IT8249251A0 - Procedimento enzimatico per la produzione di acido 3-indolpiruvico e utilizzazione farmaceutica di questo - Google Patents
Procedimento enzimatico per la produzione di acido 3-indolpiruvico e utilizzazione farmaceutica di questoInfo
- Publication number
- IT8249251A0 IT8249251A0 IT8249251A IT4925182A IT8249251A0 IT 8249251 A0 IT8249251 A0 IT 8249251A0 IT 8249251 A IT8249251 A IT 8249251A IT 4925182 A IT4925182 A IT 4925182A IT 8249251 A0 IT8249251 A0 IT 8249251A0
- Authority
- IT
- Italy
- Prior art keywords
- production
- pharmaceutical use
- enzymatic procedure
- indolpyruvic acid
- indolpyruvic
- Prior art date
Links
- RSTKLPZEZYGQPY-UHFFFAOYSA-N 3-(indol-3-yl)pyruvic acid Chemical compound C1=CC=C2C(CC(=O)C(=O)O)=CNC2=C1 RSTKLPZEZYGQPY-UHFFFAOYSA-N 0.000 title 1
- 230000002255 enzymatic effect Effects 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/10—Nitrogen as only ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
- A61K31/405—Indole-alkanecarboxylic acids; Derivatives thereof, e.g. tryptophan, indomethacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/582—Recycling of unreacted starting or intermediate materials
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Genetics & Genomics (AREA)
- Epidemiology (AREA)
- General Engineering & Computer Science (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Nutrition Science (AREA)
- Anesthesiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Indole Compounds (AREA)
Priority Applications (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IT49251/82A IT1148618B (it) | 1982-10-11 | 1982-10-11 | Procedimento enzimatico per la produzione di acido 3-indolpiruvico e utilizzazione farmaceutica di questo |
DE8383830196T DE3378742D1 (de) | 1982-10-11 | 1983-10-07 | Pharmaceutical utilisation of 3-indolpyruvic acid |
US06/540,051 US4551471A (en) | 1982-10-11 | 1983-10-07 | Use of 3-indolepyruvic acid for increasing serotonin |
EP83830196A EP0106813B1 (en) | 1982-10-11 | 1983-10-07 | Pharmaceutical utilisation of 3-indolpyruvic acid |
JP58189782A JPS5995894A (ja) | 1982-10-11 | 1983-10-11 | 医薬組成物 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IT49251/82A IT1148618B (it) | 1982-10-11 | 1982-10-11 | Procedimento enzimatico per la produzione di acido 3-indolpiruvico e utilizzazione farmaceutica di questo |
Publications (2)
Publication Number | Publication Date |
---|---|
IT8249251A0 true IT8249251A0 (it) | 1982-10-11 |
IT1148618B IT1148618B (it) | 1986-12-03 |
Family
ID=11270097
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IT49251/82A IT1148618B (it) | 1982-10-11 | 1982-10-11 | Procedimento enzimatico per la produzione di acido 3-indolpiruvico e utilizzazione farmaceutica di questo |
Country Status (5)
Country | Link |
---|---|
US (1) | US4551471A (it) |
EP (1) | EP0106813B1 (it) |
JP (1) | JPS5995894A (it) |
DE (1) | DE3378742D1 (it) |
IT (1) | IT1148618B (it) |
Families Citing this family (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IT1184282B (it) * | 1985-06-28 | 1987-10-22 | Polifarma Spa | Procedimento per la produzione di alfa-chetoacidi indolici a partire da un rispettivo alfa-ammino-acido,particolarmente per produrre acido indolpiruvico |
US4639465A (en) * | 1985-08-30 | 1987-01-27 | Commonwealth Medical Corporation Of America | Method and composition for relieving pain |
US4650789A (en) * | 1985-10-15 | 1987-03-17 | Commonwealth Medical Corporation Of America | Method and composition for increasing production of serotonin |
DE3601398A1 (de) * | 1986-01-18 | 1987-07-23 | Fresenius Ag | Verwendung von oligopeptiden zur behandlung von cerebralen stoerungen |
IT1206078B (it) * | 1987-06-03 | 1989-04-14 | Polifarma Spa | Procedimento per la produzione di acido 3-indolpiruvico e suoi derivati loro uso farmaceutico |
US4831156A (en) * | 1987-09-30 | 1989-05-16 | The University Of Tennessee Research Corp. | 3-substituted 2-alkyl indole derivatives |
IT1224546B (it) * | 1988-09-29 | 1990-10-04 | Polifarma Spa | Utilizzatore farmaceutica di acido 3 -indolpiruvico come agente inibitore di patologie degenerative |
IT1232167B (it) * | 1989-08-08 | 1992-01-25 | Polifarma Spa | Uso cosmetico di acido 3-indolpiruvico |
IT218019Z2 (it) * | 1989-09-08 | 1992-03-05 | Enea | Dispositivo protettivo individuale, portatile ad isolamento totale conatmosfera controllata |
IT1237472B (it) * | 1989-10-04 | 1993-06-07 | Polifarma Spa | Derivati di acido 3-indolpiruvico, loro procedimento di produzione ed impiego terapeutico. |
IT1261165B (it) * | 1993-01-25 | 1996-05-09 | Polifarma Spa | Agente attivo per ridurre il livello ematico di glucocorticoidi e prevenire disturbi cerebrali da stress e senilita'. |
US5654325A (en) * | 1993-11-18 | 1997-08-05 | Eli Lilly And Company | Melatonin derivatives for use in treating sleep disorders |
ATE497013T1 (de) | 2001-12-27 | 2011-02-15 | Ajinomoto Kk | Verfahren zur herstellung von glutaminsäurederivaten |
US7297800B2 (en) | 2001-12-27 | 2007-11-20 | Ajinomoto Co., Inc. | Process of producing glutamate derivatives |
CN103525847A (zh) | 2002-08-26 | 2014-01-22 | 味之素株式会社 | 新型醛缩酶和取代α-酮酸的制备方法 |
KR100723826B1 (ko) | 2002-12-09 | 2007-06-04 | 아지노모토 가부시키가이샤 | 변이형 d-아미노트랜스퍼라제 및 이를 사용하는 광학활성글루탐산 유도체의 제조방법 |
US7180370B2 (en) * | 2004-09-01 | 2007-02-20 | Micron Technology, Inc. | CMOS amplifiers with frequency compensating capacitors |
CN102027117B (zh) | 2007-08-24 | 2012-11-07 | 味之素株式会社 | 新的氧化酶基因及使用该基因生产3-吲哚-丙酮酸的方法 |
JPWO2012050125A1 (ja) | 2010-10-14 | 2014-02-24 | 味の素株式会社 | モナティンの製造方法 |
WO2020012373A1 (en) * | 2018-07-10 | 2020-01-16 | Polindols S.R.L.S. | New drugs chronic invalidating pathologies and to slow aging, based on a new metabolic tryptophan route and production process thereof |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4296119A (en) * | 1978-04-24 | 1981-10-20 | Massachusetts Institute Of Technology | Process and composition for reducing blood pressure in animals |
-
1982
- 1982-10-11 IT IT49251/82A patent/IT1148618B/it active
-
1983
- 1983-10-07 DE DE8383830196T patent/DE3378742D1/de not_active Expired
- 1983-10-07 US US06/540,051 patent/US4551471A/en not_active Expired - Lifetime
- 1983-10-07 EP EP83830196A patent/EP0106813B1/en not_active Expired
- 1983-10-11 JP JP58189782A patent/JPS5995894A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
IT1148618B (it) | 1986-12-03 |
EP0106813A3 (en) | 1986-05-07 |
DE3378742D1 (de) | 1989-02-02 |
JPS5995894A (ja) | 1984-06-02 |
US4551471A (en) | 1985-11-05 |
EP0106813B1 (en) | 1988-12-28 |
EP0106813A2 (en) | 1984-04-25 |
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Legal Events
Date | Code | Title | Description |
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TA | Fee payment date (situation as of event date), data collected since 19931001 |
Effective date: 19971021 |