GB948769A - New alkaloids of the funtumia species and processes for obtaining same - Google Patents

New alkaloids of the funtumia species and processes for obtaining same

Info

Publication number
GB948769A
GB948769A GB5360/60A GB536060A GB948769A GB 948769 A GB948769 A GB 948769A GB 5360/60 A GB5360/60 A GB 5360/60A GB 536060 A GB536060 A GB 536060A GB 948769 A GB948769 A GB 948769A
Authority
GB
United Kingdom
Prior art keywords
funtuphyllamine
alkaloids
funtumia
species
processes
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB5360/60A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
OLETTA SA
Original Assignee
OLETTA SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DES60064A external-priority patent/DE1185183B/en
Application filed by OLETTA SA filed Critical OLETTA SA
Publication of GB948769A publication Critical patent/GB948769A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/24—Apocynaceae (Dogbane family), e.g. plumeria or periwinkle
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07G—COMPOUNDS OF UNKNOWN CONSTITUTION
    • C07G5/00—Alkaloids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0005—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring the nitrogen atom being directly linked to the cyclopenta(a)hydro phenanthrene skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J7/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J75/00—Processes for the preparation of steroids in general

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Biotechnology (AREA)
  • Botany (AREA)
  • Medical Informatics (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Steroid Compounds (AREA)

Abstract

The invention comprises funtuphyllamine, having the formula: <FORM:0948769/C2/1> together with a process for the isolation of compounds of the general formula: <FORM:0948769/C2/2> (wherein R represents a ketonic or b -hydroxylic group, and R1 an -NH2, -NHCH3 or -N(CH3)2 group) which includes the alkaloids dimethyl funtumafrine, methyl funtumafrine, dimethyl funtuphyllamine, methyl funtuphyllamine and funtuphyllamine, from the ground parts of plants of the genus Funtumia (Apocynaceae), species F. Africana, comprising the steps of (1) subjecting the said parts to solvent extraction, (2) agitating the resulting solution with acid, (3) separating the acid solution and (4) rendering it alkaline, (5) extracting the alkaloid bases with ether, benzene, chloroform, ethanol, or methanol and (6) separating the individual alkaloids thus obtained by chromatography. The invention is illustrated by 3 detailed examples. The alkaloids are of therapeutic interest as hypotensors and anti-inflammatory agents. Specification 900,572 is referred to.
GB5360/60A 1957-09-27 1960-02-15 New alkaloids of the funtumia species and processes for obtaining same Expired GB948769A (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
BE443246 1957-09-27
BE561173T 1957-09-27
LU35817 1958-02-22
LU36147 1958-06-04
DES60064A DE1185183B (en) 1957-09-27 1958-09-27 Process for the extraction and production of cardiac or hormonally active compounds

Publications (1)

Publication Number Publication Date
GB948769A true GB948769A (en) 1964-02-05

Family

ID=27507596

Family Applications (2)

Application Number Title Priority Date Filing Date
GB30862/58A Expired GB900572A (en) 1957-09-27 1958-09-26 Funtumia alkaloids
GB5360/60A Expired GB948769A (en) 1957-09-27 1960-02-15 New alkaloids of the funtumia species and processes for obtaining same

Family Applications Before (1)

Application Number Title Priority Date Filing Date
GB30862/58A Expired GB900572A (en) 1957-09-27 1958-09-26 Funtumia alkaloids

Country Status (6)

Country Link
BE (1) BE561173A (en)
CH (3) CH370773A (en)
GB (2) GB900572A (en)
LU (2) LU36147A1 (en)
NL (1) NL231702A (en)
OA (1) OA01015A (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2494697A1 (en) * 1980-11-21 1982-05-28 Roussel Uclaf NOVEL 3-AMINO-STEROID DERIVATIVES, THEIR SALTS, PROCESS AND PREPARATION INTERMEDIATES, MEDICAMENT APPLICATION AND COMPOSITIONS COMPRISING THE SAME
FR2494696A1 (en) * 1980-11-21 1982-05-28 Roussel Uclaf NOVEL PROCESS FOR THE PREPARATION OF 3-AMINO STEROIDS AND THEIR SALTS
EP2556055B1 (en) 2010-04-09 2019-07-31 The Research Foundation of the State University of New York Ship inhibitors and uses thereof
AU2015280433B2 (en) 2014-06-17 2020-10-08 The Research Foundation For The State University Of New York Ship inhibition to induce expression of granulocyte colony stimulating factor in a subject

Also Published As

Publication number Publication date
CH369756A (en) 1963-06-15
NL231702A (en)
LU36147A1 (en)
OA01015A (en) 1968-08-07
BE561173A (en) 1960-05-20
GB900572A (en) 1962-07-11
CH370773A (en) 1963-07-31
CH405305A (en) 1966-01-15
LU35817A1 (en)

Similar Documents

Publication Publication Date Title
US2813873A (en) Derivatives of the ibogaine alkaloids
Rosen et al. Rauwolfia alkaloids. XLI. Methyl neoreserpate, an isomer of methyl reserpate. Part 3. Conformations and NMR spectra
Heftmann et al. Degradation of tomatine to 3β-hydroxy-5α-pregn-16-en-20-one by ripe tomatoes
Bennett Acidic limonoids of grapefruit seeds
GB948769A (en) New alkaloids of the funtumia species and processes for obtaining same
McLean et al. The constituents of Nauclea diderrichii. Part II. isolation and classification of constituents; simple β-carboline and pyridine alkaloids
Morris et al. The isolation of the toxic principles of mamey
Cantwell et al. An investigation of the Hammick reaction
Bick et al. Methyl (p-hydroxybenzoyl) acetate and an alkaloid, bellendine, from Bellendena montana
Corral et al. New Balfourodendron 4-quinolone alkaloids
US2248241A (en) Method of preparing alkaloids from koto-tsuzurafuji
Cava et al. The alkaloids of Chondodendron toxicoferum
ES280760A1 (en) L-threo-1, 3-dioxolane
Chan The stereochemistry of pteropodine and isopteropodine
GB865687A (en) New alkaloid, voacamidine from voacanga africana and a process for its isolation
Anderson et al. Nonpolar pentacyclic triterpenes of the medicinal fern Polypodium subpetiolatum
US3131192A (en) Ckjo-i
GB948485A (en) New alkaloids and other new compounds from holarrhena species and processes for obtaining the same
Rao et al. Isolation of 3, 4, 3', 5'-tetrahydroxystilbene (piceatannol) from Cassia marginata heartwood
Aplin et al. The isolation of cycloartenol and 24-methylenecycloartanol from false kola nuts (Garcinia kola Heckel)
NO123928B (en)
AT261109B (en) Process for the production of therapeutically active compounds from Valerianaceae
US2145907A (en) Therapeutically active principle from ergot and processes for its production
Simes 557. The constituents of the wood of Castanospermum australe cunn. et fras. Part I. The isolation of a new sapogenin, castanogenin
SU82167A1 (en) Method for preparing phytosterols