ES2775579T3 - Composiciones para el tratamiento del cáncer - Google Patents
Composiciones para el tratamiento del cáncer Download PDFInfo
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- ES2775579T3 ES2775579T3 ES14850583T ES14850583T ES2775579T3 ES 2775579 T3 ES2775579 T3 ES 2775579T3 ES 14850583 T ES14850583 T ES 14850583T ES 14850583 T ES14850583 T ES 14850583T ES 2775579 T3 ES2775579 T3 ES 2775579T3
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| US201361887285P | 2013-10-04 | 2013-10-04 | |
| US201361919023P | 2013-12-20 | 2013-12-20 | |
| US201462017505P | 2014-06-26 | 2014-06-26 | |
| US201462037868P | 2014-08-15 | 2014-08-15 | |
| PCT/US2014/059140 WO2015051302A1 (en) | 2013-10-04 | 2014-10-03 | Compositions and methods for treating cancers |
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| ES2775579T3 true ES2775579T3 (es) | 2020-07-27 |
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| ES14850583T Active ES2775579T3 (es) | 2013-10-04 | 2014-10-03 | Composiciones para el tratamiento del cáncer |
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| US (4) | US9567643B2 (OSRAM) |
| EP (2) | EP3650023A1 (OSRAM) |
| JP (3) | JP6946000B2 (OSRAM) |
| KR (1) | KR20160058960A (OSRAM) |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| WO2005047266A1 (en) | 2003-11-14 | 2005-05-26 | Lorus Therapeutics Inc. | Aryl imidazoles and their use as anti-cancer agents |
| WO2015051302A1 (en) | 2013-10-04 | 2015-04-09 | Aptose Biosciences Inc. | Compositions and methods for treating cancers |
| EP3464380B1 (en) | 2016-06-02 | 2024-11-06 | Immunocore Limited | Dosing regimen for gp100-specific tcr - anti-cd3 scfv fusion protein |
| CN106916788B (zh) * | 2017-04-12 | 2019-06-25 | 北京市肿瘤防治研究所 | 人紫杉醇耐药胃癌细胞hgc-27/ptx及其制备方法 |
| CN111417395A (zh) * | 2017-10-30 | 2020-07-14 | 艾普托斯生物科学公司 | 用于治疗癌症的芳基咪唑 |
| MX2022006910A (es) * | 2019-12-06 | 2022-11-09 | Univ Health Network | Tratamiento para la leucemia mieloide aguda o para el síndrome mielodisplásico. |
| US20210380586A1 (en) * | 2020-06-02 | 2021-12-09 | Aptose Biosciences Inc. | 2-indolyl imidazo[4,5-d]phenanthroline polymorphs and compositions regarding the same |
| CN113134077A (zh) * | 2021-04-06 | 2021-07-20 | 中山大学附属第六医院 | 一种高效的转录因子klf4在调控结直肠癌转移的应用 |
Family Cites Families (154)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BE585555A (OSRAM) | 1960-03-31 | |||
| US3297710A (en) | 1963-04-09 | 1967-01-10 | Du Pont | Oxoarylidene-imidazoles |
| US3773919A (en) | 1969-10-23 | 1973-11-20 | Du Pont | Polylactide-drug mixtures |
| US3714181A (en) | 1970-12-31 | 1973-01-30 | American Cyanamid Co | 2-aryl-5,10-diphenylphenanthro(9,10-d)azoles |
| US4089747A (en) | 1976-08-09 | 1978-05-16 | Eastman Kodak Company | Compositions for the detection of hydrogen peroxide |
| CA1178414A (en) | 1978-02-08 | 1984-11-27 | Toyo Boseki Kabushiki Kaisha (Trading Under The Name Of Toyobo Co., Ltd.) | Packaging material having excellent seal packaging property |
| US4275149A (en) | 1978-11-24 | 1981-06-23 | Syva Company | Macromolecular environment control in specific receptor assays |
| US4233402A (en) | 1978-04-05 | 1980-11-11 | Syva Company | Reagents and method employing channeling |
| US4376110A (en) | 1980-08-04 | 1983-03-08 | Hybritech, Incorporated | Immunometric assays using monoclonal antibodies |
| US4535058A (en) | 1982-10-01 | 1985-08-13 | Massachusetts Institute Of Technology | Characterization of oncogenes and assays based thereon |
| IE52535B1 (en) | 1981-02-16 | 1987-12-09 | Ici Plc | Continuous release pharmaceutical compositions |
| DE3141063A1 (de) | 1981-10-13 | 1983-04-28 | Schering Ag, 1000 Berlin Und 4619 Bergkamen | Neue imidazol-derivate, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische praeparate |
| US4423046A (en) | 1982-04-05 | 1983-12-27 | Sterling Drug Inc. | Antibacterial and antiprotozoal 1-methyl-5-nitro-2-(2-phenylvinyl)imidazoles |
| US4659678A (en) | 1982-09-29 | 1987-04-21 | Serono Diagnostics Limited | Immunoassay of antigens |
| HUT35524A (en) | 1983-08-02 | 1985-07-29 | Hoechst Ag | Process for preparing pharmaceutical compositions containing regulatory /regulative/ peptides providing for the retarded release of the active substance |
| US4727022A (en) | 1984-03-14 | 1988-02-23 | Syntex (U.S.A.) Inc. | Methods for modulating ligand-receptor interactions and their application |
| DE3422175A1 (de) | 1984-06-04 | 1985-12-19 | Julius Dr. 8000 München Kern | Verfahren zur beimischung von ammoniak zu saure schadstoffe enthaltenden abgasen oder luft |
| JPS614960A (ja) | 1984-06-19 | 1986-01-10 | Fuji Photo Film Co Ltd | 分析試薬および多層化学分析要素 |
| US4762706A (en) | 1984-10-17 | 1988-08-09 | Cetus Corporation | Peptide antibodies and their use in detecting oncogene products |
| US5081230A (en) | 1987-07-08 | 1992-01-14 | E. I. Dupont Denemours And Company | Monoclonal antibodies reactive with normal and oncogenic forms of the ras p21 protein |
| US5443956A (en) | 1985-01-29 | 1995-08-22 | Oncogene Science, Inc. | Detection, quantitation and classification of RAS proteins in body fluids and tissues |
| US4720459A (en) | 1985-02-14 | 1988-01-19 | Medical College Of Wisconsin Research Foundation, Inc. | Myelomas for producing human/human hybridomas |
| US4758421A (en) | 1985-03-15 | 1988-07-19 | The Board Of Trustees Of The Leland Stanford Junior University | Bleomycin conjugates and method |
| IT1214597B (it) | 1985-04-15 | 1990-01-18 | Rorer Italiana Spa | Derivati dell'imidazolo adattivita' antimicotica, procedimento ed intermedi per laloro preparazione e composizioni che li contengono. |
| US5023252A (en) | 1985-12-04 | 1991-06-11 | Conrex Pharmaceutical Corporation | Transdermal and trans-membrane delivery of drugs |
| EP0248086B1 (en) | 1985-12-12 | 1993-03-17 | Ube Industries, Ltd. | Imidazole derivatives, bactericides containing them, and process for their preparation |
| GB8607683D0 (en) | 1986-03-27 | 1986-04-30 | Ici Plc | Anti-tumor agents |
| US5024935A (en) | 1987-12-18 | 1991-06-18 | Eastman Kodak Company | Dye-providing composition, diagnostic test kit and their use in method for ligand determination using peroxidase labeled-receptor |
| US5047318A (en) | 1988-06-13 | 1991-09-10 | Eastman Kodak Company | Imidazole leuco dye composition containing 4'-hydroxyacetanilide, diagnostic kit and method using same |
| US5011472A (en) | 1988-09-06 | 1991-04-30 | Brown University Research Foundation | Implantable delivery system for biological factors |
| US5501959A (en) | 1989-01-17 | 1996-03-26 | Alamar Biosciences Laboratory, Inc. | Antibiotic and cytotoxic drug susceptibility assays using resazurin and poising agents |
| US5514550A (en) | 1989-02-03 | 1996-05-07 | Johnson & Johnson Clinical Diagnostics, Inc. | Nucleic acid test article and its use to detect a predetermined nucleic acid |
| CA2049022C (en) | 1989-03-08 | 2000-08-29 | Uwe Rockenfeller | Method and apparatus for acheiving high reaction rates in solid-gas reactor systems |
| US5441716A (en) | 1989-03-08 | 1995-08-15 | Rocky Research | Method and apparatus for achieving high reaction rates |
| JPH02258017A (ja) | 1989-03-31 | 1990-10-18 | Babcock Hitachi Kk | 固体還元剤を用いた排ガス脱硝装置 |
| US5744101A (en) | 1989-06-07 | 1998-04-28 | Affymax Technologies N.V. | Photolabile nucleoside protecting groups |
| US4970226A (en) | 1989-10-03 | 1990-11-13 | Harbor Branch Oceanographic Institution, Inc. | Bis-indole imidazole compounds which are useful antitumor and antimicrobial agents |
| US5161389A (en) | 1990-11-13 | 1992-11-10 | Rocky Research | Appliance for rapid sorption cooling and freezing |
| FI941572A7 (fi) | 1991-10-07 | 1994-05-27 | Oncologix Inc | Anti-erbB-2-monoklonaalisten vasta-aineiden yhdistelmä ja käyttömenete lmä |
| US5656644A (en) | 1994-07-20 | 1997-08-12 | Smithkline Beecham Corporation | Pyridyl imidazoles |
| IL104369A0 (en) | 1992-01-13 | 1993-05-13 | Smithkline Beecham Corp | Novel compounds and compositions |
| US5916891A (en) | 1992-01-13 | 1999-06-29 | Smithkline Beecham Corporation | Pyrimidinyl imidazoles |
| JPH08500962A (ja) | 1992-02-06 | 1996-02-06 | クリエイティブ バイオモレキュルズ，インコーポレイテッド | 癌マーカー用生物合成結合蛋白質 |
| US6177401B1 (en) | 1992-11-13 | 2001-01-23 | Max-Planck-Gesellschaft Zur Forderung Der Wissenschaften | Use of organic compounds for the inhibition of Flk-1 mediated vasculogenesis and angiogenesis |
| WO1995003297A1 (en) | 1993-07-21 | 1995-02-02 | Smithkline Beecham Corporation | Imidazoles for treating cytokine mediated disease |
| IL112248A0 (en) | 1994-01-25 | 1995-03-30 | Warner Lambert Co | Tricyclic heteroaromatic compounds and pharmaceutical compositions containing them |
| US5496702A (en) | 1994-09-01 | 1996-03-05 | Johnson & Johnson Clinical Diagnostics, Inc. | Immunoassay elements having stable leuco dye coatings |
| US5473057A (en) | 1994-11-09 | 1995-12-05 | The Regents Of The University Of California | Eleutherobin and analogs thereof |
| DK0797575T3 (da) | 1994-12-13 | 2004-02-16 | Hoffmann La Roche | Imidazolderivater som proteinkinase-inhibitorer, især EGF-R-tyrosinkinase |
| TW424172B (en) | 1995-04-19 | 2001-03-01 | Hitachi Chemical Co Ltd | Photosensitive resin composition and photosensitive element using the same |
| US5747498A (en) | 1996-05-28 | 1998-05-05 | Pfizer Inc. | Alkynyl and azido-substituted 4-anilinoquinazolines |
| US5700826A (en) | 1995-06-07 | 1997-12-23 | Ontogen Corporation | 1,2,4,5-tetra substituted imidazoles as modulators of multi-drug resistance |
| US5880141A (en) | 1995-06-07 | 1999-03-09 | Sugen, Inc. | Benzylidene-Z-indoline compounds for the treatment of disease |
| US5753687A (en) | 1995-06-19 | 1998-05-19 | Ontogen Corporation | Modulators of proteins with phosphotryrosine recognition units |
| GB9520822D0 (en) | 1995-10-11 | 1995-12-13 | Wellcome Found | Therapeutically active compounds |
| GB9624482D0 (en) | 1995-12-18 | 1997-01-15 | Zeneca Phaema S A | Chemical compounds |
| EP0885198B1 (en) | 1996-03-05 | 2001-12-19 | AstraZeneca AB | 4-anilinoquinazoline derivatives |
| EP0906099A4 (en) | 1996-04-03 | 2001-02-07 | Merck & Co Inc | METHOD FOR TREATING CANCER |
| US5693589A (en) | 1996-05-08 | 1997-12-02 | Eastman Kodak Company | Thermal imaging recording element |
| EP0812829A1 (en) | 1996-06-14 | 1997-12-17 | Ontogen Corporation | Substituted imidazoles as modulators of multi-drug resistance |
| WO1998002434A1 (en) | 1996-07-13 | 1998-01-22 | Glaxo Group Limited | Fused heterocyclic compounds as protein tyrosine kinase inhibitors |
| WO1998002437A1 (en) | 1996-07-13 | 1998-01-22 | Glaxo Group Limited | Bicyclic heteroaromatic compounds as protein tyrosine kinase inhibitors |
| IT240917Y1 (it) | 1996-10-01 | 2001-04-11 | Stefcom Spa | Scarpa con tomaia avente porzione per la traspirazione dell'internodella scarpa |
| ID18494A (id) | 1996-10-02 | 1998-04-16 | Novartis Ag | Turunan pirazola leburan dan proses pembuatannya |
| WO1998027108A2 (en) | 1996-12-16 | 1998-06-25 | Fujisawa Pharmaceutical Co., Ltd. | New amide compounds and their use as nitric oxide synthase inhibitors |
| CA2275610A1 (en) | 1996-12-16 | 1998-06-25 | Ontogen Corporation | Modulators of proteins with phosphotyrosine recognition units |
| US5945418A (en) | 1996-12-18 | 1999-08-31 | Vertex Pharmaceuticals Incorporated | Inhibitors of p38 |
| US5809775A (en) | 1997-04-02 | 1998-09-22 | Clean Diesel Technologies, Inc. | Reducing NOx emissions from an engine by selective catalytic reduction utilizing solid reagents |
| IL132318A0 (en) | 1997-04-24 | 2001-03-19 | Ortho Mcneil Pharm Inc | Substituted imidazoles useful in the treatment of inflammatory diseases |
| EP0984930B1 (en) | 1997-05-07 | 2005-04-06 | Sugen, Inc. | 2-indolinone derivatives as modulators of protein kinase activity |
| JPH10319584A (ja) | 1997-05-21 | 1998-12-04 | Brother Ind Ltd | マイクロカプセルを用いた感光性記録材料 |
| CA2291709A1 (en) | 1997-05-30 | 1998-12-03 | Merck & Co., Inc. | Novel angiogenesis inhibitors |
| DE19728343C5 (de) | 1997-07-03 | 2013-02-21 | Robert Bosch Gmbh | Verfahren und Vorrichtung zur selektiven katalytischen NOx-Reduktion |
| JP2002515400A (ja) | 1997-07-03 | 2002-05-28 | ニューロジェン・コーポレーション | ある種のジアリールイミダゾール誘導体；新規なクラスのｎｐｙ特異的リガンド |
| US5840721A (en) | 1997-07-09 | 1998-11-24 | Ontogen Corporation | Imidazole derivatives as MDR modulators |
| WO1999007701A1 (en) | 1997-08-05 | 1999-02-18 | Sugen, Inc. | Tricyclic quinoxaline derivatives as protein tyrosine kinase inhibitors |
| US6294532B1 (en) | 1997-08-22 | 2001-09-25 | Zeneca Limited | Oxindolylquinazoline derivatives as angiogenesis inhibitors |
| GB9717804D0 (en) | 1997-08-22 | 1997-10-29 | Zeneca Ltd | Chemical compounds |
| JP2001522853A (ja) | 1997-11-11 | 2001-11-20 | ファイザー・プロダクツ・インク | 抗癌剤として有用なチエノピリミジンおよびチエノピリジン誘導体 |
| JPH11199582A (ja) | 1998-01-05 | 1999-07-27 | Sagami Chem Res Center | ４（５）−（３−インドリル）イミダゾール誘導体 |
| GB9800575D0 (en) | 1998-01-12 | 1998-03-11 | Glaxo Group Ltd | Heterocyclic compounds |
| GB9800569D0 (en) | 1998-01-12 | 1998-03-11 | Glaxo Group Ltd | Heterocyclic compounds |
| WO1999047502A1 (en) | 1998-03-18 | 1999-09-23 | Wake Forest University | Cytotoxic metal chelators and methods for making and using same |
| DK2020408T3 (da) | 1998-05-29 | 2013-09-30 | Sugen Inc | Pyrrol-substitueret 2-indolinon som proteinkinaseinhibitor |
| US6288212B1 (en) | 1998-08-28 | 2001-09-11 | The University Of British Columbia | Anti-endotoxic, antimicrobial cationic peptides and methods of use therefor |
| WO2000033836A1 (en) | 1998-12-04 | 2000-06-15 | Ontogen Corporation | 5-membered heterocycles for the treatment of human diseases involving modulators of selectins |
| JP2000273088A (ja) | 1999-01-18 | 2000-10-03 | Nippon Soda Co Ltd | トリフェニルイミダゾール化合物および農園芸用殺菌剤 |
| JP2000281588A (ja) | 1999-03-30 | 2000-10-10 | Sankyo Co Ltd | ガンの予防又は治療薬及びそのスクリーニング方法 |
| DE19920936A1 (de) | 1999-05-07 | 2000-11-09 | Basf Ag | Heterozyklisch substituierte Benzimidazole, deren Herstellung und Anwendung |
| WO2000068266A1 (en) | 1999-05-11 | 2000-11-16 | Eli Lilly And Company | Amyloid precursor protein protease and related nucleic acid compounds |
| US7364868B2 (en) | 1999-05-19 | 2008-04-29 | The Uab Research Foundation | Krüppel-like transcriptional factor KLF4/GKLF and uses thereof |
| DE19925631A1 (de) | 1999-06-04 | 2000-12-07 | Georg Gros | Beschichtungsverfahren und Beschichtungsgemisch |
| WO2000078761A1 (en) | 1999-06-23 | 2000-12-28 | Sepracor, Inc. | Indolyl-benzimidazole antibacterials, and methods of use thereof |
| TWI262914B (en) | 1999-07-02 | 2006-10-01 | Agouron Pharma | Compounds and pharmaceutical compositions for inhibiting protein kinases |
| US6266955B1 (en) | 1999-08-20 | 2001-07-31 | Caterpillar Inc. | Diagnostic system for an emissions control on an engine |
| CN1087744C (zh) | 1999-09-24 | 2002-07-17 | 中国科学院化学研究所 | 一种钌（ⅱ）多吡啶配合物及其制备方法 |
| CN1088713C (zh) | 1999-09-24 | 2002-08-07 | 中国科学院化学研究所 | 用于二级pH传感的钌（Ⅱ）多吡啶配合物及其制备方法 |
| EP1221847B1 (en) | 1999-10-08 | 2009-03-25 | Taiji Biomedical, Inc. | Methods of enhancing chemotherapy |
| US7115645B2 (en) | 2000-01-14 | 2006-10-03 | Schering Aktiengesellschaft | 1,2 diarylbenzimidazoles and their pharmaceutical use |
| ES2346637T3 (es) | 2000-03-27 | 2010-10-19 | Thomas Jefferson University | Composiciones y metodos para identificar y marcar celulas cancerosas originadas en el tubo digestivo. |
| DK2796553T3 (da) | 2000-03-30 | 2019-09-30 | Whitehead Inst Biomedical Res | Rna-sekvensspecifikke formidlere af rna-interferens |
| EP1318992B1 (en) | 2000-09-21 | 2005-07-27 | Smithkline Beecham Plc | Imidazole derivatives as raf kinase inhibitors |
| KR20030063360A (ko) | 2000-10-13 | 2003-07-28 | 비온 퍼마슈티컬즈 인코포레이티드 | 에이피/에이엠피 유도 전구약물 형태 |
| EP1341768A1 (en) | 2000-12-07 | 2003-09-10 | AstraZeneca AB | Therapeutic benzimidazole compounds |
| DE60207390T2 (de) | 2001-03-09 | 2006-07-20 | Pfizer Products Inc., Groton | Entzündungshemmende benzimidazolverbindungen |
| JP2002275458A (ja) | 2001-03-21 | 2002-09-25 | Fukuoka Prefecture | フォトクロミックアモルファス材料及び高密度光記録媒体 |
| EP1432690A2 (en) | 2001-04-16 | 2004-06-30 | Tanabe Seiyaku Co., Ltd. | Imidazole, thiazole and oxazole derivatives and their use for the manufacture of a medicament for the treatment and/or prevention of pollakiuria or urinary incontinence |
| US6916440B2 (en) | 2001-05-31 | 2005-07-12 | 3M Innovative Properties Company | Processes and apparatus for making transversely drawn films with substantially uniaxial character |
| JP3759882B2 (ja) | 2001-06-01 | 2006-03-29 | 株式会社日立製作所 | ポンプ装置 |
| DE10134775A1 (de) | 2001-07-06 | 2003-01-30 | Schering Ag | 1-Alkyl-2.aryl-benzimidazolderivate, deren Verwendung zur Herstellung von Arzneimitteln sowie diese Derivate enthaltende pharmazeutische Präparate |
| US7695926B2 (en) | 2001-07-10 | 2010-04-13 | The Board Of Trustees Of The Leland Stanford Junior University | Methods and compositions for detecting receptor-ligand interactions in single cells |
| ES2274986T3 (es) | 2001-08-01 | 2007-06-01 | MERCK & CO., INC. | Derivados de benzimidazo 4,5-f/isoquinolinona. |
| JP4637481B2 (ja) | 2001-10-19 | 2011-02-23 | オーソ−マクニール・フアーマシユーチカル・インコーポレーテツド | Ｃｄｓ１／ｃｈｋ２阻害剤および癌治療における化学療法または放射線療法の補助剤としての２−フェニルベンズイミダゾールおよびイミダゾ−［４，５］−ピリジン |
| US20060058553A1 (en) | 2002-02-07 | 2006-03-16 | Axys Pharmaceuticals, Inc. | Novel bicyclic hydroxamates as inhibitors of histone deacetylase |
| US6790852B2 (en) | 2002-04-18 | 2004-09-14 | Hoffmann-La Roche Inc. | 2-(2,6-dichlorophenyl)-diarylimidazoles |
| KR100653662B1 (ko) | 2002-06-19 | 2006-12-05 | 쿠리타 고교 가부시키가이샤 | 수소 저장 방법, 수소 포접 화합물 및 그 제조 방법 |
| AU2003249977A1 (en) | 2002-07-05 | 2004-01-23 | Axxima Pharmaceuticals Ag | Imidazole compounds for the treatment of hepatitis c virus infections |
| CN101899006B (zh) | 2002-08-19 | 2013-11-06 | 劳洛斯治疗公司 | 2，4，5-三取代的咪唑及其作为抗菌剂的用途 |
| DE10251472A1 (de) | 2002-11-06 | 2004-05-19 | Robert Bosch Gmbh | Verfahren zur Nachbehandlung von Abgasen und Anordnung hierzu |
| WO2004071464A2 (en) * | 2003-02-12 | 2004-08-26 | Johns Hopkins University School Of Medicine | Diagnostic application of differentially-expressed genes in lympho-hematopoietic stem cells |
| CA2425797C (en) | 2003-04-17 | 2013-10-15 | Xerox Corporation | Organic light emitting devices |
| US7989089B2 (en) | 2003-04-17 | 2011-08-02 | Lg Display Co., Ltd. | Organic luminescent compounds and methods of making and using same |
| DE10323591A1 (de) | 2003-05-16 | 2004-12-02 | E.G.O. Elektro-Gerätebau GmbH | Verfahren und Vorrichtung zur Erzeugung eines Gases aus einem Sublimationsgut |
| WO2005047266A1 (en) * | 2003-11-14 | 2005-05-26 | Lorus Therapeutics Inc. | Aryl imidazoles and their use as anti-cancer agents |
| US20050186642A1 (en) | 2004-02-24 | 2005-08-25 | Biocare Medical, Inc. | Immunoassay reagents and methods of use thereof |
| US20050195793A1 (en) | 2004-03-05 | 2005-09-08 | Lockheed Martin Corporation | System for locally synchronizing a group of mobile devices |
| US20050282285A1 (en) | 2004-06-21 | 2005-12-22 | Eaton Corporation | Strategy for controlling NOx emissions and ammonia slip in an SCR system using a nonselective NOx/NH3 |
| US20090280047A1 (en) | 2004-08-03 | 2009-11-12 | Claus Hviid Christensen | Solid ammonia storage and delivery material |
| WO2006081824A2 (en) | 2005-02-03 | 2006-08-10 | Amminex A/S | High density storage of ammonia |
| JP5334575B2 (ja) * | 2005-05-25 | 2013-11-06 | ローラス セラピューティクス インコーポレーテッド | ２−インドリルイミダゾ［４，５‐ｄ］フェナントロリン派生物および癌治療におけるそれらの使用 |
| EP1915374B1 (en) | 2005-05-25 | 2014-04-02 | Lorus Therapeutics Inc. | 2-indolyl imidazo[4,5-d]phenanthroline derivatives and their use in the treatment of cancer |
| US20100293927A1 (en) | 2005-06-29 | 2010-11-25 | Tue Johannessen | Method and device for safe and controlled delivery of ammonia from a solid ammonia storage medium |
| KR100694181B1 (ko) | 2005-11-25 | 2007-03-12 | 연세대학교 산학협력단 | 근원세포 또는 근섬유로부터 신경세포 분화를 유도하는화합물, 이를 포함하는 약학적 조성물, 신경세포 분화를유도하는 방법 및 신경세포 분화를 유도하는 화합물을검색하는 스크리닝 방법 |
| US7763242B2 (en) | 2006-09-07 | 2010-07-27 | Scott and White Memorial Hospital | Methods for treating myelodysplastic syndrome with a human interleukin-3-diphtheria toxin conjugate |
| WO2008125883A1 (en) * | 2007-04-16 | 2008-10-23 | Cancer Research Technology Limited | Cancer markers for prognosis and screening of anti-cancer agents |
| EP2137166B1 (en) * | 2007-04-24 | 2012-05-30 | Ingenium Pharmaceuticals GmbH | 4, 6-disubstituted aminopyrimidine derivatives as inhibitors of protein kinases |
| WO2009058394A1 (en) * | 2007-11-01 | 2009-05-07 | Celgene Corporation | Cytidine analogs for treatment of myelodysplastic syndromes |
| WO2009151503A2 (en) | 2008-04-10 | 2009-12-17 | University Of Florida Research Foundation, Inc. | Compositions and methods for the treatment of a neoplasia |
| JP5340265B2 (ja) | 2008-06-27 | 2013-11-13 | 国立大学法人京都大学 | 効率的な人工多能性幹細胞の樹立方法 |
| US8399206B2 (en) | 2008-07-10 | 2013-03-19 | Nodality, Inc. | Methods for diagnosis, prognosis and methods of treatment |
| WO2010102393A1 (en) * | 2009-03-12 | 2010-09-16 | Lorus Therapeutics Inc. | 2-indolyl imidazo [4,5-d]phenanthroline derivatives and their use to inhibit angiogenesis |
| ES2413255T3 (es) | 2009-04-09 | 2013-07-16 | Lga Biotecnologie Srl | Determinación de la eficacia de 5-ASA en la prevención y/o el tratamiento de CRC mediante el análisis de la expresión génica |
| ES2571235T3 (es) * | 2009-04-10 | 2016-05-24 | Kyowa Hakko Kirin Co Ltd | Procedimiento para el tratamiento de un tumor sanguíneo que utiliza el anticuerpo anti-TIM-3 |
| EP3444333A1 (en) | 2009-10-22 | 2019-02-20 | Thomas Jefferson University | Cell-based anti-cancer compositions and methods of making and using the same |
| US8524240B2 (en) | 2009-10-26 | 2013-09-03 | Djordje Atanackovic | Diagnosis and therapy of hematological malignancies |
| WO2011085134A2 (en) | 2010-01-06 | 2011-07-14 | Georgetown University | Methods and compositions for the diagnosis, prognosis and treatment of cancer |
| KR101317513B1 (ko) | 2010-05-17 | 2013-10-15 | 가톨릭대학교 산학협력단 | 대장암 또는 난소암 진단용 조성물, 진단키트 및 진단방법 |
| MX2012014416A (es) * | 2010-06-28 | 2013-02-27 | Threshold Pharmaceuticals Inc | Tratamiento de cancer de sangre. |
| US20120172244A1 (en) | 2010-12-20 | 2012-07-05 | Steven Buechler | Biomarkers and uses thereof in prognosis and treatment strategies for right-side colon cancer disease and left-side colon cancer disease |
| EP3388535B1 (en) | 2011-12-09 | 2021-03-24 | Adaptive Biotechnologies Corporation | Diagnosis of lymphoid malignancies and minimal residual disease detection |
| TW201343920A (zh) | 2012-03-29 | 2013-11-01 | Nat Health Research Institutes | 預測前列腺癌預後之分子標記、方法與套組 |
| WO2015051302A1 (en) | 2013-10-04 | 2015-04-09 | Aptose Biosciences Inc. | Compositions and methods for treating cancers |
| WO2015108986A1 (en) | 2014-01-16 | 2015-07-23 | Clovis Oncology, Inc. | Use of parp inhibitors to treat breast or ovarian cancer patients showing a loss of heterozygosity |
| CN111417395A (zh) | 2017-10-30 | 2020-07-14 | 艾普托斯生物科学公司 | 用于治疗癌症的芳基咪唑 |
-
2014
- 2014-10-03 WO PCT/US2014/059140 patent/WO2015051302A1/en not_active Ceased
- 2014-10-03 CN CN201480064470.2A patent/CN105764511B/zh not_active Expired - Fee Related
- 2014-10-03 ES ES14850583T patent/ES2775579T3/es active Active
- 2014-10-03 US US14/506,463 patent/US9567643B2/en not_active Expired - Fee Related
- 2014-10-03 WO PCT/US2014/059142 patent/WO2015051304A1/en not_active Ceased
- 2014-10-03 EP EP19197122.5A patent/EP3650023A1/en not_active Withdrawn
- 2014-10-03 US US14/506,457 patent/US20150104392A1/en not_active Abandoned
- 2014-10-03 EP EP14850583.7A patent/EP3052102B1/en active Active
- 2014-10-03 KR KR1020167011859A patent/KR20160058960A/ko not_active Ceased
- 2014-10-03 JP JP2016519769A patent/JP6946000B2/ja not_active Expired - Fee Related
- 2014-10-03 DK DK14850583.7T patent/DK3052102T3/da active
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2016
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2018
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2019
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2021
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| EP3052102A1 (en) | 2016-08-10 |
| US9567643B2 (en) | 2017-02-14 |
| US20170335400A1 (en) | 2017-11-23 |
| JP2021121632A (ja) | 2021-08-26 |
| DK3052102T3 (da) | 2020-03-09 |
| JP2019218373A (ja) | 2019-12-26 |
| HK1225647A1 (en) | 2017-09-15 |
| CN105764511A (zh) | 2016-07-13 |
| WO2015051304A1 (en) | 2015-04-09 |
| JP2016531885A (ja) | 2016-10-13 |
| EP3052102A4 (en) | 2017-05-31 |
| EP3052102B1 (en) | 2019-12-04 |
| US20150099775A1 (en) | 2015-04-09 |
| CN105764511B (zh) | 2019-01-11 |
| WO2015051302A1 (en) | 2015-04-09 |
| JP6946000B2 (ja) | 2021-10-06 |
| KR20160058960A (ko) | 2016-05-25 |
| US20190062842A1 (en) | 2019-02-28 |
| EP3650023A1 (en) | 2020-05-13 |
| US20150104392A1 (en) | 2015-04-16 |
| US11104957B2 (en) | 2021-08-31 |
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