ES8401456A1 - Procedimiento para la preparacion de 2-aminometilfenoles. - Google Patents

Procedimiento para la preparacion de 2-aminometilfenoles.

Info

Publication number
ES8401456A1
ES8401456A1 ES520312A ES520312A ES8401456A1 ES 8401456 A1 ES8401456 A1 ES 8401456A1 ES 520312 A ES520312 A ES 520312A ES 520312 A ES520312 A ES 520312A ES 8401456 A1 ES8401456 A1 ES 8401456A1
Authority
ES
Spain
Prior art keywords
alkyl
compounds
preparation
radicals
sulfamoylphenol
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES520312A
Other languages
English (en)
Other versions
ES520312A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hoechst AG
Original Assignee
Hoechst AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst AG filed Critical Hoechst AG
Publication of ES520312A0 publication Critical patent/ES520312A0/es
Publication of ES8401456A1 publication Critical patent/ES8401456A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/22—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with hetero atoms directly attached to ring nitrogen atoms
    • C07D295/26—Sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/10—Antioedematous agents; Diuretics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Obesity (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

PROCEDIMIENTO PARA LA PREPARACION DE 2-AMINOMETILFENOLES. CONSISTE EN: HACER REACCIONAR N-FENOL DE FORMULA (II), CON UNA N-HIDROXIMETILCARBOXAMIDA DE FORMULA (III) Y POSTERIOR SEPARACION POR HIDROLISIS DE LAS RADICALES R11C Y Z; B) HACER REACCIONAR UN FENOL DE FORMULA (II) CON UNA ANIMA DE FORMULA (IV), EN PRESENCIA DE FORMALDEHIDO; C) HACER REACCIONAR COMPUESTOS DE FORMULA (V) CON AMINAS DE FORMULA (VI) Y SEPARACION POR HIDROLISIS RADICAL Y1; D) HACER REACCONAR COMPUESTOS DE FORMULA (VII) CON ANIMAS DE FORMULA GENERAL H-NFY1E HIDROLISIS O HIDROGENOLISIS DEL GRUPO PROTECTOR DE AMINO O EL GRUPO PROTECTOR DE SULFO-AMIDO; PARA FORMAR COMPUESTOS DE FORMULA (I), DONDE R1 Y R2 SON HIDROGENO, ALCOHILO DE C 1 A 8, ALQUEMILO DE C 2 A 8, CICLO ALCOHILO DE C 3 A 12 O BENCILO; R3 Y R5 SON HIDROGENO HALOGENO, ALCOHILO C 1 A 2; R4 ES HALOGENO, ALCOHILO C 3 A 12; R6 YR7 SON HIDROGENO O ALCOHILO DE C 1 A Y R2; R11 ES HIDROGENO, ALCOHILO DE C 1 A 4 O ACILO DE C 6 A 10; Y1 ES R11 H8- CO-; Y1 UN GRUPO PROTECTOR DE AMINO; Z1 GRUPO SOBRANTE ACTIVO. LAS TEMPERATURAS DE REACCION ESTAN COMPRENDIDAS ENTRE 20 GC Y 150 GC TRABAJANDOSE A TEMPERATURA GRUPO DE REFLUJO DEL DISOLVENTE.
ES520312A 1982-03-06 1983-03-04 Procedimiento para la preparacion de 2-aminometilfenoles. Expired ES8401456A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19823208189 DE3208189A1 (de) 1982-03-06 1982-03-06 2-aminomethyl-6-sulfamoylphenolderivate, verfahren zu ihrer herstellung, ihre verwendung sowie pharmazeutische praeparate auf basis dieser verbindungen

Publications (2)

Publication Number Publication Date
ES520312A0 ES520312A0 (es) 1983-12-01
ES8401456A1 true ES8401456A1 (es) 1983-12-01

Family

ID=6157555

Family Applications (1)

Application Number Title Priority Date Filing Date
ES520312A Expired ES8401456A1 (es) 1982-03-06 1983-03-04 Procedimiento para la preparacion de 2-aminometilfenoles.

Country Status (7)

Country Link
US (2) US4607030A (es)
EP (1) EP0088345B1 (es)
JP (1) JPS58170747A (es)
AT (1) ATE22284T1 (es)
CA (1) CA1245661A (es)
DE (2) DE3208189A1 (es)
ES (1) ES8401456A1 (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19608445A1 (de) 1996-03-05 1997-09-11 Bayer Ag Substituierte Arylsulfonyl(thio)harnstoffe
US6013764A (en) * 1996-07-17 2000-01-11 Ortho Pharmaceutical Corp. Liquid phase peptide synthesis of KL-4 pulmonary surfactant
WO2002079122A2 (en) * 2001-03-30 2002-10-10 Smithkline Beecham Corporation Methods of synthesizing phenol-containing compounds
EP2052604A1 (de) 2007-10-24 2009-04-29 Bayer CropScience AG Salz des 2-lodo-N-[(4-methoxy-6-methyl-1,3,5-triazin-2-yl)carbamoyl] benzolsulfonamids,Verfahren zu deren Herstellung, sowie deren Verwendung als Herbizide und Pflanzenwachstumregulatoren
EP2110019A1 (de) 2008-04-19 2009-10-21 Bayer CropScience AG Herbizide Verbindungen auf Basis von N-Azinyl-N'-phenylsulfonylharnstoffen
CA2736229C (en) * 2008-09-05 2015-06-09 Acucela Inc. Sulfur-linked compounds for treating opthalmic diseases and disorders

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1249490A (en) * 1968-12-24 1971-10-13 Leo Pharm Prod Ltd New sulphamyl-benzoic acid derivatives
IL40344A0 (en) * 1971-09-22 1972-11-28 Du Pont Substituted benzenesulfonamides,their preparation and their use for controlling mites
DE2419970C3 (de) * 1974-04-25 1980-06-12 Hoechst Ag, 6000 Frankfurt 3-<l-Pyrrolidinyl)-4-phenoxy-5sulfamoylbenzoesäure und Verfahren zu ihrer Herstellung
GB1523631A (en) * 1975-07-08 1978-09-06 Leo Pharm Prod Ltd Sulphonamide derivatives
DE2658766C2 (de) * 1976-12-24 1986-01-02 Hoechst Ag, 6230 Frankfurt 3-N-Pyrrolo-5-sulfamoylbenzoesäure-Derivate und Verfahren zu ihrer Herstellung
JPS5463048A (en) * 1977-10-26 1979-05-21 Yamanouchi Pharmaceut Co Ltd Novel phenyl ethanolamine derivatives and their preparation

Also Published As

Publication number Publication date
ES520312A0 (es) 1983-12-01
EP0088345B1 (de) 1986-09-17
US4607030A (en) 1986-08-19
US4766241A (en) 1988-08-23
EP0088345A3 (en) 1984-09-12
DE3366181D1 (en) 1986-10-23
JPS58170747A (ja) 1983-10-07
EP0088345A2 (de) 1983-09-14
ATE22284T1 (de) 1986-10-15
DE3208189A1 (de) 1983-09-08
CA1245661A (en) 1988-11-29

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