JPS5488290A - Cephalosporin derivative and its preparation - Google Patents

Cephalosporin derivative and its preparation

Info

Publication number
JPS5488290A
JPS5488290A JP15389177A JP15389177A JPS5488290A JP S5488290 A JPS5488290 A JP S5488290A JP 15389177 A JP15389177 A JP 15389177A JP 15389177 A JP15389177 A JP 15389177A JP S5488290 A JPS5488290 A JP S5488290A
Authority
JP
Japan
Prior art keywords
formula
compound
preparation
coor
nitrile
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP15389177A
Other languages
Japanese (ja)
Other versions
JPS6052712B2 (en
Inventor
Tetsuo Miyadera
Yoichi Kawano
Shinichi Sugawara
Mitsuo Yamazaki
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sankyo Co Ltd
Original Assignee
Sankyo Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sankyo Co Ltd filed Critical Sankyo Co Ltd
Priority to JP52153891A priority Critical patent/JPS6052712B2/en
Publication of JPS5488290A publication Critical patent/JPS5488290A/en
Publication of JPS6052712B2 publication Critical patent/JPS6052712B2/en
Expired legal-status Critical Current

Links

Classifications

    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Cephalosporin Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

NEW MATERIAL:Compounds of formula I [R1 is H, lower alkoxy; R2 is methyl, acetoxymethyl; R3 is H, nitrile, carboxyl, -COOR4 (R4 is alkyl, aryl)] and their salts.
EXAMPLE: 7β-[2-Ethoxycarbonyl-(1,3-diethiolan-2-ylidene)acetamide]-3-(1-methyl- 1H-tetrazole-5yl)thiomethyl-3-cephem-4-carboxylic acid.
USE: Antibacterial agents, having activity inhibiting β-lactamase and being effective against gram-positive and -negative bacteria.
PREPARATION: The reaction of a compound of formula II (R7 is protected carboxyl group) with a compound of formula III (Y is halogen; R8 is H, nitrile, -COOR4) in the presence of an acid acceptor in an inert solvent is effected and then protecting groups is eliminated to prepare a compound of formula IV.
COPYRIGHT: (C)1979,JPO&Japio
JP52153891A 1977-12-21 1977-12-21 Cephalosporin compound and its production method Expired JPS6052712B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP52153891A JPS6052712B2 (en) 1977-12-21 1977-12-21 Cephalosporin compound and its production method

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP52153891A JPS6052712B2 (en) 1977-12-21 1977-12-21 Cephalosporin compound and its production method

Publications (2)

Publication Number Publication Date
JPS5488290A true JPS5488290A (en) 1979-07-13
JPS6052712B2 JPS6052712B2 (en) 1985-11-20

Family

ID=15572363

Family Applications (1)

Application Number Title Priority Date Filing Date
JP52153891A Expired JPS6052712B2 (en) 1977-12-21 1977-12-21 Cephalosporin compound and its production method

Country Status (1)

Country Link
JP (1) JPS6052712B2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI787381B (en) * 2017-11-30 2022-12-21 以色列商艾斯卡公司 Single-sided three-way indexable cutting insert and insert mill therefor

Also Published As

Publication number Publication date
JPS6052712B2 (en) 1985-11-20

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