CN105296447A - 具有增强的稳定性和增强的保留催化活性的变体重组β-葡萄糖脑苷脂酶蛋白 - Google Patents
具有增强的稳定性和增强的保留催化活性的变体重组β-葡萄糖脑苷脂酶蛋白 Download PDFInfo
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- CN105296447A CN105296447A CN201510671991.0A CN201510671991A CN105296447A CN 105296447 A CN105296447 A CN 105296447A CN 201510671991 A CN201510671991 A CN 201510671991A CN 105296447 A CN105296447 A CN 105296447A
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- glucocerebrosidase
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- g1ccerase
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN114364794A (zh) * | 2019-09-09 | 2022-04-15 | 豪夫迈·罗氏有限公司 | 葡糖脑苷脂酶突变体 |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| US20220125892A1 (en) * | 2019-02-01 | 2022-04-28 | OXYRANE UK Ltd. | Glucocerebrosidase polypeptides |
| KR20210148101A (ko) | 2019-02-04 | 2021-12-07 | 프리라인 테라퓨틱스 리미티드 | 폴리뉴클레오티드 |
| CN115348884B (zh) * | 2020-03-29 | 2024-07-30 | 耶达研究及发展有限公司 | 用于治疗戈谢病的β-葡糖脑苷脂酶变体 |
| KR20230042513A (ko) * | 2020-07-29 | 2023-03-28 | 프리라인 테라퓨틱스 리미티드 | 폴리펩티드 |
| WO2023145812A1 (ja) * | 2022-01-31 | 2023-08-03 | 株式会社日本触媒 | グルコセレブロシダーゼ活性を有する糖鎖付加タンパク質 |
| JPWO2023145814A1 (https=) * | 2022-01-31 | 2023-08-03 | ||
| WO2023145813A1 (ja) * | 2022-01-31 | 2023-08-03 | 株式会社日本触媒 | グルコセレブロシダーゼ活性を有するタンパク質およびその製造方法 |
| EP4508206A1 (en) | 2022-04-12 | 2025-02-19 | F. Hoffmann-La Roche AG | Fusion proteins targeted to the central nervous system |
| CN118715316B (zh) * | 2022-10-08 | 2025-09-19 | 凌意(杭州)生物科技有限公司 | 用于治疗GCase缺乏相关疾病的多核苷酸 |
| TW202532096A (zh) * | 2023-12-08 | 2025-08-16 | 美商戴納立製藥公司 | 經修飾之葡萄糖腦苷脂酶多肽及其使用方法 |
| WO2026006173A1 (en) * | 2024-06-24 | 2026-01-02 | Denali Therapeutics Inc. | Fusion proteins comprising modified glucocerebrosidase polypeptides and methods thereof |
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| US20020127219A1 (en) * | 1999-12-30 | 2002-09-12 | Okkels Jens Sigurd | Lysosomal enzymes and lysosomal enzyme activators |
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| DE68926569T2 (de) | 1988-12-23 | 1996-09-26 | Genzyme Corp | Cho-zellen befähigt enzymatisch aktive rekombinante-glukocerebrosidase zu produzieren |
| EP0979311A1 (en) | 1997-04-30 | 2000-02-16 | Of The University Of Minnesota Regents | $i(IN VIVO) USE OF RECOMBINAGENIC OLIGONUCLEOBASES TO CORRECT GENETIC LESIONS IN HEPATOCYTES |
| US6524613B1 (en) | 1997-04-30 | 2003-02-25 | Regents Of The University Of Minnesota | Hepatocellular chimeraplasty |
| IL135578A0 (en) | 1997-10-29 | 2001-05-20 | Genzyme Corp | Compositions and methods for treating lysosomal storage disease |
| WO2000012740A2 (en) | 1998-08-28 | 2000-03-09 | Duke University | ADENOVIRUSES DELETED IN THE IVa2, 100K AND/OR PRETERMINAL PROTEIN SEQUENCES |
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| WO2005089047A2 (en) | 2004-03-18 | 2005-09-29 | Glycofi, Inc. | Glycosylated glucocerebrosidase expression in fungal hosts |
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