIC ACID COMPOUNDS AND PROCEDURES FOR THEIR PREPARATION |
FR2432521A1 (en) * | 1978-03-31 | 1980-02-29 | Roussel Uclaf | NOVEL O-SUBSTITUTED OXIMES DERIVED FROM 7-AMINO THIAZOLYL ACETAMIDO CEPHALOSPORANIC ACID, THEIR PREPARATION PROCESS AND THEIR USE AS MEDICAMENTS |
FR2421907A1 (en) * | 1978-04-07 | 1979-11-02 | Roussel Uclaf | NEW CEPHALOSPORINS DERIVED FROM 7- / 2- (2-AMINO 4-THIAZOLYL) 2- (CARBOXYMETHOXYIMINO / ACETAMIDO 3-SUBSTITUTE CEPHALOSPORANIC ACID, THEIR METHOD OF PREPARATION AND THEIR APPLICATION AS MEDICINAL PRODUCTS |
ZA792583B (en) * | 1978-05-26 | 1980-07-30 | Glaxo Group Ltd | Cephalosporin antibiotics |
NL7904125A (en) * | 1978-05-26 | 1979-11-28 | Glaxo Group Ltd | CEPHALOSPORIN COMPOUNDS. |
NZ190556A (en) * | 1978-05-26 | 1982-05-25 | Glaxo Group Ltd | Cephalosporin antibiotics and pharmaceutical compositions |
GB1604722A (en) * | 1978-05-26 | 1981-12-16 | Glaxo Operations Ltd | 7-(2-(2-amino-4-thiozolyl)-2-oxymino-acetamido)-cephem derivatives |
AR229882A1 (en) * | 1978-05-26 | 1983-12-30 | Glaxo Group Ltd | PROCEDURE FOR PREPARING CEPHALOSPORIN ANTIBIOTICS |
DE2967356D1 (en) * | 1978-07-17 | 1985-02-28 | Fujisawa Pharmaceutical Co | Cephalosporin derivatives, process for their preparation and pharmaceutical compositions containing them |
US4237128A (en) * | 1979-04-12 | 1980-12-02 | E. R. Squibb & Sons, Inc. | 7-[2-(2-Amino-4-thiazolyl)-2-[(1-carboxy-1,1-dialkyl)alkoxyimino]acetamido]cephem sulfoxides |
JPS5858353A (en) * | 1981-09-30 | 1983-04-06 | ピ−シ−株式会社 | Compression anchoring method of concrete member |
-
1979
- 1979-08-30 BE BE0/196949A patent/BE878514A/en not_active IP Right Cessation
- 1979-08-31 DE DE19792935232 patent/DE2935232A1/en not_active Withdrawn
- 1979-08-31 FR FR7921925A patent/FR2434810A1/en active Granted
- 1979-09-03 SE SE7907320A patent/SE7907320L/en not_active Application Discontinuation
- 1979-09-03 JP JP11314779A patent/JPS5535096A/en active Granted
- 1979-09-03 ES ES483839A patent/ES483839A1/en not_active Expired
- 1979-09-04 CH CH798279A patent/CH643849A5/en not_active IP Right Cessation
- 1979-09-04 NL NL7906624A patent/NL7906624A/en not_active Application Discontinuation
-
1980
- 1980-04-25 ES ES490888A patent/ES490888A0/en active Granted
Also Published As
Publication number | Publication date |
---|---|
DE2935232A1 (en) | 1980-03-13 |
JPS5535096A (en) | 1980-03-11 |
CH643849A5 (en) | 1984-06-29 |
ES8102142A1 (en) | 1980-12-16 |
FR2434810B1 (en) | 1983-06-03 |
ES490888A0 (en) | 1980-12-16 |
JPH0240678B2 (en) | 1990-09-12 |
ES483839A1 (en) | 1980-09-01 |
NL7906624A (en) | 1980-03-06 |
BE878514A (en) | 1980-02-29 |
FR2434810A1 (en) | 1980-03-28 |
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Legal Events
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---|---|---|---|
NAV | Patent application has lapsed |
Ref document number: 7907320-1 Effective date: 19860806 Format of ref document f/p: F |