ES8403889A1 - Un metodo para preparar un compuesto de 1,4-dihidropiridina. - Google Patents

Un metodo para preparar un compuesto de 1,4-dihidropiridina.

Info

Publication number
ES8403889A1
ES8403889A1 ES519990A ES519990A ES8403889A1 ES 8403889 A1 ES8403889 A1 ES 8403889A1 ES 519990 A ES519990 A ES 519990A ES 519990 A ES519990 A ES 519990A ES 8403889 A1 ES8403889 A1 ES 8403889A1
Authority
ES
Spain
Prior art keywords
preparation
dihydropyridine compound
compound
dihydropyridine
ethyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES519990A
Other languages
English (en)
Other versions
ES519990A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
INST ORGANICHESKOGO SINTEZA AK
Nikken Chemicals Co Ltd
Original Assignee
INST ORGANICHESKOGO SINTEZA AK
Nikken Chemicals Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by INST ORGANICHESKOGO SINTEZA AK, Nikken Chemicals Co Ltd filed Critical INST ORGANICHESKOGO SINTEZA AK
Publication of ES519990A0 publication Critical patent/ES519990A0/es
Publication of ES8403889A1 publication Critical patent/ES8403889A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE COMPUESTOS DE 1,4-DIHIDROPIRIDINA, DE FORMULA (I), EN LA QUE R Y RK SON METILO, ETILO O PROPILO.CONSISTE EN LA REACCION DE 2-FORMIL-P-DIOXENO, UN ESTER DE ALCOHILO INFERIOR DEL ACIDO ACETOACETICO, DE FORMULA (II), Y UN ESTER DE ALCOHILO INFERIOR DEL ACIDO BAMINOCROTONICO DE FORMULA (III), EN LAS QUE R Y RK TIENEN EL MISMO SIGNIFICADO QUE EN LA FORMULA (I). LA REACCION SE LLEVA A CABO A UNA TEMPERATURA COMPRENDIDA ENTRE 50JC Y 200JC.ESTOS COMPUESTOS TIENEN APLICACIONES FARMACOLOGICAS PARA EL TRATAMIENTO DE ENFERMEDADES HEPATICAS.
ES519990A 1982-02-23 1983-02-22 Un metodo para preparar un compuesto de 1,4-dihidropiridina. Expired ES8403889A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP57026790A JPS58159490A (ja) 1982-02-23 1982-02-23 １，４−ジヒドロピリジン化合物

Publications (2)

Publication Number Publication Date
ES519990A0 ES519990A0 (es) 1984-04-01
ES8403889A1 true ES8403889A1 (es) 1984-04-01

Family

ID=12203104

Family Applications (1)

Application Number Title Priority Date Filing Date
ES519990A Expired ES8403889A1 (es) 1982-02-23 1983-02-22 Un metodo para preparar un compuesto de 1,4-dihidropiridina.

Country Status (5)

Country Link
US (1) US4495356A (es)
EP (1) EP0087156B1 (es)
JP (1) JPS58159490A (es)
DE (1) DE3361093D1 (es)
ES (1) ES8403889A1 (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES8601891A1 (es) * 1983-03-04 1985-11-01 Nikken Chemicals Co Ltd Un metodo para preparar compuestos de 1, 4-dihidropiridina
DE3577184D1 (de) * 1984-01-13 1990-05-23 Yamanouchi Pharma Co Ltd Arzneimittel fuer die behandlung und verhuetung von leberschaedigungen.
US4833150A (en) * 1985-03-14 1989-05-23 Nelson Research & Development Co. 1,4-dihydropyridines
US4849436A (en) * 1986-03-11 1989-07-18 Nelson Research & Development Co. 1,4-dihydropyridines
DE68909873T2 (de) * 1988-07-28 1994-02-10 Nikken Chemicals Co Ltd 1,4-Dihydropyridin-Derivate.
GB9119983D0 (en) * 1991-09-19 1991-11-06 Erba Carlo Spa Dihydropyridine derivatives useful in antitumor therapy

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3511847A (en) * 1967-02-07 1970-05-12 Smithkline Corp 2,6-di-lower alkyl - 1,4-dihydro - 4-(2-trifluoromethylphenyl) - 3,5 - pyridinedicarboxylic acid esters
DE1670827C3 (de) * 1967-03-20 1974-10-24 Bayer Ag, 5090 Leverkusen 4-(2'-Nitrophenyl)-2,6-dimethyl-3,5-dicarbmethoxy-1,4-dihydropyridin
DE1813436C3 (de) * 1968-12-07 1979-01-11 Bayer Ag, 5090 Leverkusen N-Substituierte 2,6-Dimethyl-l,4dihydropyridine
DE1923990C3 (de) * 1969-05-10 1978-11-23 Bayer Ag Verfahren zur Herstellung von N-substituierten M-Dihydropyridin-S.S-dicarbonsäureestern
DE2117571C3 (de) * 1971-04-10 1979-10-11 Bayer Ag, 5090 Leverkusen Unsymmetrische 1,4-Dihydropyridin-33-dicarbonsäureester, Verfahren zu ihrer Herstellung sowie ihre Verwendung als Arzneimittel
DE2117573C3 (de) * 1971-04-10 1978-07-27 Bayer Ag, 5090 Leverkusen Verfahren zur Herstellung von unsymmetrischen l,4-Dihydropyridin-3,5dicarbonsäureestern, sowie ihre Verwendung als Arzneimittel
DE2218644C3 (de) * 1972-04-18 1982-08-19 Bayer Ag, 5090 Leverkusen Basische Ester von 1,4-Dihydropyridinen, Verfahren zu ihrer Herstellung sowie ihre Verwendung als Arzneimittel
GB1426499A (en) * 1973-10-02 1976-02-25 I Organischeskogo Sinteza Akad Pharmaceutical composition for treating liver diseases
DE3022030A1 (de) * 1980-06-12 1981-12-17 Bayer Ag, 5090 Leverkusen 4-thiazol- bzw. 4-imidazol-substituierte, 1,4-dihydropyridine, verfahren zu deren herstellung sowie diese enthaltende arzneimittel

Also Published As

Publication number Publication date
ES519990A0 (es) 1984-04-01
JPH0129794B2 (es) 1989-06-14
JPS58159490A (ja) 1983-09-21
EP0087156B1 (en) 1985-10-30
DE3361093D1 (en) 1985-12-05
EP0087156A1 (en) 1983-08-31
US4495356A (en) 1985-01-22

Similar Documents

Publication Publication Date Title
AU576474B2 (en) N-pyridylsuphonyl - n'- pyrimidinyl and - n'-triazinylureas
AU7477387A (en) Synergist for biocide
WO1991018866A3 (en) 1,4-diamino-2,3-dihydroxybutanes
AU5942090A (en) Improved bipyridilium herbicidal compositions
AU6800887A (en) Fungicidal compositions
ES8403889A1 (es) Un metodo para preparar un compuesto de 1,4-dihidropiridina.
AU554803B2 (en) Concentrated emulsion composition
AU7779391A (en) Flame-proofing compositions
AU546935B2 (en) 5-hydroxydecanoic acid compositions
AU7420191A (en) Insecticidal compositions
AU6991891A (en) Herbicidal compositions
AU4447885A (en) Combustion inhibiting composition
AU7928191A (en) Compositions
AU3088984A (en) Antibodies and compositions thereof for inhibiting dental induced by s. abitans
IE831840L (en) Cardiotonic agents
IE832291L (en) 3-aminopropoxyphenyl derivatives.
AU573230B2 (en) (amino alkyl) amino, -9, 10,-anthracenediones
AU8596391A (en) Synergistic herbicidal compositions
AU5727586A (en) Herbicidal compositions
TW344650B (en) Fungicidal compositions and the process for the preparation thereof
IE830282L (en) Ergot alkaloids
AU570478B2 (en) Fungicidal compositions
AU6780287A (en) Herbicidal composition
AU1589683A (en) Fuel compositions
GB9117961D0 (en) Herbicidal compositions