ES8405778A1 - Procedimiento para la preparacion de nuevos benzo-heterociclos. - Google Patents

Procedimiento para la preparacion de nuevos benzo-heterociclos.

Info

Publication number
ES8405778A1
ES8405778A1 ES521871A ES521871A ES8405778A1 ES 8405778 A1 ES8405778 A1 ES 8405778A1 ES 521871 A ES521871 A ES 521871A ES 521871 A ES521871 A ES 521871A ES 8405778 A1 ES8405778 A1 ES 8405778A1
Authority
ES
Spain
Prior art keywords
hydrogen
image
methyl
represents hydrogen
alkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES521871A
Other languages
English (en)
Other versions
ES521871A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Boehringer Ingelheim GmbH
Original Assignee
Boehringer Ingelheim GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim GmbH filed Critical Boehringer Ingelheim GmbH
Publication of ES8405778A1 publication Critical patent/ES8405778A1/es
Publication of ES521871A0 publication Critical patent/ES521871A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/52—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
    • C07D263/54—Benzoxazoles; Hydrogenated benzoxazoles
    • C07D263/58—Benzoxazoles; Hydrogenated benzoxazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
    • C07D265/34—1,4-Oxazines; Hydrogenated 1,4-oxazines condensed with carbocyclic rings
    • C07D265/36—1,4-Oxazines; Hydrogenated 1,4-oxazines condensed with carbocyclic rings condensed with one six-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Pulmonology (AREA)
  • Urology & Nephrology (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Feed For Specific Animals (AREA)
  • Fodder In General (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

PROCEDIMIENTO PARA LA PREPARACION DE BENZO-HETEROCICLOS, DE FORMULA GENERAL (I), EN LA QUE A SIGNIFICA UN ENLACE SIMPLE O EL GRUPO -CH2-CH2-; R1 SIGNIFICA OH, O-ACILO, CLORO O HIDROGENO; R2 SIGNIFICA HIDROGENO, METILO O ETILO; Y R3 SIGNIFICA UN RADICAL, Y SUS SALES FARMACEUTICAMENTE ACEPTABLES.CONSISTE EN HIDROGENAR UN COMPUESTO DE FORMULA (II), EN LA QUE A Y R2 TIENEN LOS SIGNIFICADOS YA INDICADOS; R1 SIGNIFICA UN GRUPO BENCILOXI; R3 REPRESENTA R3; Y R REPRESENTA HIDROGENO O BENCILO EVENTUALMENTE SUSTITUIDO. LA REACCION DE HIDROGENACION SE EFECTUA EN UN DISOLVENTEA TEMPERATURA AMBIENTE Y EN PRESENCIA DE UN CATALIZADOR DE HIDROGENACION, HASTA LA ABSORCION DE LA CANTIDAD CALCULADA DE HIDROGENO.DE APLICACION EN LA PREPARACION DE MEDICAMENTOS POR SUS EFECTOS BRONCOLITICOS, ESPASMOLITICOS Y ANTIALERGICOS.
ES521871A 1981-09-01 1983-04-27 Procedimiento para la preparacion de nuevos benzo-heterociclos. Granted ES521871A0 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19813134590 DE3134590A1 (de) 1981-09-01 1981-09-01 Neue benzo-heterocyclen

Publications (2)

Publication Number Publication Date
ES8405778A1 true ES8405778A1 (es) 1984-06-16
ES521871A0 ES521871A0 (es) 1984-06-16

Family

ID=6140603

Family Applications (3)

Application Number Title Priority Date Filing Date
ES515380A Granted ES515380A0 (es) 1981-09-01 1982-08-31 "procedimiento para la preparacion de nuevos benzo-heterociclos".
ES521871A Granted ES521871A0 (es) 1981-09-01 1983-04-27 Procedimiento para la preparacion de nuevos benzo-heterociclos.
ES521870A Granted ES521870A0 (es) 1981-09-01 1983-04-27 Procedimiento para la preparacion de nuevos benzo-heterociclos.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES515380A Granted ES515380A0 (es) 1981-09-01 1982-08-31 "procedimiento para la preparacion de nuevos benzo-heterociclos".

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES521870A Granted ES521870A0 (es) 1981-09-01 1983-04-27 Procedimiento para la preparacion de nuevos benzo-heterociclos.

Country Status (25)

Country Link
EP (1) EP0073505B1 (es)
JP (1) JPS5852278A (es)
KR (1) KR890000380B1 (es)
AR (2) AR231976A1 (es)
AT (1) ATE16703T1 (es)
AU (1) AU553589B2 (es)
CA (1) CA1180012A (es)
CS (1) CS236679B2 (es)
DD (1) DD204477A5 (es)
DE (2) DE3134590A1 (es)
DK (1) DK158664C (es)
ES (3) ES515380A0 (es)
FI (1) FI78475C (es)
GB (1) GB2106105B (es)
GR (1) GR77275B (es)
HU (1) HU186112B (es)
IE (1) IE53615B1 (es)
IL (1) IL66683A0 (es)
NO (1) NO157738C (es)
NZ (1) NZ201777A (es)
PL (1) PL139375B1 (es)
PT (1) PT75478A (es)
SU (1) SU1149876A3 (es)
YU (1) YU42794B (es)
ZA (1) ZA826349B (es)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4554284A (en) * 1984-09-12 1985-11-19 Smithkline Beckman Corporation 7-(2-Aminoethyl)-1,3-benzthia- or oxa-zol-2(3H)-ones
DE3743265A1 (de) * 1987-12-19 1989-06-29 Boehringer Ingelheim Kg Neue ammoniumverbindungen, ihre herstellung und verwendung
TW372967B (en) * 1994-12-27 1999-11-01 Kanebo Ltd 1,4 benzoxazine derivative, pharmaceutical composition containing the same and use thereof
DE10253282A1 (de) * 2002-11-15 2004-05-27 Boehringer Ingelheim Pharma Gmbh & Co. Kg Neue Arzneimittel zur Behandlung von chronisch obstruktiver Lungenerkrankung
US7056916B2 (en) 2002-11-15 2006-06-06 Boehringer Ingelheim Pharma Gmbh & Co. Kg Medicaments for the treatment of chronic obstructive pulmonary disease
PE20040950A1 (es) 2003-02-14 2005-01-01 Theravance Inc DERIVADOS DE BIFENILO COMO AGONISTAS DE LOS RECEPTORES ADRENERGICOS ß2 Y COMO ANTAGONISTAS DE LOS RECEPTORES MUSCARINICOS
GB0307856D0 (en) * 2003-04-04 2003-05-14 Novartis Ag Organic compounds
JP4516064B2 (ja) * 2003-04-04 2010-08-04 ノバルティス アーゲー 気道疾患の処置のためのキノリン−２−オン誘導体
CA2565243A1 (en) * 2004-05-13 2005-11-24 Boehringer Ingelheim International Gmbh Hydroxy-substituted benzo-condensed heterocycles for use as beta agonists in the treatment of respiratory diseases
US7307076B2 (en) 2004-05-13 2007-12-11 Boehringer Ingelheim International Gmbh Beta agonists for the treatment of respiratory diseases
DE102004024453A1 (de) * 2004-05-14 2006-01-05 Boehringer Ingelheim Pharma Gmbh & Co. Kg Neue langwirksame Bronchodilatoren zur Behandlung von Atemwegserkrankungen
DE102004024454A1 (de) * 2004-05-14 2005-12-08 Boehringer Ingelheim Pharma Gmbh & Co. Kg Neue Enantiomerenreine Betaagonisten, Verfahren zu deren Herstellung und deren Verwendung als Arzneimittel
DE102004024452A1 (de) * 2004-05-14 2005-12-08 Boehringer Ingelheim Pharma Gmbh & Co. Kg Aerosolformulierung für die Inhalation von Betaagonisten
US7745621B2 (en) 2004-05-14 2010-06-29 Boehringer Ingelheim International Gmbh Long acting bronchodilators for the treatment of respiratory diseases
DE102004024451A1 (de) * 2004-05-14 2005-12-22 Boehringer Ingelheim Pharma Gmbh & Co. Kg Pulverformulierungen für die Inhalation, die Enantiomerenreine Betaagonisten enthalten
US7220742B2 (en) 2004-05-14 2007-05-22 Boehringer Ingelheim International Gmbh Enantiomerically pure beta agonists, process for the manufacture thereof and use thereof as medicaments
KR101360803B1 (ko) * 2005-08-15 2014-02-11 베링거 인겔하임 인터내셔날 게엠베하 베타모방제의 제조방법
US20070088030A1 (en) * 2005-10-10 2007-04-19 Barbara Niklaus-Humke Aerosol formulations for the inhalation of beta-agonists
GB0602778D0 (en) 2006-02-10 2006-03-22 Glaxo Group Ltd Novel compound
JP2010500319A (ja) * 2006-08-07 2010-01-07 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング 鏡像体上純粋な新規ベータアゴニスト、それらの製造方法及び医薬としてのそれらの使用
UY30543A1 (es) * 2006-08-18 2008-03-31 Boehringer Ingelheim Int Formulacion de aerosol para la inhalacion de beta- agonistas
AR065017A1 (es) * 2007-01-25 2009-05-13 Boehringer Ingelheim Int Procedimiento para la preparacion de betamimeticos

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2035749A1 (es) * 1969-02-06 1970-12-24 Bellon Labor Sa Roger
CA1041523A (en) * 1974-06-19 1978-10-31 Queen's University Preparation of 1-oxapenicillins and novel intermediates therefor

Also Published As

Publication number Publication date
HU186112B (en) 1985-06-28
JPH035392B2 (es) 1991-01-25
DE3134590A1 (de) 1983-03-10
IE53615B1 (en) 1988-12-21
CA1180012A (en) 1984-12-27
AR231977A1 (es) 1985-04-30
AU8787482A (en) 1983-03-10
SU1149876A3 (en) 1985-04-07
FI78475B (fi) 1989-04-28
FI78475C (fi) 1989-08-10
EP0073505A1 (de) 1983-03-09
DE3267702D1 (en) 1986-01-09
CS236679B2 (en) 1985-05-15
NO157738B (no) 1988-02-01
PL139375B1 (en) 1987-01-31
ES8402279A1 (es) 1984-01-16
FI822985A0 (fi) 1982-08-30
GB2106105B (en) 1985-07-10
ZA826349B (en) 1984-04-25
KR890000380B1 (ko) 1989-03-15
ES8308318A1 (es) 1983-08-16
IL66683A0 (en) 1982-12-31
NO822932L (no) 1983-03-02
GB2106105A (en) 1983-04-07
ES515380A0 (es) 1983-08-16
DK158664B (da) 1990-07-02
ATE16703T1 (de) 1985-12-15
NZ201777A (en) 1985-08-30
DK158664C (da) 1991-01-14
YU194982A (en) 1984-12-31
KR840001560A (ko) 1984-05-07
GR77275B (es) 1984-09-11
PL238077A1 (en) 1984-04-09
FI822985L (fi) 1983-03-02
DD204477A5 (de) 1983-11-30
NO157738C (no) 1988-05-11
AU553589B2 (en) 1986-07-24
IE822105L (en) 1983-03-01
AR231976A1 (es) 1985-04-30
YU42794B (en) 1988-12-31
DK389082A (da) 1983-03-02
PT75478A (en) 1982-09-01
EP0073505B1 (de) 1985-11-27
ES521870A0 (es) 1984-01-16
JPS5852278A (ja) 1983-03-28
ES521871A0 (es) 1984-06-16

Similar Documents

Publication Publication Date Title
ES8308318A1 (es) "procedimiento para la preparacion de nuevos benzo-heterociclos".
ZA837976B (en) Imidazolylalkylthienyl-tetrahydropyridazines and processes for their preparation
ES8405766A1 (es) Procedimiento para preparar derivados de fenil-1-piperidino-2-propanol
ES8304145A1 (es) "procedimiento para la preparacion de nuevas amidas de acidos carboxilicos".
EP0231003A3 (en) Basic substituted phenylacetonitriles, their preparation and medicaments containing them
ES8307249A1 (es) Procedimiento de preparacion de nuevos derivados del adamantano.
ES8607247A1 (es) Procedimiento para preparar nuevos compuestos de 3-(aminoal-quilaminocarbonilmetoxi)-5-fenilpirazol
ES461785A1 (es) Un metodo para la preparacion de un ester de acido behenico.
DE3374005D1 (en) 1-methyl-5-nitro-imidazoline derivatives and therapeutic compositions which contain them as active principle
SE8004351L (sv) (3-alkylamino-2-hydroxipropoxi)-furan-2-karbonsyra-anilider och fysiologiskt fordragbara syraadditionssalter derav samt lekemedel med en halt av dessa foreningar
DE3470741D1 (en) Azolylmethylcycloacetals, process for their preparation and their use as medicaments
DE3269505D1 (en) Substituted 1-benzoyl-2-phenylimino-imidazolidines, their acid addition salts, process for their preparation and pharmaceutical compositions containing them
JPS57156409A (en) Production of high-concentration pearlescent dispersion
ES489925A1 (es) Procedimiento para la preparacion de n,n'-difenil-monohidra-zida de acido 2-(3-metil-3-butenil)-malonico
ES8305319A1 (es) "procedimiento para la preparacion de acidos antranilicos sustituidos con radicales basicos"
JPS55145737A (en) Cleaning agent for apparatus having polyamide
ES8200658A1 (es) Procedimiento para la preparacion de sales de alcohileter- isotiuronio
ES8504688A1 (es) Procedimiento para la obtencion de esteres del acido halogenoalquilcarbamico
JPS5414961A (en) Novel 3-hydroxyazetidine-3-carboxylic derivative
JPS5432492A (en) Novel cyclopropylmethylamine derivatives and their preparation
JPS56127368A (en) Piperazinylalkoxyindanes and their acid addition salts
DE3160719D1 (en) Benzothiopyrano(2,3-c) pyridines and their acid addition salts, their preparation, their use as medicaments and compositions containing them
JPS52148030A (en) Gamma-l-glutamylanilides
ES466205A1 (es) Procedimiento para preparar 3-sustituido-tetrahidro-1,2,4 triazinas
JPS5223049A (en) Preparation of 4-acloxy-4'- cyanobiphenyls

Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19970203