GB1334705A - Pharmaceutical compositions containing kynurenic acid derivatives - Google Patents
Pharmaceutical compositions containing kynurenic acid derivativesInfo
- Publication number
- GB1334705A GB1334705A GB1334705DA GB1334705A GB 1334705 A GB1334705 A GB 1334705A GB 1334705D A GB1334705D A GB 1334705DA GB 1334705 A GB1334705 A GB 1334705A
- Authority
- GB
- United Kingdom
- Prior art keywords
- ester
- pharmaceutical compositions
- compositions containing
- acid derivatives
- alkoxy
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
- C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
- C07D221/04—Ortho- or peri-condensed ring systems
- C07D221/06—Ring systems of three rings
- C07D221/10—Aza-phenanthrenes
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
1334705 Derivatives of 4-oxo-1,4-dihydroquinoline-2-carboxylic acid IMPERIAL CHEMICAL INDUSTRIES Ltd 19 May 1971 [19 June 1970] 29905/70 Heading C2C [Also in Division A5] The invention comprises (with numerous exceptions) compounds of formula wherein R<SP>1</SP> is H, Me or Et, R<SP>2</SP> is OH or C 1-6 alkoxy, and ring A may be substituted by 1 or 2 of C 1-5 alkyl and alkoxy, benzyl, benzyloxy, acetyl, halogen, CF 3 , NO 2 or NH 2 , or it may be fused with a 5,6- or 7,8-benzene ring, a methoxysubstituted benzene ring, or with (CH 2 ) 4 ; and their non-toxic pharmaceutically acceptable salts. In examples, the acids are prepared by hydrolysing the esters, which are in turn made by reacting a correspondingly substituted aniline with an ester of oxaloacetic or acetylenedicarboxylic acid, and heating the ester of 1-phenylaminoethylene-1,2-dicarboxylic acid so formed; exceptionally, an ester of the above formula containing an NH 2 substitute is prepared by reducing the corresponding nitrocompound.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB2990570 | 1970-06-19 |
Publications (1)
Publication Number | Publication Date |
---|---|
GB1334705A true GB1334705A (en) | 1973-10-24 |
Family
ID=10299112
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB1334705D Expired GB1334705A (en) | 1970-06-19 | 1970-06-19 | Pharmaceutical compositions containing kynurenic acid derivatives |
Country Status (3)
Country | Link |
---|---|
DE (1) | DE2130408A1 (en) |
FR (1) | FR2100798B1 (en) |
GB (1) | GB1334705A (en) |
Cited By (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4128649A (en) | 1977-06-29 | 1978-12-05 | Sandoz, Inc. | 4-Hydroxy-pyrido[2,3-b]pyridine-2(1H)-one-3-carboxylic acids and esters |
US4273930A (en) * | 1977-06-20 | 1981-06-16 | Sandoz, Inc. | 4-Hydroxy-2-quinolinone-3-carboxylic acid esters |
US4281131A (en) | 1977-06-20 | 1981-07-28 | Sandoz, Inc. | 4-Hydroxy-2-quinolinone-3-carboxylic acids and salts thereof |
EP0062001A2 (en) * | 1981-03-24 | 1982-10-06 | Ciba-Geigy Ag | Acyl quinolinone derivatives, processes for their preparation, pharmaceutical compositions containing them and their use |
EP0303387A1 (en) * | 1987-08-12 | 1989-02-15 | Merck Sharp & Dohme Ltd. | Kynurenic acid derivatives useful in the treatment of neurodegenerative disorders |
EP0339485A1 (en) * | 1988-04-26 | 1989-11-02 | The Du Pont Merck Pharmaceutical Company | 4-Quinoline carboxylic acid derivatives useful as immunosuppressive agents |
US4963566A (en) * | 1986-03-28 | 1990-10-16 | Otsuka Pharmaceutical Co., Ltd. | Benzimidazolyl-sulfinyl-tetrahydroquinolines |
US5204329A (en) * | 1990-06-11 | 1993-04-20 | Du Pont Merck Pharmaceutical Company | Treatment of organ transplantation rejection |
US5270309A (en) * | 1987-08-12 | 1993-12-14 | Merck Sharp & Dohme Limited | Kynurenic acid derivatives useful in the treatment of neurodegenerative disorders |
US6861424B2 (en) | 2001-06-06 | 2005-03-01 | Schering Aktiengesellschaft | Platelet adenosine diphosphate receptor antagonists |
US7056923B2 (en) | 2002-12-11 | 2006-06-06 | Schering Aktiengesellschaft | Platelet adenosine diphosphate receptor antagonists |
EP1851739A2 (en) * | 2004-12-29 | 2007-11-07 | Naturon, Inc. | Xanthurenic acid derivative pharmaceutical compositoins and methods related thereto |
WO2010128345A1 (en) * | 2009-05-05 | 2010-11-11 | Szegedi Tudományegyetem | Kynurenic acid analogues, pharmaceutical compositions containing same and use of said compounds for the treatment of headache |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3865831A (en) * | 1972-06-09 | 1975-02-11 | Upjohn Co | 1,1{40 ,4,4{40 -tetrahydro-4,4{40 -dioxo(6,6{40 biquinoline)-2,2{40 -dicarboxylates |
FR2827599A1 (en) * | 2001-07-20 | 2003-01-24 | Neuro3D | Treating central nervous system disorders, e.g. anxiety, depression, schizophrenia or pain, using new or known 2-substituted quinoline or quinoxaline derivatives having xanthenuric acid modulating action |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1207771A (en) * | 1968-03-18 | 1970-10-07 | Warner Lambert Pharmaceutical | Anti-virally active quinoline derivatives |
-
1970
- 1970-06-19 GB GB1334705D patent/GB1334705A/en not_active Expired
-
1971
- 1971-06-18 DE DE19712130408 patent/DE2130408A1/en active Pending
- 1971-06-18 FR FR7122365A patent/FR2100798B1/fr not_active Expired
Cited By (23)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4273930A (en) * | 1977-06-20 | 1981-06-16 | Sandoz, Inc. | 4-Hydroxy-2-quinolinone-3-carboxylic acid esters |
US4281131A (en) | 1977-06-20 | 1981-07-28 | Sandoz, Inc. | 4-Hydroxy-2-quinolinone-3-carboxylic acids and salts thereof |
US4128649A (en) | 1977-06-29 | 1978-12-05 | Sandoz, Inc. | 4-Hydroxy-pyrido[2,3-b]pyridine-2(1H)-one-3-carboxylic acids and esters |
EP0062001A2 (en) * | 1981-03-24 | 1982-10-06 | Ciba-Geigy Ag | Acyl quinolinone derivatives, processes for their preparation, pharmaceutical compositions containing them and their use |
US4476132A (en) * | 1981-03-24 | 1984-10-09 | Ciba-Geigy Corporation | Acylquinolinone derivatives, and antiallergic preparations and methods of inhibiting allergic reactions using them |
EP0062001B1 (en) * | 1981-03-24 | 1987-05-27 | Ciba-Geigy Ag | Acyl quinolinone derivatives, processes for their preparation, pharmaceutical compositions containing them and their use |
US4963566A (en) * | 1986-03-28 | 1990-10-16 | Otsuka Pharmaceutical Co., Ltd. | Benzimidazolyl-sulfinyl-tetrahydroquinolines |
US5270309A (en) * | 1987-08-12 | 1993-12-14 | Merck Sharp & Dohme Limited | Kynurenic acid derivatives useful in the treatment of neurodegenerative disorders |
EP0303387A1 (en) * | 1987-08-12 | 1989-02-15 | Merck Sharp & Dohme Ltd. | Kynurenic acid derivatives useful in the treatment of neurodegenerative disorders |
EP0339485A1 (en) * | 1988-04-26 | 1989-11-02 | The Du Pont Merck Pharmaceutical Company | 4-Quinoline carboxylic acid derivatives useful as immunosuppressive agents |
US5204329A (en) * | 1990-06-11 | 1993-04-20 | Du Pont Merck Pharmaceutical Company | Treatment of organ transplantation rejection |
US7176207B2 (en) | 2001-06-06 | 2007-02-13 | Schering Aktiengesellschaft | Platelet adenosine diphosphate receptor antagonists |
US6861424B2 (en) | 2001-06-06 | 2005-03-01 | Schering Aktiengesellschaft | Platelet adenosine diphosphate receptor antagonists |
US6995156B2 (en) | 2001-06-06 | 2006-02-07 | Schering Aktiengesellschaft | Platelet adenosine diphosphate receptor antagonists |
US7026323B2 (en) | 2001-06-06 | 2006-04-11 | Schering Aktiengesellschaft | Platelet adenosine diphosphate receptor antagonists |
US7056923B2 (en) | 2002-12-11 | 2006-06-06 | Schering Aktiengesellschaft | Platelet adenosine diphosphate receptor antagonists |
US7084142B2 (en) | 2002-12-11 | 2006-08-01 | Schering Aktiengesellschaft | Platelet adenosine diphosphate receptor antagonists |
EP1851739A2 (en) * | 2004-12-29 | 2007-11-07 | Naturon, Inc. | Xanthurenic acid derivative pharmaceutical compositoins and methods related thereto |
EP1851739A4 (en) * | 2004-12-29 | 2012-08-29 | Naturon Inc | Xanthurenic acid derivative pharmaceutical compositoins and methods related thereto |
US8361734B2 (en) | 2004-12-29 | 2013-01-29 | Naturon, Inc. | Xanthurenic acid derivative pharmaceutical compositions and methods related thereto |
US8697674B2 (en) | 2004-12-29 | 2014-04-15 | Naturon, Inc. | Xanthurenic acid derivative pharmaceutical compositions and methods related thereto |
US10370335B2 (en) | 2004-12-29 | 2019-08-06 | Naturon, Inc. | Xanthurenic acid derivative pharmaceutical compositions and methods related thereto |
WO2010128345A1 (en) * | 2009-05-05 | 2010-11-11 | Szegedi Tudományegyetem | Kynurenic acid analogues, pharmaceutical compositions containing same and use of said compounds for the treatment of headache |
Also Published As
Publication number | Publication date |
---|---|
FR2100798B1 (en) | 1975-10-10 |
DE2130408A1 (en) | 1971-12-23 |
FR2100798A1 (en) | 1972-03-24 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PS | Patent sealed | ||
PLNP | Patent lapsed through nonpayment of renewal fees |