JP6946000B2 - がんの治療用組成物及び方法 - Google Patents

がんの治療用組成物及び方法 Download PDF

Info

Publication number
JP6946000B2
JP6946000B2 JP2016519769A JP2016519769A JP6946000B2 JP 6946000 B2 JP6946000 B2 JP 6946000B2 JP 2016519769 A JP2016519769 A JP 2016519769A JP 2016519769 A JP2016519769 A JP 2016519769A JP 6946000 B2 JP6946000 B2 JP 6946000B2
Authority
JP
Japan
Prior art keywords
cancer
cell
lor
leukemia
klf4
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
JP2016519769A
Other languages
English (en)
Japanese (ja)
Other versions
JP2016531885A (ja
JP2016531885A5 (OSRAM
Inventor
ウィリアム ジー． ライス，
ウィリアム ジー． ライス，
Original Assignee
アプトース バイオサイエンシーズ， インコーポレイテッド
アプトース バイオサイエンシーズ， インコーポレイテッド
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by アプトース バイオサイエンシーズ， インコーポレイテッド, アプトース バイオサイエンシーズ， インコーポレイテッド filed Critical アプトース バイオサイエンシーズ， インコーポレイテッド
Publication of JP2016531885A publication Critical patent/JP2016531885A/ja
Publication of JP2016531885A5 publication Critical patent/JP2016531885A5/ja
Priority to JP2021088367A priority Critical patent/JP2021121632A/ja
Application granted granted Critical
Publication of JP6946000B2 publication Critical patent/JP6946000B2/ja
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/0004—Screening or testing of compounds for diagnosis of disorders, assessment of conditions, e.g. renal clearance, gastric emptying, testing for diabetes, allergy, rheuma, pancreas functions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/106—Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Pathology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Analytical Chemistry (AREA)
  • Zoology (AREA)
  • Immunology (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Diabetes (AREA)
  • Microbiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Hospice & Palliative Care (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Endocrinology (AREA)
  • Biotechnology (AREA)
  • Rheumatology (AREA)
  • Toxicology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
JP2016519769A 2013-10-04 2014-10-03 がんの治療用組成物及び方法 Expired - Fee Related JP6946000B2 (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2021088367A JP2021121632A (ja) 2013-10-04 2021-05-26 がんの治療用組成物及び方法

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
US201361887285P 2013-10-04 2013-10-04
US61/887,285 2013-10-04
US201361919023P 2013-12-20 2013-12-20
US61/919,023 2013-12-20
US201462017505P 2014-06-26 2014-06-26
US62/017,505 2014-06-26
US201462037868P 2014-08-15 2014-08-15
US62/037,868 2014-08-15
PCT/US2014/059140 WO2015051302A1 (en) 2013-10-04 2014-10-03 Compositions and methods for treating cancers

Related Child Applications (2)

Application Number Title Priority Date Filing Date
JP2019148510A Division JP2019218373A (ja) 2013-10-04 2019-08-13 がんの治療用組成物及び方法
JP2021088367A Division JP2021121632A (ja) 2013-10-04 2021-05-26 がんの治療用組成物及び方法

Publications (3)

Publication Number Publication Date
JP2016531885A JP2016531885A (ja) 2016-10-13
JP2016531885A5 JP2016531885A5 (OSRAM) 2017-11-09
JP6946000B2 true JP6946000B2 (ja) 2021-10-06

Family

ID=52777444

Family Applications (3)

Application Number Title Priority Date Filing Date
JP2016519769A Expired - Fee Related JP6946000B2 (ja) 2013-10-04 2014-10-03 がんの治療用組成物及び方法
JP2019148510A Pending JP2019218373A (ja) 2013-10-04 2019-08-13 がんの治療用組成物及び方法
JP2021088367A Pending JP2021121632A (ja) 2013-10-04 2021-05-26 がんの治療用組成物及び方法

Family Applications After (2)

Application Number Title Priority Date Filing Date
JP2019148510A Pending JP2019218373A (ja) 2013-10-04 2019-08-13 がんの治療用組成物及び方法
JP2021088367A Pending JP2021121632A (ja) 2013-10-04 2021-05-26 がんの治療用組成物及び方法

Country Status (8)

Country Link
US (4) US9567643B2 (OSRAM)
EP (2) EP3650023A1 (OSRAM)
JP (3) JP6946000B2 (OSRAM)
KR (1) KR20160058960A (OSRAM)
CN (1) CN105764511B (OSRAM)
DK (1) DK3052102T3 (OSRAM)
ES (1) ES2775579T3 (OSRAM)
WO (2) WO2015051302A1 (OSRAM)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005047266A1 (en) 2003-11-14 2005-05-26 Lorus Therapeutics Inc. Aryl imidazoles and their use as anti-cancer agents
WO2015051302A1 (en) 2013-10-04 2015-04-09 Aptose Biosciences Inc. Compositions and methods for treating cancers
EP3464380B1 (en) 2016-06-02 2024-11-06 Immunocore Limited Dosing regimen for gp100-specific tcr - anti-cd3 scfv fusion protein
CN106916788B (zh) * 2017-04-12 2019-06-25 北京市肿瘤防治研究所 人紫杉醇耐药胃癌细胞hgc-27/ptx及其制备方法
CN111417395A (zh) * 2017-10-30 2020-07-14 艾普托斯生物科学公司 用于治疗癌症的芳基咪唑
MX2022006910A (es) * 2019-12-06 2022-11-09 Univ Health Network Tratamiento para la leucemia mieloide aguda o para el síndrome mielodisplásico.
US20210380586A1 (en) * 2020-06-02 2021-12-09 Aptose Biosciences Inc. 2-indolyl imidazo[4,5-d]phenanthroline polymorphs and compositions regarding the same
CN113134077A (zh) * 2021-04-06 2021-07-20 中山大学附属第六医院 一种高效的转录因子klf4在调控结直肠癌转移的应用

Family Cites Families (154)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE585555A (OSRAM) 1960-03-31
US3297710A (en) 1963-04-09 1967-01-10 Du Pont Oxoarylidene-imidazoles
US3773919A (en) 1969-10-23 1973-11-20 Du Pont Polylactide-drug mixtures
US3714181A (en) 1970-12-31 1973-01-30 American Cyanamid Co 2-aryl-5,10-diphenylphenanthro(9,10-d)azoles
US4089747A (en) 1976-08-09 1978-05-16 Eastman Kodak Company Compositions for the detection of hydrogen peroxide
CA1178414A (en) 1978-02-08 1984-11-27 Toyo Boseki Kabushiki Kaisha (Trading Under The Name Of Toyobo Co., Ltd.) Packaging material having excellent seal packaging property
US4275149A (en) 1978-11-24 1981-06-23 Syva Company Macromolecular environment control in specific receptor assays
US4233402A (en) 1978-04-05 1980-11-11 Syva Company Reagents and method employing channeling
US4376110A (en) 1980-08-04 1983-03-08 Hybritech, Incorporated Immunometric assays using monoclonal antibodies
US4535058A (en) 1982-10-01 1985-08-13 Massachusetts Institute Of Technology Characterization of oncogenes and assays based thereon
IE52535B1 (en) 1981-02-16 1987-12-09 Ici Plc Continuous release pharmaceutical compositions
DE3141063A1 (de) 1981-10-13 1983-04-28 Schering Ag, 1000 Berlin Und 4619 Bergkamen Neue imidazol-derivate, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische praeparate
US4423046A (en) 1982-04-05 1983-12-27 Sterling Drug Inc. Antibacterial and antiprotozoal 1-methyl-5-nitro-2-(2-phenylvinyl)imidazoles
US4659678A (en) 1982-09-29 1987-04-21 Serono Diagnostics Limited Immunoassay of antigens
HUT35524A (en) 1983-08-02 1985-07-29 Hoechst Ag Process for preparing pharmaceutical compositions containing regulatory /regulative/ peptides providing for the retarded release of the active substance
US4727022A (en) 1984-03-14 1988-02-23 Syntex (U.S.A.) Inc. Methods for modulating ligand-receptor interactions and their application
DE3422175A1 (de) 1984-06-04 1985-12-19 Julius Dr. 8000 München Kern Verfahren zur beimischung von ammoniak zu saure schadstoffe enthaltenden abgasen oder luft
JPS614960A (ja) 1984-06-19 1986-01-10 Fuji Photo Film Co Ltd 分析試薬および多層化学分析要素
US4762706A (en) 1984-10-17 1988-08-09 Cetus Corporation Peptide antibodies and their use in detecting oncogene products
US5081230A (en) 1987-07-08 1992-01-14 E. I. Dupont Denemours And Company Monoclonal antibodies reactive with normal and oncogenic forms of the ras p21 protein
US5443956A (en) 1985-01-29 1995-08-22 Oncogene Science, Inc. Detection, quantitation and classification of RAS proteins in body fluids and tissues
US4720459A (en) 1985-02-14 1988-01-19 Medical College Of Wisconsin Research Foundation, Inc. Myelomas for producing human/human hybridomas
US4758421A (en) 1985-03-15 1988-07-19 The Board Of Trustees Of The Leland Stanford Junior University Bleomycin conjugates and method
IT1214597B (it) 1985-04-15 1990-01-18 Rorer Italiana Spa Derivati dell'imidazolo adattivita' antimicotica, procedimento ed intermedi per laloro preparazione e composizioni che li contengono.
US5023252A (en) 1985-12-04 1991-06-11 Conrex Pharmaceutical Corporation Transdermal and trans-membrane delivery of drugs
EP0248086B1 (en) 1985-12-12 1993-03-17 Ube Industries, Ltd. Imidazole derivatives, bactericides containing them, and process for their preparation
GB8607683D0 (en) 1986-03-27 1986-04-30 Ici Plc Anti-tumor agents
US5024935A (en) 1987-12-18 1991-06-18 Eastman Kodak Company Dye-providing composition, diagnostic test kit and their use in method for ligand determination using peroxidase labeled-receptor
US5047318A (en) 1988-06-13 1991-09-10 Eastman Kodak Company Imidazole leuco dye composition containing 4'-hydroxyacetanilide, diagnostic kit and method using same
US5011472A (en) 1988-09-06 1991-04-30 Brown University Research Foundation Implantable delivery system for biological factors
US5501959A (en) 1989-01-17 1996-03-26 Alamar Biosciences Laboratory, Inc. Antibiotic and cytotoxic drug susceptibility assays using resazurin and poising agents
US5514550A (en) 1989-02-03 1996-05-07 Johnson & Johnson Clinical Diagnostics, Inc. Nucleic acid test article and its use to detect a predetermined nucleic acid
CA2049022C (en) 1989-03-08 2000-08-29 Uwe Rockenfeller Method and apparatus for acheiving high reaction rates in solid-gas reactor systems
US5441716A (en) 1989-03-08 1995-08-15 Rocky Research Method and apparatus for achieving high reaction rates
JPH02258017A (ja) 1989-03-31 1990-10-18 Babcock Hitachi Kk 固体還元剤を用いた排ガス脱硝装置
US5744101A (en) 1989-06-07 1998-04-28 Affymax Technologies N.V. Photolabile nucleoside protecting groups
US4970226A (en) 1989-10-03 1990-11-13 Harbor Branch Oceanographic Institution, Inc. Bis-indole imidazole compounds which are useful antitumor and antimicrobial agents
US5161389A (en) 1990-11-13 1992-11-10 Rocky Research Appliance for rapid sorption cooling and freezing
FI941572A7 (fi) 1991-10-07 1994-05-27 Oncologix Inc Anti-erbB-2-monoklonaalisten vasta-aineiden yhdistelmä ja käyttömenete lmä
US5656644A (en) 1994-07-20 1997-08-12 Smithkline Beecham Corporation Pyridyl imidazoles
IL104369A0 (en) 1992-01-13 1993-05-13 Smithkline Beecham Corp Novel compounds and compositions
US5916891A (en) 1992-01-13 1999-06-29 Smithkline Beecham Corporation Pyrimidinyl imidazoles
JPH08500962A (ja) 1992-02-06 1996-02-06 クリエイティブ バイオモレキュルズ，インコーポレイテッド 癌マーカー用生物合成結合蛋白質
US6177401B1 (en) 1992-11-13 2001-01-23 Max-Planck-Gesellschaft Zur Forderung Der Wissenschaften Use of organic compounds for the inhibition of Flk-1 mediated vasculogenesis and angiogenesis
WO1995003297A1 (en) 1993-07-21 1995-02-02 Smithkline Beecham Corporation Imidazoles for treating cytokine mediated disease
IL112248A0 (en) 1994-01-25 1995-03-30 Warner Lambert Co Tricyclic heteroaromatic compounds and pharmaceutical compositions containing them
US5496702A (en) 1994-09-01 1996-03-05 Johnson & Johnson Clinical Diagnostics, Inc. Immunoassay elements having stable leuco dye coatings
US5473057A (en) 1994-11-09 1995-12-05 The Regents Of The University Of California Eleutherobin and analogs thereof
DK0797575T3 (da) 1994-12-13 2004-02-16 Hoffmann La Roche Imidazolderivater som proteinkinase-inhibitorer, især EGF-R-tyrosinkinase
TW424172B (en) 1995-04-19 2001-03-01 Hitachi Chemical Co Ltd Photosensitive resin composition and photosensitive element using the same
US5747498A (en) 1996-05-28 1998-05-05 Pfizer Inc. Alkynyl and azido-substituted 4-anilinoquinazolines
US5700826A (en) 1995-06-07 1997-12-23 Ontogen Corporation 1,2,4,5-tetra substituted imidazoles as modulators of multi-drug resistance
US5880141A (en) 1995-06-07 1999-03-09 Sugen, Inc. Benzylidene-Z-indoline compounds for the treatment of disease
US5753687A (en) 1995-06-19 1998-05-19 Ontogen Corporation Modulators of proteins with phosphotryrosine recognition units
GB9520822D0 (en) 1995-10-11 1995-12-13 Wellcome Found Therapeutically active compounds
GB9624482D0 (en) 1995-12-18 1997-01-15 Zeneca Phaema S A Chemical compounds
EP0885198B1 (en) 1996-03-05 2001-12-19 AstraZeneca AB 4-anilinoquinazoline derivatives
EP0906099A4 (en) 1996-04-03 2001-02-07 Merck & Co Inc METHOD FOR TREATING CANCER
US5693589A (en) 1996-05-08 1997-12-02 Eastman Kodak Company Thermal imaging recording element
EP0812829A1 (en) 1996-06-14 1997-12-17 Ontogen Corporation Substituted imidazoles as modulators of multi-drug resistance
WO1998002434A1 (en) 1996-07-13 1998-01-22 Glaxo Group Limited Fused heterocyclic compounds as protein tyrosine kinase inhibitors
WO1998002437A1 (en) 1996-07-13 1998-01-22 Glaxo Group Limited Bicyclic heteroaromatic compounds as protein tyrosine kinase inhibitors
IT240917Y1 (it) 1996-10-01 2001-04-11 Stefcom Spa Scarpa con tomaia avente porzione per la traspirazione dell'internodella scarpa
ID18494A (id) 1996-10-02 1998-04-16 Novartis Ag Turunan pirazola leburan dan proses pembuatannya
WO1998027108A2 (en) 1996-12-16 1998-06-25 Fujisawa Pharmaceutical Co., Ltd. New amide compounds and their use as nitric oxide synthase inhibitors
CA2275610A1 (en) 1996-12-16 1998-06-25 Ontogen Corporation Modulators of proteins with phosphotyrosine recognition units
US5945418A (en) 1996-12-18 1999-08-31 Vertex Pharmaceuticals Incorporated Inhibitors of p38
US5809775A (en) 1997-04-02 1998-09-22 Clean Diesel Technologies, Inc. Reducing NOx emissions from an engine by selective catalytic reduction utilizing solid reagents
IL132318A0 (en) 1997-04-24 2001-03-19 Ortho Mcneil Pharm Inc Substituted imidazoles useful in the treatment of inflammatory diseases
EP0984930B1 (en) 1997-05-07 2005-04-06 Sugen, Inc. 2-indolinone derivatives as modulators of protein kinase activity
JPH10319584A (ja) 1997-05-21 1998-12-04 Brother Ind Ltd マイクロカプセルを用いた感光性記録材料
CA2291709A1 (en) 1997-05-30 1998-12-03 Merck & Co., Inc. Novel angiogenesis inhibitors
DE19728343C5 (de) 1997-07-03 2013-02-21 Robert Bosch Gmbh Verfahren und Vorrichtung zur selektiven katalytischen NOx-Reduktion
JP2002515400A (ja) 1997-07-03 2002-05-28 ニューロジェン・コーポレーション ある種のジアリールイミダゾール誘導体；新規なクラスのｎｐｙ特異的リガンド
US5840721A (en) 1997-07-09 1998-11-24 Ontogen Corporation Imidazole derivatives as MDR modulators
WO1999007701A1 (en) 1997-08-05 1999-02-18 Sugen, Inc. Tricyclic quinoxaline derivatives as protein tyrosine kinase inhibitors
US6294532B1 (en) 1997-08-22 2001-09-25 Zeneca Limited Oxindolylquinazoline derivatives as angiogenesis inhibitors
GB9717804D0 (en) 1997-08-22 1997-10-29 Zeneca Ltd Chemical compounds
JP2001522853A (ja) 1997-11-11 2001-11-20 ファイザー・プロダクツ・インク 抗癌剤として有用なチエノピリミジンおよびチエノピリジン誘導体
JPH11199582A (ja) 1998-01-05 1999-07-27 Sagami Chem Res Center ４（５）−（３−インドリル）イミダゾール誘導体
GB9800575D0 (en) 1998-01-12 1998-03-11 Glaxo Group Ltd Heterocyclic compounds
GB9800569D0 (en) 1998-01-12 1998-03-11 Glaxo Group Ltd Heterocyclic compounds
WO1999047502A1 (en) 1998-03-18 1999-09-23 Wake Forest University Cytotoxic metal chelators and methods for making and using same
DK2020408T3 (da) 1998-05-29 2013-09-30 Sugen Inc Pyrrol-substitueret 2-indolinon som proteinkinaseinhibitor
US6288212B1 (en) 1998-08-28 2001-09-11 The University Of British Columbia Anti-endotoxic, antimicrobial cationic peptides and methods of use therefor
WO2000033836A1 (en) 1998-12-04 2000-06-15 Ontogen Corporation 5-membered heterocycles for the treatment of human diseases involving modulators of selectins
JP2000273088A (ja) 1999-01-18 2000-10-03 Nippon Soda Co Ltd トリフェニルイミダゾール化合物および農園芸用殺菌剤
JP2000281588A (ja) 1999-03-30 2000-10-10 Sankyo Co Ltd ガンの予防又は治療薬及びそのスクリーニング方法
DE19920936A1 (de) 1999-05-07 2000-11-09 Basf Ag Heterozyklisch substituierte Benzimidazole, deren Herstellung und Anwendung
WO2000068266A1 (en) 1999-05-11 2000-11-16 Eli Lilly And Company Amyloid precursor protein protease and related nucleic acid compounds
US7364868B2 (en) 1999-05-19 2008-04-29 The Uab Research Foundation Krüppel-like transcriptional factor KLF4/GKLF and uses thereof
DE19925631A1 (de) 1999-06-04 2000-12-07 Georg Gros Beschichtungsverfahren und Beschichtungsgemisch
WO2000078761A1 (en) 1999-06-23 2000-12-28 Sepracor, Inc. Indolyl-benzimidazole antibacterials, and methods of use thereof
TWI262914B (en) 1999-07-02 2006-10-01 Agouron Pharma Compounds and pharmaceutical compositions for inhibiting protein kinases
US6266955B1 (en) 1999-08-20 2001-07-31 Caterpillar Inc. Diagnostic system for an emissions control on an engine
CN1087744C (zh) 1999-09-24 2002-07-17 中国科学院化学研究所 一种钌（ⅱ）多吡啶配合物及其制备方法
CN1088713C (zh) 1999-09-24 2002-08-07 中国科学院化学研究所 用于二级pH传感的钌（Ⅱ）多吡啶配合物及其制备方法
EP1221847B1 (en) 1999-10-08 2009-03-25 Taiji Biomedical, Inc. Methods of enhancing chemotherapy
US7115645B2 (en) 2000-01-14 2006-10-03 Schering Aktiengesellschaft 1,2 diarylbenzimidazoles and their pharmaceutical use
ES2346637T3 (es) 2000-03-27 2010-10-19 Thomas Jefferson University Composiciones y metodos para identificar y marcar celulas cancerosas originadas en el tubo digestivo.
DK2796553T3 (da) 2000-03-30 2019-09-30 Whitehead Inst Biomedical Res Rna-sekvensspecifikke formidlere af rna-interferens
EP1318992B1 (en) 2000-09-21 2005-07-27 Smithkline Beecham Plc Imidazole derivatives as raf kinase inhibitors
KR20030063360A (ko) 2000-10-13 2003-07-28 비온 퍼마슈티컬즈 인코포레이티드 에이피/에이엠피 유도 전구약물 형태
EP1341768A1 (en) 2000-12-07 2003-09-10 AstraZeneca AB Therapeutic benzimidazole compounds
DE60207390T2 (de) 2001-03-09 2006-07-20 Pfizer Products Inc., Groton Entzündungshemmende benzimidazolverbindungen
JP2002275458A (ja) 2001-03-21 2002-09-25 Fukuoka Prefecture フォトクロミックアモルファス材料及び高密度光記録媒体
EP1432690A2 (en) 2001-04-16 2004-06-30 Tanabe Seiyaku Co., Ltd. Imidazole, thiazole and oxazole derivatives and their use for the manufacture of a medicament for the treatment and/or prevention of pollakiuria or urinary incontinence
US6916440B2 (en) 2001-05-31 2005-07-12 3M Innovative Properties Company Processes and apparatus for making transversely drawn films with substantially uniaxial character
JP3759882B2 (ja) 2001-06-01 2006-03-29 株式会社日立製作所 ポンプ装置
DE10134775A1 (de) 2001-07-06 2003-01-30 Schering Ag 1-Alkyl-2.aryl-benzimidazolderivate, deren Verwendung zur Herstellung von Arzneimitteln sowie diese Derivate enthaltende pharmazeutische Präparate
US7695926B2 (en) 2001-07-10 2010-04-13 The Board Of Trustees Of The Leland Stanford Junior University Methods and compositions for detecting receptor-ligand interactions in single cells
ES2274986T3 (es) 2001-08-01 2007-06-01 MERCK & CO., INC. Derivados de benzimidazo 4,5-f/isoquinolinona.
JP4637481B2 (ja) 2001-10-19 2011-02-23 オーソ−マクニール・フアーマシユーチカル・インコーポレーテツド Ｃｄｓ１／ｃｈｋ２阻害剤および癌治療における化学療法または放射線療法の補助剤としての２−フェニルベンズイミダゾールおよびイミダゾ−［４，５］−ピリジン
US20060058553A1 (en) 2002-02-07 2006-03-16 Axys Pharmaceuticals, Inc. Novel bicyclic hydroxamates as inhibitors of histone deacetylase
US6790852B2 (en) 2002-04-18 2004-09-14 Hoffmann-La Roche Inc. 2-(2,6-dichlorophenyl)-diarylimidazoles
KR100653662B1 (ko) 2002-06-19 2006-12-05 쿠리타 고교 가부시키가이샤 수소 저장 방법, 수소 포접 화합물 및 그 제조 방법
AU2003249977A1 (en) 2002-07-05 2004-01-23 Axxima Pharmaceuticals Ag Imidazole compounds for the treatment of hepatitis c virus infections
CN101899006B (zh) 2002-08-19 2013-11-06 劳洛斯治疗公司 2，4，5-三取代的咪唑及其作为抗菌剂的用途
DE10251472A1 (de) 2002-11-06 2004-05-19 Robert Bosch Gmbh Verfahren zur Nachbehandlung von Abgasen und Anordnung hierzu
WO2004071464A2 (en) * 2003-02-12 2004-08-26 Johns Hopkins University School Of Medicine Diagnostic application of differentially-expressed genes in lympho-hematopoietic stem cells
CA2425797C (en) 2003-04-17 2013-10-15 Xerox Corporation Organic light emitting devices
US7989089B2 (en) 2003-04-17 2011-08-02 Lg Display Co., Ltd. Organic luminescent compounds and methods of making and using same
DE10323591A1 (de) 2003-05-16 2004-12-02 E.G.O. Elektro-Gerätebau GmbH Verfahren und Vorrichtung zur Erzeugung eines Gases aus einem Sublimationsgut
WO2005047266A1 (en) * 2003-11-14 2005-05-26 Lorus Therapeutics Inc. Aryl imidazoles and their use as anti-cancer agents
US20050186642A1 (en) 2004-02-24 2005-08-25 Biocare Medical, Inc. Immunoassay reagents and methods of use thereof
US20050195793A1 (en) 2004-03-05 2005-09-08 Lockheed Martin Corporation System for locally synchronizing a group of mobile devices
US20050282285A1 (en) 2004-06-21 2005-12-22 Eaton Corporation Strategy for controlling NOx emissions and ammonia slip in an SCR system using a nonselective NOx/NH3
US20090280047A1 (en) 2004-08-03 2009-11-12 Claus Hviid Christensen Solid ammonia storage and delivery material
WO2006081824A2 (en) 2005-02-03 2006-08-10 Amminex A/S High density storage of ammonia
JP5334575B2 (ja) * 2005-05-25 2013-11-06 ローラス セラピューティクス インコーポレーテッド ２−インドリルイミダゾ［４，５‐ｄ］フェナントロリン派生物および癌治療におけるそれらの使用
EP1915374B1 (en) 2005-05-25 2014-04-02 Lorus Therapeutics Inc. 2-indolyl imidazo[4,5-d]phenanthroline derivatives and their use in the treatment of cancer
US20100293927A1 (en) 2005-06-29 2010-11-25 Tue Johannessen Method and device for safe and controlled delivery of ammonia from a solid ammonia storage medium
KR100694181B1 (ko) 2005-11-25 2007-03-12 연세대학교 산학협력단 근원세포 또는 근섬유로부터 신경세포 분화를 유도하는화합물, 이를 포함하는 약학적 조성물, 신경세포 분화를유도하는 방법 및 신경세포 분화를 유도하는 화합물을검색하는 스크리닝 방법
US7763242B2 (en) 2006-09-07 2010-07-27 Scott and White Memorial Hospital Methods for treating myelodysplastic syndrome with a human interleukin-3-diphtheria toxin conjugate
WO2008125883A1 (en) * 2007-04-16 2008-10-23 Cancer Research Technology Limited Cancer markers for prognosis and screening of anti-cancer agents
EP2137166B1 (en) * 2007-04-24 2012-05-30 Ingenium Pharmaceuticals GmbH 4, 6-disubstituted aminopyrimidine derivatives as inhibitors of protein kinases
WO2009058394A1 (en) * 2007-11-01 2009-05-07 Celgene Corporation Cytidine analogs for treatment of myelodysplastic syndromes
WO2009151503A2 (en) 2008-04-10 2009-12-17 University Of Florida Research Foundation, Inc. Compositions and methods for the treatment of a neoplasia
JP5340265B2 (ja) 2008-06-27 2013-11-13 国立大学法人京都大学 効率的な人工多能性幹細胞の樹立方法
US8399206B2 (en) 2008-07-10 2013-03-19 Nodality, Inc. Methods for diagnosis, prognosis and methods of treatment
WO2010102393A1 (en) * 2009-03-12 2010-09-16 Lorus Therapeutics Inc. 2-indolyl imidazo [4,5-d]phenanthroline derivatives and their use to inhibit angiogenesis
ES2413255T3 (es) 2009-04-09 2013-07-16 Lga Biotecnologie Srl Determinación de la eficacia de 5-ASA en la prevención y/o el tratamiento de CRC mediante el análisis de la expresión génica
ES2571235T3 (es) * 2009-04-10 2016-05-24 Kyowa Hakko Kirin Co Ltd Procedimiento para el tratamiento de un tumor sanguíneo que utiliza el anticuerpo anti-TIM-3
EP3444333A1 (en) 2009-10-22 2019-02-20 Thomas Jefferson University Cell-based anti-cancer compositions and methods of making and using the same
US8524240B2 (en) 2009-10-26 2013-09-03 Djordje Atanackovic Diagnosis and therapy of hematological malignancies
WO2011085134A2 (en) 2010-01-06 2011-07-14 Georgetown University Methods and compositions for the diagnosis, prognosis and treatment of cancer
KR101317513B1 (ko) 2010-05-17 2013-10-15 가톨릭대학교 산학협력단 대장암 또는 난소암 진단용 조성물, 진단키트 및 진단방법
MX2012014416A (es) * 2010-06-28 2013-02-27 Threshold Pharmaceuticals Inc Tratamiento de cancer de sangre.
US20120172244A1 (en) 2010-12-20 2012-07-05 Steven Buechler Biomarkers and uses thereof in prognosis and treatment strategies for right-side colon cancer disease and left-side colon cancer disease
EP3388535B1 (en) 2011-12-09 2021-03-24 Adaptive Biotechnologies Corporation Diagnosis of lymphoid malignancies and minimal residual disease detection
TW201343920A (zh) 2012-03-29 2013-11-01 Nat Health Research Institutes 預測前列腺癌預後之分子標記、方法與套組
WO2015051302A1 (en) 2013-10-04 2015-04-09 Aptose Biosciences Inc. Compositions and methods for treating cancers
WO2015108986A1 (en) 2014-01-16 2015-07-23 Clovis Oncology, Inc. Use of parp inhibitors to treat breast or ovarian cancer patients showing a loss of heterozygosity
CN111417395A (zh) 2017-10-30 2020-07-14 艾普托斯生物科学公司 用于治疗癌症的芳基咪唑

Also Published As

Publication number Publication date
EP3052102A1 (en) 2016-08-10
US9567643B2 (en) 2017-02-14
US20170335400A1 (en) 2017-11-23
JP2021121632A (ja) 2021-08-26
DK3052102T3 (da) 2020-03-09
JP2019218373A (ja) 2019-12-26
HK1225647A1 (en) 2017-09-15
CN105764511A (zh) 2016-07-13
WO2015051304A1 (en) 2015-04-09
JP2016531885A (ja) 2016-10-13
EP3052102A4 (en) 2017-05-31
ES2775579T3 (es) 2020-07-27
EP3052102B1 (en) 2019-12-04
US20150099775A1 (en) 2015-04-09
CN105764511B (zh) 2019-01-11
WO2015051302A1 (en) 2015-04-09
KR20160058960A (ko) 2016-05-25
US20190062842A1 (en) 2019-02-28
EP3650023A1 (en) 2020-05-13
US20150104392A1 (en) 2015-04-16
US11104957B2 (en) 2021-08-31

Similar Documents

Publication Publication Date Title
JP6946000B2 (ja) がんの治療用組成物及び方法
TWI827550B (zh) 癌症之診斷及治療方法
JP2023159152A (ja) がんを治療するための組成物及び方法
JP2022017495A (ja) 癌を治療するための併用療法
US20210338684A1 (en) Diagnostic and therapeutic methods for cancer
AU2018359967A1 (en) Diagnostic and therapeutic methods for cancer
EP4233879A1 (en) Deoxy- cytidine derivatives for use in cancer therapies
JP7319688B2 (ja) 長鎖ノンコーディングｒｎａを標的とするがん治療剤およびがん診断方法
RU2677656C2 (ru) Способ прогнозирования терапевтического эффекта для пациента с колоректальным раком, у которого повышена экспрессия белка tk1
WO2022031859A2 (en) Methylmalonic acid and metabolism thereof is a cancer biomarker and target
HK1225647B (en) Compositions for treating cancers
HK1226331A1 (en) Compositions and methods for treating cancers
JP2024509887A (ja) Ｅｐ３００分解剤および神経芽細胞腫におけるその使用
HK40032701A (en) Diagnostic and therapeutic methods for cancer

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20170927

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20170927

A977 Report on retrieval

Free format text: JAPANESE INTERMEDIATE CODE: A971007

Effective date: 20180427

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20180524

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20180823

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20181024

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20181126

A02 Decision of refusal

Free format text: JAPANESE INTERMEDIATE CODE: A02

Effective date: 20190410

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20190813

C60 Trial request (containing other claim documents, opposition documents)

Free format text: JAPANESE INTERMEDIATE CODE: C60

Effective date: 20190813

C11 Written invitation by the commissioner to file amendments

Free format text: JAPANESE INTERMEDIATE CODE: C11

Effective date: 20190822

A911 Transfer to examiner for re-examination before appeal (zenchi)

Free format text: JAPANESE INTERMEDIATE CODE: A911

Effective date: 20190930

C21 Notice of transfer of a case for reconsideration by examiners before appeal proceedings

Free format text: JAPANESE INTERMEDIATE CODE: C21

Effective date: 20191001

A912 Re-examination (zenchi) completed and case transferred to appeal board

Free format text: JAPANESE INTERMEDIATE CODE: A912

Effective date: 20191115

C211 Notice of termination of reconsideration by examiners before appeal proceedings

Free format text: JAPANESE INTERMEDIATE CODE: C211

Effective date: 20191119

C22 Notice of designation (change) of administrative judge

Free format text: JAPANESE INTERMEDIATE CODE: C22

Effective date: 20201002

C13 Notice of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: C13

Effective date: 20201126

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20210224

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20210325

C22 Notice of designation (change) of administrative judge

Free format text: JAPANESE INTERMEDIATE CODE: C22

Effective date: 20210407

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20210423

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20210526

C22 Notice of designation (change) of administrative judge

Free format text: JAPANESE INTERMEDIATE CODE: C22

Effective date: 20210715

C23 Notice of termination of proceedings

Free format text: JAPANESE INTERMEDIATE CODE: C23

Effective date: 20210804

C03 Trial/appeal decision taken

Free format text: JAPANESE INTERMEDIATE CODE: C03

Effective date: 20210902

C30A Notification sent

Free format text: JAPANESE INTERMEDIATE CODE: C3012

Effective date: 20210902

A61 First payment of annual fees (during grant procedure)

Free format text: JAPANESE INTERMEDIATE CODE: A61

Effective date: 20210915

R150 Certificate of patent or registration of utility model

Ref document number: 6946000

Country of ref document: JP

Free format text: JAPANESE INTERMEDIATE CODE: R150

LAPS Cancellation because of no payment of annual fees