RS51269B - Upotreba 2-fenil-1,2-etandiol-(di)karbamata za tretiranje epileptogeneze - Google Patents
Upotreba 2-fenil-1,2-etandiol-(di)karbamata za tretiranje epileptogenezeInfo
- Publication number
- RS51269B RS51269B RSP-2010/0264A RSP20100264A RS51269B RS 51269 B RS51269 B RS 51269B RS P20100264 A RSP20100264 A RS P20100264A RS 51269 B RS51269 B RS 51269B
- Authority
- RS
- Serbia
- Prior art keywords
- phenyl
- group
- alkyl
- ethanediol
- carbamates
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/27—Esters, e.g. nitroglycerine, selenocyanates of carbamic or thiocarbamic acids, meprobamate, carbachol, neostigmine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/325—Carbamic acids; Thiocarbamic acids; Anhydrides or salts thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
Landscapes
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Emergency Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurosurgery (AREA)
- Engineering & Computer Science (AREA)
- Neurology (AREA)
- Pain & Pain Management (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Jedinjenje, ili njegova farmaceutski prihvatljiva so ili njegov estar, biraju se iz grupe koju čine Formula (I) i Formula (II):pri čemu,fenil je supstituisan u položaju X sa jednim do pet atoma halogena, koji se biraju iz grupe koju čine fluor, hlor, brom i jod; aR1, R2, R3, R4, R5 i R6 se nezavisno biraju iz grupe koju čine vodonik i C1-C4 alkil; pri čemu je C1-C4 alkil opciono supstituisan sa fenil (pri čemu je fenil opciono supstituisan sa supstituentima koji se nezavisno biraju iz grupe koju čine halogen, C1-C4 alkil, C1-C4 alkoksi, amino, nitro i cijano),koje se upotrebljava za tretiranje, prevenciju, uzvraćanje, zaustavljanje ili inhibiciju epileptogeneze kod nekog humanog subjekta koji je pod rizikom razvoja epilepsije ili nekog poremećaja povezanog sa napadima, ali nema epilepsiju ili kliničke znake napada.Prijava sadrži još 39 zavisnih patentnih zahteva.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US61027604P | 2004-09-16 | 2004-09-16 | |
US69862505P | 2005-07-12 | 2005-07-12 | |
US70724205P | 2005-08-11 | 2005-08-11 | |
PCT/US2005/032861 WO2006033947A2 (en) | 2004-09-16 | 2005-09-15 | Use of 2-phenyl-1, 2-ethanediol- (di) carbamates for treating epileptogenesis and epilepsy |
Publications (1)
Publication Number | Publication Date |
---|---|
RS51269B true RS51269B (sr) | 2010-12-31 |
Family
ID=36087909
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
RSP-2010/0264A RS51269B (sr) | 2004-09-16 | 2005-09-15 | Upotreba 2-fenil-1,2-etandiol-(di)karbamata za tretiranje epileptogeneze |
Country Status (23)
Country | Link |
---|---|
US (2) | US20060194873A1 (sr) |
JP (1) | JP2008513466A (sr) |
KR (1) | KR20070057939A (sr) |
CN (1) | CN101056629B (sr) |
AT (1) | ATE464044T1 (sr) |
AU (1) | AU2005287174B2 (sr) |
BR (1) | BRPI0515374A (sr) |
CA (1) | CA2580640A1 (sr) |
CO (1) | CO6382111A2 (sr) |
CR (1) | CR9053A (sr) |
DE (1) | DE602005020667D1 (sr) |
DK (1) | DK1809273T3 (sr) |
EA (1) | EA200700642A1 (sr) |
ES (1) | ES2342185T3 (sr) |
HK (1) | HK1105583A1 (sr) |
HR (1) | HRP20100304T1 (sr) |
IL (1) | IL181910A0 (sr) |
MX (1) | MX2007003278A (sr) |
NO (1) | NO20071921L (sr) |
NZ (1) | NZ553813A (sr) |
PT (1) | PT1809273E (sr) |
RS (1) | RS51269B (sr) |
WO (1) | WO2006033947A2 (sr) |
Families Citing this family (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NZ517407A (en) * | 1999-08-10 | 2003-10-31 | Uab Research Foundation | Use of GABA agonists for treatment of spastic disorders, convulsions, and epilepsy |
CA2584854A1 (en) * | 2004-10-15 | 2006-04-27 | Janssen Pharmaceutica N.V. | Carbamate compounds for use in treating neurodegenerative disorders |
PE20070325A1 (es) * | 2005-06-29 | 2007-05-12 | Alza Corp | Formas de dosificacion oral que comprenden compuestos derivados de carbamato |
US20070021500A1 (en) * | 2005-07-12 | 2007-01-25 | Twyman Roy E | Methods for neuroprotection |
US20070043120A1 (en) * | 2005-08-18 | 2007-02-22 | Bettina Beyreuther | Therapeutic combination for painful medical conditions |
TWI397417B (zh) | 2006-06-15 | 2013-06-01 | Ucb Pharma Gmbh | 具有協同抗驚厥功效之醫藥組成物 |
WO2008045391A2 (en) * | 2006-10-06 | 2008-04-17 | Janssen Pharmaceutica Nv | Novel crystal of (s)-(+)-2-(2-chlorophenyl)-2-hydroxy-ethyl carbamate |
CA2667909A1 (en) * | 2006-10-31 | 2008-05-08 | Janssen Pharmaceutica N.V. | Treatment of pervasive developmental disorders |
US9018253B2 (en) | 2010-07-02 | 2015-04-28 | Bio-Pharm Solutions Co., Ltd. | Phenylcarbamate compound and muscle relaxant containing the same |
US8609849B1 (en) | 2010-11-30 | 2013-12-17 | Fox Chase Chemical Diversity Center, Inc. | Hydroxylated sulfamides exhibiting neuroprotective action and their method of use |
WO2013100566A1 (en) * | 2011-12-27 | 2013-07-04 | Bio-Pharm Solutions Co., Ltd. | Phenyl alkyl carbamate derivative compound and pharmaceutical composition containing the same |
JP6062077B2 (ja) * | 2013-03-12 | 2017-01-18 | バイオ−ファーム ソリューションズ カンパニー リミテッド | 小児てんかん及びてんかん関連症侯群の予防又は治療用フェニルカルバメート化合物{phenylcarbamatecompoundsforuseinpreventingortreatingpediatricepilesyandepilesy−relatedsyndromes} |
JP6200527B2 (ja) * | 2013-03-12 | 2017-09-20 | バイオ−ファーム ソリューションズ カンパニー リミテッド | 神経保護用フェニルカルバメート化合物及びこれを含む組成物 |
JP6807941B2 (ja) * | 2016-02-29 | 2021-01-06 | バイオ−ファーム ソリューションズ カンパニー リミテッド | スルファメート誘導体化合物、その製造方法および用途 |
CN106053510A (zh) * | 2016-05-16 | 2016-10-26 | 山东省分析测试中心 | 一种基于氢核磁共振快速测定普瑞巴林原料药纯度的方法 |
KR102421006B1 (ko) * | 2016-05-19 | 2022-07-14 | 에스케이바이오팜 주식회사 | 두통의 예방학적 치료를 위한 카바메이트 화합물의 용도 |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3313692A (en) * | 1958-04-21 | 1967-04-11 | Armour Pharma | Method of inducing calming and muscle relaxation with carbamates |
US3265728A (en) * | 1962-07-18 | 1966-08-09 | Armour Pharma | Substituted phenethyl carbamates |
US20010034365A1 (en) * | 1996-01-16 | 2001-10-25 | Choi Yong Moon | Halogen substituted carbamate compounds from 2-phenyl-1,2-ethanediol |
US5698588A (en) * | 1996-01-16 | 1997-12-16 | Yukong Limited | Halogen substituted carbamate compounds from 2-phenyl-1,2-ethanediol |
AU3304997A (en) * | 1996-05-31 | 1998-01-05 | Southern Illinois University | Methods of modulating aspects of brain neural plasticity by vagus nerve stimulation |
DE60003791T2 (de) * | 1999-02-09 | 2004-02-05 | The University Of Virginia Alumni Patents Foundation | Felbamat-derivate |
ES2304969T3 (es) * | 1999-07-26 | 2008-11-01 | Sk Holdings Co., Ltd. | Composiciones anticonvulsivas transnasales. |
US6562867B2 (en) * | 2001-02-27 | 2003-05-13 | Ortho-Mcneil Pharmaceutical, Inc. | Carbamate compounds for use in preventing or treating bipolar disorder |
NZ527989A (en) * | 2001-02-27 | 2005-12-23 | Ortho Mcneil Pharm Inc | Use of a halogenated 2-phenyl-1,2-ethanediol dicarbamate enantiomer or enantiomeric mixture wherein one enantiomer predominates for preventing or treating bipolar disorder |
DE60220043T2 (de) * | 2001-02-27 | 2008-01-10 | Ortho-Mcneil Pharmaceutical, Inc. | Carbamatverbindungen zur vorbeugung oder behandlung von neurodegenerativen störungen |
-
2005
- 2005-09-15 WO PCT/US2005/032861 patent/WO2006033947A2/en active Application Filing
- 2005-09-15 PT PT05810288T patent/PT1809273E/pt unknown
- 2005-09-15 MX MX2007003278A patent/MX2007003278A/es active IP Right Grant
- 2005-09-15 DK DK05810288.0T patent/DK1809273T3/da active
- 2005-09-15 CN CN2005800387418A patent/CN101056629B/zh active Active
- 2005-09-15 CA CA002580640A patent/CA2580640A1/en not_active Abandoned
- 2005-09-15 RS RSP-2010/0264A patent/RS51269B/sr unknown
- 2005-09-15 DE DE602005020667T patent/DE602005020667D1/de active Active
- 2005-09-15 ES ES05810288T patent/ES2342185T3/es active Active
- 2005-09-15 AU AU2005287174A patent/AU2005287174B2/en not_active Expired - Fee Related
- 2005-09-15 NZ NZ553813A patent/NZ553813A/en not_active IP Right Cessation
- 2005-09-15 KR KR1020077008402A patent/KR20070057939A/ko not_active Application Discontinuation
- 2005-09-15 AT AT05810288T patent/ATE464044T1/de active
- 2005-09-15 JP JP2007532446A patent/JP2008513466A/ja active Pending
- 2005-09-15 EA EA200700642A patent/EA200700642A1/ru unknown
- 2005-09-15 BR BRPI0515374-3A patent/BRPI0515374A/pt not_active IP Right Cessation
- 2005-09-15 US US11/227,247 patent/US20060194873A1/en not_active Abandoned
-
2007
- 2007-03-13 IL IL181910A patent/IL181910A0/en unknown
- 2007-03-29 CO CO07031825A patent/CO6382111A2/es not_active Application Discontinuation
- 2007-04-13 CR CR9053A patent/CR9053A/es not_active Application Discontinuation
- 2007-04-16 NO NO20071921A patent/NO20071921L/no not_active Application Discontinuation
- 2007-10-08 HK HK07110872.5A patent/HK1105583A1/xx unknown
- 2007-11-15 US US11/940,710 patent/US20110152362A1/en not_active Abandoned
-
2010
- 2010-05-27 HR HR20100304T patent/HRP20100304T1/hr unknown
Also Published As
Publication number | Publication date |
---|---|
JP2008513466A (ja) | 2008-05-01 |
WO2006033947A3 (en) | 2006-06-29 |
ES2342185T3 (es) | 2010-07-02 |
CN101056629A (zh) | 2007-10-17 |
DE602005020667D1 (de) | 2010-05-27 |
PT1809273E (pt) | 2010-05-10 |
BRPI0515374A (pt) | 2008-07-22 |
CO6382111A2 (es) | 2012-02-15 |
AU2005287174B2 (en) | 2012-01-12 |
NZ553813A (en) | 2010-09-30 |
US20060194873A1 (en) | 2006-08-31 |
AU2005287174A1 (en) | 2006-03-30 |
EA200700642A1 (ru) | 2007-10-26 |
IL181910A0 (en) | 2007-07-04 |
US20110152362A1 (en) | 2011-06-23 |
CN101056629B (zh) | 2012-01-11 |
CA2580640A1 (en) | 2006-03-30 |
ATE464044T1 (de) | 2010-04-15 |
HK1105583A1 (en) | 2008-02-22 |
NO20071921L (no) | 2007-06-12 |
CR9053A (es) | 2009-10-30 |
MX2007003278A (es) | 2007-10-08 |
WO2006033947A2 (en) | 2006-03-30 |
DK1809273T3 (da) | 2010-08-02 |
KR20070057939A (ko) | 2007-06-07 |
HRP20100304T1 (hr) | 2010-09-30 |
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