RS55405B1 - Varijantni, rekombinantni proteini beta-glukocerebrozidaze sa povećanom stabilnošću i povećanom zadržanom katalitičkom aktivnošću - Google Patents
Varijantni, rekombinantni proteini beta-glukocerebrozidaze sa povećanom stabilnošću i povećanom zadržanom katalitičkom aktivnošćuInfo
- Publication number
- RS55405B1 RS55405B1 RS20161010A RSP20161010A RS55405B1 RS 55405 B1 RS55405 B1 RS 55405B1 RS 20161010 A RS20161010 A RS 20161010A RS P20161010 A RSP20161010 A RS P20161010A RS 55405 B1 RS55405 B1 RS 55405B1
- Authority
- RS
- Serbia
- Prior art keywords
- increased
- variant
- catalytic activity
- recombinant beta
- glucocerebrosidase proteins
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/52—Genes encoding for enzymes or proenzymes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/47—Hydrolases (3) acting on glycosyl compounds (3.2), e.g. cellulases, lactases
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/24—Hydrolases (3) acting on glycosyl compounds (3.2)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/24—Hydrolases (3) acting on glycosyl compounds (3.2)
- C12N9/2402—Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y302/00—Hydrolases acting on glycosyl compounds, i.e. glycosylases (3.2)
- C12Y302/01—Glycosidases, i.e. enzymes hydrolysing O- and S-glycosyl compounds (3.2.1)
- C12Y302/01045—Glucosylceramidase (3.2.1.45), i.e. beta-glucocerebrosidase
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- General Health & Medical Sciences (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- Molecular Biology (AREA)
- Microbiology (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Obesity (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Plant Pathology (AREA)
- Enzymes And Modification Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US41133110P | 2010-11-08 | 2010-11-08 | |
| US41218010P | 2010-11-10 | 2010-11-10 | |
| EP11839428.7A EP2638152B1 (en) | 2010-11-08 | 2011-11-08 | Variant, recombinant beta-glucocerebrosidase proteins with increased stability and increased retained catalytic activity |
| PCT/US2011/059731 WO2012064709A2 (en) | 2010-11-08 | 2011-11-08 | Variant, recombinant beta-glucocerebrosidase proteins with increased stability and increased retained catalytic activity |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| RS55405B1 true RS55405B1 (sr) | 2017-04-28 |
Family
ID=46051505
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RS20161010A RS55405B1 (sr) | 2010-11-08 | 2011-11-08 | Varijantni, rekombinantni proteini beta-glukocerebrozidaze sa povećanom stabilnošću i povećanom zadržanom katalitičkom aktivnošću |
Country Status (19)
| Country | Link |
|---|---|
| US (4) | US8962564B2 (sr) |
| EP (2) | EP3144386B1 (sr) |
| JP (2) | JP6073796B2 (sr) |
| KR (1) | KR101901467B1 (sr) |
| CN (2) | CN103314105B (sr) |
| BR (1) | BR112013011152A2 (sr) |
| CA (1) | CA2817011C (sr) |
| CY (1) | CY1118843T1 (sr) |
| DK (1) | DK2638152T3 (sr) |
| ES (2) | ES2604490T3 (sr) |
| HR (1) | HRP20161560T1 (sr) |
| HU (1) | HUE030932T2 (sr) |
| LT (1) | LT2638152T (sr) |
| PL (1) | PL2638152T3 (sr) |
| PT (1) | PT2638152T (sr) |
| RS (1) | RS55405B1 (sr) |
| SI (1) | SI2638152T1 (sr) |
| SM (1) | SMT201600431B (sr) |
| WO (1) | WO2012064709A2 (sr) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA3127162A1 (en) | 2019-02-01 | 2020-08-06 | Oxyrane Uk Ltd | Glucocerebrosidase polypeptides |
| CN114364794A (zh) * | 2019-09-09 | 2022-04-15 | 豪夫迈·罗氏有限公司 | 葡糖脑苷脂酶突变体 |
| KR20230042513A (ko) * | 2020-07-29 | 2023-03-28 | 프리라인 테라퓨틱스 리미티드 | 폴리펩티드 |
| WO2023145812A1 (ja) * | 2022-01-31 | 2023-08-03 | 株式会社日本触媒 | グルコセレブロシダーゼ活性を有する糖鎖付加タンパク質 |
| WO2023145813A1 (ja) * | 2022-01-31 | 2023-08-03 | 株式会社日本触媒 | グルコセレブロシダーゼ活性を有するタンパク質およびその製造方法 |
| WO2023145814A1 (ja) * | 2022-01-31 | 2023-08-03 | 株式会社日本触媒 | 向上した酵素活性または向上した安定性を有する組換えグルコセレブロシダーゼタンパク質 |
| WO2023198661A1 (en) | 2022-04-12 | 2023-10-19 | F. Hoffmann-La Roche Ag | Fusion proteins targeted to the central nervous system |
| WO2024074142A1 (en) * | 2022-10-08 | 2024-04-11 | Lingyi Biotech Co., Ltd. | Polynucleotides for the treatment of disease associated with gcase deficiency |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH03503721A (ja) * | 1988-12-23 | 1991-08-22 | ジェンザイム コーポレイション | 酵素的に活性な組換えグルコセレブロシダーゼ |
| ES2093642T3 (es) | 1988-12-23 | 1997-01-01 | Genzyme Corp | Celulas cho que producen gluco-cerebrosidasa re-combinante enzimaticamente activa. |
| US6524613B1 (en) | 1997-04-30 | 2003-02-25 | Regents Of The University Of Minnesota | Hepatocellular chimeraplasty |
| EP0979311A1 (en) | 1997-04-30 | 2000-02-16 | Of The University Of Minnesota Regents | $i(IN VIVO) USE OF RECOMBINAGENIC OLIGONUCLEOBASES TO CORRECT GENETIC LESIONS IN HEPATOCYTES |
| DE69835367T2 (de) | 1997-10-29 | 2007-08-02 | Genzyme Corp., Framingham | Gentherapie für gaucher-krankheit |
| AU764686B2 (en) | 1998-08-28 | 2003-08-28 | Duke University | Adenoviruses deleted in the IVa2, 100K, polymerase and/or preterminal protein sequences |
| EP1246915A2 (en) * | 1999-12-30 | 2002-10-09 | Maxygen Aps | Improved lysosomal enzymes and lysosomal enzyme activators |
| US20020127219A1 (en) * | 1999-12-30 | 2002-09-12 | Okkels Jens Sigurd | Lysosomal enzymes and lysosomal enzyme activators |
| WO2001077307A2 (en) * | 2000-04-06 | 2001-10-18 | Exegenics, Inc. | Expression system for efficiently producing clinically effective lysosomal enzymes (glucocerebrosidase) |
| WO2002002597A2 (en) * | 2000-06-30 | 2002-01-10 | Maxygen Aps | Peptide extended glycosylated polypeptides |
| WO2004091475A2 (en) * | 2003-04-16 | 2004-10-28 | Yeda Research And Development Co. Ltd. | Gaucher disease drugs and methods of identifying same |
| WO2005089047A2 (en) | 2004-03-18 | 2005-09-29 | Glycofi, Inc. | Glycosylated glucocerebrosidase expression in fungal hosts |
| MX2009011473A (es) * | 2007-04-26 | 2010-01-18 | Amicus Therapeutics Inc | Regimenes de dosificacion para el tratamiento de enfermedades por almacenamiento lisosomal que utilizan chaperonas farmacologicas. |
| CN104530068B (zh) * | 2007-05-22 | 2017-05-03 | 阿米库斯治疗学公司 | 用于制备异法戈明的化合物 |
| EP2220218A4 (en) | 2007-11-02 | 2010-12-08 | Scripps Research Inst | BORONIC AMINO ACID GENETICALLY CODED |
| MX2010004807A (es) | 2007-11-02 | 2010-08-02 | Scripss Res Inst | Evolucion dirigida utilizando proteinas que comprenden aminoacidos no naturales. |
-
2011
- 2011-11-08 EP EP16178095.2A patent/EP3144386B1/en active Active
- 2011-11-08 KR KR1020137014671A patent/KR101901467B1/ko active IP Right Grant
- 2011-11-08 LT LTEP11839428.7T patent/LT2638152T/lt unknown
- 2011-11-08 CA CA2817011A patent/CA2817011C/en active Active
- 2011-11-08 DK DK11839428.7T patent/DK2638152T3/en active
- 2011-11-08 CN CN201180064243.6A patent/CN103314105B/zh active Active
- 2011-11-08 JP JP2013538823A patent/JP6073796B2/ja active Active
- 2011-11-08 EP EP11839428.7A patent/EP2638152B1/en active Active
- 2011-11-08 HU HUE11839428A patent/HUE030932T2/en unknown
- 2011-11-08 PL PL11839428T patent/PL2638152T3/pl unknown
- 2011-11-08 PT PT118394287T patent/PT2638152T/pt unknown
- 2011-11-08 ES ES11839428.7T patent/ES2604490T3/es active Active
- 2011-11-08 SI SI201131025A patent/SI2638152T1/sl unknown
- 2011-11-08 RS RS20161010A patent/RS55405B1/sr unknown
- 2011-11-08 BR BR112013011152A patent/BR112013011152A2/pt not_active Application Discontinuation
- 2011-11-08 WO PCT/US2011/059731 patent/WO2012064709A2/en active Application Filing
- 2011-11-08 ES ES16178095T patent/ES2743825T3/es active Active
- 2011-11-08 CN CN201510671991.0A patent/CN105296447A/zh active Pending
- 2011-11-08 US US13/884,126 patent/US8962564B2/en active Active
-
2015
- 2015-02-02 US US14/611,495 patent/US9254313B2/en active Active
-
2016
- 2016-01-04 US US14/987,204 patent/US9566316B2/en active Active
- 2016-11-23 HR HRP20161560TT patent/HRP20161560T1/hr unknown
- 2016-11-24 SM SM201600431T patent/SMT201600431B/it unknown
- 2016-11-29 CY CY20161101239T patent/CY1118843T1/el unknown
-
2017
- 2017-01-05 JP JP2017000301A patent/JP6457559B2/ja active Active
- 2017-02-13 US US15/430,682 patent/US9821038B2/en active Active
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| IL280949B (en) | Ph20 polypeptide variants, formulations and uses thereof | |
| HRP20180854T1 (hr) | Polipeptid koji ima aktivnost beta-glukozidaze i njegova uporaba | |
| LT2638152T (lt) | Variantiniai rekombinantiniai beta-gliukocerebrozidazės baltymai su padidintu stabilumu ir padidintu išlaikomu katalitiniu aktyvumu | |
| PL2588492T3 (pl) | Polipeptyd mający aktywność beta-glukozydazy i jego zastosowania | |
| ZA201501541B (en) | Supported catalyst and active form thereof, and preparation method and use thereof | |
| ZA201207969B (en) | Vanadia-based denox catalysts and catalyst supports | |
| EP2551187A4 (en) | CAP, FIXED STRUCTURE THEREFOR AND PLANE WITH THAT FIXED STRUCTURE | |
| PT2718440T (pt) | Proteína que tem atividade de nuclease, proteínas de fusão e utilizações das mesmas | |
| SG2014011894A (en) | Catalyst support and catalysts prepared therefrom | |
| EP2468859A4 (en) | NEW PROTEIN WITH B-GLUCOSIDASE ACTIVITY AND ITS USE | |
| GB201103826D0 (en) | Exhaust system comprising nox storage catalyst and csf | |
| ZA201108577B (en) | Cellulase variants with improved expression, activity and/or stability, and use thereof | |
| ZA201300066B (en) | Fusion protein having factor vii activity | |
| SG10201507873YA (en) | Catalyst supports, catalysts and their manufacture and use | |
| PL2407147T3 (pl) | Kompozycja o działaniu bioregeneracyjnym, wzmacniającym i eutrofizującym | |
| EP2580231A4 (en) | PEPTIDES, CONSTRUCTIONS AND USES THEREOF | |
| EP2740797A4 (en) | PROTEIN MANIFESTANT ACTIVITY ENHANCING THE ENHANCEMENT OF THE FATTY ACIDS, GENE ENCODING SAME AND USE THEREOF | |
| EP2631249A4 (en) | FUSION PROTEIN WITH FACTOR IX EFFECT | |
| IL226108A0 (en) | Highly efficient catalysts, their preparation and use | |
| EP2781597A4 (en) | PROTEIN WITH GLYCOALKALOIDOBOSYNTHASE ACTIVITY AND GENE GENERATING THEREOF | |
| EP2417151B8 (fr) | Peptides cycliques à activité antiparasitaire | |
| HUE054139T2 (hu) | Béta-glukozidáz aktivitású polipeptid és alkalmazásai |