IT8249251A0 - Procedimento enzimatico per la produzione di acido 3-indolpiruvico e utilizzazione farmaceutica di questo - Google Patents

Procedimento enzimatico per la produzione di acido 3-indolpiruvico e utilizzazione farmaceutica di questo

Info

Publication number
IT8249251A0
IT8249251A0 IT8249251A IT4925182A IT8249251A0 IT 8249251 A0 IT8249251 A0 IT 8249251A0 IT 8249251 A IT8249251 A IT 8249251A IT 4925182 A IT4925182 A IT 4925182A IT 8249251 A0 IT8249251 A0 IT 8249251A0
Authority
IT
Italy
Prior art keywords
production
pharmaceutical use
enzymatic procedure
indolpyruvic acid
indolpyruvic
Prior art date
Application number
IT8249251A
Other languages
English (en)
Other versions
IT1148618B (it
Inventor
Mario Materazzi
Giovanna De Luca
Giovanni Di Stazio
Vincenzo Politi
Original Assignee
Polifarma Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Polifarma Spa filed Critical Polifarma Spa
Priority to IT49251/82A priority Critical patent/IT1148618B/it
Publication of IT8249251A0 publication Critical patent/IT8249251A0/it
Priority to DE8383830196T priority patent/DE3378742D1/de
Priority to US06/540,051 priority patent/US4551471A/en
Priority to EP83830196A priority patent/EP0106813B1/en
Priority to JP58189782A priority patent/JPS5995894A/ja
Application granted granted Critical
Publication of IT1148618B publication Critical patent/IT1148618B/it

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/10—Nitrogen as only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A61K31/405—Indole-alkanecarboxylic acids; Derivatives thereof, e.g. tryptophan, indomethacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/582—Recycling of unreacted starting or intermediate materials

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Epidemiology (AREA)
  • Psychiatry (AREA)
  • Microbiology (AREA)
  • Pain & Pain Management (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Anesthesiology (AREA)
  • Nutrition Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Indole Compounds (AREA)
IT49251/82A 1982-10-11 1982-10-11 Procedimento enzimatico per la produzione di acido 3-indolpiruvico e utilizzazione farmaceutica di questo IT1148618B (it)

Priority Applications (5)

Application Number Priority Date Filing Date Title
IT49251/82A IT1148618B (it) 1982-10-11 1982-10-11 Procedimento enzimatico per la produzione di acido 3-indolpiruvico e utilizzazione farmaceutica di questo
DE8383830196T DE3378742D1 (de) 1982-10-11 1983-10-07 Pharmaceutical utilisation of 3-indolpyruvic acid
US06/540,051 US4551471A (en) 1982-10-11 1983-10-07 Use of 3-indolepyruvic acid for increasing serotonin
EP83830196A EP0106813B1 (en) 1982-10-11 1983-10-07 Pharmaceutical utilisation of 3-indolpyruvic acid
JP58189782A JPS5995894A (ja) 1982-10-11 1983-10-11 医薬組成物

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT49251/82A IT1148618B (it) 1982-10-11 1982-10-11 Procedimento enzimatico per la produzione di acido 3-indolpiruvico e utilizzazione farmaceutica di questo

Publications (2)

Publication Number Publication Date
IT8249251A0 true IT8249251A0 (it) 1982-10-11
IT1148618B IT1148618B (it) 1986-12-03

Family

ID=11270097

Family Applications (1)

Application Number Title Priority Date Filing Date
IT49251/82A IT1148618B (it) 1982-10-11 1982-10-11 Procedimento enzimatico per la produzione di acido 3-indolpiruvico e utilizzazione farmaceutica di questo

Country Status (5)

Country Link
US (1) US4551471A (it)
EP (1) EP0106813B1 (it)
JP (1) JPS5995894A (it)
DE (1) DE3378742D1 (it)
IT (1) IT1148618B (it)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1184282B (it) * 1985-06-28 1987-10-22 Polifarma Spa Procedimento per la produzione di alfa-chetoacidi indolici a partire da un rispettivo alfa-ammino-acido,particolarmente per produrre acido indolpiruvico
US4639465A (en) * 1985-08-30 1987-01-27 Commonwealth Medical Corporation Of America Method and composition for relieving pain
US4650789A (en) * 1985-10-15 1987-03-17 Commonwealth Medical Corporation Of America Method and composition for increasing production of serotonin
DE3601398A1 (de) * 1986-01-18 1987-07-23 Fresenius Ag Verwendung von oligopeptiden zur behandlung von cerebralen stoerungen
IT1206078B (it) * 1987-06-03 1989-04-14 Polifarma Spa Procedimento per la produzione di acido 3-indolpiruvico e suoi derivati loro uso farmaceutico
US4831156A (en) * 1987-09-30 1989-05-16 The University Of Tennessee Research Corp. 3-substituted 2-alkyl indole derivatives
IT1224546B (it) * 1988-09-29 1990-10-04 Polifarma Spa Utilizzatore farmaceutica di acido 3 -indolpiruvico come agente inibitore di patologie degenerative
IT1232167B (it) * 1989-08-08 1992-01-25 Polifarma Spa Uso cosmetico di acido 3-indolpiruvico
IT218019Z2 (it) * 1989-09-08 1992-03-05 Enea Dispositivo protettivo individuale, portatile ad isolamento totale conatmosfera controllata
IT1237472B (it) * 1989-10-04 1993-06-07 Polifarma Spa Derivati di acido 3-indolpiruvico, loro procedimento di produzione ed impiego terapeutico.
IT1261165B (it) * 1993-01-25 1996-05-09 Polifarma Spa Agente attivo per ridurre il livello ematico di glucocorticoidi e prevenire disturbi cerebrali da stress e senilita'.
US5654325A (en) * 1993-11-18 1997-08-05 Eli Lilly And Company Melatonin derivatives for use in treating sleep disorders
ATE497013T1 (de) 2001-12-27 2011-02-15 Ajinomoto Kk Verfahren zur herstellung von glutaminsäurederivaten
US7297800B2 (en) 2001-12-27 2007-11-20 Ajinomoto Co., Inc. Process of producing glutamate derivatives
CN103525847A (zh) 2002-08-26 2014-01-22 味之素株式会社 新型醛缩酶和取代α-酮酸的制备方法
KR100723826B1 (ko) 2002-12-09 2007-06-04 아지노모토 가부시키가이샤 변이형 ｄ－아미노트랜스퍼라제 및 이를 사용하는 광학활성글루탐산 유도체의 제조방법
US7180370B2 (en) * 2004-09-01 2007-02-20 Micron Technology, Inc. CMOS amplifiers with frequency compensating capacitors
CN102027117B (zh) 2007-08-24 2012-11-07 味之素株式会社 新的氧化酶基因及使用该基因生产3-吲哚-丙酮酸的方法
JPWO2012050125A1 (ja) 2010-10-14 2014-02-24 味の素株式会社 モナティンの製造方法
WO2020012373A1 (en) * 2018-07-10 2020-01-16 Polindols S.R.L.S. New drugs chronic invalidating pathologies and to slow aging, based on a new metabolic tryptophan route and production process thereof

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4296119A (en) * 1978-04-24 1981-10-20 Massachusetts Institute Of Technology Process and composition for reducing blood pressure in animals

Also Published As

Publication number Publication date
IT1148618B (it) 1986-12-03
EP0106813A3 (en) 1986-05-07
DE3378742D1 (de) 1989-02-02
JPS5995894A (ja) 1984-06-02
US4551471A (en) 1985-11-05
EP0106813B1 (en) 1988-12-28
EP0106813A2 (en) 1984-04-25

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