ES8603807A1 - Procedimiento para preparar nuevos derivados acilhidroxilaminicos de acidos grasos insaturados. - Google Patents

Procedimiento para preparar nuevos derivados acilhidroxilaminicos de acidos grasos insaturados.

Info

Publication number
ES8603807A1
ES8603807A1 ES525219A ES525219A ES8603807A1 ES 8603807 A1 ES8603807 A1 ES 8603807A1 ES 525219 A ES525219 A ES 525219A ES 525219 A ES525219 A ES 525219A ES 8603807 A1 ES8603807 A1 ES 8603807A1
Authority
ES
Spain
Prior art keywords
inflammatory
arachidonic acid
acid analogues
antiallergic agents
allergic reactions
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES525219A
Other languages
English (en)
Other versions
ES525219A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Syntex USA LLC
Original Assignee
Syntex USA LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Syntex USA LLC filed Critical Syntex USA LLC
Publication of ES8603807A1 publication Critical patent/ES8603807A1/es
Publication of ES525219A0 publication Critical patent/ES525219A0/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
    • C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D257/04—Five-membered rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C29/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring
    • C07C29/09—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by hydrolysis
    • C07C29/10—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by hydrolysis of ethers, including cyclic ethers, e.g. oxiranes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C33/00—Unsaturated compounds having hydroxy or O-metal groups bound to acyclic carbon atoms
    • C07C33/04—Acyclic alcohols with carbon-to-carbon triple bonds
    • C07C33/048—Acyclic alcohols with carbon-to-carbon triple bonds with double and triple bonds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/64—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by introduction of functional groups containing oxygen only in singly bound form
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/20—Unsaturated compounds containing keto groups bound to acyclic carbon atoms
    • C07C49/24—Unsaturated compounds containing keto groups bound to acyclic carbon atoms containing hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/18—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms with only carbon-to-carbon triple bonds as unsaturation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/10—Oxygen atoms
    • C07D309/12—Oxygen atoms only hydrogen atoms and one oxygen atom directly attached to ring carbon atoms, e.g. tetrahydropyranyl ethers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Rheumatology (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Fats And Perfumes (AREA)
  • Steroid Compounds (AREA)

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE DERIVADOS ACILHIDROXILAMINICOS DE ACIDOS GRASOS INSATURADOS Y DE SUS SALES NO TOXICA FISIOLOGICAMENTE COMPATIBLES, DE FORMULA (I), (II), O (III), EN LAS QUE X REPRESENTA C(O)NHOH; A Y B SON DOS ATOMOS DE CARBONO UNIDOS POR ENLACE SENCILLO O MULTIPLE Y Z ES ALQUILO C1C4. CONSISTE EN LA REACCION DE UN COMPUESTO DE FORMULAS (I), (II) O (III) EN LAS QUE X ES GRUPO CARBOXILICO O UN DERIVADO REACTIVO DEL MISMO, CON HIDROXILAMINA. LA REACCION SE LLEVA A CABO EMPLEANDO EN EXCESO DE HIDROXILAMINA, EN UN DISOLVENTE ORGANICO ACUOSO, COMO METANOL-AGUA, A UN PH COMPRENDIDO ENTRE 7 Y 10, A LA TEMPERATURA AMBIENTE; Y EL PRODUCTO FORMADO SE AISLA Y PURIFICA SIGUIENDO METODOS CONVENCIONALES. ESTOS COMPUESTOS TIENEN APLICACIONES FARMACOLOGICAS PARA EL TRATAMIENTO DE PROCESOS INFLAMATORIOS, REACCIONES DE DOLOR Y ALERGICAS.
ES525219A 1982-08-30 1983-08-29 Procedimiento para preparar nuevos derivados acilhidroxilaminicos de acidos grasos insaturados. Expired ES8603807A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/412,477 US4497827A (en) 1982-08-30 1982-08-30 Arachidonic acid analogues as anti-inflammatory and anti-allergic agents

Publications (2)

Publication Number Publication Date
ES8603807A1 true ES8603807A1 (es) 1986-01-16
ES525219A0 ES525219A0 (es) 1986-01-16

Family

ID=23633154

Family Applications (4)

Application Number Title Priority Date Filing Date
ES525219A Expired ES8603807A1 (es) 1982-08-30 1983-08-29 Procedimiento para preparar nuevos derivados acilhidroxilaminicos de acidos grasos insaturados.
ES540855A Expired ES8607955A1 (es) 1982-08-30 1985-03-01 Procedimiento para preparar nuevos derivados tetrazolicos deacidos grasos insaturados
ES540853A Expired ES8606235A1 (es) 1982-08-30 1985-03-01 Procedimiento para preparar nuevos derivados hidroximetilce-tonicos de acidos grasos insaturados
ES540854A Expired ES8704878A1 (es) 1982-08-30 1985-03-01 Procedimiento para preparar nuevos derivados amidicos de acidos grasos insaturados

Family Applications After (3)

Application Number Title Priority Date Filing Date
ES540855A Expired ES8607955A1 (es) 1982-08-30 1985-03-01 Procedimiento para preparar nuevos derivados tetrazolicos deacidos grasos insaturados
ES540853A Expired ES8606235A1 (es) 1982-08-30 1985-03-01 Procedimiento para preparar nuevos derivados hidroximetilce-tonicos de acidos grasos insaturados
ES540854A Expired ES8704878A1 (es) 1982-08-30 1985-03-01 Procedimiento para preparar nuevos derivados amidicos de acidos grasos insaturados

Country Status (15)

Country Link
US (1) US4497827A (es)
EP (1) EP0104468B1 (es)
JP (1) JPS5965036A (es)
KR (1) KR840005722A (es)
AT (1) ATE20885T1 (es)
AU (1) AU1852083A (es)
CA (1) CA1209578A (es)
DE (1) DE3364718D1 (es)
DK (1) DK393583A (es)
ES (4) ES8603807A1 (es)
FI (1) FI833062A (es)
IE (1) IE55902B1 (es)
NO (1) NO833092L (es)
NZ (1) NZ205403A (es)
ZA (1) ZA836395B (es)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4604407A (en) * 1985-04-04 1986-08-05 E. R. Squibb & Sons, Inc. Hydroxamates
DE3518655A1 (de) * 1985-05-24 1986-11-27 Grünenthal GmbH, 5190 Stolberg Neue phenolderivate, diese enthaltende arzneimittel und verfahren zur herstellung dieser verbindungen und arzneimittel
FR2584400B1 (fr) * 1985-07-05 1988-02-19 Cird Esters et amides de l'acide eicosatriynoique et leur application en pharmacie et en cosmetique
DE3604050A1 (de) * 1986-02-08 1987-08-13 Boehringer Mannheim Gmbh Thioether, verfahren zu deren herstellung sowie diese verbindungen enthaltende arzneimittel
US4761403A (en) * 1986-04-09 1988-08-02 Abbott Laboratories Lipoxygenase inhibiting compounds
US4672075A (en) * 1986-08-26 1987-06-09 E. R. Squibb & Sons 7-Oxabicyclo(2.2.1)heptane hydroxamic acid derivatives useful as antiinflammatory, antiasthma and antipsoriatic agents
US4707494A (en) * 1986-08-26 1987-11-17 E. R. Squibb & Sons, Inc. 7-oxabicyclo(2.2.1)heptane compounds useful in the treatment of inflammation
US4908384A (en) * 1986-08-29 1990-03-13 Mcneilab, Inc. Fatty acid leukotriene synthesis inhibitors
FR2609026B1 (fr) * 1986-12-31 1989-03-31 Cird Amides de l'acide eicosatetraynoique et leur application en pharmacie et en cosmetique
US5145861A (en) * 1987-11-04 1992-09-08 Merrell Dow Pharmaceuticals Inc. Fluorinated arachidonic acid derivatives
US4963541A (en) * 1989-02-22 1990-10-16 Abbott Laboratories Pyrimido-pyrimidine lipoxygenase inhibiting compounds
US5225429A (en) * 1989-05-02 1993-07-06 Merrell Dow Pharmaceuticals Inc. Fluorinated arachidonic acid derivatives
EP0396841B1 (en) * 1989-05-02 1994-02-02 Merrell Dow Pharmaceuticals Inc. Fluorinated arachidonic acid derivatives
ATE247097T1 (de) * 1998-05-04 2003-08-15 Univ Connecticut Analgetische und immunomodulierende cannabinoiden
US7897598B2 (en) * 1998-06-09 2011-03-01 Alexandros Makriyannis Inhibitors of the anandamide transporter
IL125731A (en) 1998-08-11 2004-06-20 Zvi Yehuda Acylates which are products of neurotransmitters and essential fatty acids, pharmaceutical compositions containing them, use of such acylates in the manufacture of medicaments, and method for treating nervous diseases in non-human animals
US7161016B1 (en) 1998-11-24 2007-01-09 University Of Connecticut Cannabimimetic lipid amides as useful medications
US7276613B1 (en) 1998-11-24 2007-10-02 University Of Connecticut Retro-anandamides, high affinity and stability cannabinoid receptor ligands
US6900236B1 (en) * 1999-10-18 2005-05-31 University Of Connecticut Cannabimimetic indole derivatives
US7741365B2 (en) * 1999-10-18 2010-06-22 University Of Connecticut Peripheral cannabinoid receptor (CB2) selective ligands
US7393842B2 (en) * 2001-08-31 2008-07-01 University Of Connecticut Pyrazole analogs acting on cannabinoid receptors
US6943266B1 (en) 1999-10-18 2005-09-13 University Of Connecticut Bicyclic cannabinoid agonists for the cannabinoid receptor
AU778159B2 (en) 1999-10-18 2004-11-18 University Of Connecticut, The Peripheral cannabinoid receptor (CB2) selective ligands
US7119108B1 (en) * 1999-10-18 2006-10-10 University Of Connecticut Pyrazole derivatives as cannabinoid receptor antagonists
US8084467B2 (en) * 1999-10-18 2011-12-27 University Of Connecticut Pyrazole derivatives as cannabinoid receptor antagonists
EP1361876A4 (en) * 2001-01-26 2004-03-31 Univ Connecticut NEW CANNABIMIMETIC LIGANDS
CA2436133A1 (en) 2001-01-29 2002-08-08 University Of Connecticut Receptor selective cannabimimetic aminoalkylindoles
WO2003005960A2 (en) * 2001-07-13 2003-01-23 University Of Connecticut Novel bicyclic and tricyclic cannabinoids
EP1448557A4 (en) * 2001-10-26 2005-02-02 Univ Connecticut HETEROINDANE: A NEW CLASS OF HIGH-ACTIVITY CANNABIMIMETIC LIGANDS
CA2496097A1 (en) 2002-08-23 2004-03-04 University Of Connecticut Keto cannabinoids with therapeutic indications

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE319677B (es) * 1965-03-27 1970-01-19 Sumitomo Chemical Co
GB1074693A (en) * 1966-01-03 1967-07-05 Sumitomo Chemical Co Purification of fatty acid amide derivatives
US3427316A (en) * 1966-05-02 1969-02-11 Millmaster Onyx Corp Quaternary ammonium hydroxamates
US3995059A (en) * 1966-10-04 1976-11-30 Sumitomo Chemical Company, Limited Pharmaceutical compositions containing fatty acid amide derivatives
FR2140369A1 (en) * 1971-06-11 1973-01-19 Ceskoslovenska Akademie Ved Ethanol palmitamide - for treatment of upper respiratory infections and for detoxication
BE788209A (fr) * 1971-09-01 1973-02-28 Pfizer Derives tetrazoyliques des prostaglandines naturelles
NL7208324A (en) * 1972-06-19 1973-12-21 Animal feed supplement - consisting of long chain acylhydroxyamide
DE2256347C3 (de) * 1972-11-17 1982-01-07 Basf Ag, 6700 Ludwigshafen Verfahren zur Herstellung von α,β -ungestättigten Ketonen
DE2343055A1 (de) * 1973-08-25 1975-03-06 Basf Ag Ungesaettigte nitrile
FR2264522A1 (en) * 1974-03-22 1975-10-17 Rouchy Maurice Vitamin F cpds having surface active properties - comprise linoleic, linolenic and arachidonic acid radical joined via O or N to polyalcohols
JPS601283B2 (ja) * 1976-06-08 1985-01-14 帝人株式会社 包接化合物並びにその製造法
NL7614113A (nl) * 1976-12-18 1978-06-20 Akzo Nv Hydroxamzuren.
US4336372A (en) * 1979-04-02 1982-06-22 The Upjohn Company 2-Decarboxy-2-tetrazolyl-PG2 compounds
US4277410A (en) * 1980-05-02 1981-07-07 Emery Industries, Inc. Process for the production of carboxylic amides using alkyltin catalysts

Also Published As

Publication number Publication date
IE832016L (en) 1984-02-29
IE55902B1 (en) 1991-02-14
ATE20885T1 (de) 1986-08-15
DK393583D0 (da) 1983-08-29
NZ205403A (en) 1986-10-08
ES8704878A1 (es) 1987-05-01
EP0104468A1 (en) 1984-04-04
EP0104468B1 (en) 1986-07-23
ES540853A0 (es) 1986-04-16
DE3364718D1 (en) 1986-08-28
JPS5965036A (ja) 1984-04-13
US4497827A (en) 1985-02-05
ES525219A0 (es) 1986-01-16
DK393583A (da) 1984-03-01
ES540854A0 (es) 1987-05-01
AU1852083A (en) 1984-03-08
ES540855A0 (es) 1986-06-16
KR840005722A (ko) 1984-11-16
CA1209578A (en) 1986-08-12
ES8607955A1 (es) 1986-06-16
NO833092L (no) 1984-03-01
FI833062A0 (fi) 1983-08-29
FI833062A (fi) 1984-03-01
ES8606235A1 (es) 1986-04-16
ZA836395B (en) 1985-04-24

Similar Documents

Publication Publication Date Title
DE3364718D1 (en) Arachidonic acid analogues as anti-inflammatory and antiallergic agents
ATE251158T1 (de) Indolizin spal2 inhibitoren
ATA242288A (de) Dosierungsform für die behandlung kardiovaskulärer erkrankungen
DE3585981D1 (de) Behandlung gewebedegenerativer entzuendungskrankheiten.
PT915842E (pt) Esteres nitratos e sua utilizacao para condicoes neurologicas
IL55227A (en) Pharmaceutical compositions comprising(all-z)-5,8,11,14,17-eicosapentaenoic acid or its salts,esters or amides for the treatment and prophylaxis of thromboembolic conditions
ATE106867T1 (de) 13-trans-retinsäureester.
ES2005073A6 (es) Procedimiento para preparar benzamidas y bencenoacetamidas
PT83474A (en) Therapeutic agents
DE3875286D1 (de) Essentielle fettsaeure enthaltende zusammensetzungen.
IT1148618B (it) Procedimento enzimatico per la produzione di acido 3-indolpiruvico e utilizzazione farmaceutica di questo
DE59504267D1 (de) Härten von ungesättigten fetten, fettsäuren oder fettsäureestern
ATE284217T1 (de) Verwendung von sulphoquinovosyldiacylglycerols zur behandlung von entzündlichen hauterkrankungen
DE3866653D1 (de) Zusammensetzung fuer die behandlung der epidermis.
DE3780942T2 (de) Mittel zur neutralisierung des antriebs fuer die haspel von landwirtschaftlichen maschinen.
DE3762526D1 (de) Hochkonzentrierte saeurezusammensetzungen fuer die behandlung von wasser und die reinigung von anlagen.
ATE86611T1 (de) Topische vorstufen von arzneimitteln zur behandlung von akne und hautkrankheiten.
IE811612L (en) Thiazoles
RO86562A2 (ro) Compozitie vegetala medicamentoasa pentru tratarea unor afectiuni hepato-biliare
MX149636A (es) Metodo mejorado para controlar la composicion de una solucion acida utilizada en el decapado de acero inoxidable
IT7823020A0 (it) Derivati di ammino acidi utili come inibitori dell'enzima che converte l'angiotensina.
CS181991B1 (en) Waste water treatment from the production of unsaturated acid esters