NL7413014A - 7-(Alpha-Mercapto-acetamido)-cephalosporanic acid derivs - prepd. e.g. by N-acylation of 7-unsubstd. amino cpds. - Google Patents

7-(Alpha-Mercapto-acetamido)-cephalosporanic acid derivs - prepd. e.g. by N-acylation of 7-unsubstd. amino cpds.

Info

Publication number
NL7413014A
NL7413014A NL7413014A NL7413014A NL7413014A NL 7413014 A NL7413014 A NL 7413014A NL 7413014 A NL7413014 A NL 7413014A NL 7413014 A NL7413014 A NL 7413014A NL 7413014 A NL7413014 A NL 7413014A
Authority
NL
Netherlands
Prior art keywords
lower alkyl
prepd
acetamido
carboxy
formula
Prior art date
Application number
NL7413014A
Other languages
Dutch (nl)
Original Assignee
Fujisawa Pharmaceutical Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP11168673A external-priority patent/JPS5062990A/ja
Priority claimed from JP11168473A external-priority patent/JPS5652910B2/ja
Priority claimed from JP11168573A external-priority patent/JPS5715596B2/ja
Application filed by Fujisawa Pharmaceutical Co filed Critical Fujisawa Pharmaceutical Co
Publication of NL7413014A publication Critical patent/NL7413014A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
    • C07D285/01—Five-membered rings
    • C07D285/02—Thiadiazoles; Hydrogenated thiadiazoles
    • C07D285/04—Thiadiazoles; Hydrogenated thiadiazoles not condensed with other rings
    • C07D285/12—1,3,4-Thiadiazoles; Hydrogenated 1,3,4-thiadiazoles
    • C07D285/125—1,3,4-Thiadiazoles; Hydrogenated 1,3,4-thiadiazoles with oxygen, sulfur or nitrogen atoms, directly attached to ring carbon atoms, the nitrogen atoms not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C317/00—Sulfones; Sulfoxides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Cephalosporin Compounds (AREA)

Abstract

Cephalosporanic acid derivs. of formula (I) (where R1 is H, lower hydroxyalkylthio or hetercyclylthio opt. substd. by lower alkyl or alkanoyloxyl-(lower alkyl); R2 is lower alkyl, (lower alkylthio)-(lower alkyl), acyl-(lower alkyl), acylamino- (lower alkyl), lower alkenyl, aryl-(lower alkenyl or lower alkynyl; R3 is H, lower alkyl or aryl; and X is S. SO or SO2; provided that R2 is not lower alkyl when R1 is H) (e.g. 7-(2 -methanesulphinyl-2-phenyl-acetamido)-3-(5-methyl-1, 3, 4 -thiadiazol-2-yl)thiomethyl-3-cephem-4-carboxylic acid) and their carboxy derivs. and pharmaceutically tolerable salts are new cpds. They may be prepd. by reacting a cpd. of formula (II) or a carboxy deriv. or salt thereof with a cpd. of the formula R2-X-CHR3-COOH (III) or with a carboxy deriv. or salt thereof. Further processes for preparing cpds. (I) in which R1 is a thio substituent are also claimed. (I) are antibacterials active against both gram-positive and gram-negative bacteria.
NL7413014A 1973-10-03 1974-10-02 7-(Alpha-Mercapto-acetamido)-cephalosporanic acid derivs - prepd. e.g. by N-acylation of 7-unsubstd. amino cpds. NL7413014A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP11168673A JPS5062990A (en) 1973-10-03 1973-10-03
JP11168473A JPS5652910B2 (en) 1973-10-03 1973-10-03
JP11168573A JPS5715596B2 (en) 1973-10-03 1973-10-03

Publications (1)

Publication Number Publication Date
NL7413014A true NL7413014A (en) 1975-04-07

Family

ID=27312016

Family Applications (1)

Application Number Title Priority Date Filing Date
NL7413014A NL7413014A (en) 1973-10-03 1974-10-02 7-(Alpha-Mercapto-acetamido)-cephalosporanic acid derivs - prepd. e.g. by N-acylation of 7-unsubstd. amino cpds.

Country Status (1)

Country Link
NL (1) NL7413014A (en)

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Legal Events

Date Code Title Description
BV The patent application has lapsed