ES8601694A1 - Procedimiento para preparar un compuesto de inclusion a base de n,n-dimetil-2-cloro-5(3-metil-2-(fenilimino)-4-tiazolin-4-il)-fenilsulfonamida y b-ciclodextrina - Google Patents

Procedimiento para preparar un compuesto de inclusion a base de n,n-dimetil-2-cloro-5(3-metil-2-(fenilimino)-4-tiazolin-4-il)-fenilsulfonamida y b-ciclodextrina

Info

Publication number
ES8601694A1
ES8601694A1 ES535135A ES535135A ES8601694A1 ES 8601694 A1 ES8601694 A1 ES 8601694A1 ES 535135 A ES535135 A ES 535135A ES 535135 A ES535135 A ES 535135A ES 8601694 A1 ES8601694 A1 ES 8601694A1
Authority
ES
Spain
Prior art keywords
thiazolin
phenylimino
chloro
dimethyl
methyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES535135A
Other languages
English (en)
Other versions
ES535135A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hoechst AG
Original Assignee
Hoechst AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst AG filed Critical Hoechst AG
Publication of ES535135A0 publication Critical patent/ES535135A0/es
Publication of ES8601694A1 publication Critical patent/ES8601694A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/08—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
    • A61K47/6949—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit inclusion complexes, e.g. clathrates, cavitates or fullerenes
    • A61K47/6951—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit inclusion complexes, e.g. clathrates, cavitates or fullerenes using cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/0006—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid
    • C08B37/0009—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid alpha-D-Glucans, e.g. polydextrose, alternan, glycogen; (alpha-1,4)(alpha-1,6)-D-Glucans; (alpha-1,3)(alpha-1,4)-D-Glucans, e.g. isolichenan or nigeran; (alpha-1,4)-D-Glucans; (alpha-1,3)-D-Glucans, e.g. pseudonigeran; Derivatives thereof
    • C08B37/0012—Cyclodextrin [CD], e.g. cycle with 6 units (alpha), with 7 units (beta) and with 8 units (gamma), large-ring cyclodextrin or cycloamylose with 9 units or more; Derivatives thereof
    • C08B37/0015—Inclusion compounds, i.e. host-guest compounds, e.g. polyrotaxanes

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Nanotechnology (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Materials Engineering (AREA)
  • Medical Informatics (AREA)
  • Polymers & Plastics (AREA)
  • Biotechnology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Thiazole And Isothizaole Compounds (AREA)

Abstract

PROCEDIMIENTO PARA PREPARAR UN COMPUESTO DE INCLUSION A BASE DE N,N-DIMETIL-2-CLORO-5-3-METIL-2-(FENILIMINO)-4-TIAZOLIN-4-IL-FENILSULFONAMIDA Y BETA-CICLODEXTRINA. COMPRENDE: A) HACER REACCIONAR BETA-CICLODEXTRINA Y N,N-METIL-2-CLORO-5-3-METIL-2-(FENILIMINA)-4-TIAZOLIN-4-IL-FENILSULFONAMIDA, CON CALENTAMIENTO HASTA LA TEMPERATURA DE EBULLICION Y EN SOLUCION ACIDA DE ACIDO CLORHIDRICO EN RELACION MOLAR DE 2 A 1 RESPECTIVAMENTE; B) ENFRIAR PARA PRECIPITAR EL COMPUESTO DE INCLUSION; Y C) SEPARAR POR FILTRACION, PARA OBTENER EL COMPUESTO DE INCLUSION A BASE DE N,N-DIMETIL-2-CLORO-5-3-METIL-2-(FENILIMINO)-4-TIAZOLIN-4-IL-FENILSULFONAMIDA Y BETA-CICLODEXTRINA. SE UTILIZA COMO SUSTITUTIVO DE HCG 497, DEBIDO A SU MAYOR HIDROSOLUBILIDAD, PARA PRODUCIR EFECTOS POLIPEDEMICOS.
ES535135A 1983-08-16 1984-08-14 Procedimiento para preparar un compuesto de inclusion a base de n,n-dimetil-2-cloro-5(3-metil-2-(fenilimino)-4-tiazolin-4-il)-fenilsulfonamida y b-ciclodextrina Expired ES8601694A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19833329517 DE3329517A1 (de) 1983-08-16 1983-08-16 Einschlussverbindung von n,n-dimethyl-2-chlor-5-(3-methyl-2-(phenylimino)-4-thiazolin-4-yl)phenylsulfonamid, verfahren zu ihrer herstellung sowie pharmazeutische praeparate

Publications (2)

Publication Number Publication Date
ES535135A0 ES535135A0 (es) 1985-11-16
ES8601694A1 true ES8601694A1 (es) 1985-11-16

Family

ID=6206641

Family Applications (1)

Application Number Title Priority Date Filing Date
ES535135A Expired ES8601694A1 (es) 1983-08-16 1984-08-14 Procedimiento para preparar un compuesto de inclusion a base de n,n-dimetil-2-cloro-5(3-metil-2-(fenilimino)-4-tiazolin-4-il)-fenilsulfonamida y b-ciclodextrina

Country Status (10)

Country Link
EP (1) EP0141076A1 (es)
JP (1) JPS6058969A (es)
KR (1) KR850001737A (es)
AU (1) AU3196184A (es)
DE (1) DE3329517A1 (es)
DK (1) DK392384A (es)
ES (1) ES8601694A1 (es)
GR (1) GR80116B (es)
PT (1) PT79080B (es)
ZA (1) ZA846327B (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6081166A (ja) * 1983-10-11 1985-05-09 Fujisawa Pharmaceut Co Ltd ２−ニトロオキシメチル−６−クロロピリジンのβ−シクロデキストリン包接化合物およびその製造法
JPH08777B2 (ja) * 1985-04-08 1996-01-10 武田薬品工業株式会社 経口用抗菌固型組成物
SI8810082A8 (en) * 1988-01-18 1995-12-31 Lek Tovarna Farmacevtskih Process for preparing new inclusion complex of nicardipine or its hydrochloride with beta-cyclodextrine
KR100503200B1 (ko) * 2000-09-05 2005-07-25 주식회사 포스코 석탄 건조설비의 석탄 불출량 제어장치

Also Published As

Publication number Publication date
PT79080A (de) 1984-09-01
GR80116B (en) 1984-12-14
DE3329517A1 (de) 1985-02-28
EP0141076A1 (de) 1985-05-15
ES535135A0 (es) 1985-11-16
DK392384D0 (da) 1984-08-15
ZA846327B (en) 1985-03-27
KR850001737A (ko) 1985-04-01
PT79080B (de) 1986-09-08
DK392384A (da) 1985-02-17
JPS6058969A (ja) 1985-04-05
AU3196184A (en) 1985-02-21

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