ES8202007A1 - Un procedimiento de preparacion de un nuevo derivado de es- ter de octahidroindolquinolisina - Google Patents
Un procedimiento de preparacion de un nuevo derivado de es- ter de octahidroindolquinolisinaInfo
- Publication number
- ES8202007A1 ES8202007A1 ES499287A ES499287A ES8202007A1 ES 8202007 A1 ES8202007 A1 ES 8202007A1 ES 499287 A ES499287 A ES 499287A ES 499287 A ES499287 A ES 499287A ES 8202007 A1 ES8202007 A1 ES 8202007A1
- Authority
- ES
- Spain
- Prior art keywords
- procedure
- octahidroindolquinolisina
- preparation
- ester derivative
- formula
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 238000000034 method Methods 0.000 title abstract 2
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract 2
- KDLHZDBZIXYQEI-UHFFFAOYSA-N Palladium Chemical compound [Pd] KDLHZDBZIXYQEI-UHFFFAOYSA-N 0.000 abstract 2
- 239000002253 acid Substances 0.000 abstract 2
- 150000007513 acids Chemical class 0.000 abstract 1
- 239000003054 catalyst Substances 0.000 abstract 1
- 238000009903 catalytic hydrogenation reaction Methods 0.000 abstract 1
- 238000006243 chemical reaction Methods 0.000 abstract 1
- 230000003287 optical effect Effects 0.000 abstract 1
- 239000003960 organic solvent Substances 0.000 abstract 1
- 229910052763 palladium Inorganic materials 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/14—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D461/00—Heterocyclic compounds containing indolo [3,2,1-d,e] pyrido [3,2,1,j] [1,5]-naphthyridine ring systems, e.g. vincamine
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Cardiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Heart & Thoracic Surgery (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Cephalosporin Compounds (AREA)
Abstract
PROCEDIMIENTO PARA LA OBTENCION DE UN DERIVADO DE ETER DE OCTAHIDROINDOL-QUINOLISINA, DE FORMULAS (I) Y/O (II), EN LAS QUE R1 Y R2 SON RADICAL ALCOHILO C1-6, ASI COMO DE SUS SALES DE ADICION DE ACIDOS FISIOLOGICAMENTE COMPATIBLES E ISOMEROS OPTICOS. CONSISTE EN LA REACCION DE HIDROGENACION CATALITICA DE UN ESTER DE HEXAHIDROINDOLQUINOLISINIO DE FORMULA (III) O (IV), EN LAS QUE R1 Y R2 TIENEN EL MISMO SIGNIFICADO QUE EN LA FORMULA (I) Y X ES UN RADICAL ACIDO. LA REACCION SE LLEVA A CABO EN PRESENCIA DE UN CATALIZADOR DE PALADIO SOBRE CARBON ACTIVADO, EN UNA DISOLVENTE ORGANICO INERTE, A TEMPERATURA AMBIENTE Y A PRESION ATMOSFERICA.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| HU79RI713A HU181495B (en) | 1979-05-31 | 1979-05-31 | Process for producing hydroxy-imino-eburnane derivatives |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES499287A0 ES499287A0 (es) | 1982-01-01 |
| ES8202007A1 true ES8202007A1 (es) | 1982-01-01 |
Family
ID=11001097
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES491992A Granted ES491992A0 (es) | 1979-05-31 | 1980-05-30 | Un procedimiento para la preparacion de nuevos derivados de hidroxiamino-eburnano |
| ES499288A Granted ES499288A0 (es) | 1979-05-31 | 1981-02-10 | Un procedimiento de preparacion de un nuevo derivado de es- ter de hexahidroindolquinolisinio |
| ES499286A Granted ES499286A0 (es) | 1979-05-31 | 1981-02-10 | Un procedimiento de preparacion de un nuevo derivado de mo- noester de octahidroindolquinolisina |
| ES499287A Expired ES8202007A1 (es) | 1979-05-31 | 1981-02-10 | Un procedimiento de preparacion de un nuevo derivado de es- ter de octahidroindolquinolisina |
Family Applications Before (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES491992A Granted ES491992A0 (es) | 1979-05-31 | 1980-05-30 | Un procedimiento para la preparacion de nuevos derivados de hidroxiamino-eburnano |
| ES499288A Granted ES499288A0 (es) | 1979-05-31 | 1981-02-10 | Un procedimiento de preparacion de un nuevo derivado de es- ter de hexahidroindolquinolisinio |
| ES499286A Granted ES499286A0 (es) | 1979-05-31 | 1981-02-10 | Un procedimiento de preparacion de un nuevo derivado de mo- noester de octahidroindolquinolisina |
Country Status (26)
| Country | Link |
|---|---|
| US (1) | US4345082A (es) |
| JP (1) | JPS55162784A (es) |
| AT (1) | AT373252B (es) |
| AU (1) | AU540977B2 (es) |
| BE (1) | BE883576A (es) |
| CA (1) | CA1148157A (es) |
| CH (1) | CH646970A5 (es) |
| DD (2) | DD151939A5 (es) |
| DE (1) | DE3020695A1 (es) |
| DK (1) | DK153149C (es) |
| ES (4) | ES491992A0 (es) |
| FI (1) | FI801757A7 (es) |
| FR (2) | FR2457867A1 (es) |
| GB (2) | GB2051794B (es) |
| GR (1) | GR68469B (es) |
| HU (1) | HU181495B (es) |
| IL (1) | IL60058A (es) |
| IT (1) | IT1147741B (es) |
| NL (1) | NL8002959A (es) |
| NO (2) | NO801627L (es) |
| NZ (1) | NZ193795A (es) |
| PT (1) | PT71328A (es) |
| SE (2) | SE446003B (es) |
| SU (2) | SU927116A3 (es) |
| YU (1) | YU145480A (es) |
| ZA (1) | ZA802888B (es) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4446139A (en) * | 1979-05-31 | 1984-05-01 | Richter Gedeon Vegyeszeti Gyar R.T. | Hexahydroindoloquinolizinium and octahydroindoloquinolizine esters, and method of increasing blood flow in an animal with hydroxyamino-eburnane derivatives |
| HU183207B (en) * | 1980-09-10 | 1984-04-28 | Richter Gedeon Vegyeszet | Process for preparing apovincaminic acid esters |
| HU183234B (en) * | 1980-10-17 | 1984-04-28 | Richter Gedeon Vegyeszet | Process for the enantioselective synthesis of optically active cys-14-oxo-e-homo-eburnan |
| HU182411B (en) * | 1981-11-03 | 1984-01-30 | Richter Gedeon Vegyeszet | Process for preparing eburnamonine derivatives |
| HU186891B (en) * | 1981-06-12 | 1985-10-28 | Richter Gedeon Vegyeszet | Process for producing esters of apovincaminic acid |
| HU182380B (en) * | 1981-09-30 | 1983-12-28 | Richter Gedeon Vegyeszet | Process for producing esters of vincaminic acid |
| HU191403B (en) * | 1984-04-02 | 1987-02-27 | Richter Gedeon Vegyeszeti Gyar Rt,Hu | Process for preparing new, raceme and optically active 14-hydroxyimino-eburnane |
| JP2851133B2 (ja) * | 1989-06-21 | 1999-01-27 | リヒター ゲデオン ベジェセティ ジャール アール．テー． | 新規ラセミ及び光学的活性オクタヒドロ―インド―ロ〔２，３―ａ〕テトラヒドロピラニル〔２，３―ｃ〕キノリジンジエステル誘導体及びその調製方法 |
| BE1004455A3 (fr) * | 1989-06-21 | 1992-11-24 | Richter Gedeon Vegyeszet | Nouveaux derives diester d'octahydro-indolo-[2,3-a]-quinolizine et leurs sels et procede pour les preparer. |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HU163143B (es) * | 1971-05-07 | 1973-06-28 | ||
| US4035370A (en) * | 1971-11-03 | 1977-07-12 | Richter Gedeon Vegyeszeti Gyar Rt. | Alkaloid esters |
| HU172068B (hu) * | 1975-06-13 | 1978-05-28 | Richter Gedeon Vegyeszet | Sposob asimmetricheskogo sinteza oktagidro-indolo/2,3-a/ khinolizidinov |
| HU174502B (hu) * | 1976-12-30 | 1980-01-28 | Richter Gedeon Vegyeszet | Sposob poluchenija novykh proizvodnykh oktagidro-indolo/2,3-a/-khinolizina |
| HU175527B (hu) * | 1977-03-28 | 1980-08-28 | Richter Gedeon Vegyeszet | Sposob dlja totalsinteze slozhnykh efirov apovinkaminnojj kisloty i gomologov |
| HU180514B (hu) * | 1977-05-26 | 1983-03-28 | Richter Gedeon Vegyeszet | Eljárás apovinkaminsav-észterek, illetve vinkaminsav-észterek és apovinkaminsavészterek egyidejű előállítására |
| FR2398746A1 (fr) * | 1977-07-25 | 1979-02-23 | Roussel Uclaf | Nouveaux derives d'alcaloides pentacycliques, leur procede de preparation, leur application comme medicaments, et leur application a la synthese de produits du groupe de l'eburnamonine |
-
1979
- 1979-05-31 HU HU79RI713A patent/HU181495B/hu not_active IP Right Cessation
-
1980
- 1980-05-12 IL IL60058A patent/IL60058A/xx unknown
- 1980-05-14 ZA ZA00802888A patent/ZA802888B/xx unknown
- 1980-05-14 CH CH378580A patent/CH646970A5/de not_active IP Right Cessation
- 1980-05-21 NZ NZ193795A patent/NZ193795A/xx unknown
- 1980-05-22 NL NL8002959A patent/NL8002959A/xx not_active Application Discontinuation
- 1980-05-27 GB GB8017318A patent/GB2051794B/en not_active Expired
- 1980-05-27 IT IT67826/80A patent/IT1147741B/it active
- 1980-05-27 GR GR62053A patent/GR68469B/el unknown
- 1980-05-27 GB GB8104950A patent/GB2072660B/en not_active Expired
- 1980-05-29 PT PT71328A patent/PT71328A/pt not_active IP Right Cessation
- 1980-05-29 US US06/154,329 patent/US4345082A/en not_active Expired - Lifetime
- 1980-05-29 DD DD80221446A patent/DD151939A5/de not_active IP Right Cessation
- 1980-05-29 DD DD80232903A patent/DD201592A5/de not_active IP Right Cessation
- 1980-05-29 DK DK232080A patent/DK153149C/da not_active IP Right Cessation
- 1980-05-30 BE BE0/200842A patent/BE883576A/fr not_active IP Right Cessation
- 1980-05-30 SU SU802927202A patent/SU927116A3/ru active
- 1980-05-30 FI FI801757A patent/FI801757A7/fi not_active Application Discontinuation
- 1980-05-30 NO NO801627A patent/NO801627L/no unknown
- 1980-05-30 AU AU58921/80A patent/AU540977B2/en not_active Ceased
- 1980-05-30 DE DE19803020695 patent/DE3020695A1/de active Granted
- 1980-05-30 SE SE8004079A patent/SE446003B/sv not_active IP Right Cessation
- 1980-05-30 AT AT0287880A patent/AT373252B/de not_active IP Right Cessation
- 1980-05-30 FR FR8012011A patent/FR2457867A1/fr active Granted
- 1980-05-30 CA CA000353141A patent/CA1148157A/en not_active Expired
- 1980-05-30 ES ES491992A patent/ES491992A0/es active Granted
- 1980-05-30 YU YU01454/80A patent/YU145480A/xx unknown
- 1980-05-30 JP JP7162580A patent/JPS55162784A/ja active Granted
-
1981
- 1981-02-10 ES ES499288A patent/ES499288A0/es active Granted
- 1981-02-10 ES ES499286A patent/ES499286A0/es active Granted
- 1981-02-10 ES ES499287A patent/ES8202007A1/es not_active Expired
- 1981-04-16 SU SU813269604A patent/SU1005663A3/ru active
- 1981-06-18 FR FR8112057A patent/FR2479828B1/fr not_active Expired
-
1985
- 1985-03-05 SE SE8501069A patent/SE461653B/sv not_active IP Right Cessation
- 1985-06-07 NO NO852308A patent/NO852308L/no unknown
Also Published As
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD1A | Patent lapsed |
Effective date: 19971001 |