ES2978312T3 - Método para generar linfocitos T compatibles para trasplante alogénico - Google Patents

Método para generar linfocitos T compatibles para trasplante alogénico Download PDF

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Publication number
ES2978312T3
ES2978312T3 ES19219954T ES19219954T ES2978312T3 ES 2978312 T3 ES2978312 T3 ES 2978312T3 ES 19219954 T ES19219954 T ES 19219954T ES 19219954 T ES19219954 T ES 19219954T ES 2978312 T3 ES2978312 T3 ES 2978312T3
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cell
cells
engineered
expression
tcr
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Laurent Poirot
David Sourdive
Philippe Duchateau
Jean-Pierre Cabaniols
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Cellectis SA
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Cellectis SA
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14Blood; Artificial blood
    • A61K35/17Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
    • AHUMAN NECESSITIES
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    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/28Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
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    • C12N15/09Recombinant DNA-technology
    • C12N15/11DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1138Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against receptors or cell surface proteins
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    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
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    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/87Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • C12N15/90Stable introduction of foreign DNA into chromosome
    • C12N15/902Stable introduction of foreign DNA into chromosome using homologous recombination
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    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06Animal cells or tissues; Human cells or tissues
    • C12N5/0602Vertebrate cells
    • C12N5/0634Cells from the blood or the immune system
    • C12N5/0636T lymphocytes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/51Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/515Animal cells
    • A61K2039/5156Animal cells expressing foreign proteins
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    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/51Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/515Animal cells
    • A61K2039/5158Antigen-pulsed cells, e.g. T-cells
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    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503Immunoglobulin superfamily
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    • C07K2317/00Immunoglobulins specific features
    • C07K2317/20Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
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    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/60Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622Single chain antibody (scFv)
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    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • C07K2319/01Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/03Fusion polypeptide containing a localisation/targetting motif containing a transmembrane segment

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  • Wood Science & Technology (AREA)
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  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
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  • Toxicology (AREA)
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ES19219954T 2014-03-11 2015-03-11 Método para generar linfocitos T compatibles para trasplante alogénico Active ES2978312T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DKPA201470119 2014-03-11

Publications (1)

Publication Number Publication Date
ES2978312T3 true ES2978312T3 (es) 2024-09-10

Family

ID=50336023

Family Applications (3)

Application Number Title Priority Date Filing Date
ES15709185T Active ES2782125T3 (es) 2014-03-11 2015-03-11 Método para generar linfocitos T compatibles para trasplante alogénico
ES19219954T Active ES2978312T3 (es) 2014-03-11 2015-03-11 Método para generar linfocitos T compatibles para trasplante alogénico
ES24153261T Active ES3017080T3 (en) 2014-03-11 2015-03-11 Method for generating t-cells compatible for allogenic transplantation

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ES15709185T Active ES2782125T3 (es) 2014-03-11 2015-03-11 Método para generar linfocitos T compatibles para trasplante alogénico

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES24153261T Active ES3017080T3 (en) 2014-03-11 2015-03-11 Method for generating t-cells compatible for allogenic transplantation

Country Status (17)

Country Link
US (4) US20170016025A1 (OSRAM)
EP (3) EP3116902B1 (OSRAM)
JP (2) JP6681837B2 (OSRAM)
KR (1) KR102228828B1 (OSRAM)
CN (1) CN106103475B (OSRAM)
AU (1) AU2015228844B2 (OSRAM)
BR (1) BR112016019071A8 (OSRAM)
CA (1) CA2942113C (OSRAM)
DK (3) DK4368705T3 (OSRAM)
ES (3) ES2782125T3 (OSRAM)
HU (3) HUE048558T2 (OSRAM)
IL (1) IL247064B (OSRAM)
MX (1) MX373460B (OSRAM)
PL (3) PL3693384T3 (OSRAM)
PT (3) PT3116902T (OSRAM)
RU (1) RU2752933C2 (OSRAM)
WO (1) WO2015136001A1 (OSRAM)

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