ES2998534T3 - Phenyl carbamate compounds for use in preventing or treating pediatric epilesy - Google Patents

Phenyl carbamate compounds for use in preventing or treating pediatric epilesy Download PDF

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Publication number
ES2998534T3
ES2998534T3 ES14762362T ES14762362T ES2998534T3 ES 2998534 T3 ES2998534 T3 ES 2998534T3 ES 14762362 T ES14762362 T ES 14762362T ES 14762362 T ES14762362 T ES 14762362T ES 2998534 T3 ES2998534 T3 ES 2998534T3
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ES
Spain
Prior art keywords
chlorophenyl
hydroxypropyl
carbamate
preparation example
epilepsy
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Application number
ES14762362T
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English (en)
Spanish (es)
Inventor
Yong Moon Choi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bio Pharm Solutions Co Ltd
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Bio Pharm Solutions Co Ltd
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Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/325Carbamic acids; Thiocarbamic acids; Anhydrides or salts thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/16Amides, e.g. hydroxamic acids
    • A61K31/165Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/166Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the carbon of a carboxamide group directly attached to the aromatic ring, e.g. procainamide, procarbazine, metoclopramide, labetalol
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/02Halogenated hydrocarbons
    • A61K31/025Halogenated hydrocarbons carbocyclic
    • A61K31/03Halogenated hydrocarbons carbocyclic aromatic
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/045Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/045Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A61K31/047Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates having two or more hydroxy groups, e.g. sorbitol
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/045Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A61K31/05Phenols
    • A61K31/055Phenols the aromatic ring being substituted by halogen
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/13Amines
    • A61K31/135Amines having aromatic rings, e.g. ketamine, nortriptyline
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/21Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/27Esters, e.g. nitroglycerine, selenocyanates of carbamic or thiocarbamic acids, meprobamate, carbachol, neostigmine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00Drugs for disorders of the muscular or neuromuscular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02Muscle relaxants, e.g. for tetanus or cramps
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/08Antiepileptics; Anticonvulsants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/08Antiepileptics; Anticonvulsants
    • A61P25/10Antiepileptics; Anticonvulsants for petit-mal
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/08Antiepileptics; Anticonvulsants
    • A61P25/12Antiepileptics; Anticonvulsants for grand-mal
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16Anti-Parkinson drugs
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06Esters of carbamic acids
    • C07C271/08Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/10Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C271/12Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06Esters of carbamic acids
    • C07C271/08Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/24Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atom of at least one of the carbamate groups bound to a carbon atom of a ring other than a six-membered aromatic ring
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00Systems containing only non-condensed rings
    • C07C2601/02Systems containing only non-condensed rings with a three-membered ring
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00Systems containing only non-condensed rings
    • C07C2601/12Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14The ring being saturated
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00Systems containing only non-condensed rings
    • C07C2601/12Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/16Systems containing only non-condensed rings with a six-membered ring the ring being unsaturated
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00Systems containing two condensed rings
    • C07C2602/36Systems containing two condensed rings the rings having more than two atoms in common
    • C07C2602/42Systems containing two condensed rings the rings having more than two atoms in common the bicyclo ring system containing seven carbon atoms

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Emergency Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Psychology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
ES14762362T 2013-03-12 2014-03-07 Phenyl carbamate compounds for use in preventing or treating pediatric epilesy Active ES2998534T3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361776926P 2013-03-12 2013-03-12
PCT/KR2014/001903 WO2014142477A1 (en) 2013-03-12 2014-03-07 Phenyl carbamate compounds for use in preventing or treating pediatric epilesy and epilesy-related syndromes

Publications (1)

Publication Number Publication Date
ES2998534T3 true ES2998534T3 (en) 2025-02-20

Family

ID=51530016

Family Applications (3)

Application Number Title Priority Date Filing Date
ES14762362T Active ES2998534T3 (en) 2013-03-12 2014-03-07 Phenyl carbamate compounds for use in preventing or treating pediatric epilesy
ES14764907T Active ES3046835T3 (en) 2013-03-12 2014-03-11 Phenyl carbamate compounds for use in preventing or treating epilepsy or epilepsy-related syndrome
ES14764227T Active ES2881850T3 (es) 2013-03-12 2014-03-11 Compuestos de carmato de fenil alquilo para su uso en la prevención o tratamiento de la epilepsia o síndrome relacionado con la epilepsia

Family Applications After (2)

Application Number Title Priority Date Filing Date
ES14764907T Active ES3046835T3 (en) 2013-03-12 2014-03-11 Phenyl carbamate compounds for use in preventing or treating epilepsy or epilepsy-related syndrome
ES14764227T Active ES2881850T3 (es) 2013-03-12 2014-03-11 Compuestos de carmato de fenil alquilo para su uso en la prevención o tratamiento de la epilepsia o síndrome relacionado con la epilepsia

Country Status (7)

Country Link
US (5) US9504668B2 (enExample)
EP (4) EP2968210B1 (enExample)
JP (5) JP6062077B2 (enExample)
KR (5) KR101717872B1 (enExample)
CN (6) CN109939092B (enExample)
ES (3) ES2998534T3 (enExample)
WO (4) WO2014142477A1 (enExample)

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CN109939092B (zh) * 2013-03-12 2022-03-22 比皮艾思药物研发有限公司 用于预防或治疗小儿癫痫和癫痫相关综合征的苯基氨基甲酸酯化合物
CN110478343A (zh) 2013-03-12 2019-11-22 比皮艾思药物研发有限公司 氨基甲酸苯酯化合物和包含该化合物的用于预防或治疗神经性毒气引起的疾病的组合物
WO2017150903A1 (en) * 2016-02-29 2017-09-08 Bio-Pharm Solutions Co., Ltd. Sulfamate derivative compounds, processes for preparing them and their uses
KR102635941B1 (ko) * 2016-12-14 2024-02-13 에스케이바이오팜 주식회사 진전 또는 진전 증후군의 예방, 경감 또는 치료를 위한 카바메이트 화합물의 용도
CN109920550A (zh) * 2018-12-25 2019-06-21 天津大学 一种基于dMRI研究青少年肌阵挛性癫痫的方法
CA3191072A1 (en) 2020-08-31 2022-03-03 Bio-Pharm Solutions Co., Ltd. Phenyl alkyl carbamate compounds for use in preventing or treating neurodegenerative disease
CN116234798A (zh) 2020-09-10 2023-06-06 生物药品解决方案有限公司 用于治疗或缓解精神疾病的氨基磺酸酯衍生物化合物
US12054449B2 (en) 2021-08-05 2024-08-06 Bio-Pharm Solutions Co., Ltd. Phenylcarbamate crystalline form and method for manufacturing the same
CN119552104B (zh) * 2024-12-03 2025-07-15 西安瑞谱源生物技术有限公司 一种氘代维生素a的制备方法

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CN110478343A (zh) 2013-03-12 2019-11-22 比皮艾思药物研发有限公司 氨基甲酸苯酯化合物和包含该化合物的用于预防或治疗神经性毒气引起的疾病的组合物

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Publication number Publication date
JP6062078B2 (ja) 2017-01-18
EP2968210B1 (en) 2024-09-11
EP2968212B1 (en) 2025-09-10
JP2016512232A (ja) 2016-04-25
US20160024000A1 (en) 2016-01-28
KR20150119955A (ko) 2015-10-26
KR20150120520A (ko) 2015-10-27
CN111419830A (zh) 2020-07-17
CN109939092A (zh) 2019-06-28
CN105188690A (zh) 2015-12-23
KR20170060168A (ko) 2017-05-31
KR101717873B1 (ko) 2017-03-17
US9956197B2 (en) 2018-05-01
US9872847B2 (en) 2018-01-23
US20160030382A1 (en) 2016-02-04
KR101992035B1 (ko) 2019-06-21
EP2968213A4 (en) 2016-12-21
CN111419830B (zh) 2024-01-30
WO2014142477A1 (en) 2014-09-18
KR101739676B1 (ko) 2017-05-24
EP2968213A1 (en) 2016-01-20
KR20150120518A (ko) 2015-10-27
US20140275243A1 (en) 2014-09-18
WO2014142518A1 (en) 2014-09-18
JP2016512233A (ja) 2016-04-25
CN105188690B (zh) 2020-06-12
EP2968212A1 (en) 2016-01-20
JP6215971B2 (ja) 2017-10-18
JP6062077B2 (ja) 2017-01-18
CN109939092B (zh) 2022-03-22
JP2016510811A (ja) 2016-04-11
KR101717872B1 (ko) 2017-03-17
JP6200526B2 (ja) 2017-09-20
CN105188689A (zh) 2015-12-23
JP2017206546A (ja) 2017-11-24
US20160023999A1 (en) 2016-01-28
KR20150122211A (ko) 2015-10-30
EP2968212A4 (en) 2017-01-11
WO2014142520A1 (en) 2014-09-18
CN105228604A (zh) 2016-01-06
EP2968210A4 (en) 2016-12-28
EP2968211B1 (en) 2021-05-12
EP2968210A1 (en) 2016-01-20
EP2968211A4 (en) 2017-01-04
US9682059B2 (en) 2017-06-20
ES3046835T3 (en) 2025-12-02
ES2881850T3 (es) 2021-11-30
US9504668B2 (en) 2016-11-29
CN105209027A (zh) 2015-12-30
US20160296493A1 (en) 2016-10-13
EP2968211A1 (en) 2016-01-20
JP2016510812A (ja) 2016-04-11
WO2014142519A1 (en) 2014-09-18
CN105188689B (zh) 2020-04-10

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