ES8403025A1 - Procedimiento para preparar una solucion de insulina estabilizada. - Google Patents

Procedimiento para preparar una solucion de insulina estabilizada.

Info

Publication number
ES8403025A1
ES8403025A1 ES516963A ES516963A ES8403025A1 ES 8403025 A1 ES8403025 A1 ES 8403025A1 ES 516963 A ES516963 A ES 516963A ES 516963 A ES516963 A ES 516963A ES 8403025 A1 ES8403025 A1 ES 8403025A1
Authority
ES
Spain
Prior art keywords
preparation
insulin preparations
stabilized insulin
stabilized
preparations
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES516963A
Other languages
English (en)
Other versions
ES516963A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novo Nordisk AS
Original Assignee
Novo Industri AS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novo Industri AS filed Critical Novo Industri AS
Publication of ES8403025A1 publication Critical patent/ES8403025A1/es
Publication of ES516963A0 publication Critical patent/ES516963A0/es
Granted legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/28—Insulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/24—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing atoms other than carbon, hydrogen, oxygen, halogen, nitrogen or sulfur, e.g. cyclomethicone or phospholipids

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Endocrinology (AREA)
  • Immunology (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Manufacturing Of Micro-Capsules (AREA)

Abstract

PROCEDIMIENTO PARA PREPARAR UNA SOLUCION DE INSULINA ESTABILIZADA, QUE COMPRENDE OPCIONALMENTE ZINC, UN AGENTE CONSERVADOR, UN AGENTE QUE HACE ISOTONICA A LA SOLUCION Y UN AGENTE TAMPON.COMPRENDE LAS SIGUIENTES OPERACIONES: PRIMERA, SE DISUELVE INSULINA EN AGUA QUE CONTIENE UN ACIDO; SEGUNDA, SE AÑADE UNA BASE PARA AJUSTAR EL PH A UN VALOR APROXIMADAMENTE NEUTRO; TERCERA, SE AÑADE UN FOSFOLIPIDO, DE FORMULA GENERAL (I), EN LA QUE RK Y RL SON IGUALES O DIFERENTES, REPRESENTANDO CADA UNA DE ELLAS HIDROGENO, ALCOHILCARBONILO O ALQUENILCARBONILO; Y POR ULTIMO, SE AÑADE UN AGENTE DE CONSERVACION,UN AGENTE QUE HACE ISOTONICA LA SOLUCION Y UN AGENTE TAMPON Y, SI ES NECESARIO, SE AJUSTA EL VALOR DEL PH A UN VALOR COMPRENDIDO ENTRE 6,5 Y 8.
ES516963A 1981-10-30 1982-10-29 Procedimiento para preparar una solucion de insulina estabilizada. Granted ES516963A0 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DK478681 1981-10-30
DK324782 1982-07-20

Publications (2)

Publication Number Publication Date
ES8403025A1 true ES8403025A1 (es) 1984-03-01
ES516963A0 ES516963A0 (es) 1984-03-01

Family

ID=26066963

Family Applications (1)

Application Number Title Priority Date Filing Date
ES516963A Granted ES516963A0 (es) 1981-10-30 1982-10-29 Procedimiento para preparar una solucion de insulina estabilizada.

Country Status (20)

Country Link
US (1) US4614730A (es)
AT (1) AT382079B (es)
AU (1) AU549593B2 (es)
BE (1) BE894885A (es)
CA (1) CA1198673A (es)
CH (1) CH649922A5 (es)
DE (1) DE3240177A1 (es)
ES (1) ES516963A0 (es)
FI (1) FI80595C (es)
FR (1) FR2515517B1 (es)
GB (1) GB2107985B (es)
GR (1) GR77360B (es)
IE (1) IE54029B1 (es)
IT (1) IT1153315B (es)
LU (1) LU84447A1 (es)
NL (1) NL193099C (es)
NO (1) NO168086C (es)
NZ (1) NZ202328A (es)
PT (1) PT75766B (es)
SE (1) SE460576B (es)

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WO1985005029A1 (en) * 1984-05-09 1985-11-21 Medaphore Inc. Oral insulin and a method of making the same
DE3443877A1 (de) * 1984-06-09 1985-12-12 Hoechst Ag Insulinzubereitungen, verfahren zu deren herstellung und deren verwendung
CA1257199A (en) * 1986-05-20 1989-07-11 Paul Y. Wang Preparation containing bioactive macromolecular substance for multi-months release in vivo
FR2605449B1 (fr) * 1986-10-17 1988-12-02 Thomson Cgr Bloc magnetique a aimantation ajustable pour la production d'un champ magnetique permanent dans une zone d'interet
NZ222907A (en) * 1986-12-16 1990-08-28 Novo Industri As Preparation for intranasal administration containing a phospholipid absorption enhancing system
US5179079A (en) * 1986-12-16 1993-01-12 Novo Nordisk A/S Nasal formulation and intranasal administration therewith
US5266310A (en) * 1987-09-17 1993-11-30 Boehringer Ingelheim International Gmbh Stabilization of therapeutically active proteins in pharmaceutical preparations
NO179479C (no) * 1988-03-11 1996-10-16 Teikoku Seiyaku Kk Fremgangsmåte for fremstilling av et intravaginalt farmasöytisk preparat
US5725871A (en) * 1989-08-18 1998-03-10 Danbiosyst Uk Limited Drug delivery compositions comprising lysophosphoglycerolipid
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DE4208552A1 (de) * 1992-03-17 1993-09-23 Liedtke Pharmed Gmbh Topische arzneiformen mit insulin
KR100419037B1 (ko) 1994-03-07 2004-06-12 넥타르 테라퓨틱스 폐를통한인슐린의전달방법및그조성물
US6214375B1 (en) 1996-07-16 2001-04-10 Generex Pharmaceuticals, Inc. Phospholipid formulations
DE19726167B4 (de) 1997-06-20 2008-01-24 Sanofi-Aventis Deutschland Gmbh Insulin, Verfahren zu seiner Herstellung und es enthaltende pharmazeutische Zubereitung
US6221378B1 (en) 1998-02-10 2001-04-24 Generex Pharmaceuticals Incorporated Mixed micellar delivery system and method of preparation
US7070799B1 (en) * 1998-02-10 2006-07-04 Generex Pharmaceuticals, Inc. Method for administering insulin to the buccal region
US6350458B1 (en) 1998-02-10 2002-02-26 Generex Pharmaceuticals Incorporated Mixed micellar drug deliver system and method of preparation
US6017545A (en) * 1998-02-10 2000-01-25 Modi; Pankaj Mixed micellar delivery system and method of preparation
US6290987B1 (en) 1998-09-27 2001-09-18 Generex Pharmaceuticals, Inc. Mixed liposome pharmaceutical formulation with amphiphiles and phospholipids
US6375975B1 (en) 1998-12-21 2002-04-23 Generex Pharmaceuticals Incorporated Pharmaceutical compositions for buccal and pulmonary application
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US6451286B1 (en) 1998-12-21 2002-09-17 Generex Pharmaceuticals Incorporated Pharmaceutical compositions for buccal and pulmonary administration comprising an alkali metal alkyl sulfate and at least three micelle-forming compounds
US7087215B2 (en) * 1998-12-21 2006-08-08 Generex Pharmaceuticals Incorporated Methods of administering and enhancing absorption of pharmaceutical agents
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DE10114178A1 (de) 2001-03-23 2002-10-10 Aventis Pharma Gmbh Zinkfreie und zinkarme Insulinzubereitungen mit verbesserter Stabilität
US20030068361A1 (en) * 2001-10-09 2003-04-10 Rimona Margalit Liposome-encapsulated insulin formulations
AU2003236201A1 (en) 2002-05-07 2003-11-11 Novo Nordisk A/S Soluble formulations comprising monomeric insulin and acylated insulin
US20040018237A1 (en) * 2002-05-31 2004-01-29 Perricone Nicholas V. Topical drug delivery using phosphatidylcholine
US8435942B2 (en) * 2002-05-31 2013-05-07 Transdermal Biotechnology, Inc. Methods for formulating stabilized insulin compositions
DE10227232A1 (de) * 2002-06-18 2004-01-15 Aventis Pharma Deutschland Gmbh Saure Insulinzubereitungen mit verbesserter Stabilität
US8911751B2 (en) * 2005-10-11 2014-12-16 Yissum Research Development Company Of The Hebrew University Of Jerusalem Compositions for nasal delivery
JP5749155B2 (ja) 2008-03-18 2015-07-15 ノボ・ノルデイスク・エー／エス プロテアーゼ安定化アシル化インスリンアナログ
EP3228320B1 (de) 2008-10-17 2019-12-18 Sanofi-Aventis Deutschland GmbH Kombination von einem insulin und einem glp-1-agonisten
UY33025A (es) 2009-11-13 2011-06-30 Sanofi Aventis Deustschland Gmbh Composicion farmaceutica que comprende un agonista de glp-1 metionina
AR080669A1 (es) 2009-11-13 2012-05-02 Sanofi Aventis Deutschland Composicion farmaceutica que comprende un agonista de glp-1, una insulina y metionina
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US9821032B2 (en) 2011-05-13 2017-11-21 Sanofi-Aventis Deutschland Gmbh Pharmaceutical combination for improving glycemic control as add-on therapy to basal insulin
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US8871257B2 (en) 2012-09-19 2014-10-28 Transdermal Biotechnology, Inc. Prevention and treatment of cardiovascular diseases using systems and methods for transdermal nitric oxide delivery
US8871254B2 (en) 2012-09-19 2014-10-28 Transdermal Biotechnology, Inc. Systems and methods for treatment of acne vulgaris and other conditions with a topical nitric oxide delivery system
US9687520B2 (en) 2013-03-13 2017-06-27 Transdermal Biotechnology, Inc. Memory or learning improvement using peptide and other compositions
US9314433B2 (en) 2013-03-13 2016-04-19 Transdermal Biotechnology, Inc. Methods and systems for treating or preventing cancer
US9314422B2 (en) 2013-03-13 2016-04-19 Transdermal Biotechnology, Inc. Peptide systems and methods for metabolic conditions
US9320706B2 (en) 2013-03-13 2016-04-26 Transdermal Biotechnology, Inc. Immune modulation using peptides and other compositions
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DE2652636A1 (de) * 1976-11-19 1978-05-24 Hans Uwe Dr Rer Nat Wolf Verfahren zur stabilisierung von proteinen und verwandten verbindungen waehrend ihrer reinigung, isolierung und lagerung
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Also Published As

Publication number Publication date
DE3240177C2 (es) 1993-07-22
AT382079B (de) 1987-01-12
AU8986182A (en) 1983-05-05
FR2515517B1 (fr) 1987-07-03
DE3240177A1 (de) 1983-05-11
NO168086B (no) 1991-10-07
IT8223990A0 (it) 1982-10-29
FI823702L (fi) 1983-05-01
NL8203944A (nl) 1983-05-16
PT75766A (en) 1982-11-01
IE822602L (en) 1983-04-30
US4614730A (en) 1986-09-30
SE460576B (sv) 1989-10-30
CA1198673A (en) 1985-12-31
FI823702A0 (fi) 1982-10-29
FI80595B (fi) 1990-03-30
AU549593B2 (en) 1986-01-30
NO823603L (no) 1983-05-02
CH649922A5 (de) 1985-06-28
GR77360B (es) 1984-09-11
NL193099C (nl) 1998-11-03
SE8206168D0 (sv) 1982-10-29
NL193099B (nl) 1998-07-01
ATA392482A (de) 1986-06-15
IE54029B1 (en) 1989-05-24
FI80595C (fi) 1990-07-10
IT1153315B (it) 1987-01-14
NO168086C (no) 1992-01-15
NZ202328A (en) 1985-07-12
FR2515517A1 (fr) 1983-05-06
GB2107985B (en) 1984-11-14
LU84447A1 (fr) 1983-06-13
GB2107985A (en) 1983-05-11
BE894885A (fr) 1983-04-29
ES516963A0 (es) 1984-03-01
SE8206168L (sv) 1983-05-01
PT75766B (en) 1985-12-09

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