ES8400092A1 - Procedimiento para la obtencion de derivados de quinolinona. - Google Patents

Procedimiento para la obtencion de derivados de quinolinona.

Info

Publication number
ES8400092A1
ES8400092A1 ES510685A ES510685A ES8400092A1 ES 8400092 A1 ES8400092 A1 ES 8400092A1 ES 510685 A ES510685 A ES 510685A ES 510685 A ES510685 A ES 510685A ES 8400092 A1 ES8400092 A1 ES 8400092A1
Authority
ES
Spain
Prior art keywords
radical
aliphatic
together represent
hydrogen
heterocyclic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES510685A
Other languages
English (en)
Other versions
ES510685A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis AG
Original Assignee
Ciba Geigy AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ciba Geigy AG filed Critical Ciba Geigy AG
Publication of ES510685A0 publication Critical patent/ES510685A0/es
Publication of ES8400092A1 publication Critical patent/ES8400092A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/04—1,3-Oxazines; Hydrogenated 1,3-oxazines
    • C07D265/12—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems
    • C07D265/14—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D265/24—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring with hetero atoms directly attached in positions 2 and 4
    • C07D265/26—Two oxygen atoms, e.g. isatoic anhydride
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/32—Oxygen atoms
    • C07D209/34—Oxygen atoms in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/32—Oxygen atoms
    • C07D209/38—Oxygen atoms in positions 2 and 3, e.g. isatin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
    • C07D215/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3 with oxygen atoms in position 4

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pulmonology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Quinoline Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE DERIVADOS DE QUINOLINONA.CONSISTE EN CICLIZAR INTRAMOLECULARMENTE UN COMPUESTO (II) DONDE Z ES UN RESTO DISOCIABLE O UN TAUTOMERO. EL COMPUESTO OBTENIDO (I), PUEDE TRANSFORMARSE EN LA SAL O EL COMPUESTO LIBRE CORRESPONDIENTE. LA REACCION PUEDE TENER LUGAR POR CALENTAMIENTO A TEMPERATURAS DE 150 A 250JC EN PRESENCIA DE UN AGENTE DE CONDENSACION Y EN CASO NECESARIO DE UN DISOLVENTE INERTE Y DE UN GAS INERTE TAL COMO NITROGENO. COMO DISOLVENTE PUEDE EMPLEARSE TOLUENO, XILENO; ETERES; AMIDAS DE ACIDO CARBOXILICO TERCIARIAS. COMO AGENTES DE CONDENSACION PUEDEN EMPLEARSEACIDOS PROTONICOS O LOS ESTERES DE LOS ACIDOS DEL ACIDO MINERAL O BIEN LOS ACIDOS DE LEWIS.
ES510685A 1981-03-24 1982-03-23 Procedimiento para la obtencion de derivados de quinolinona. Expired ES8400092A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH198681 1981-03-24

Publications (2)

Publication Number Publication Date
ES510685A0 ES510685A0 (es) 1983-10-16
ES8400092A1 true ES8400092A1 (es) 1983-10-16

Family

ID=4223231

Family Applications (7)

Application Number Title Priority Date Filing Date
ES510685A Expired ES8400092A1 (es) 1981-03-24 1982-03-23 Procedimiento para la obtencion de derivados de quinolinona.
ES523339A Expired ES8503663A1 (es) 1981-03-24 1983-06-16 Procedimiento para la obtencion de derivados de quinolinona. (como desglose y con prioridad de la patente espanola no. 510.685, presentada el 23 de marzo de 1.982)
ES523342A Granted ES523342A0 (es) 1981-03-24 1983-06-16 Procedimiento para la obtencion de derivados de quinolinona. (como desglose y con prioridad de la patente espanola no. 510.685, presentada el 23 de marzo de 1.982)
ES523340A Granted ES523340A0 (es) 1981-03-24 1983-06-16 Procedimiento para la obtencion de derivados de quinolinona. (como desglose y con prioridad de la patente espanola no. 510.685, presentada el 23 de marzo de 1.982)
ES523337A Expired ES8503661A1 (es) 1981-03-24 1983-06-16 Procedimiento para la obtencion de derivados de quinolinona.
ES523338A Expired ES8503662A1 (es) 1981-03-24 1983-06-16 Procedimiento para la obtencion de derivados de quinolinona. (como desglose y con prioridad de la patente espanola no.510.685, presentada el 23 de marzo de 1.982).
ES523341A Expired ES8503334A1 (es) 1981-03-24 1983-06-16 Procedimiento para la obtencion de derivados de quinolinona. (como desglose y con prioridad de la patente espanola no. 510.685, presentada el 23 de marzo de 1.982)

Family Applications After (6)

Application Number Title Priority Date Filing Date
ES523339A Expired ES8503663A1 (es) 1981-03-24 1983-06-16 Procedimiento para la obtencion de derivados de quinolinona. (como desglose y con prioridad de la patente espanola no. 510.685, presentada el 23 de marzo de 1.982)
ES523342A Granted ES523342A0 (es) 1981-03-24 1983-06-16 Procedimiento para la obtencion de derivados de quinolinona. (como desglose y con prioridad de la patente espanola no. 510.685, presentada el 23 de marzo de 1.982)
ES523340A Granted ES523340A0 (es) 1981-03-24 1983-06-16 Procedimiento para la obtencion de derivados de quinolinona. (como desglose y con prioridad de la patente espanola no. 510.685, presentada el 23 de marzo de 1.982)
ES523337A Expired ES8503661A1 (es) 1981-03-24 1983-06-16 Procedimiento para la obtencion de derivados de quinolinona.
ES523338A Expired ES8503662A1 (es) 1981-03-24 1983-06-16 Procedimiento para la obtencion de derivados de quinolinona. (como desglose y con prioridad de la patente espanola no.510.685, presentada el 23 de marzo de 1.982).
ES523341A Expired ES8503334A1 (es) 1981-03-24 1983-06-16 Procedimiento para la obtencion de derivados de quinolinona. (como desglose y con prioridad de la patente espanola no. 510.685, presentada el 23 de marzo de 1.982)

Country Status (22)

Country Link
US (1) US4476132A (es)
EP (1) EP0062001B1 (es)
JP (1) JPH066576B2 (es)
AR (4) AR242189A1 (es)
AT (1) ATE27451T1 (es)
AU (1) AU560003B2 (es)
CY (1) CY1412A (es)
DE (1) DE3276432D1 (es)
DK (1) DK159427C (es)
ES (7) ES8400092A1 (es)
FI (1) FI77853C (es)
GB (1) GB2095668B (es)
GR (1) GR78345B (es)
HK (1) HK3988A (es)
HU (1) HU192103B (es)
IE (1) IE53158B1 (es)
IL (1) IL65327A0 (es)
MY (1) MY8700806A (es)
NO (1) NO160074C (es)
NZ (1) NZ200106A (es)
PT (1) PT74634B (es)
ZA (1) ZA821957B (es)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS58219166A (ja) * 1982-06-14 1983-12-20 Nippon Shinyaku Co Ltd ４−キノロン誘導体
JPS58225065A (ja) * 1982-06-21 1983-12-27 Nippon Shinyaku Co Ltd ２−キノロン誘導体
US4675432A (en) * 1986-08-29 1987-06-23 American Cyanamid Company Method for the preparation of anilinofumarate
US6034100A (en) * 1993-03-10 2000-03-07 Otsuka Pharmaceutical Co., Ltd. Method for inhibiting cytokine secretion
KR100818965B1 (ko) * 2000-10-02 2008-04-04 얀센 파마슈티카 엔.브이. 대사자극성 글루타메이트 수용체 길항제
JP4573533B2 (ja) * 2002-03-29 2010-11-04 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ 放射能標識付きキノリンおよびキノリノン誘導体および代謝向性グルタメート受容体リガンドとしてのそれらの使用
KR20150070348A (ko) 2012-10-16 2015-06-24 얀센 파마슈티카 엔.브이. RoRγt의 헤테로아릴 결합 퀴놀리닐 조절제
PT2909192T (pt) 2012-10-16 2017-08-04 Janssen Pharmaceutica Nv Moduladores de ror-gama-t quinolinilo ligados por metileno
MX2015004784A (es) 2012-10-16 2015-08-14 Janssen Pharmaceutica Nv Moduladores de quinolinilo unidos a fenilo de receptor nuclear de acido retinoico-gamma-t.
US9403816B2 (en) 2013-10-15 2016-08-02 Janssen Pharmaceutica Nv Phenyl linked quinolinyl modulators of RORγt
US9284308B2 (en) 2013-10-15 2016-03-15 Janssen Pharmaceutica Nv Methylene linked quinolinyl modulators of RORγt
CN105848483A (zh) 2013-10-15 2016-08-10 詹森药业有限公司 RORγt 的喹啉基调节剂
US9221804B2 (en) 2013-10-15 2015-12-29 Janssen Pharmaceutica Nv Secondary alcohol quinolinyl modulators of RORγt
US10555941B2 (en) 2013-10-15 2020-02-11 Janssen Pharmaceutica Nv Alkyl linked quinolinyl modulators of RORγt
WO2015057629A1 (en) 2013-10-15 2015-04-23 Janssen Pharmaceutica Nv ALKYL LINKED QUINOLINYL MODULATORS OF RORyt
US9328095B2 (en) 2013-10-15 2016-05-03 Janssen Pharmaceutica Nv Heteroaryl linked quinolinyl modulators of RORgammat

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB830832A (en) * 1957-02-15 1960-03-23 Ici Ltd New quinolones and therapeutic compositions containing them
GB1013224A (en) * 1962-06-21 1965-12-15 Ici Ltd Heterocyclic aminoethanols
CH519304A (de) * 1966-09-29 1972-02-29 Ciba Geigy Ag Verwendung von heterocyclischen Carbonsäureverbindungen zur Aufzucht von Geflügel
US3496184A (en) * 1969-03-18 1970-02-17 Ciba Geigy Corp Cyclopropylmethoxy-3-quinoline carboxylic acids and esters
DE2103805C3 (de) * 1970-01-28 1980-03-20 Sumitomo Chemical Co., Ltd., Osaka (Japan) Verfahren zur Herstellung von N-substituierten 6,7-Methylendioxy-4chinolonen
GB1334705A (en) * 1970-06-19 1973-10-24 Ici Ltd Pharmaceutical compositions containing kynurenic acid derivatives
CA942748A (en) * 1970-09-18 1974-02-26 Venkatachala L. Narayanan 1-aziridinylcarbonyl substituted-3-quinolinecarboxylic acid compounds
US4190659A (en) * 1973-08-27 1980-02-26 Sandoz, Inc. Pharmaceutical preparation and use of 4-hydroxy-2-quinolinone-3-carboxylic acid esters
US4086349A (en) * 1975-07-30 1978-04-25 Mitsubishi Yuka Pharmaceutical Co., Ltd. Quinolopyran-4-one-2-carboxylic acid derivatives and salts thereof as novel compounds and as medicines for treatment of allergic asthma
JPS609511B2 (ja) * 1976-07-16 1985-03-11 大塚製薬株式会社 ５−カルボスチリルメタノ−ル誘導体
JPS609713B2 (ja) * 1976-10-08 1985-03-12 大塚製薬株式会社 カルボスチリル誘導体
US4186201A (en) * 1977-02-07 1980-01-29 Riker Laboratories, Inc. Methods of using 8(tetrazol-5-ylcarbamoyl)isoquinoline compounds
US4187309A (en) * 1977-06-20 1980-02-05 Sandoz, Inc. 4-Hydroxy-2-quinolinone-3-carboxylic acids and salts thereof
US4119720A (en) * 1977-07-06 1978-10-10 Sandoz, Inc. Unsaturated esters of 4-hydroxy-2-quinolinone-3-carboxylic acids and salts thereof
DE2806879A1 (de) * 1978-02-17 1979-08-23 Sandoz Ag 4-hydroxy-2-chinolinon-3-carbonsaeure- esterderivate

Also Published As

Publication number Publication date
ES523337A0 (es) 1985-03-01
DK130382A (da) 1982-09-25
DK159427B (da) 1990-10-15
AU8181982A (en) 1982-09-30
NO160074C (no) 1989-03-08
ES8503664A1 (es) 1985-03-01
IE53158B1 (en) 1988-08-03
JPS57192366A (en) 1982-11-26
US4476132A (en) 1984-10-09
ATE27451T1 (de) 1987-06-15
ES8503661A1 (es) 1985-03-01
AR240044A1 (es) 1990-01-31
GR78345B (es) 1984-09-26
AR242189A1 (es) 1993-03-31
EP0062001A3 (en) 1983-01-26
PT74634A (de) 1982-04-01
NO820959L (no) 1982-09-27
FI77853C (fi) 1989-05-10
FI77853B (fi) 1989-01-31
AU560003B2 (en) 1987-03-26
AR240739A1 (es) 1990-10-31
ES510685A0 (es) 1983-10-16
ZA821957B (en) 1983-02-23
DK159427C (da) 1991-03-18
PT74634B (de) 1984-11-26
NZ200106A (en) 1985-07-31
CY1412A (en) 1988-04-22
ES523341A0 (es) 1985-02-16
FI820983L (fi) 1982-09-25
DE3276432D1 (en) 1987-07-02
EP0062001B1 (de) 1987-05-27
HU192103B (en) 1987-05-28
IL65327A0 (en) 1982-05-31
MY8700806A (en) 1987-12-31
ES523338A0 (es) 1985-03-01
GB2095668A (en) 1982-10-06
GB2095668B (en) 1985-04-11
JPH066576B2 (ja) 1994-01-26
IE820670L (en) 1982-09-24
ES523339A0 (es) 1985-03-01
ES8503662A1 (es) 1985-03-01
ES523340A0 (es) 1985-03-01
AR242376A1 (es) 1993-03-31
ES8503334A1 (es) 1985-02-16
NO160074B (no) 1988-11-28
EP0062001A2 (de) 1982-10-06
ES8503665A1 (es) 1985-03-01
ES523342A0 (es) 1985-03-01
ES8503663A1 (es) 1985-03-01
HK3988A (en) 1988-01-22

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