ES8303417A1 - "un procedimiento para preparar compuestos de mitosano antibioticos". - Google Patents

"un procedimiento para preparar compuestos de mitosano antibioticos".

Info

Publication number
ES8303417A1
ES8303417A1 ES511874A ES511874A ES8303417A1 ES 8303417 A1 ES8303417 A1 ES 8303417A1 ES 511874 A ES511874 A ES 511874A ES 511874 A ES511874 A ES 511874A ES 8303417 A1 ES8303417 A1 ES 8303417A1
Authority
ES
Spain
Prior art keywords
lower alkyl
radical
substituted
mono
cyano
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES511874A
Other languages
English (en)
Other versions
ES511874A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University Patents Inc
Original Assignee
University Patents Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University Patents Inc filed Critical University Patents Inc
Publication of ES511874A0 publication Critical patent/ES511874A0/es
Publication of ES8303417A1 publication Critical patent/ES8303417A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE COMPUESTOS DE MITOSANO ANTIBIOTICOS, DE FORMULA (I), EN LA QUE Y ES HIDROGENO O ALCOHILO INFERIOR; Y X PUEDE SER UNO DE VARIOS TIPOS DE RADICALES. CONSISTE EN LA REACCION DE MITROMICINA A O N-ALCOHIL-MITROMICINA A CON UNA AMINA ADECUADA. LA REACCION SE LLEVA A CABO SIGUIENDO METODOS CONVENCIONALES QUE DEPENDEN DEL TIPO DE DERIVADO QUE SE PRETENDE OBTENER. LOS PRODUCTOS OBTENIDOS SE SEPARAN Y PURIFICAN POR METODOS YA CONOCIDOS. ESTOS COMPUESTOS TIENEN APLICACIONES PARA EL TRATAMIENTO DE ESTADOS DE ENFERMEDAD NEOPLASTICA DE ANIMALES.
ES511874A 1981-05-15 1982-05-03 "un procedimiento para preparar compuestos de mitosano antibioticos". Expired ES8303417A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US26418781A 1981-05-15 1981-05-15

Publications (2)

Publication Number Publication Date
ES511874A0 ES511874A0 (es) 1983-02-01
ES8303417A1 true ES8303417A1 (es) 1983-02-01

Family

ID=23004963

Family Applications (1)

Application Number Title Priority Date Filing Date
ES511874A Expired ES8303417A1 (es) 1981-05-15 1982-05-03 "un procedimiento para preparar compuestos de mitosano antibioticos".

Country Status (27)

Country Link
JP (1) JPS57188590A (es)
KR (1) KR890000935B1 (es)
AT (1) AT375943B (es)
AU (1) AU559686B2 (es)
BE (1) BE893162A (es)
CA (1) CA1244412A (es)
CH (1) CH655116A5 (es)
DE (1) DE3217769A1 (es)
DK (1) DK161078C (es)
ES (1) ES8303417A1 (es)
FI (1) FI78100C (es)
FR (1) FR2505839B1 (es)
GB (1) GB2106096B (es)
GR (1) GR76033B (es)
HU (1) HU186510B (es)
IE (1) IE52956B1 (es)
IL (1) IL64998A0 (es)
IT (1) IT1156453B (es)
LU (1) LU84144A1 (es)
NL (1) NL8200839A (es)
NO (1) NO158743C (es)
NZ (1) NZ199617A (es)
PH (1) PH20358A (es)
PT (1) PT74895B (es)
SE (1) SE450895B (es)
YU (1) YU44819B (es)
ZA (1) ZA82923B (es)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA833967B (en) * 1982-06-04 1984-02-29 Bristol Myers Co Amidines
EP0116208B1 (en) * 1982-12-07 1988-03-30 Kyowa Hakko Kogyo Co., Ltd. Mitomycin analogues
NZ206932A (en) * 1983-02-07 1987-08-31 University Patents Inc Certain 6-(heterocyclyl or amino) mitosanes and pharmaceutical compositions
US4803212A (en) * 1983-04-11 1989-02-07 Bristol-Myers Company Amino disulfides
US4642352A (en) * 1983-12-23 1987-02-10 Bristol-Myers Company Acylamino mitosanes
JPS60255789A (ja) * 1984-06-01 1985-12-17 Kyowa Hakko Kogyo Co Ltd マイトマイシン誘導体，その製造法および抗腫瘍剤
FR2571373A1 (fr) * 1984-10-09 1986-04-11 Bristol Myers Co Procede de preparation de derives n7-substitues de la mitomycine c
DE3674043D1 (de) * 1985-04-10 1990-10-18 Kyowa Hakko Kogyo Kk Pharmakologisch aktive mitomycinderivate.
US5023253A (en) * 1987-12-21 1991-06-11 University Patents, Inc. 6-substituted mitomycin analogs
CN107266345B (zh) 2011-10-20 2021-08-17 奥瑞泽恩基因组学股份有限公司 作为lsd1抑制剂的(杂)芳基环丙胺化合物

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL129868C (es) * 1963-06-07
US3420846A (en) * 1964-08-25 1969-01-07 Kyowa Hakko Kogyo Kk 7-substituted mitomycin a
US3332944A (en) * 1964-11-02 1967-07-25 American Cyanamid Co Antibiotic derivatives of mitomycins a, b, c and porfiromycin
JPS5439098A (en) * 1977-08-31 1979-03-24 Kyowa Hakko Kogyo Co Ltd Mitomycin c derivatives
US4268676A (en) * 1979-12-05 1981-05-19 University Patents, Inc. Mitomycin analogs
JPS5686184A (en) * 1979-12-17 1981-07-13 Kyowa Hakko Kogyo Co Ltd Novel mitomycin c derivative

Also Published As

Publication number Publication date
SE450895B (sv) 1987-08-10
JPS57188590A (en) 1982-11-19
FI78100B (fi) 1989-02-28
YU97282A (en) 1985-04-30
FI821241A0 (fi) 1982-04-07
IT1156453B (it) 1987-02-04
ES511874A0 (es) 1983-02-01
KR830009102A (ko) 1983-12-17
HU186510B (en) 1985-08-28
IT8267321A0 (it) 1982-03-15
NO158743C (no) 1988-10-26
PH20358A (en) 1986-12-04
NO821598L (no) 1982-11-16
DK161078B (da) 1991-05-27
FI821241L (fi) 1982-11-16
PT74895B (en) 1984-08-02
ZA82923B (en) 1983-01-26
BE893162A (fr) 1982-08-30
DE3217769A1 (de) 1982-12-09
LU84144A1 (fr) 1982-09-13
NZ199617A (en) 1985-08-30
FR2505839A1 (fr) 1982-11-19
CH655116A5 (de) 1986-03-27
DK219182A (da) 1982-11-16
FI78100C (fi) 1989-06-12
YU44819B (en) 1991-02-28
PT74895A (en) 1982-06-01
DK161078C (da) 1991-11-11
GR76033B (es) 1984-08-03
SE8203035L (sv) 1982-11-16
GB2106096A (en) 1983-04-07
IL64998A0 (en) 1982-04-30
NL8200839A (nl) 1982-12-01
FR2505839B1 (fr) 1985-11-08
IE820431L (en) 1982-11-15
NO158743B (no) 1988-07-18
CA1244412A (en) 1988-11-08
AU8268282A (en) 1983-11-17
AT375943B (de) 1984-09-25
GB2106096B (en) 1985-12-04
AU559686B2 (en) 1987-03-19
KR890000935B1 (ko) 1989-04-14
ATA184482A (de) 1984-02-15
IE52956B1 (en) 1988-04-27

Similar Documents

Publication Publication Date Title
ES8303417A1 (es) "un procedimiento para preparar compuestos de mitosano antibioticos".
NZ332645A (en) use of a bis-indolylmaleimide derivative for treating VEGF related diseases
ZA945157B (en) Imidazo [1,2-a] pyrazin-4-one derivatives, their preparation and medicaments containing them
NZ218243A (en) B-carboline derivatives and pharmaceutical compositions
PH31303A (en) Piperazine derivatives.
EP0324109A3 (en) New 6-substituted mitomycin analogs
IL86981A (en) 1,2-benzisoxazole and 1,2-benzisothiazole derivatives, process for their preparation and pharmaceutical compositions containing them
ES8607305A1 (es) Un procedimiento para preparar derivados de mitomicina
AU2175083A (en) 2-(substituted amino)-pyrimid-4-one derivatives
ES8607224A1 (es) Un procedimiento para preparar esteres de acidos (alquilsulfonil)-metanosulfonicos
GR3002944T3 (en) Tetrahydro-beta-carbolines, process for their preparation and their use as medicaments
GB2247237B (en) 1-(N'-Cyanoguanyl) derivatives of N-containing five-membered ring heterocycles
ES8401456A1 (es) Procedimiento para la preparacion de 2-aminometilfenoles.
DE3560027D1 (en) Process for the preparation of o,o'-dithiobenzamides
DE3477490D1 (en) Substituted pyridoû1,2-c¨imidazoû1,2-a¨benzimidazoles, process for their preparation, their use and pharmaceutical preparations containing them
ZA886209B (en) Imidazo benzodiazepines and their acid addition salts
IL103807A0 (en) Aminoalkylpyrrolidinylthio-carbapenem derivatives
JO1274B1 (en) Pyridine derivatives
DE3166867D1 (en) Thiovinyl-3-cephalosporin derivatives, their preparation and pharmaceutical compositions containing them
DE69525145D1 (en) Carbamoylmethylharnstoffderivate
AU4535293A (en) Process for preparing 1,3-dioxolane derivatives
ES8604888A1 (es) Un procedimiento para producir un compuesto
BG50556A1 (en) Heterocyclic derivatives of 2- amino- 3- hydroxypyridine and method for their preparation
GR3005034T3 (es)
FI921298A (fi) Menetelmä lääkeaineena käyttökelpoisen 5-(6-imidatso/1,2-a/pyridyyli)pyridiini-johdannaisen valmistamiseksi

Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19960603