ES8404363A1 - Procedimiento para la preparacion de tiazolo(3,2-a)pirimidinas sustituidas. - Google Patents
Procedimiento para la preparacion de tiazolo(3,2-a)pirimidinas sustituidas.Info
- Publication number
- ES8404363A1 ES8404363A1 ES520642A ES520642A ES8404363A1 ES 8404363 A1 ES8404363 A1 ES 8404363A1 ES 520642 A ES520642 A ES 520642A ES 520642 A ES520642 A ES 520642A ES 8404363 A1 ES8404363 A1 ES 8404363A1
- Authority
- ES
- Spain
- Prior art keywords
- alkyl
- pyrimidines
- preparation
- hydrogen
- halogen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 150000003230 pyrimidines Chemical class 0.000 title abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- 229910052739 hydrogen Inorganic materials 0.000 abstract 3
- 239000001257 hydrogen Substances 0.000 abstract 3
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 2
- ZUOUZKKEUPVFJK-UHFFFAOYSA-N diphenyl Chemical compound C1=CC=CC=C1C1=CC=CC=C1 ZUOUZKKEUPVFJK-UHFFFAOYSA-N 0.000 abstract 2
- 229910052736 halogen Inorganic materials 0.000 abstract 2
- 150000002367 halogens Chemical class 0.000 abstract 2
- 125000004076 pyridyl group Chemical group 0.000 abstract 2
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 1
- 125000004423 acyloxy group Chemical group 0.000 abstract 1
- 125000003302 alkenyloxy group Chemical group 0.000 abstract 1
- 230000003110 anti-inflammatory effect Effects 0.000 abstract 1
- 230000000026 anti-ulcerogenic effect Effects 0.000 abstract 1
- 235000010290 biphenyl Nutrition 0.000 abstract 1
- 239000004305 biphenyl Substances 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 1
- -1 formyloxy Chemical group 0.000 abstract 1
- 150000002431 hydrogen Chemical group 0.000 abstract 1
- 125000001624 naphthyl group Chemical group 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 230000003248 secreting effect Effects 0.000 abstract 1
- 125000001544 thienyl group Chemical group 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biochemistry (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Molecular Biology (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
PROCEDIMIENTO PARA LA PREPARACION DE TIAZOLO3,2-APIRIMIDINAS SUSTITUIDAS, DE FORMULA GENERAL (I), EN LA QUE A COMPLETA UN ENLACE; R1 Y R2 REPRESENTAN INDEPENDIENTEMENTE UN ATOMO DE HIDROGENO, HALOGENO, TIENILO, PIRIDILO, UN GRUPO FENILO O UN GRUPO FENILO SUSTITUIDO; R3 REPRESENTA UN ATOMO DE HIDROGENO, HALOGENO O ALCOHILO C1-C4; Y R4 REPRESENTA UN GRUPO PIRIDILO, Y SUS SALES FARMACEUTICAMENTE ACEPTABLES.CONSISTE EN HACER REACCIONAR UN COMPUESTO DE FORMULA (II), EN LA QUE R1, R2 Y R3 TIENEN LOS SIGNIFICADOS YA MENCIONADOS; Q ES ARILO O ALCOHILO C1-C6; E Y(-) REPRESENTA UNANION ACIDO, CON UN ALDEHIDO DE FORMULA: R4-CHO, EN LA QUE R4 TIENE EL SIGNIFICADO YA MENCIONADO.DE APLICACION EN TERAPIA, POR EJEMPLO EN LA PREVENCION Y TRATAMIENTO DE ULCERAS PEPTICAS.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB8121979 | 1981-07-15 | ||
| GB8201621 | 1982-01-20 | ||
| GB8212430 | 1982-04-29 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES8404363A1 true ES8404363A1 (es) | 1984-05-01 |
| ES520642A0 ES520642A0 (es) | 1984-05-01 |
Family
ID=27261230
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES513808A Granted ES513808A0 (es) | 1981-07-15 | 1982-07-08 | "procedimiento para la preparacion de tiazolo(3,2-a)pirimidinas sustituidas". |
| ES520642A Granted ES520642A0 (es) | 1981-07-15 | 1983-03-16 | Procedimiento para la preparacion de tiazolo(3,2-a)pirimidinas sustituidas. |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES513808A Granted ES513808A0 (es) | 1981-07-15 | 1982-07-08 | "procedimiento para la preparacion de tiazolo(3,2-a)pirimidinas sustituidas". |
Country Status (25)
| Country | Link |
|---|---|
| US (2) | US4444773A (es) |
| KR (1) | KR880002301B1 (es) |
| AT (1) | AT384614B (es) |
| AU (1) | AU551718B2 (es) |
| CA (1) | CA1208635A (es) |
| CH (1) | CH653036A5 (es) |
| DE (1) | DE3226516A1 (es) |
| DK (1) | DK156222C (es) |
| ES (2) | ES513808A0 (es) |
| FI (1) | FI71940C (es) |
| FR (1) | FR2509734B1 (es) |
| GB (1) | GB2103608B (es) |
| GR (1) | GR76208B (es) |
| HU (1) | HU186951B (es) |
| IE (1) | IE53426B1 (es) |
| IL (1) | IL66316A (es) |
| IT (1) | IT1190914B (es) |
| LU (1) | LU84262A1 (es) |
| NL (1) | NL8202706A (es) |
| NO (1) | NO822441L (es) |
| NZ (1) | NZ201194A (es) |
| PT (1) | PT75240B (es) |
| SE (2) | SE453295B (es) |
| SU (1) | SU1358786A3 (es) |
| YU (1) | YU151582A (es) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL8202706A (nl) * | 1981-07-15 | 1983-02-01 | Erba Farmitalia | Gesubstitueerde thiazolo3,2-apyrimidinen en werkwijzen ter bereiding ervan. |
| US4537962A (en) * | 1982-02-04 | 1985-08-27 | Farmitalia Carlo Erba, S.P.A. | Substituted 1,3,4-thiadiazolo[3,2-A]pyrimidines and compositions containing them |
| US4546101A (en) * | 1982-09-10 | 1985-10-08 | Fujisawa Pharmaceutical Co., Ltd. | New cephem compounds useful for treating infectious diseases in human being and animals and processes for preparation thereof |
| GB8300728D0 (en) * | 1983-01-12 | 1983-02-16 | Erba Farmitalia | Substituted carboxy-thiazolo / 3 2 - a / pyrimidine derivatives |
| DE10112197A1 (de) * | 2001-03-14 | 2002-09-19 | Gruenenthal Gmbh | Substituierte Pyrazolo- und Thiazolopyrimidine |
| EA018133B1 (ru) * | 2008-01-11 | 2013-05-30 | Гленмарк Фармасьютикалс, С.А. | Конденсированные пиримидиновые производные как модуляторы trpv3 |
| US8119647B2 (en) * | 2008-04-23 | 2012-02-21 | Glenmark Pharmaceuticals S.A. | Fused pyrimidineone compounds as TRPV3 modulators |
| ES2408654T3 (es) * | 2008-07-02 | 2013-06-21 | Avexa Limited | Tiazopirimidinonas y uso de las mismas |
| CN106916168B (zh) * | 2017-03-13 | 2019-08-27 | 牡丹江医学院 | 一种治疗重症胰腺炎的化合物及其制备方法 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3594378A (en) * | 1969-10-24 | 1971-07-20 | Ayerst Mckenna & Harrison | Thiazolopyrimidine derivatives and preparation thereof |
| US3888983A (en) * | 1970-08-14 | 1975-06-10 | Seperic | Derivatives of thiazolino-pyrimidin-6-ones, in inducing analgesia |
| GB2084568A (en) * | 1980-08-16 | 1982-04-15 | Beecham Group Ltd | Imidazothiazole derivatives |
| NL8202706A (nl) * | 1981-07-15 | 1983-02-01 | Erba Farmitalia | Gesubstitueerde thiazolo3,2-apyrimidinen en werkwijzen ter bereiding ervan. |
-
1982
- 1982-07-06 NL NL8202706A patent/NL8202706A/nl not_active Application Discontinuation
- 1982-07-06 AU AU85648/82A patent/AU551718B2/en not_active Ceased
- 1982-07-07 NZ NZ201194A patent/NZ201194A/en unknown
- 1982-07-07 LU LU84262A patent/LU84262A1/xx unknown
- 1982-07-08 AT AT0266182A patent/AT384614B/de not_active IP Right Cessation
- 1982-07-08 ES ES513808A patent/ES513808A0/es active Granted
- 1982-07-12 YU YU01515/82A patent/YU151582A/xx unknown
- 1982-07-12 SE SE8204292A patent/SE453295B/sv not_active IP Right Cessation
- 1982-07-12 IT IT22353/82A patent/IT1190914B/it active
- 1982-07-12 FI FI822468A patent/FI71940C/fi not_active IP Right Cessation
- 1982-07-12 SE SE8204292D patent/SE8204292L/xx not_active Application Discontinuation
- 1982-07-13 CH CH4272/82A patent/CH653036A5/de not_active IP Right Cessation
- 1982-07-13 SU SU823466583A patent/SU1358786A3/ru active
- 1982-07-13 PT PT75240A patent/PT75240B/pt unknown
- 1982-07-14 GB GB08220385A patent/GB2103608B/en not_active Expired
- 1982-07-14 NO NO822441A patent/NO822441L/no unknown
- 1982-07-14 IE IE1692/82A patent/IE53426B1/en unknown
- 1982-07-14 GR GR68755A patent/GR76208B/el unknown
- 1982-07-14 US US06/398,302 patent/US4444773A/en not_active Expired - Fee Related
- 1982-07-14 IL IL66316A patent/IL66316A/xx unknown
- 1982-07-14 HU HU822289A patent/HU186951B/hu not_active IP Right Cessation
- 1982-07-14 DK DK314682A patent/DK156222C/da not_active IP Right Cessation
- 1982-07-14 CA CA000407223A patent/CA1208635A/en not_active Expired
- 1982-07-15 FR FR8212391A patent/FR2509734B1/fr not_active Expired
- 1982-07-15 KR KR8203145A patent/KR880002301B1/ko active
- 1982-07-15 DE DE19823226516 patent/DE3226516A1/de not_active Ceased
-
1983
- 1983-03-16 ES ES520642A patent/ES520642A0/es active Granted
-
1984
- 1984-05-30 US US06/615,346 patent/US4551457A/en not_active Expired - Fee Related
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