ES8105315A1 - Un procedimiento para la preparacion de 5'-deoxi-5-fluo- rouridina - Google Patents

Un procedimiento para la preparacion de 5'-deoxi-5-fluo- rouridina

Info

Publication number
ES8105315A1
ES8105315A1 ES492456A ES492456A ES8105315A1 ES 8105315 A1 ES8105315 A1 ES 8105315A1 ES 492456 A ES492456 A ES 492456A ES 492456 A ES492456 A ES 492456A ES 8105315 A1 ES8105315 A1 ES 8105315A1
Authority
ES
Spain
Prior art keywords
deoxi
beta
procedure
fluorouracilo
ribofuranosil
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES492456A
Other languages
English (en)
Spanish (es)
Other versions
ES492456A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Publication of ES492456A0 publication Critical patent/ES492456A0/es
Publication of ES8105315A1 publication Critical patent/ES8105315A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/02—Acyclic radicals, not substituted by cyclic structures
    • C07H15/04—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Cephalosporin Compounds (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
ES492456A 1979-06-15 1980-06-14 Un procedimiento para la preparacion de 5'-deoxi-5-fluo- rouridina Expired ES8105315A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH562579 1979-06-15

Publications (2)

Publication Number Publication Date
ES492456A0 ES492456A0 (es) 1981-06-01
ES8105315A1 true ES8105315A1 (es) 1981-06-01

Family

ID=4296736

Family Applications (1)

Application Number Title Priority Date Filing Date
ES492456A Expired ES8105315A1 (es) 1979-06-15 1980-06-14 Un procedimiento para la preparacion de 5'-deoxi-5-fluo- rouridina

Country Status (15)

Country Link
US (1) US4340729A (enExample)
EP (1) EP0021231B1 (enExample)
JP (2) JPS565497A (enExample)
KR (1) KR830001842B1 (enExample)
AT (1) ATE4904T1 (enExample)
CA (1) CA1135258A (enExample)
DE (1) DE3065146D1 (enExample)
DK (1) DK148060C (enExample)
ES (1) ES8105315A1 (enExample)
FI (1) FI71566C (enExample)
GR (1) GR68760B (enExample)
HU (1) HU181712B (enExample)
NO (1) NO148109C (enExample)
PT (1) PT71382B (enExample)
YU (1) YU42664B (enExample)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU671491B2 (en) * 1992-12-18 1996-08-29 F. Hoffmann-La Roche Ag N-oxycarbonyl substituted 5'-deoxy-5-fluorcytidines
JPH10507763A (ja) * 1994-10-24 1998-07-28 ジェネンコア インターナショナル インコーポレーテッド Ｌ−ピラノシルヌクレオシド
US5559101A (en) * 1994-10-24 1996-09-24 Genencor International, Inc. L-ribofuranosyl nucleosides
IT1291983B1 (it) * 1997-05-23 1999-01-25 Pro Bio Sint Srl Prodcedimento per la preparazione di un derivato della desossiuridina
US6593467B2 (en) 1997-05-23 2003-07-15 Clariant Finance (Bvi) Limited Process for the preparation of a deoxyuridine derivative
JPH1192386A (ja) * 1997-09-17 1999-04-06 Nikken Chem Co Ltd ５−フルオロウリジン誘導体を有効成分とする抗癌剤
ITMI20032059A1 (it) * 2003-10-22 2005-04-23 Clariant Lsm Italia Spa Processo per la preparazione di doxifluridina.
KR100908363B1 (ko) 2007-02-28 2009-07-20 한미약품 주식회사 트라이-Ｏ-아세틸-5-데옥시-β-Ｄ-라이보퓨라노즈의입체선택적 제조방법 및 이의 분리방법
US20100298550A1 (en) * 2007-10-05 2010-11-25 Api Corporation Process for production of ribofuranose derivatives
KR101013312B1 (ko) 2007-11-19 2011-02-09 한미홀딩스 주식회사 카페시타빈의 제조방법 및 이에 사용되는 β-아노머가강화된 트리알킬카보네이트 화합물의 제조방법
AR064165A1 (es) 2007-12-06 2009-03-18 Richmond Sa Com Ind Y Financie Un procedimiento para la preparacion de capecitabina e intermediarios utilizables en dicho procedimiento
EP2210895A1 (en) * 2009-01-27 2010-07-28 F. Hoffmann-La Roche AG Process for the recovery of beta-Acetylfuranoside
CN102260298B (zh) * 2010-05-24 2014-04-09 重庆福安药业(集团)股份有限公司 一种合成1，2，3-O-三乙酰基-5-脱氧-β-D-核糖的方法
CN103772450A (zh) * 2012-10-18 2014-05-07 黑龙江福和华星制药集团股份有限公司 一种1,2,3-三乙酰基-5-脱氧-d-核糖的制法
CN102993254A (zh) * 2012-12-28 2013-03-27 山东铂源药业有限公司 卡培他滨的中间体5′-脱氧-2′,3′-o-异亚丙基-5-氟胞苷的制备方法
CN103232498A (zh) * 2013-05-08 2013-08-07 浙江新三和医药化工股份有限公司 1-甲基-2,3-0-异亚丙基-5-脱氧-d-呋喃核糖的制备方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1812268U (de) 1959-07-03 1960-06-02 Telefunken Gmbh Faraday-isolator.
FR1489919A (fr) 1965-07-22 1967-07-28 Hoffmann La Roche Procédé pour la préparation de nucléosides
DE1812268A1 (de) * 1968-12-03 1970-06-25 Technochemie Gmbh Verfahren zur Herstellung von isomerenfreien hoehermolekularen,sekundaeren Alkylbromiden
JPS52153977A (en) * 1976-06-11 1977-12-21 Daikin Ind Ltd Synthesis of 5-fluorouracil and its derivatives
US4071680A (en) * 1976-12-20 1978-01-31 Hoffmann-La Roche Inc. 5'-Deoxy-5-fluoropyrimidine nucleosides

Also Published As

Publication number Publication date
EP0021231A3 (en) 1981-04-01
US4340729A (en) 1982-07-20
DK256380A (da) 1980-12-16
ES492456A0 (es) 1981-06-01
JPS59144798A (ja) 1984-08-18
DK148060B (da) 1985-02-18
FI71566B (fi) 1986-10-10
JPS6140239B2 (enExample) 1986-09-08
DK148060C (da) 1985-09-16
EP0021231A2 (de) 1981-01-07
HU181712B (en) 1983-11-28
PT71382B (en) 1981-10-21
FI801450A7 (fi) 1980-12-16
NO148109B (no) 1983-05-02
YU42664B (en) 1988-10-31
CA1135258A (en) 1982-11-09
KR830002803A (ko) 1983-05-30
PT71382A (en) 1980-07-01
FI71566C (fi) 1987-01-19
KR830001842B1 (ko) 1983-09-14
JPS632960B2 (enExample) 1988-01-21
EP0021231B1 (de) 1983-10-05
GR68760B (enExample) 1982-02-17
JPS565497A (en) 1981-01-20
NO148109C (no) 1983-08-10
YU97280A (en) 1983-02-28
DE3065146D1 (en) 1983-11-10
ATE4904T1 (de) 1983-10-15
NO801777L (no) 1980-12-16

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