ES2743825T3 - Proteínas beta-glucocerebrosidasa recombinantes, variantes con estabilidad aumentada y actividad catalítica retenida aumentada - Google Patents
Proteínas beta-glucocerebrosidasa recombinantes, variantes con estabilidad aumentada y actividad catalítica retenida aumentada Download PDFInfo
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- ES2743825T3 ES2743825T3 ES16178095T ES16178095T ES2743825T3 ES 2743825 T3 ES2743825 T3 ES 2743825T3 ES 16178095 T ES16178095 T ES 16178095T ES 16178095 T ES16178095 T ES 16178095T ES 2743825 T3 ES2743825 T3 ES 2743825T3
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- C12Y302/00—Hydrolases acting on glycosyl compounds, i.e. glycosylases (3.2)
- C12Y302/01—Glycosidases, i.e. enzymes hydrolysing O- and S-glycosyl compounds (3.2.1)
- C12Y302/01045—Glucosylceramidase (3.2.1.45), i.e. beta-glucocerebrosidase
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
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Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US41133110P | 2010-11-08 | 2010-11-08 | |
| US41218010P | 2010-11-10 | 2010-11-10 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2743825T3 true ES2743825T3 (es) | 2020-02-20 |
Family
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| ES11839428.7T Active ES2604490T3 (es) | 2010-11-08 | 2011-11-08 | Proteínas beta-glucocerebrosidasa recombinantes, variantes con estabilidad aumentada y actividad catalítica retenida aumentada |
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| ES11839428.7T Active ES2604490T3 (es) | 2010-11-08 | 2011-11-08 | Proteínas beta-glucocerebrosidasa recombinantes, variantes con estabilidad aumentada y actividad catalítica retenida aumentada |
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| EP (2) | EP3144386B1 (https=) |
| JP (2) | JP6073796B2 (https=) |
| KR (1) | KR101901467B1 (https=) |
| CN (2) | CN105296447A (https=) |
| BR (1) | BR112013011152A2 (https=) |
| CA (1) | CA2817011C (https=) |
| CY (1) | CY1118843T1 (https=) |
| DK (1) | DK2638152T3 (https=) |
| ES (2) | ES2743825T3 (https=) |
| HR (1) | HRP20161560T1 (https=) |
| HU (1) | HUE030932T2 (https=) |
| LT (1) | LT2638152T (https=) |
| PL (1) | PL2638152T3 (https=) |
| PT (1) | PT2638152T (https=) |
| RS (1) | RS55405B1 (https=) |
| SI (1) | SI2638152T1 (https=) |
| SM (1) | SMT201600431B (https=) |
| WO (1) | WO2012064709A2 (https=) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
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| US20220125892A1 (en) * | 2019-02-01 | 2022-04-28 | OXYRANE UK Ltd. | Glucocerebrosidase polypeptides |
| KR20210148101A (ko) | 2019-02-04 | 2021-12-07 | 프리라인 테라퓨틱스 리미티드 | 폴리뉴클레오티드 |
| EP4028048A1 (en) * | 2019-09-09 | 2022-07-20 | F. Hoffmann-La Roche AG | Glucocerebrosidase mutants |
| CN115348884B (zh) * | 2020-03-29 | 2024-07-30 | 耶达研究及发展有限公司 | 用于治疗戈谢病的β-葡糖脑苷脂酶变体 |
| KR20230042513A (ko) * | 2020-07-29 | 2023-03-28 | 프리라인 테라퓨틱스 리미티드 | 폴리펩티드 |
| WO2023145812A1 (ja) * | 2022-01-31 | 2023-08-03 | 株式会社日本触媒 | グルコセレブロシダーゼ活性を有する糖鎖付加タンパク質 |
| JPWO2023145814A1 (https=) * | 2022-01-31 | 2023-08-03 | ||
| WO2023145813A1 (ja) * | 2022-01-31 | 2023-08-03 | 株式会社日本触媒 | グルコセレブロシダーゼ活性を有するタンパク質およびその製造方法 |
| EP4508206A1 (en) | 2022-04-12 | 2025-02-19 | F. Hoffmann-La Roche AG | Fusion proteins targeted to the central nervous system |
| CN118715316B (zh) * | 2022-10-08 | 2025-09-19 | 凌意(杭州)生物科技有限公司 | 用于治疗GCase缺乏相关疾病的多核苷酸 |
| TW202532096A (zh) * | 2023-12-08 | 2025-08-16 | 美商戴納立製藥公司 | 經修飾之葡萄糖腦苷脂酶多肽及其使用方法 |
| WO2026006173A1 (en) * | 2024-06-24 | 2026-01-02 | Denali Therapeutics Inc. | Fusion proteins comprising modified glucocerebrosidase polypeptides and methods thereof |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH03503721A (ja) * | 1988-12-23 | 1991-08-22 | ジェンザイム コーポレイション | 酵素的に活性な組換えグルコセレブロシダーゼ |
| DE68926569T2 (de) | 1988-12-23 | 1996-09-26 | Genzyme Corp | Cho-zellen befähigt enzymatisch aktive rekombinante-glukocerebrosidase zu produzieren |
| EP0979311A1 (en) | 1997-04-30 | 2000-02-16 | Of The University Of Minnesota Regents | $i(IN VIVO) USE OF RECOMBINAGENIC OLIGONUCLEOBASES TO CORRECT GENETIC LESIONS IN HEPATOCYTES |
| US6524613B1 (en) | 1997-04-30 | 2003-02-25 | Regents Of The University Of Minnesota | Hepatocellular chimeraplasty |
| IL135578A0 (en) | 1997-10-29 | 2001-05-20 | Genzyme Corp | Compositions and methods for treating lysosomal storage disease |
| WO2000012740A2 (en) | 1998-08-28 | 2000-03-09 | Duke University | ADENOVIRUSES DELETED IN THE IVa2, 100K AND/OR PRETERMINAL PROTEIN SEQUENCES |
| US20020127219A1 (en) | 1999-12-30 | 2002-09-12 | Okkels Jens Sigurd | Lysosomal enzymes and lysosomal enzyme activators |
| AU2352201A (en) | 1999-12-30 | 2001-07-16 | Maxygen Aps | Improved lysosomal enzymes and lysosomal enzyme activators |
| WO2001077307A2 (en) | 2000-04-06 | 2001-10-18 | Exegenics, Inc. | Expression system for efficiently producing clinically effective lysosomal enzymes (glucocerebrosidase) |
| CA2412882A1 (en) * | 2000-06-30 | 2002-01-10 | Maxygen Aps | Peptide extended glycosylated polypeptides |
| US7855063B2 (en) * | 2003-04-16 | 2010-12-21 | Yeda Research And Development Co. Ltd. | Partially deglycosylated glucocerebrosidase polypeptide and crystals thereof |
| WO2005089047A2 (en) | 2004-03-18 | 2005-09-29 | Glycofi, Inc. | Glycosylated glucocerebrosidase expression in fungal hosts |
| MX2009011473A (es) * | 2007-04-26 | 2010-01-18 | Amicus Therapeutics Inc | Regimenes de dosificacion para el tratamiento de enfermedades por almacenamiento lisosomal que utilizan chaperonas farmacologicas. |
| CA2688850C (en) * | 2007-05-22 | 2015-08-11 | Amicus Therapeutics, Inc. | New method for preparing isofagomine and its derivatives |
| JP5513398B2 (ja) | 2007-11-02 | 2014-06-04 | ザ スクリプス リサーチ インスティチュート | 非天然アミノ酸を含有する蛋白質を使用する指向的進化 |
| WO2009059056A2 (en) | 2007-11-02 | 2009-05-07 | The Scripps Research Institute | A genetically encoded boronate amino acid |
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2011
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- 2011-11-08 CN CN201510671991.0A patent/CN105296447A/zh active Pending
- 2011-11-08 HU HUE11839428A patent/HUE030932T2/en unknown
- 2011-11-08 ES ES16178095T patent/ES2743825T3/es active Active
- 2011-11-08 CN CN201180064243.6A patent/CN103314105B/zh not_active Expired - Fee Related
- 2011-11-08 US US13/884,126 patent/US8962564B2/en active Active
- 2011-11-08 ES ES11839428.7T patent/ES2604490T3/es active Active
- 2011-11-08 LT LTEP11839428.7T patent/LT2638152T/lt unknown
- 2011-11-08 JP JP2013538823A patent/JP6073796B2/ja active Active
- 2011-11-08 EP EP16178095.2A patent/EP3144386B1/en active Active
- 2011-11-08 PT PT118394287T patent/PT2638152T/pt unknown
- 2011-11-08 CA CA2817011A patent/CA2817011C/en active Active
- 2011-11-08 HR HRP20161560TT patent/HRP20161560T1/hr unknown
- 2011-11-08 KR KR1020137014671A patent/KR101901467B1/ko active Active
- 2011-11-08 BR BR112013011152A patent/BR112013011152A2/pt not_active Application Discontinuation
- 2011-11-08 DK DK11839428.7T patent/DK2638152T3/en active
- 2011-11-08 PL PL11839428T patent/PL2638152T3/pl unknown
- 2011-11-08 WO PCT/US2011/059731 patent/WO2012064709A2/en not_active Ceased
- 2011-11-08 EP EP11839428.7A patent/EP2638152B1/en active Active
- 2011-11-08 RS RS20161010A patent/RS55405B1/sr unknown
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2015
- 2015-02-02 US US14/611,495 patent/US9254313B2/en active Active
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2016
- 2016-01-04 US US14/987,204 patent/US9566316B2/en active Active
- 2016-11-24 SM SM201600431T patent/SMT201600431B/it unknown
- 2016-11-29 CY CY20161101239T patent/CY1118843T1/el unknown
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2017
- 2017-01-05 JP JP2017000301A patent/JP6457559B2/ja active Active
- 2017-02-13 US US15/430,682 patent/US9821038B2/en active Active
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