JPS5479295A - 7-substituted-3-cephem-4-carboxylic acid derivative and its preparation - Google Patents

7-substituted-3-cephem-4-carboxylic acid derivative and its preparation

Info

Publication number
JPS5479295A
JPS5479295A JP14632777A JP14632777A JPS5479295A JP S5479295 A JPS5479295 A JP S5479295A JP 14632777 A JP14632777 A JP 14632777A JP 14632777 A JP14632777 A JP 14632777A JP S5479295 A JPS5479295 A JP S5479295A
Authority
JP
Japan
Prior art keywords
formula
cephem
carboxylic acid
substituted
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP14632777A
Other languages
Japanese (ja)
Other versions
JPS6146477B2 (en
Inventor
Takao Takatani
Takashi Ogino
Takashi Masugi
Kiryo Tsuji
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Fujisawa Pharmaceutical Co Ltd
Original Assignee
Fujisawa Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fujisawa Pharmaceutical Co Ltd filed Critical Fujisawa Pharmaceutical Co Ltd
Priority to JP14632777A priority Critical patent/JPS5479295A/en
Priority to BE183828A priority patent/BE862300A/en
Priority to NL7714319A priority patent/NL7714319A/en
Priority to GB1512980A priority patent/GB1597849A/en
Priority to GB53732/77A priority patent/GB1597848A/en
Priority to FR7739259A priority patent/FR2378786A1/en
Priority to DE19772758159 priority patent/DE2758159A1/en
Priority to ES77465460A priority patent/ES465460A1/en
Priority to AT931977A priority patent/AT360647B/en
Priority to DK581277A priority patent/DK581277A/en
Priority to CH1607077A priority patent/CH638220A5/en
Priority to FR7819377A priority patent/FR2383938A1/en
Publication of JPS5479295A publication Critical patent/JPS5479295A/en
Priority to US06/178,898 priority patent/US4371531A/en
Priority to CH267082A priority patent/CH642958A5/en
Priority to US06/428,658 priority patent/US4500709A/en
Publication of JPS6146477B2 publication Critical patent/JPS6146477B2/ja
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D279/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one sulfur atom as the only ring hetero atoms
    • C07D279/10—1,4-Thiazines; Hydrogenated 1,4-thiazines
    • C07D279/12—1,4-Thiazines; Hydrogenated 1,4-thiazines not condensed with other rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D327/00—Heterocyclic compounds containing rings having oxygen and sulfur atoms as the only ring hetero atoms
    • C07D327/02—Heterocyclic compounds containing rings having oxygen and sulfur atoms as the only ring hetero atoms one oxygen atom and one sulfur atom
    • C07D327/06—Six-membered rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D339/00—Heterocyclic compounds containing rings having two sulfur atoms as the only ring hetero atoms
    • C07D339/02—Five-membered rings
    • C07D339/06—Five-membered rings having the hetero atoms in positions 1 and 3, e.g. cyclic dithiocarbonates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D339/00—Heterocyclic compounds containing rings having two sulfur atoms as the only ring hetero atoms
    • C07D339/08—Six-membered rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Cephalosporin Compounds (AREA)

Abstract

NEW MATERIAL:A 7-substituted-3-cephem-4-carboxylic acid of formula I: [R1 is formula II, III, or IV (X is S, O, or imino, acylimino group); R2 is H, lower alkenyl, lower alkyl group; R4 is H, halogen, or lower alkyl group], its derivative at the carboxyl group, and its salt.
EXAMPLE: 7-[2-(2,3-dihydro-1,4-dithiin-5-yl)-2-methoxyimino acetamide]-3-cephem- 4-carboxylic acid (syn-isomer).
USE: Antibacterials having a wide antibacterial spectrum. The syn-isomer has an outstanding antibacterial activity.
PROCESS: A compound of formula V: (Y is halogen) is reacted with a thiol compound of formula HX-R-SH (R is carbonyl, ethylene, or o-phenylene group) to form the compound of formula I.
COPYRIGHT: (C)1979,JPO&Japio
JP14632777A 1976-12-27 1977-12-05 7-substituted-3-cephem-4-carboxylic acid derivative and its preparation Granted JPS5479295A (en)

Priority Applications (15)

Application Number Priority Date Filing Date Title
JP14632777A JPS5479295A (en) 1977-12-05 1977-12-05 7-substituted-3-cephem-4-carboxylic acid derivative and its preparation
BE183828A BE862300A (en) 1976-12-27 1977-12-23 NEW CEPHALOSPORIN COMPOUNDS AND METHODS FOR THEIR PREPARATION
NL7714319A NL7714319A (en) 1976-12-27 1977-12-23 CEPHALOSPORIN COMPOUNDS AND METHODS FOR PREPARING THEM.
GB1512980A GB1597849A (en) 1976-12-27 1977-12-23 A-heterocyclyl-a-hydroxyliminoacetic acid and derivatives thereof
GB53732/77A GB1597848A (en) 1976-12-27 1977-12-23 Cephalosporin compounds and processes for the preparation thereof
ES77465460A ES465460A1 (en) 1976-12-27 1977-12-27 Cephalosporin compounds
DE19772758159 DE2758159A1 (en) 1976-12-27 1977-12-27 CEPHALOSPORINE COMPOUNDS, PROCESS FOR THEIR MANUFACTURING AND PHARMACEUTICAL PRODUCTS CONTAINING THEM
FR7739259A FR2378786A1 (en) 1976-12-27 1977-12-27 NEW CEPHALOSPORIN COMPOUNDS AND METHODS FOR THEIR PREPARATION
AT931977A AT360647B (en) 1976-12-27 1977-12-27 METHOD FOR PRODUCING NEW CEPHALOS PORINE COMPOUNDS
DK581277A DK581277A (en) 1976-12-27 1977-12-27 PROCEDURE FOR PREPARING CEPHALOSPORINE COMPOUNDS
CH1607077A CH638220A5 (en) 1977-12-05 1978-01-01 Cephalosporin compounds and pharmaceutical agents containing them
FR7819377A FR2383938A1 (en) 1976-12-27 1978-06-28 DISUBSTITUTED ACETIC ACIDS, USED FOR THE SYNTHESIS OF CEPHALOSPORIN COMPOUNDS
US06/178,898 US4371531A (en) 1976-12-27 1980-08-18 Cephalosporin compounds
CH267082A CH642958A5 (en) 1977-12-05 1982-04-30 2-Disubstituted acetic acids and their halides, anhydrides, activated esters, activated amides and salts
US06/428,658 US4500709A (en) 1976-12-27 1982-09-30 Thiinyl and oxothiolyl derivatives

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP14632777A JPS5479295A (en) 1977-12-05 1977-12-05 7-substituted-3-cephem-4-carboxylic acid derivative and its preparation

Publications (2)

Publication Number Publication Date
JPS5479295A true JPS5479295A (en) 1979-06-25
JPS6146477B2 JPS6146477B2 (en) 1986-10-14

Family

ID=15405158

Family Applications (1)

Application Number Title Priority Date Filing Date
JP14632777A Granted JPS5479295A (en) 1976-12-27 1977-12-05 7-substituted-3-cephem-4-carboxylic acid derivative and its preparation

Country Status (2)

Country Link
JP (1) JPS5479295A (en)
CH (1) CH638220A5 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS54144390A (en) * 1978-04-28 1979-11-10 Fujisawa Pharmaceut Co Ltd 7-substituted-3-cephem-4-carboxylic acid derivative and its preparation

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0189373U (en) * 1987-12-03 1989-06-13

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS54144390A (en) * 1978-04-28 1979-11-10 Fujisawa Pharmaceut Co Ltd 7-substituted-3-cephem-4-carboxylic acid derivative and its preparation

Also Published As

Publication number Publication date
JPS6146477B2 (en) 1986-10-14
CH638220A5 (en) 1983-09-15

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