IE790752L - Cephalosporin derivatives - Google Patents
Cephalosporin derivativesInfo
- Publication number
- IE790752L IE790752L IE790752A IE75279A IE790752L IE 790752 L IE790752 L IE 790752L IE 790752 A IE790752 A IE 790752A IE 75279 A IE75279 A IE 75279A IE 790752 L IE790752 L IE 790752L
- Authority
- IE
- Ireland
- Prior art keywords
- ceph
- esp
- iii
- ring
- antibiotics
- Prior art date
Links
- 229940124587 cephalosporin Drugs 0.000 title abstract 2
- 229930186147 Cephalosporin Natural products 0.000 title 1
- 150000001780 cephalosporins Chemical class 0.000 title 1
- FZEVMBJWXHDLDB-ZCFIWIBFSA-N (6r)-5-thia-1-azabicyclo[4.2.0]oct-2-en-8-one Chemical group S1CC=CN2C(=O)C[C@H]21 FZEVMBJWXHDLDB-ZCFIWIBFSA-N 0.000 abstract 2
- 239000003242 anti bacterial agent Substances 0.000 abstract 2
- 229940088710 antibiotic agent Drugs 0.000 abstract 2
- 238000006243 chemical reaction Methods 0.000 abstract 2
- SXBDXXFTJVHSAF-ZCFIWIBFSA-N (6r)-5-thia-1-azabicyclo[4.2.0]oct-3-en-8-one Chemical group S1C=CCN2C(=O)C[C@H]21 SXBDXXFTJVHSAF-ZCFIWIBFSA-N 0.000 abstract 1
- 241000894006 Bacteria Species 0.000 abstract 1
- 241001465754 Metazoa Species 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000004414 alkyl thio group Chemical group 0.000 abstract 1
- 230000000903 blocking effect Effects 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 230000007062 hydrolysis Effects 0.000 abstract 1
- 238000006460 hydrolysis reaction Methods 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 239000012948 isocyanate Substances 0.000 abstract 1
- 150000002513 isocyanates Chemical class 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
- C07F9/65613—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings containing the ring system (X = CH2, O, S, NH) optionally with an additional double bond and/or substituents, e.g. cephalosporins and analogs
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Cephalosporin Compounds (AREA)
Abstract
Prodn. of 3-carbamoyloxymethyl-cephalosporins (I) comprises reacting 3-hydroxymethylcephalosporins (II) with a dihalophosphinyl isocyanate (II), then converting the reaction prod., pref. by hydrolysis, to (I). Cpds. of formula (N) and their salts are new (where is R1 protected amino R2 is H or blocking gp. R3 is H, lower alkyl, alkylthio or alkoxy. Z is S or S right arrow O (alpha or beta). The dotted line indicates a ceph-3-em or ceph-2-em ring). Esp. Z is S,R2, is H and the ring is ceph-3-em. (I) are known antibiotics. (III) are easy to prepare and can be used without purificn. (IV) are intermediates during reaction of (II) and (III) and some also have activity against Gram negative and positive bacteria. They are very soluble in water and are esp. useful for treating humans and animals requiring amts of antibiotics in soln.
[FR2429221A1]
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB1380178 | 1978-04-07 | ||
| GB1379978 | 1978-04-07 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IE790752L true IE790752L (en) | 1979-10-07 |
| IE48286B1 IE48286B1 (en) | 1984-11-28 |
Family
ID=26250016
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IE752/79A IE48286B1 (en) | 1978-04-07 | 1979-08-08 | 3-phosphonocarbamoyl-oxymethyl cephalosporins and the production of 3-carbamoyloxymethyl cephalosporins |
Country Status (11)
| Country | Link |
|---|---|
| AU (1) | AU534617B2 (en) |
| DE (1) | DE2914000A1 (en) |
| DK (1) | DK143679A (en) |
| FI (1) | FI791148A (en) |
| FR (1) | FR2429221A1 (en) |
| IE (1) | IE48286B1 (en) |
| IT (1) | IT1117214B (en) |
| NL (1) | NL7902732A (en) |
| NZ (1) | NZ190128A (en) |
| SE (1) | SE7903096L (en) |
| YU (1) | YU82379A (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2453176A1 (en) * | 1979-04-06 | 1980-10-31 | Glaxo Group Ltd | PROCESS FOR THE PREPARATION OF CEPHALOSPORINS SUBSTITUTED BY A CARBAMOYLOXYMETHYL GROUP IN POSITION 3 |
-
1979
- 1979-04-06 SE SE7903096A patent/SE7903096L/en not_active Application Discontinuation
- 1979-04-06 DK DK143679A patent/DK143679A/en not_active Application Discontinuation
- 1979-04-06 DE DE19792914000 patent/DE2914000A1/en not_active Withdrawn
- 1979-04-06 YU YU00823/79A patent/YU82379A/en unknown
- 1979-04-06 NZ NZ190128A patent/NZ190128A/en unknown
- 1979-04-06 AU AU45896/79A patent/AU534617B2/en not_active Ceased
- 1979-04-06 FI FI791148A patent/FI791148A/en not_active Application Discontinuation
- 1979-04-06 FR FR7908746A patent/FR2429221A1/en active Granted
- 1979-04-06 IT IT48658/79A patent/IT1117214B/en active
- 1979-04-06 NL NL7902732A patent/NL7902732A/en not_active Application Discontinuation
- 1979-08-08 IE IE752/79A patent/IE48286B1/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| FI791148A (en) | 1979-10-08 |
| DE2914000A1 (en) | 1979-11-15 |
| SE7903096L (en) | 1979-12-17 |
| IT1117214B (en) | 1986-02-17 |
| IT7948658A0 (en) | 1979-04-06 |
| FR2429221B1 (en) | 1983-04-22 |
| DK143679A (en) | 1979-10-08 |
| YU82379A (en) | 1983-01-21 |
| NZ190128A (en) | 1982-03-16 |
| AU4589679A (en) | 1979-10-11 |
| FR2429221A1 (en) | 1980-01-18 |
| AU534617B2 (en) | 1984-02-09 |
| NL7902732A (en) | 1979-10-09 |
| IE48286B1 (en) | 1984-11-28 |
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