DE3364718D1 - Arachidonic acid analogues as anti-inflammatory and antiallergic agents - Google Patents

Arachidonic acid analogues as anti-inflammatory and antiallergic agents

Info

Publication number
DE3364718D1
DE3364718D1 DE8383108499T DE3364718T DE3364718D1 DE 3364718 D1 DE3364718 D1 DE 3364718D1 DE 8383108499 T DE8383108499 T DE 8383108499T DE 3364718 T DE3364718 T DE 3364718T DE 3364718 D1 DE3364718 D1 DE 3364718D1
Authority
DE
Germany
Prior art keywords
inflammatory
arachidonic acid
acid analogues
antiallergic agents
allergic reactions
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
DE8383108499T
Other languages
English (en)
Inventor
Peter Harold Nelson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Syntex USA LLC
Original Assignee
Syntex USA LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Syntex USA LLC filed Critical Syntex USA LLC
Application granted granted Critical
Publication of DE3364718D1 publication Critical patent/DE3364718D1/de
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
    • C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D257/04—Five-membered rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C29/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring
    • C07C29/09—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by hydrolysis
    • C07C29/10—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by hydrolysis of ethers, including cyclic ethers, e.g. oxiranes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C33/00—Unsaturated compounds having hydroxy or O-metal groups bound to acyclic carbon atoms
    • C07C33/04—Acyclic alcohols with carbon-to-carbon triple bonds
    • C07C33/048—Acyclic alcohols with carbon-to-carbon triple bonds with double and triple bonds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/64—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by introduction of functional groups containing oxygen only in singly bound form
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/20—Unsaturated compounds containing keto groups bound to acyclic carbon atoms
    • C07C49/24—Unsaturated compounds containing keto groups bound to acyclic carbon atoms containing hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/18—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms with only carbon-to-carbon triple bonds as unsaturation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/10—Oxygen atoms
    • C07D309/12—Oxygen atoms only hydrogen atoms and one oxygen atom directly attached to ring carbon atoms, e.g. tetrahydropyranyl ethers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Pulmonology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Immunology (AREA)
  • Rheumatology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Fats And Perfumes (AREA)
  • Steroid Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
DE8383108499T 1982-08-30 1983-08-29 Arachidonic acid analogues as anti-inflammatory and antiallergic agents Expired DE3364718D1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/412,477 US4497827A (en) 1982-08-30 1982-08-30 Arachidonic acid analogues as anti-inflammatory and anti-allergic agents

Publications (1)

Publication Number Publication Date
DE3364718D1 true DE3364718D1 (en) 1986-08-28

Family

ID=23633154

Family Applications (1)

Application Number Title Priority Date Filing Date
DE8383108499T Expired DE3364718D1 (en) 1982-08-30 1983-08-29 Arachidonic acid analogues as anti-inflammatory and antiallergic agents

Country Status (15)

Country Link
US (1) US4497827A (de)
EP (1) EP0104468B1 (de)
JP (1) JPS5965036A (de)
KR (1) KR840005722A (de)
AT (1) ATE20885T1 (de)
AU (1) AU1852083A (de)
CA (1) CA1209578A (de)
DE (1) DE3364718D1 (de)
DK (1) DK393583A (de)
ES (4) ES8603807A1 (de)
FI (1) FI833062A (de)
IE (1) IE55902B1 (de)
NO (1) NO833092L (de)
NZ (1) NZ205403A (de)
ZA (1) ZA836395B (de)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4604407A (en) * 1985-04-04 1986-08-05 E. R. Squibb & Sons, Inc. Hydroxamates
DE3518655A1 (de) * 1985-05-24 1986-11-27 Grünenthal GmbH, 5190 Stolberg Neue phenolderivate, diese enthaltende arzneimittel und verfahren zur herstellung dieser verbindungen und arzneimittel
FR2584400B1 (fr) * 1985-07-05 1988-02-19 Cird Esters et amides de l'acide eicosatriynoique et leur application en pharmacie et en cosmetique
DE3604050A1 (de) * 1986-02-08 1987-08-13 Boehringer Mannheim Gmbh Thioether, verfahren zu deren herstellung sowie diese verbindungen enthaltende arzneimittel
US4761403A (en) * 1986-04-09 1988-08-02 Abbott Laboratories Lipoxygenase inhibiting compounds
US4707494A (en) * 1986-08-26 1987-11-17 E. R. Squibb & Sons, Inc. 7-oxabicyclo(2.2.1)heptane compounds useful in the treatment of inflammation
US4672075A (en) * 1986-08-26 1987-06-09 E. R. Squibb & Sons 7-Oxabicyclo(2.2.1)heptane hydroxamic acid derivatives useful as antiinflammatory, antiasthma and antipsoriatic agents
US4908384A (en) * 1986-08-29 1990-03-13 Mcneilab, Inc. Fatty acid leukotriene synthesis inhibitors
FR2609026B1 (fr) * 1986-12-31 1989-03-31 Cird Amides de l'acide eicosatetraynoique et leur application en pharmacie et en cosmetique
US5145861A (en) * 1987-11-04 1992-09-08 Merrell Dow Pharmaceuticals Inc. Fluorinated arachidonic acid derivatives
US4963541A (en) * 1989-02-22 1990-10-16 Abbott Laboratories Pyrimido-pyrimidine lipoxygenase inhibiting compounds
US5225429A (en) * 1989-05-02 1993-07-06 Merrell Dow Pharmaceuticals Inc. Fluorinated arachidonic acid derivatives
ATE101114T1 (de) * 1989-05-02 1994-02-15 Merrell Dow Pharma Flourierte abkoemmlinge von archidsaeuren.
WO1999057106A1 (en) * 1998-05-04 1999-11-11 The University Of Connecticut Novel analgesic and immunomodulatory cannabinoids
US7897598B2 (en) * 1998-06-09 2011-03-01 Alexandros Makriyannis Inhibitors of the anandamide transporter
IL125731A (en) 1998-08-11 2004-06-20 Zvi Yehuda Acylates which are products of neurotransmitters and essential fatty acids, pharmaceutical compositions containing them, use of such acylates in the manufacture of medicaments, and method for treating nervous diseases in non-human animals
US7276613B1 (en) 1998-11-24 2007-10-02 University Of Connecticut Retro-anandamides, high affinity and stability cannabinoid receptor ligands
US7161016B1 (en) 1998-11-24 2007-01-09 University Of Connecticut Cannabimimetic lipid amides as useful medications
US8084467B2 (en) * 1999-10-18 2011-12-27 University Of Connecticut Pyrazole derivatives as cannabinoid receptor antagonists
CA2387764A1 (en) 1999-10-18 2001-04-26 University Of Connecticut Peripheral cannabinoid receptor (cb2) selective ligands
US6900236B1 (en) 1999-10-18 2005-05-31 University Of Connecticut Cannabimimetic indole derivatives
US7741365B2 (en) * 1999-10-18 2010-06-22 University Of Connecticut Peripheral cannabinoid receptor (CB2) selective ligands
US7393842B2 (en) * 2001-08-31 2008-07-01 University Of Connecticut Pyrazole analogs acting on cannabinoid receptors
US7119108B1 (en) * 1999-10-18 2006-10-10 University Of Connecticut Pyrazole derivatives as cannabinoid receptor antagonists
US6943266B1 (en) 1999-10-18 2005-09-13 University Of Connecticut Bicyclic cannabinoid agonists for the cannabinoid receptor
JP2004532185A (ja) * 2001-01-26 2004-10-21 ユニバーシティ オブ コネチカット 新規なカンナビミメティックリガンド
CA2436133A1 (en) 2001-01-29 2002-08-08 University Of Connecticut Receptor selective cannabimimetic aminoalkylindoles
US7057076B2 (en) * 2001-07-13 2006-06-06 University Of Connecticut Bicyclic and tricyclic cannabinoids
EP1448557A4 (de) * 2001-10-26 2005-02-02 Univ Connecticut Heteroindane: eine neue klasse hochwirksamer cannabimimetischer liganden
CA2496097A1 (en) 2002-08-23 2004-03-04 University Of Connecticut Keto cannabinoids with therapeutic indications

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE319677B (de) * 1965-03-27 1970-01-19 Sumitomo Chemical Co
GB1074693A (en) * 1966-01-03 1967-07-05 Sumitomo Chemical Co Purification of fatty acid amide derivatives
US3427316A (en) * 1966-05-02 1969-02-11 Millmaster Onyx Corp Quaternary ammonium hydroxamates
US3995059A (en) * 1966-10-04 1976-11-30 Sumitomo Chemical Company, Limited Pharmaceutical compositions containing fatty acid amide derivatives
FR2140369A1 (en) * 1971-06-11 1973-01-19 Ceskoslovenska Akademie Ved Ethanol palmitamide - for treatment of upper respiratory infections and for detoxication
BE788209A (fr) * 1971-09-01 1973-02-28 Pfizer Derives tetrazoyliques des prostaglandines naturelles
NL7208324A (en) * 1972-06-19 1973-12-21 Animal feed supplement - consisting of long chain acylhydroxyamide
DE2256347C3 (de) * 1972-11-17 1982-01-07 Basf Ag, 6700 Ludwigshafen Verfahren zur Herstellung von α,β -ungestättigten Ketonen
DE2343055A1 (de) * 1973-08-25 1975-03-06 Basf Ag Ungesaettigte nitrile
FR2264522A1 (en) * 1974-03-22 1975-10-17 Rouchy Maurice Vitamin F cpds having surface active properties - comprise linoleic, linolenic and arachidonic acid radical joined via O or N to polyalcohols
JPS601283B2 (ja) * 1976-06-08 1985-01-14 帝人株式会社 包接化合物並びにその製造法
NL7614113A (nl) * 1976-12-18 1978-06-20 Akzo Nv Hydroxamzuren.
US4336372A (en) * 1979-04-02 1982-06-22 The Upjohn Company 2-Decarboxy-2-tetrazolyl-PG2 compounds
US4277410A (en) * 1980-05-02 1981-07-07 Emery Industries, Inc. Process for the production of carboxylic amides using alkyltin catalysts

Also Published As

Publication number Publication date
ES525219A0 (es) 1986-01-16
FI833062A0 (fi) 1983-08-29
ZA836395B (en) 1985-04-24
JPS5965036A (ja) 1984-04-13
ES8606235A1 (es) 1986-04-16
NO833092L (no) 1984-03-01
DK393583D0 (da) 1983-08-29
ES8704878A1 (es) 1987-05-01
IE55902B1 (en) 1991-02-14
NZ205403A (en) 1986-10-08
ES540855A0 (es) 1986-06-16
EP0104468B1 (de) 1986-07-23
EP0104468A1 (de) 1984-04-04
AU1852083A (en) 1984-03-08
DK393583A (da) 1984-03-01
KR840005722A (ko) 1984-11-16
ES540854A0 (es) 1987-05-01
ES540853A0 (es) 1986-04-16
ES8607955A1 (es) 1986-06-16
ES8603807A1 (es) 1986-01-16
US4497827A (en) 1985-02-05
ATE20885T1 (de) 1986-08-15
CA1209578A (en) 1986-08-12
IE832016L (en) 1984-02-29
FI833062A (fi) 1984-03-01

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee