ES8306378A1 - "un procedimiento para la preparacion de derivados de adenosina". - Google Patents

"un procedimiento para la preparacion de derivados de adenosina".

Info

Publication number
ES8306378A1
ES8306378A1 ES511039A ES511039A ES8306378A1 ES 8306378 A1 ES8306378 A1 ES 8306378A1 ES 511039 A ES511039 A ES 511039A ES 511039 A ES511039 A ES 511039A ES 8306378 A1 ES8306378 A1 ES 8306378A1
Authority
ES
Spain
Prior art keywords
atoms
acyl radical
antiinflammatory
radical containing
formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES511039A
Other languages
English (en)
Other versions
ES511039A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bioresearch SRL
Original Assignee
Bioresearch SRL
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bioresearch SRL filed Critical Bioresearch SRL
Publication of ES511039A0 publication Critical patent/ES511039A0/es
Publication of ES8306378A1 publication Critical patent/ES8306378A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pain & Pain Management (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Rheumatology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE 5 -DEOXI-5 -5 -METILTIOADENOSINA. CONSISTE EN LA REACCION DE HIDROLISIS REACTIVANTE DE 5-ADENOSILMETIONINA EN DISOLUCION ACUOSA CONCENTRADA, MEDIANTE CALENTAMIENTO BAJO VACIO DE 35 C A 40 C HASTA APROXIMADAMENTE 1/10 DE SU VOLUMEN INICIAL; EBULLICION A REFLUJO DURANTE UNOS 30 MINUTOS, Y AJUSTE DEL PH A 7 CON HIDROXIDO SODICO; LA DISOLUCION SE DEJA EN REPOSO ENTRE 0 C Y 5 C HASTA PRECIPITACION COMPLETA. ESTE COMPUESTO TIENE APLICACIONES FARMACOLOGICAS POR SU ACTIVIDAD ANTIINFLAMATORIA, ANALGESICA Y ANTIPIRETICA.
ES511039A 1980-04-22 1982-04-01 "un procedimiento para la preparacion de derivados de adenosina". Expired ES8306378A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT21550/80A IT1193529B (it) 1980-04-22 1980-04-22 Derivati adenosinici ad attivita' antinfiammatoria ed analgesica e composizioni terapeutiche che li contengono come principio attivo

Publications (2)

Publication Number Publication Date
ES511039A0 ES511039A0 (es) 1983-06-01
ES8306378A1 true ES8306378A1 (es) 1983-06-01

Family

ID=11183457

Family Applications (2)

Application Number Title Priority Date Filing Date
ES501539A Expired ES8206551A1 (es) 1980-04-22 1981-04-21 Un procedimiento para la preparacion de derivados de adeno- sina
ES511039A Expired ES8306378A1 (es) 1980-04-22 1982-04-01 "un procedimiento para la preparacion de derivados de adenosina".

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES501539A Expired ES8206551A1 (es) 1980-04-22 1981-04-21 Un procedimiento para la preparacion de derivados de adeno- sina

Country Status (17)

Country Link
JP (2) JPS56166117A (es)
AR (1) AR231144A1 (es)
BE (1) BE888472A (es)
CA (1) CA1198105A (es)
CH (2) CH645544A5 (es)
DE (1) DE3116067A1 (es)
DK (1) DK159453C (es)
ES (2) ES8206551A1 (es)
FI (1) FI70227C (es)
FR (1) FR2491761A1 (es)
GB (3) GB2074446B (es)
IT (1) IT1193529B (es)
LU (1) LU83307A1 (es)
MX (1) MX9203630A (es)
NL (1) NL192111C (es)
NO (1) NO150515C (es)
SE (3) SE460198B (es)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1177373B (it) * 1984-12-06 1987-08-26 Bioresearch Spa Sali della 5'-metiltio-5'-deossiadenosina con acidi solfonici a lunga catena alchilica
IT1227049B (it) * 1988-07-29 1991-03-14 Bioresearch Spa Impiego di derivati adenosinici per la preparazione di composizioni farmaceutiche aventi attivita' immunostimolante.
JPH0497287A (ja) * 1990-08-10 1992-03-30 Nec Ic Microcomput Syst Ltd 画像表示集積回路
MX2007011327A (es) 2005-03-17 2008-01-28 Proyecto Biomedicina Cima Sl Empleo de 5'-metiltioadenosina (mta) en la prevencion y/o tratamiento de enfermedades autoinmunes y/o rechazo de transplantes.
ES2259552B1 (es) * 2005-03-17 2007-06-16 Proyecto De Biomedicina Cima, S.L. Empleo de 5'-metiltioadenosina (mta) en la prevencion y/o tratamiento de enfermedades autoinmunes y/o rechazo de transplantes.
DE102010027595A1 (de) * 2010-07-23 2012-01-26 Helmut Vorbrüggen Vermeidung von Ischämie- oder Degenerations-Schäden im Gehirn bei Anwendung von Adenosin-Derivaten
DE102011005232A1 (de) * 2011-03-08 2012-09-13 AristoCon GmbH & Co. KG Adenosin und seine Derivate zur Verwendung in der Schmerztherapie
WO2014163151A1 (ja) * 2013-04-05 2014-10-09 ライオン株式会社 酵母培養物及び内服組成物
WO2014163152A1 (ja) * 2013-04-05 2014-10-09 ライオン株式会社 ノンレム睡眠促進剤、深睡眠促進剤および自然睡眠誘発剤
WO2014163150A1 (ja) * 2013-04-05 2014-10-09 ライオン株式会社 内服組成物

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1259341B (de) * 1962-12-22 1968-01-25 Boehringer & Soehne Gmbh Verfahren zur Herstellung neuer 5'-Sulfoxyde von Nucleosiden
DE1545645A1 (de) * 1965-12-06 1969-08-21 Boehringer Mannheim Gmbh Verfahren zur Herstellung von disubstituierten Adenosin-Derivaten
FR2252405B1 (es) * 1973-11-27 1978-04-28 Ajinomoto Kk
FR2313937A1 (fr) * 1975-06-09 1977-01-07 Anvar Medicament a base de 5' thioethers de l'adenosine
FR2424027A1 (fr) * 1978-04-28 1979-11-23 Merieux Inst Nouveau medicament, notamment sedatif et inducteur de sommeil et compositions pharmaceutiques la renfermant

Also Published As

Publication number Publication date
ES511039A0 (es) 1983-06-01
SE8700914L (sv) 1987-03-04
SE8700914D0 (sv) 1987-03-04
GB8413454D0 (en) 1984-07-04
GB2074446B (en) 1985-04-11
SE8700913D0 (sv) 1987-03-04
NL192111B (nl) 1996-10-01
FI70227C (fi) 1986-09-15
GB8321947D0 (en) 1983-09-14
DK159453B (da) 1990-10-15
MX9203630A (es) 1992-09-01
ES501539A0 (es) 1982-08-16
JPH0246599B2 (es) 1990-10-16
CH650514A5 (de) 1985-07-31
FI811249L (fi) 1981-10-23
SE464635B (sv) 1991-05-27
DK176481A (da) 1981-10-23
SE460198B (sv) 1989-09-18
DE3116067A1 (de) 1982-03-11
BE888472A (fr) 1981-08-17
LU83307A1 (fr) 1981-07-24
FI70227B (fi) 1986-02-28
NL192111C (nl) 1997-02-04
NO150515C (no) 1984-10-31
NL8101984A (nl) 1981-11-16
JPH0249288B2 (es) 1990-10-29
AR231144A1 (es) 1984-09-28
FR2491761B1 (es) 1984-01-06
FR2491761A1 (fr) 1982-04-16
CH645544A5 (de) 1984-10-15
ES8206551A1 (es) 1982-08-16
GB2144409B (en) 1985-09-11
SE8700913L (sv) 1987-03-04
IT8021550A0 (it) 1980-04-22
IT1193529B (it) 1988-07-08
NO811346L (no) 1981-10-23
CA1198105A (en) 1985-12-17
GB2144038A (en) 1985-02-27
GB2074446A (en) 1981-11-04
JPS56166117A (en) 1981-12-21
SE8102489L (sv) 1981-10-23
NO150515B (no) 1984-07-23
DE3116067C2 (es) 1992-12-17
DK159453C (da) 1991-03-18
GB2144038B (en) 1985-08-29
SE466238B (sv) 1992-01-20
GB2144409A (en) 1985-03-06
JPH01301692A (ja) 1989-12-05

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