ZA821957B - Acylquinolinone derivatives, processes for their manufacture, pharmaceutical preparations containing them and their use - Google Patents
Acylquinolinone derivatives, processes for their manufacture, pharmaceutical preparations containing them and their useInfo
- Publication number
- ZA821957B ZA821957B ZA821957A ZA821957A ZA821957B ZA 821957 B ZA821957 B ZA 821957B ZA 821957 A ZA821957 A ZA 821957A ZA 821957 A ZA821957 A ZA 821957A ZA 821957 B ZA821957 B ZA 821957B
- Authority
- ZA
- South Africa
- Prior art keywords
- acylquinolinone
- derivatives
- manufacture
- processes
- pharmaceutical preparations
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D265/04—1,3-Oxazines; Hydrogenated 1,3-oxazines
- C07D265/12—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems
- C07D265/14—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C07D265/24—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring with hetero atoms directly attached in positions 2 and 4
- C07D265/26—Two oxygen atoms, e.g. isatoic anhydride
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/32—Oxygen atoms
- C07D209/34—Oxygen atoms in position 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/32—Oxygen atoms
- C07D209/38—Oxygen atoms in positions 2 and 3, e.g. isatin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
- C07D215/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3 with oxygen atoms in position 4
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pulmonology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Immunology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Quinoline Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CH198681 | 1981-03-24 |
Publications (1)
Publication Number | Publication Date |
---|---|
ZA821957B true ZA821957B (en) | 1983-02-23 |
Family
ID=4223231
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ZA821957A ZA821957B (en) | 1981-03-24 | 1982-03-23 | Acylquinolinone derivatives, processes for their manufacture, pharmaceutical preparations containing them and their use |
Country Status (22)
Country | Link |
---|---|
US (1) | US4476132A (es) |
EP (1) | EP0062001B1 (es) |
JP (1) | JPH066576B2 (es) |
AR (4) | AR242189A1 (es) |
AT (1) | ATE27451T1 (es) |
AU (1) | AU560003B2 (es) |
CY (1) | CY1412A (es) |
DE (1) | DE3276432D1 (es) |
DK (1) | DK159427C (es) |
ES (7) | ES8400092A1 (es) |
FI (1) | FI77853C (es) |
GB (1) | GB2095668B (es) |
GR (1) | GR78345B (es) |
HK (1) | HK3988A (es) |
HU (1) | HU192103B (es) |
IE (1) | IE53158B1 (es) |
IL (1) | IL65327A0 (es) |
MY (1) | MY8700806A (es) |
NO (1) | NO160074C (es) |
NZ (1) | NZ200106A (es) |
PT (1) | PT74634B (es) |
ZA (1) | ZA821957B (es) |
Families Citing this family (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS58219166A (ja) * | 1982-06-14 | 1983-12-20 | Nippon Shinyaku Co Ltd | 4−キノロン誘導体 |
JPS58225065A (ja) * | 1982-06-21 | 1983-12-27 | Nippon Shinyaku Co Ltd | 2−キノロン誘導体 |
US4675432A (en) * | 1986-08-29 | 1987-06-23 | American Cyanamid Company | Method for the preparation of anilinofumarate |
US6034100A (en) * | 1993-03-10 | 2000-03-07 | Otsuka Pharmaceutical Co., Ltd. | Method for inhibiting cytokine secretion |
AU2001293847B2 (en) * | 2000-10-02 | 2007-05-24 | Janssen Pharmaceutica N.V. | Metabotropic glutamate receptor antagonists |
CN1642580B (zh) * | 2002-03-29 | 2010-05-26 | 詹森药业有限公司 | 放射性标记的喹啉和喹啉酮衍生物及其作为代谢性谷氨酸受体配体的制造用途 |
CN105073729A (zh) | 2012-10-16 | 2015-11-18 | 詹森药业有限公司 | RORγt的苯基连接的喹啉基调节剂 |
JP6250686B2 (ja) | 2012-10-16 | 2017-12-20 | ヤンセン ファーマシューティカ エヌ.ベー. | Rorγtのヘテロアリール結合させたキノリニルモジュレータ |
EP2909192B1 (en) | 2012-10-16 | 2017-05-17 | Janssen Pharmaceutica NV | Methylene linked quinolinyl modulators of ror-gamma-t |
US9284308B2 (en) | 2013-10-15 | 2016-03-15 | Janssen Pharmaceutica Nv | Methylene linked quinolinyl modulators of RORγt |
US9403816B2 (en) | 2013-10-15 | 2016-08-02 | Janssen Pharmaceutica Nv | Phenyl linked quinolinyl modulators of RORγt |
CA2926339A1 (en) | 2013-10-15 | 2015-04-23 | Janssen Pharmaceutica Nv | Alkyl linked quinolinyl modulators of roryt |
US9221804B2 (en) | 2013-10-15 | 2015-12-29 | Janssen Pharmaceutica Nv | Secondary alcohol quinolinyl modulators of RORγt |
US9328095B2 (en) | 2013-10-15 | 2016-05-03 | Janssen Pharmaceutica Nv | Heteroaryl linked quinolinyl modulators of RORgammat |
US10555941B2 (en) | 2013-10-15 | 2020-02-11 | Janssen Pharmaceutica Nv | Alkyl linked quinolinyl modulators of RORγt |
EP3057422B1 (en) | 2013-10-15 | 2019-05-15 | Janssen Pharmaceutica NV | Quinolinyl modulators of ror(gamma)t |
Family Cites Families (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB830832A (en) * | 1957-02-15 | 1960-03-23 | Ici Ltd | New quinolones and therapeutic compositions containing them |
GB1013224A (en) * | 1962-06-21 | 1965-12-15 | Ici Ltd | Heterocyclic aminoethanols |
CH538476A (de) * | 1966-09-29 | 1973-06-30 | Ciba Geigy Ag | Verfahren zur Herstellung von heterocyclischen Carbonsäuren |
US3496184A (en) * | 1969-03-18 | 1970-02-17 | Ciba Geigy Corp | Cyclopropylmethoxy-3-quinoline carboxylic acids and esters |
CA947301A (en) * | 1970-01-28 | 1974-05-14 | Sumitomo Chemical Company | Process for the preparation of compound having antibacterial action |
GB1334705A (en) * | 1970-06-19 | 1973-10-24 | Ici Ltd | Pharmaceutical compositions containing kynurenic acid derivatives |
CA942748A (en) * | 1970-09-18 | 1974-02-26 | Venkatachala L. Narayanan | 1-aziridinylcarbonyl substituted-3-quinolinecarboxylic acid compounds |
US4190659A (en) * | 1973-08-27 | 1980-02-26 | Sandoz, Inc. | Pharmaceutical preparation and use of 4-hydroxy-2-quinolinone-3-carboxylic acid esters |
US4086349A (en) * | 1975-07-30 | 1978-04-25 | Mitsubishi Yuka Pharmaceutical Co., Ltd. | Quinolopyran-4-one-2-carboxylic acid derivatives and salts thereof as novel compounds and as medicines for treatment of allergic asthma |
JPS609511B2 (ja) * | 1976-07-16 | 1985-03-11 | 大塚製薬株式会社 | 5−カルボスチリルメタノ−ル誘導体 |
JPS609713B2 (ja) * | 1976-10-08 | 1985-03-12 | 大塚製薬株式会社 | カルボスチリル誘導体 |
US4186201A (en) * | 1977-02-07 | 1980-01-29 | Riker Laboratories, Inc. | Methods of using 8(tetrazol-5-ylcarbamoyl)isoquinoline compounds |
US4187309A (en) * | 1977-06-20 | 1980-02-05 | Sandoz, Inc. | 4-Hydroxy-2-quinolinone-3-carboxylic acids and salts thereof |
US4119720A (en) * | 1977-07-06 | 1978-10-10 | Sandoz, Inc. | Unsaturated esters of 4-hydroxy-2-quinolinone-3-carboxylic acids and salts thereof |
DE2806879A1 (de) * | 1978-02-17 | 1979-08-23 | Sandoz Ag | 4-hydroxy-2-chinolinon-3-carbonsaeure- esterderivate |
-
1982
- 1982-03-18 DE DE8282810126T patent/DE3276432D1/de not_active Expired
- 1982-03-18 AT AT82810126T patent/ATE27451T1/de not_active IP Right Cessation
- 1982-03-18 EP EP82810126A patent/EP0062001B1/de not_active Expired
- 1982-03-19 US US06/360,016 patent/US4476132A/en not_active Expired - Lifetime
- 1982-03-22 PT PT74634A patent/PT74634B/pt not_active IP Right Cessation
- 1982-03-22 FI FI820983A patent/FI77853C/fi not_active IP Right Cessation
- 1982-03-22 GR GR67672A patent/GR78345B/el unknown
- 1982-03-23 NO NO820959A patent/NO160074C/no unknown
- 1982-03-23 AU AU81819/82A patent/AU560003B2/en not_active Ceased
- 1982-03-23 NZ NZ200106A patent/NZ200106A/en unknown
- 1982-03-23 ZA ZA821957A patent/ZA821957B/xx unknown
- 1982-03-23 IL IL65327A patent/IL65327A0/xx not_active IP Right Cessation
- 1982-03-23 ES ES510685A patent/ES8400092A1/es not_active Expired
- 1982-03-23 CY CY141282A patent/CY1412A/xx unknown
- 1982-03-23 HU HU82881A patent/HU192103B/hu not_active IP Right Cessation
- 1982-03-23 GB GB8208394A patent/GB2095668B/en not_active Expired
- 1982-03-23 DK DK130382A patent/DK159427C/da not_active IP Right Cessation
- 1982-03-23 IE IE670/82A patent/IE53158B1/en not_active IP Right Cessation
- 1982-03-24 JP JP57045754A patent/JPH066576B2/ja not_active Expired - Lifetime
- 1982-03-24 AR AR82288857A patent/AR242189A1/es active
-
1983
- 1983-06-16 ES ES523337A patent/ES523337A0/es active Granted
- 1983-06-16 ES ES523342A patent/ES523342A0/es active Granted
- 1983-06-16 ES ES523338A patent/ES8503662A1/es not_active Expired
- 1983-06-16 ES ES523339A patent/ES523339A0/es active Granted
- 1983-06-16 ES ES523340A patent/ES8503664A1/es not_active Expired
- 1983-06-16 ES ES523341A patent/ES523341A0/es active Granted
- 1983-11-30 AR AR29497383A patent/AR240739A1/es active
- 1983-11-30 AR AR294972A patent/AR240044A1/es active
- 1983-11-30 AR AR83294975A patent/AR242376A1/es active
-
1987
- 1987-12-30 MY MY806/87A patent/MY8700806A/xx unknown
-
1988
- 1988-01-14 HK HK39/88A patent/HK3988A/xx unknown
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