ES8607305A1 - Un procedimiento para preparar derivados de mitomicina - Google Patents

Un procedimiento para preparar derivados de mitomicina

Info

Publication number
ES8607305A1
ES8607305A1 ES529478A ES529478A ES8607305A1 ES 8607305 A1 ES8607305 A1 ES 8607305A1 ES 529478 A ES529478 A ES 529478A ES 529478 A ES529478 A ES 529478A ES 8607305 A1 ES8607305 A1 ES 8607305A1
Authority
ES
Spain
Prior art keywords
lower alkyl
substituted
radical
nitro
hydroxy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES529478A
Other languages
English (en)
Other versions
ES529478A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University Patents Inc
Original Assignee
University Patents Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University Patents Inc filed Critical University Patents Inc
Publication of ES8607305A1 publication Critical patent/ES8607305A1/es
Publication of ES529478A0 publication Critical patent/ES529478A0/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

SINTESIS DE DERIVADOS DE MITOMICINA. COMPRENDE: A) HACER REACCIONAR MITOMICINA A O N-ALQUIL-MITOMICINA A CON ANILINA SUSTITUIDA CON ACETAMINO, ACETILO, CARBAMIDO, CIANO Y OTROS, A 20JC; B) AISLAR EL PRODUCTO DE LA REACCION POR FILTRACION Y EVAPORACION A PRESION REDUCIDA; Y C) PURIFICAR POR CROMATOGRAFIA DE CAPA DELGADA USANDO UNA PLACA DE GEL DE SILICE PRE-RECUBIERTA Y UNA MEZCLA DE CLOROFORMO Y METANOL 8 A 2 EN VOLUMEN, PARA OBTENER EL COMPUESTO DE FORMULA (I). SIENDO: X, RADICAL 1-PIRROLIDINILO SUSTITUIDO CON HIDROXI, O PIPERIDILO SUSTITUIDO CON ALQUILO INFERIOR, Y OTROS; E Y, HIDROGENO O ALQUILO INFERIOR. SE UTILIZA EN FARMACOLOGIA COMO ANTIBIOTICO PARA EL TRATAMIENTO DE ENFERMEDADES NEOPLASTICAS EN ANIMALES.
ES529478A 1983-02-07 1984-02-06 Un procedimiento para preparar derivados de mitomicina Expired ES8607305A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US46461283A 1983-02-07 1983-02-07

Publications (2)

Publication Number Publication Date
ES8607305A1 true ES8607305A1 (es) 1986-05-16
ES529478A0 ES529478A0 (es) 1986-05-16

Family

ID=23844605

Family Applications (1)

Application Number Title Priority Date Filing Date
ES529478A Expired ES8607305A1 (es) 1983-02-07 1984-02-06 Un procedimiento para preparar derivados de mitomicina

Country Status (29)

Country Link
JP (1) JPS59152384A (es)
KR (1) KR900006854B1 (es)
AT (1) AT385509B (es)
AU (1) AU571193B2 (es)
BE (1) BE898856A (es)
CA (1) CA1252789A (es)
CH (1) CH658658A5 (es)
DD (1) DD233844A5 (es)
DE (1) DE3403922A1 (es)
DK (1) DK161890C (es)
ES (1) ES8607305A1 (es)
FI (1) FI80698C (es)
FR (1) FR2540500B1 (es)
GB (1) GB2134514B (es)
GR (1) GR81455B (es)
HU (1) HU190236B (es)
IE (1) IE56814B1 (es)
IL (1) IL70897A (es)
IT (1) IT1178855B (es)
LU (1) LU85199A1 (es)
NL (1) NL8400338A (es)
NO (1) NO161374C (es)
NZ (1) NZ206932A (es)
OA (1) OA07654A (es)
PH (1) PH20249A (es)
PT (1) PT78067B (es)
SE (1) SE461982B (es)
YU (1) YU44984B (es)
ZA (1) ZA84788B (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4487769A (en) * 1982-06-04 1984-12-11 Bristol-Myers Company Amidines
CA1282069C (en) * 1985-09-12 1991-03-26 Damon L. Meyer Antibody complexes of hapten-modified diagnostic or therapeutic agents
JPS63150282A (ja) * 1986-12-13 1988-06-22 Kyowa Hakko Kogyo Co Ltd マイトマイシン誘導体
JPS63246379A (ja) * 1987-03-31 1988-10-13 Kyowa Hakko Kogyo Co Ltd ７−ｎ，８−ｎ−エチレンマイトマイシン８−イミン類
EP0485904B1 (en) * 1990-11-13 1997-08-20 Kyowa Hakko Kogyo Co., Ltd. Mitomycin derivatives

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3332944A (en) * 1964-11-02 1967-07-25 American Cyanamid Co Antibiotic derivatives of mitomycins a, b, c and porfiromycin
JPS5439098A (en) * 1977-08-31 1979-03-24 Kyowa Hakko Kogyo Co Ltd Mitomycin c derivatives
US4268676A (en) * 1979-12-05 1981-05-19 University Patents, Inc. Mitomycin analogs
JPS5686184A (en) * 1979-12-17 1981-07-13 Kyowa Hakko Kogyo Co Ltd Novel mitomycin c derivative
NZ199617A (en) * 1981-05-15 1985-08-30 University Patents Inc Azirino(2',3',:3,4)pyrrolo(1,2-a)indole-4,7-dione derivatives and pharmaceutical compositions
US4487769A (en) * 1982-06-04 1984-12-11 Bristol-Myers Company Amidines
US4642352A (en) * 1983-12-23 1987-02-10 Bristol-Myers Company Acylamino mitosanes

Also Published As

Publication number Publication date
AU2407384A (en) 1984-08-16
BE898856A (fr) 1984-05-30
FI840502A (fi) 1984-08-08
FI840502A0 (fi) 1984-02-07
DE3403922A1 (de) 1984-08-09
NO161374C (no) 1989-08-09
CH658658A5 (de) 1986-11-28
PH20249A (en) 1986-11-10
IE56814B1 (en) 1991-12-18
DK161890B (da) 1991-08-26
PT78067A (en) 1984-03-01
IL70897A (en) 1989-01-31
IT1178855B (it) 1987-09-16
OA07654A (fr) 1985-05-23
DK161890C (da) 1992-02-03
IE840272L (en) 1984-08-07
GB2134514B (en) 1987-04-01
NL8400338A (nl) 1984-09-03
SE8400628L (sv) 1984-08-08
IT8467113A0 (it) 1984-02-07
KR900006854B1 (ko) 1990-09-22
LU85199A1 (fr) 1984-05-30
ATA37684A (de) 1987-09-15
DD233844A5 (de) 1986-03-12
FR2540500B1 (fr) 1987-07-17
AU571193B2 (en) 1988-04-14
NO840433L (no) 1984-08-08
CA1252789A (en) 1989-04-18
GB2134514A (en) 1984-08-15
KR840007726A (ko) 1984-12-10
HU190236B (en) 1986-08-28
SE461982B (sv) 1990-04-23
SE8400628D0 (sv) 1984-02-07
PT78067B (en) 1986-03-20
YU44984B (en) 1991-06-30
ES529478A0 (es) 1986-05-16
IL70897A0 (en) 1984-05-31
GR81455B (es) 1984-12-11
FI80698B (fi) 1990-03-30
DK52484D0 (da) 1984-02-06
AT385509B (de) 1988-04-11
GB8402233D0 (en) 1984-02-29
NO161374B (no) 1989-05-02
JPS59152384A (ja) 1984-08-31
ZA84788B (en) 1984-09-26
FI80698C (fi) 1990-07-10
FR2540500A1 (fr) 1984-08-10
YU21784A (en) 1986-10-31
DK52484A (da) 1984-08-08
NZ206932A (en) 1987-08-31

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19970203